Primary Site >> Colorectal Cancer
Gene >> PLAUR
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Expression and release of plasminogen activators, their inhibitors and receptor by human tumor cell lines. PMID: 7872665 Ref: Human urokinase receptor expression is inhibited by amiloride and induced by tumor necrosis factor and phorbol ester in colon cancer cells. PMID: 7926038 Ref: Chromosomal localization of the human urokinase plasminogen activator receptor and plasminogen activator inhibitor type-2 genes: implications in colorectal cancer. PMID: 7948815 |
Ref: Plasmin-catalyzed proteolysis in colorectal neoplasia. PMID: 7553650 Ref: Antigen levels of urokinase plasminogen activator and its receptor at the tumor-host interface of colorectal adenocarcinomas are related to tumor aggressiveness. PMID: 7557947 Ref: Expression of urokinase receptor in various stromal-cell populations in human colon cancer: immunoelectron microscopical analysis. PMID: 7558416 Ref: Butyrate regulates gene expression of the plasminogen activating system in colon cancer cells. PMID: 7665235 Ref: Sodium butyrate inhibits expression of urokinase and its receptor mRNAs at both transcription and post-transcription levels in colon cancer cells. PMID: 7867787 |
Ref: A highly polymorphic CA/GT repeat in intron 3 of the human urokinase receptor gene (PLAUR). PMID: 8557253 Ref: Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene. PMID: 8798512 Ref: Modulation of the plasminogen activation system by inflammatory cytokines in human colon carcinoma cells. PMID: 8826848 |
Ref: ELISA determination of soluble urokinase receptor in blood from healthy donors and cancer patients. PMID: 9342006 |
Ref: Inhibition of establishment of primary and micrometastatic tumors by a urokinase plasminogen activator receptor antagonist. PMID: 9502073 Ref: Urokinase receptor genotypes in colorectal cancer. PMID: 9667756 Ref: Urokinase type plasminogen activator receptor expression in colorectal neoplasms. PMID: 9824607 Ref: Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice. PMID: 10326034 Ref: Urokinase receptor antagonists: novel agents for the treatment of cancer. PMID: 15991980 |
Ref: Plasma urokinase receptor levels in patients with colorectal cancer: relationship to prognosis. PMID: 10340907 Ref: A region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor. PMID: 10447677 Ref: Larger and more invasive colorectal carcinoma contains larger amounts of plasminogen activator inhibitor type 1 and its relative ratio over urokinase receptor correlates well with tumor size. PMID: 10594855 |
Ref: Clinicopathologic significance of urokinase receptor- and MMP-9-positive stromal cells in human colorectal cancer: functional multiplicity of matrix degradation on hematogenous metastasis. PMID: 10728590 Ref: The use of the CELLection kit in the isolation of carcinoma cells from mononuclear cell suspensions. PMID: 10758243 Ref: Urokinase-type plasminogen activator and its receptor in colorectal cancer: independent prognostic factors of metastasis and cancer-specific survival and potential therapeutic targets. PMID: 11008205 Ref: Plasminogen activator system, vascular endothelial growth factor, and colorectal cancer progression. PMID: 11193049 Ref: [The inhibitory effect of asODNs on the invasion of colorectal cancer cell line CCL229]. PMID: 12548848 |
Ref: Inhibition of colon cancer metastasis by a 3'- end antisense urokinase receptor mRNA in a nude mouse model. PMID: 11291054 Ref: Urokinase receptor and vascular endothelial growth factor are synergistically associated with the liver metastasis of colorectal cancer. PMID: 11376560 Ref: Hemostatic alterations in patients with benign and malignant colorectal disease during major abdominal surgery. PMID: 11738072 |
Ref: High tumor tissue concentration of plasminogen activator inhibitor 2 (PAI-2) is an independent marker for shorter progression-free survival in patients with early stage endometrial cancer. PMID: 11774293 Ref: Plasmin/plasminogen system in colorectal cancer. PMID: 11965442 Ref: Cytokeratin-positive cells in preoperative peripheral blood and bone marrow aspirates of patients with colorectal cancer. PMID: 12002413 Ref: Interferon-alpha (Intron A) upregulates urokinase-type plasminogen activator receptor gene expression. PMID: 12070711 Ref: Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. PMID: 12405290 Ref: Serum tetranectin is an independent prognostic marker in colorectal cancer and weakly correlated with plasma suPAR, plasma PAI-1 and serum CEA. PMID: 12529016 |
