Primary Site >> Colorectal Cancer

Gene >> PLA2G2A

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Ref: Absence of secretory phospholipase A2 gene alterations in human colorectal cancer.
PMID: 7585570
Ref: Human homologue of a candidate for the Mom1 locus, the secretory type II phospholipase A2 (PLA2S-II), maps to 1p35-36.1/D1S199.
PMID: 7585622
Ref: The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.
PMID: 7781071
Ref: Emergent issues in the genetics of intestinal neoplasia.
PMID: 8718526
 Ref: [Genetic steps in colorectal cancer].
PMID: 8920676
 Ref: Lack of phospholipase A2 mutations in neuroblastoma, melanoma and colon-cancer cell lines.
PMID: 9219842
Ref: Loss of the PLA2G2A gene in a sporadic colorectal tumor of a patient with a PLA2G2A germline mutation and absence of PLA2G2A germline alterations in patients with FAP.
PMID: 9272153
 Ref: Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients.
PMID: 9458096
Ref: The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions.
PMID: 9684289
Ref: Secretory type II phospholipase A2 (PLA2G2A) expression status in colorectal carcinoma derived cell lines and in normal colonic mucosa.
PMID: 9788445
Ref: Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells.
PMID: 9823300
 Ref: The effect of phospholipase A2 inhibitors on proliferation and apoptosis of murine intestinal cells.
PMID: 10334889
 Ref: Transcriptional regulation of cyclooxygenase-2 gene expression: novel effects of nonsteroidal anti-inflammatory drugs.
PMID: 10706128
Ref: The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64.
PMID: 10918573
Ref: Evaluation of 1p losses in primary carcinomas, local recurrences and peripheral metastases from colorectal cancer patients.
PMID: 11228544
 Ref: Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis.
PMID: 11274413
 Ref: Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis.
PMID: 11818567
 Ref: Generation of a unique strain of multiple intestinal neoplasia (Apc(+/Min-FCCC)) mice with significantly increased numbers of colorectal adenomas.
PMID: 15937958
 Ref: Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon.
PMID: 16969489
Ref: Platelet-activating factor and human meningiomas.
PMID: 17083481
 Ref: Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth.
PMID: 17091473
Ref: Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.
PMID: 17435219
Ref: Increased expression and activity of group IIA and X secretory phospholipase A2 in peritumoral versus central colon carcinoma tissue.
PMID: 17970059
 Ref: Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.
PMID: 18212756
Ref: The roles of sPLA2-IIA (Pla2g2a) in cancer of the small and large intestine.
PMID: 18508504
Ref: Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
PMID: 18992148
 Ref: PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma.
PMID: 19276398
Ref: Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and pathways.
PMID: 19759415
 Ref: Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases.
PMID: 20584290
Ref: The expression and distribution of group IIA phospholipase A2 in human colorectal tumours.
PMID: 20938784
 Ref: Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats.
PMID: 22496968
 Ref: Elevated phospholipase A2 activities in plasma samples from multiple cancers.
PMID: 23451150
 Ref: Human cancer xenografts in outbred nude mice can be confounded by polymorphisms in a modifier of tumorigenesis.
PMID: 24913681
 Ref: PLA2G2A overexpression is associated with poor therapeutic response and inferior outcome in rectal cancer patients receiving neoadjuvant concurrent chemoradiotherapy.
PMID: 25393083
 Ref: Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.
PMID: 27292189
 Ref: Group III phospholipase A2 promotes colitis and colorectal cancer.
PMID: 28947740