Primary Site >> Colorectal Cancer
Gene >> PIK3R1
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Ref: Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of phosphatidylinositol 3-kinase: use of the antibodies in recognition of mutant p85. PMID: 7541019 Ref: Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha. PMID: 7797556 |
Ref: A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. PMID: 11042696 |
Ref: The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. PMID: 11606375 |
Ref: Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. PMID: 14578160 |
Ref: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cells. PMID: 16127743 |
Ref: FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. PMID: 17317726 Ref: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. PMID: 17615082 |
Ref: Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. PMID: 17620308 Ref: Association between phosphatidylinositol 3-kinase regulatory subunit p85alpha Met326Ile genetic polymorphism and colon cancer risk. PMID: 18245521 |
Ref: Heregulin-induced VEGF expression via the ErbB3 signaling pathway in colon cancer. PMID: 19797898 Ref: Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. PMID: 19962665 |
Ref: Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. PMID: 21978709 |
Ref: PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer. PMID: 22285706 Ref: Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib. PMID: 22553375 |
Ref: PI3K is required for the physical interaction and functional inhibition of NF-kappaB by beta-catenin in colorectal cancer cells. PMID: 23583404 Ref: Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling. PMID: 23754208 |
Ref: The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study. PMID: 24700299 Ref: The double life of p85. PMID: 25314071 Ref: Comparison analysis in synchronous and metachronous metastatic colorectal cancer based on microarray expression profile. PMID: 25699354 |
Ref: Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/FoxO3a signalling in experimental colon cancer. PMID: 25554016 Ref: Screening of potential diagnostic markers and therapeutic targets against colorectal cancer. PMID: 26185457 Ref: Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PMID: 26469692 Ref: Activin and TGFbeta use diverging mitogenic signaling in advanced colon cancer. PMID: 26497569 |
Ref: Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway. PMID: 26530054 Ref: Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K. PMID: 26863299 Ref: Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression. PMID: 27096627 |
Ref: Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma. PMID: 28476018 Ref: Genome-wide network-based pathway analysis of CSF t-tau/Abeta1-42 ratio in the ADNI cohort. PMID: 28558704 Ref: Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. PMID: 28714374 Ref: alpha7 nicotinic acetylcholine receptor in tumor-associated macrophages inhibits colorectal cancer metastasis through the JAK2/STAT3 signaling pathway. PMID: 28901507 Ref: EGFR pathway subgroups in Chilean colorectal cancer patients, detected by mutational and expression profiles, associated to different clinicopathological features. PMID: 28936923 |
Ref: A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-kappaB Signaling in KRAS-Mutant Colon Cancer Cells. PMID: 29545333 Ref: Inflammatory genes are novel prognostic biomarkers for colorectal cancer. PMID: 29693170 Ref: miR-486-5p regulates the migration and invasion of colorectal cancer cells through targeting PIK3R1. PMID: 29725442 |