Ref: Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. PMID: 12615733 Ref: Quantitative expression of protein markers of plasminogen activation system in prognosis of colorectal cancer. PMID: 12619063 Ref: Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach. PMID: 12627382 Ref: Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells. PMID: 12675519 Ref: The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology. PMID: 12706368 Ref: Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin. PMID: 12856716 Ref: Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells. PMID: 12865932 Ref: ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. PMID: 12892714 Ref: Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. PMID: 12958170 Ref: Evaluation of urinary plasminogen activator, its receptor, matrix metalloproteinase-9, and von Willebrand factor in pancreatic cancer. PMID: 14581368 |
Ref: RNA interference-mediated silencing of the S100A10 gene attenuates plasmin generation and invasiveness of Colo 222 colorectal cancer cells. PMID: 14570893 Ref: Identification of Tcf-4 as a transcriptional target of p53 signalling. PMID: 14990988 Ref: Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness. PMID: 15004225 Ref: The prognostic value of plasma soluble urokinase plasminogen activator receptor (suPAR) levels in stage III ovarian cancer patients. PMID: 15274388 Ref: (177)Lu-Labeled DOTA-conjugated AE105 peptide (Asp-Cha-Phe-(d)Ser-(d)Arg-Tyr-Leu-Trp-Ser-CONH2) PMID: 23166959 |
Ref: Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. PMID: 15769846 Ref: Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor. PMID: 15849510 Ref: Association of interleukin-8 and plasminogen activator system in the progression of colorectal cancer. PMID: 16088182 Ref: A bisanthracycline (WP631) represses uPAR gene expression and cell migration of RKO colon cancer cells by interfering with transcription factor binding to a chromatin-accessible -148/-124 promoter region. PMID: 16261846 |
Ref: Specific immunofluorimetric assay detecting the chemotactic epitope of the urokinase receptor (uPAR). PMID: 16386755 Ref: Aspirin upregulates expression of urokinase type plasminogen activator receptor (uPAR) gene in human colon cancer cells through AP1. PMID: 16893520 Ref: Plasticity in urokinase-type plasminogen activator receptor (uPAR) display in colon cancer yields metastable subpopulations oscillating in cell surface uPAR density--implications in tumor progression. PMID: 16912170 Ref: Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer. PMID: 16916471 |
Ref: Different matrix micro-environments in colon cancer and diverticular disease. PMID: 17021746 Ref: Domain 5 of kininogen inhibits proliferation of human colon cancer cell line (HCT-116) by interfering with G1/S in the cell cycle. PMID: 17155949 Ref: Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer. PMID: 17510314 Ref: A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. PMID: 17893885 |
Ref: Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer. PMID: 18076013 Ref: Antigen levels of urokinase-type plasminogen activator receptor and its gene polymorphism related to microvessel density in colorectal cancer. PMID: 18511987 Ref: Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling. PMID: 18593907 Ref: Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas. PMID: 18619649 Ref: Differential proteome expression associated with urokinase plasminogen activator receptor (uPAR) suppression in malignant epithelial cancer. PMID: 18808175 |
Ref: New time-dependent approach to analyse the prognostic significance of immunohistochemical biomarkers in colon cancer and diffuse large B-cell lymphoma. PMID: 18977805 Ref: Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. PMID: 19123477 Ref: PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling. PMID: 19383367 Ref: Targeting the urokinase plasminogen activator receptor with a monoclonal antibody impairs the growth of human colorectal cancer in the liver. PMID: 19484792 Ref: Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells. PMID: 19540205 Ref: [Effects of allicin on invasion and metastasis of colon cancer LoVo cell line in vitro]. PMID: 19671326 Ref: Intact and cleaved forms of the urokinase receptor enhance discrimination of cancer from non-malignant conditions in patients presenting with symptoms related to colorectal cancer. PMID: 19672256 |
Ref: Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer. PMID: 19740518 Ref: Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells. PMID: 19782465 Ref: Selective suicide gene therapy of colon cancer exploiting the urokinase plasminogen activator receptor promoter. PMID: 20199127 Ref: Prognostic value of intact and cleaved forms of the urokinase plasminogen activator receptor in a retrospective study of 518 colorectal cancer patients. PMID: 20524776 Ref: DNAzyme as an efficient tool to modulate invasiveness of human carcinoma cells. PMID: 20725651 Ref: A pharmacological analysis of the cholinergic regulation of urokinase-type plasminogen activator secretion in the human colon cancer cell line, HT-29. PMID: 20727878 Ref: A new assay for measurement of the liberated domain I of the urokinase receptor in plasma improves the prediction of survival in colorectal cancer. PMID: 20802096 |
