Primary Site >> Stomach Cancer
Gene >> PIK3CD
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Ref: Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. PMID: 15900596 |
Ref: How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions. PMID: 16627973 Ref: Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1. PMID: 16707418 Ref: FGF signaling network in the gastrointestinal tract (review). PMID: 16773196 Ref: CoCl2-induced HIF-1alpha expression correlates with proliferation and apoptosis in MKN-1 cells: a possible role for the PI3K/Akt pathway. PMID: 16865270 Ref: Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis. PMID: 17088902 |
Ref: RhoA and RhoC -siRNA inhibit the proliferation and invasiveness activity of human gastric carcinoma by Rho/PI3K/Akt pathway. PMID: 17659701 Ref: 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. PMID: 17680560 Ref: Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2. PMID: 18025257 Ref: Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin. PMID: 18365868 |
Ref: Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway. PMID: 18604870 Ref: Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells. PMID: 18627290 Ref: HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells. PMID: 18974395 Ref: [Impact of PI3K /Akt /mdm2 signaling pathway on the sensitivity of gastric cancer cell line SGC7901 to doxorubicin]. PMID: 19062713 |
Ref: Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. PMID: 18823436 Ref: Inhibition of PI3K/Akt partially leads to the inhibition of PrP(C)-induced drug resistance in gastric cancer cells. PMID: 19143835 Ref: Targeting apoptosis as an approach for gastrointestinal cancer therapy. PMID: 19278896 Ref: Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways. PMID: 19533808 Ref: Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells. PMID: 19755509 Ref: Macrophage migration inhibitory factor regulates proliferation of gastric cancer cells via the PI3K/Akt pathway. PMID: 19938192 |
Ref: BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. PMID: 19835871 Ref: Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines. PMID: 20428833 Ref: Programmed cell death 4 (PDCD4) enhances the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by inhibiting the PI3K/Akt signaling pathway. PMID: 20560677 Ref: The sequence-dependent cytotoxic effect of trastuzumab in combination with 5-Fluorouracil or cisplatin on gastric cancer cell lines. PMID: 20590442 Ref: Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals. PMID: 20600540 Ref: LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells. PMID: 20704765 Ref: Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway. PMID: 20718712 Ref: Blocking of PI3K/AKT induces apoptosis by its effect on NF-kappaB activity in gastric carcinoma cell line SGC7901. PMID: 20947290 Ref: Phosphoinositide 3-kinase/Akt and nuclear factor kappaB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells. PMID: 21472268 |
Ref: Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis. PMID: 20585984 Ref: Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells. PMID: 21287681 Ref: Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake. PMID: 21712451 Ref: Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. PMID: 21826665 Ref: Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells. PMID: 21943213 Ref: Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. PMID: 21975935 |
Ref: Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. PMID: 22139054 Ref: NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. PMID: 22159814 Ref: Regulation of SHP2 by PTEN/AKT/GSK-3beta signaling facilitates IFN-gamma resistance in hyperproliferating gastric cancer. PMID: 22325465 Ref: Anti-invasive effects of decitabine, a DNA methyltransferase inhibitor, through tightening of tight junctions and inhibition of matrix metalloproteinase activities in AGS human gastric carcinoma cells. PMID: 22710922 Ref: Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. PMID: 22876838 Ref: Notch2 regulates matrix metallopeptidase 9 via PI3K/AKT signaling in human gastric carcinoma cell MKN-45. PMID: 23326131 Ref: Roles of the PI3K/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implications. PMID: 24175221 |
Ref: Effect of PI3K gene silencing on growth, migration and related proteins expression of CD40 signal-mediated gastric cancer cells. PMID: 23114914 Ref: PI3K/Akt-dependent phosphorylation of GSK3beta and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration. PMID: 23123500 Ref: Cytotoxicity of 5-Aza-2'-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of P16(INK4A). PMID: 23201008 Ref: VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. PMID: 23270925 Ref: Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells. PMID: 23376640 Ref: Markers CD40, VEGF, AKT, PI3K, and S100 correlate with tumor stage in gastric cancer. PMID: 23429328 Ref: Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. PMID: 23432957 Ref: miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. PMID: 23466500 Ref: Effect of silencing of high mobility group A2 gene on gastric cancer MKN-45 cells. PMID: 23482887 Ref: PTEN expression and suppression of proliferation are associated with Cdx2 overexpression in gastric cancer