Ref: Expression and activation of proteases in co-cultures. PMID: 19836935 Ref: beta-Catenin and NF-kappaB cooperate to regulate the uPA/uPAR system in cancer cells. PMID: 20473943 Ref: Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells. PMID: 21576240 Ref: VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients. PMID: 21743435 Ref: Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients. PMID: 21744990 Ref: Clinical relevance of uPA, uPAR, PAI 1 and PAI 2 tissue expression and plasma PAI 1 level in colorectal carcinoma patients. PMID: 22234062 |
Ref: New peptide receptor radionuclide therapy of invasive cancer cells: in vivo studies using 177Lu-DOTA-AE105 targeting uPAR in human colorectal cancer xenografts. PMID: 22739362 Ref: Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade. PMID: 22927998 Ref: Metastasis-associated factors facilitating the progression of colorectal cancer. PMID: 22938401 |
Ref: The critical role of dysregulated FOXM1-PLAUR signaling in human colon cancer progression and metastasis. PMID: 23136192 Ref: Evaluation of alpha 1-antitrypsin and the levels of mRNA expression of matrix metalloproteinase 7, urokinase type plasminogen activator receptor and COX-2 for the diagnosis of colorectal cancer. PMID: 23300952 Ref: Human sprouty1 suppresses urokinase receptor-stimulated cell migration and invasion. PMID: 25937961 |
Ref: Urokinase-type plasminogen activator receptor (uPAR) on tumor-associated macrophages is a marker of poor prognosis in colorectal cancer. PMID: 24889870 Ref: Genome-wide analysis in human colorectal cancer cells reveals ischemia-mediated expression of motility genes via DNA hypomethylation. PMID: 25079072 Ref: Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway. PMID: 25113506 Ref: Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor. PMID: 25175595 Ref: Characterization of the interaction between heterodimeric alphavbeta6 integrin and urokinase plasminogen activator receptor (uPAR) using functional proteomics. PMID: 25318615 Ref: A8, an anti-uPA agonistic antibody, promotes metastasis of cancer cells via ERK pathway. PMID: 25357998 Ref: Soluble urokinase-type plasminogen activator receptor and ferritin concentration in patients with advanced alimentary tract carcinoma. Relationship to localization, surgical treatment and the stage of the disease--preliminary report. PMID: 25618124 |
Ref: Circulating intact and cleaved forms of the urokinase-type plasminogen activator receptor: biological variation, reference intervals and clinical useful cut-points. PMID: 25305537 Ref: Epithelial and stromal cell urokinase plasminogen activator receptor expression differentially correlates with survival in rectal cancer stages B and C patients. PMID: 25692297 Ref: uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery. PMID: 25895028 Ref: Spontaneous lung and lymph node metastasis in transgenic breast cancer is independent of the urokinase receptor uPAR. PMID: 26040548 Ref: Prognostic role of urokinase plasminogen activator receptor in gastric and colorectal cancer: A systematic review and meta-analysis. PMID: 26150727 Ref: [Molecular Image of Superparamagnetic Iron Oxide Nanopariticle Labeled with hATF in Colon Tumor Models]. PMID: 26964313 |
Ref: Adhesion molecules in peritoneal dissemination: function, prognostic relevance and therapeutic options. PMID: 27074785 |
Ref: LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells. PMID: 28238780 Ref: Prognostic Role of Circulating Soluble uPAR in Various Cancers: a Systematic Review and Meta-Analysis. PMID: 28627814 Ref: Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors. PMID: 28839232 Ref: Sushi repeat-containing protein X-linked 2 promotes angiogenesis through the urokinase-type plasminogen activator receptor dependent integrin alphavbeta3/focal adhesion kinase pathways. PMID: 28867754 Ref: A Preliminary Study of the Value of Plasma microRNA-193b and Soluble Urokinase-Type Plasminogen Activator Receptor in Identifying Patients with Early-Stage Colorectal Cancer and. PMID: 29226653 |
Ref: Up-regulation of miR-324-5p inhibits proliferation and invasion of colorectal cancer cells by targeting ELAVL1. PMID: 29386086 Ref: Serum levels of soluble urokinase plasminogen activator receptor (suPAR) predict outcome after resection of colorectal liver metastases. PMID: 29930748 Ref: Novel Inhibitors of Urokinase-type Plasminogen Activators: 4-(3H-imidazo[4,5-b]pyridin-2-yl)-N-Substituted Benzamide and Benzamidine Compounds. PMID: 30112993 |