cells. PMID: 23546539 Ref: A polymorphism (rs2295080) in mTOR promoter region and its association with gastric cancer in a Chinese population. PMID: 23555892 Ref: [Perspectives of the stomach cancer treatment: the introduction of molecular targeted therapy and the hope for cure]. PMID: 23575230 Ref: Inhibition of the PI3K/Akt pathway increases the chemosensitivity of gastric cancer to vincristine. PMID: 23743572 Ref: Anti-tumor effects of Mfn2 in gastric cancer. PMID: 23797661 Ref: Upregulation of GPR34 expression affects the progression and prognosis of human gastric adenocarcinoma by PI3K/PDK1/AKT pathway. PMID: 23836308 Ref: Capsosiphon fulvescens glycoprotein reduces AGS gastric cancer cell migration by downregulating transforming growth factor-beta1 and integrin expression. PMID: 23934170 Ref: Gastric cancer-molecular and clinical dimensions. PMID: 24061039 Ref: A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors. PMID: 24252402 Ref: Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase/Akt signal transduction in gastric cancer cells. PMID: 24273605 Ref: Akt inhibitors: mechanism of action and implications for anticancer therapeutics. PMID: 24330834 |
Ref: Tamoxifen reduces P-gp-mediated multidrug resistance via inhibiting the PI3K/Akt signaling pathway in ER-negative human gastric cancer cells. PMID: 24184201 Ref: PPP1R1B-STARD3 chimeric fusion transcript in human gastric cancer promotes tumorigenesis through activation of PI3K/AKT signaling. PMID: 24276243 Ref: Celastrol induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-kappaB signaling pathway. PMID: 24434352 Ref: Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways. PMID: 24504547 Ref: [Relationship between CD133 and chemoresistance in human gastric cancer and its associated mechanism]. PMID: 24577774 Ref: Her3 is associated with poor survival of gastric adenocarcinoma: Her3 promotes proliferation, survival and migration of human gastric cancer mediated by PI3K/AKT signaling pathway. PMID: 24623015 Ref: Celecoxib regulates apoptosis and autophagy via the PI3K/Akt signaling pathway in SGC-7901 gastric cancer cells. PMID: 24676394 Ref: MGr1-Ag/37LRP induces cell adhesion-mediated drug resistance through FAK/PI3K and MAPK pathway in gastric cancer. PMID: 24703465 Ref: Clinicopathological significance of PI3K, Akt and survivin expression in gastric cancer. PMID: 24726064 Ref: The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance. PMID: 24844205 Ref: Molecular basis underlying inhibition of metastasis of gastric cancer by anti-VEGFa treatment. PMID: 24850176 Ref: The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma. PMID: 25003395 Ref: beta-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway. PMID: 25009698 Ref: Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells. PMID: 25015565 Ref: Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer. PMID: 25119174 Ref: The role of HER3 in gastric cancer. PMID: 25194439 Ref: CEACAM6 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition via PI3K/AKT signaling pathway. PMID: 25398131 Ref: MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer. PMID: 25400827 Ref: Gastric Cancer: New Drugs - New Strategies. PMID: 26674336 Ref: PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways. PMID: 27919028 |
Ref: Effects of 5fluorouracil and class III phosphoinositide 3kinase small interfering RNA combination therapy on SGC7901 human gastric cancer cells. PMID: 25385552 Ref: Downregulation of c-Met expression does not enhance the sensitivity of gastric cancer cell line MKN-45 to gefitinib. PMID: 25395073 Ref: Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3beta and ZEB2 in the BGC-823 gastric cancer cell line. PMID: 25435948 Ref: The unfolded protein response potentiates epithelial-to-mesenchymal transition (EMT) of gastric cancer cells under severe hypoxic conditions. PMID: 25502090 Ref: CCR7 pathway induces epithelial-mesenchymal transition through up-regulation of Snail signaling in gastric cancer. PMID: 25572817 Ref: Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients. PMID: 25590580 Ref: Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells. PMID: 25609923 Ref: HER-2-induced PI3K signaling pathway was involved in the pathogenesis of gastric cancer. PMID: 25613482 Ref: G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro. PMID: 25673461 Ref: Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer. PMID: 25683757 Ref: Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. PMID: 25697906 Ref: Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis. PMID: 25703932 Ref: Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-kappaB signaling pathway for gastric cancer metastasis. PMID: 25727320 Ref: Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and N PMID: 25767376 Ref: Hyperglycemia Promotes Human Gastric Carcinoma Progression via Aquaporin 3. PMID: 25777259 Ref: Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells. PMID: 25777964 Ref: Anthocyanins From the Fruit of Vitis coignetiae Pulliat Potentiate the Cisplatin Activity by Inhibiting PI3K/Akt Signaling Pathways in Human Gastric Cancer Cells. PMID: 25853103 Ref: Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells. PMID: 25872479 Ref: Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer. PMID: 25909166 Ref: Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. PMID: 25981581 Ref: Metformin inhibits gastric cancer via the inhibition of HIF1alpha/PKM2 signaling. PMID: 26101707 Ref: Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling. PMID: 26109806 Ref: Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells. PMID: 26171059 Ref: Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. PMID: 26201693 Ref: HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-kappaB activation. PMID: 26259977 Ref: Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling. PMID: 26317215 Ref: Association of MTOR and AKT Gene Polymorphisms with Susceptibility and Survival of Gastric Cancer. PMID: 26317520 Ref: The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis. PMID: 26366097 Ref: [miR-29b Reduces Cisplatin Resistance of Gastric Cancer Cell by Targeting PI3K/Akt Pathway]. PMID: 26564501 Ref: Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway. PMID: 26622467 Ref: Role of annexin A6 in cancer. PMID: 26622779 |
Ref: Potential role of O-GlcNAcylation and involvement of PI3K/Akt1 pathway in the expression of oncogenic phenotypes of gastric cancer cells in vitro. PMID: 26333304 Ref: Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN-regulated PI3K/Akt signaling pathway. PMID: 26530632 Ref: 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone, a polymethoxyflavone, exerts antitumor effect on PI3K/Akt signaling pathway in human gastric cancer cell BGC-7901. PMID: 26671739 Ref: The proliferation impairment induced by AQP3 deficiency is the result of glycerol uptake and metabolism inhibition in gastric cancer cells. PMID: 26768614 Ref: DCT015, a new sorafenib derivate, inhibits tumor growth and angiogenesis in gastric cancer models. PMID: 26768619 Ref: C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits. PMID: 26855187 Ref: Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cells. PMID: 26877709 Ref: PlGF knockdown inhibited tumor survival and migration in gastric cancer cell via PI3K/Akt and p38MAPK pathways. PMID: 26968576 Ref: miR-196b regulates gastric cancer cell proliferation and invasion via PI3K/AKT/mTOR signaling pathway. PMID: 26998071 Ref: Grifola frondosa Glycoprotein GFG-3a Arrests S phase, Alters Proteome, and Induces Apoptosis in Human Gastric Cancer Cells. PMID: 27040446 Ref: Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma. PMID: 27058427 Ref: AURKA induces EMT by regulating histone modification through Wnt/beta-catenin and PI3K/Akt signaling pathway in gastric cancer. PMID: 27121204 Ref: PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells. PMID: 27147579 Ref: JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients. PMID: 27167206 Ref: High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial. PMID: 27179038 Ref: Recent updates of precision therapy for gastric cancer: Towards optimal tailored management. PMID: 27217696 Ref: The natural secolignan peperomin E induces apoptosis of human gastric carcinoma cells via the mitochondrial and PI3K/Akt signaling pathways in vitro and in vivo. PMID: 27288917 Ref: Autophagy regulation and its role in gastric cancer and colorectal cancer. PMID: 27314289 Ref: Gastrokine-2 suppresses epithelial mesenchymal transition through PI3K/AKT/GSK3beta signaling in gastric cancer. PMID: 27323966 Ref: Type II cGMPdependent protein kinase inhibits EGFinduced JAK/STAT signaling in gastric cancer cells. PMID: 27357186 Ref: CXCL10/CXCR3 axis promotes the invasion of gastric cancer via PI3K/AKT pathway-dependent MMPs production. PMID: 27470388 Ref: Sinularin Induces Apoptosis through Mitochondria Dysfunction and Inactivation of the pI3K/Akt/mTOR Pathway in Gastric Carcinoma Cells. PMID: 27472346 Ref: Amarogentin secoiridoid inhibits in vivo cancer cell growth in xenograft mice model and induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. PMID: 27569081 Ref: PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. PMID: 27572739 Ref: Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer. PMID: 27573785 Ref: Bone marrow-derived mesenchymal stem cells increase drug resistance in CD133-expressing gastric cancer cells by regulating the PI3K/AKT pathway. PMID: 27619680 Ref: Matrine Suppresses Proliferation and Invasion of SGC7901 Cells through Inactivation of PI3K/Akt/uPA Pathway. PMID: 27650610 Ref: Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway. PMID: 27659528 Ref: Knockdown of Rap1b Enhances Apoptosis and Autophagy in Gastric Cancer Cells via the PI3K/Akt/mTOR Pathway. PMID: 27712585 Ref: Identification of HRAS as cancer-promoting gene in gastric carcinoma cell aggressiveness. PMID: 27725900 Ref: Erratum: Amarogentin secoiridoid inhibits in vivo cancer cell growth in xenograft mice model and induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. PMID: 27837645 Ref: Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes? PMID: 27915478 |
Ref: Liver X receptor alpha (LXRalpha) promoted invasion and EMT of gastric cancer cells by regulation of NF-kappaB activity. PMID: 28091828 Ref: Cordycepin induces apoptosis in SGC7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS. PMID: 28197639 Ref: UBE2C induces EMT through Wnt/betacatenin and PI3K/Akt signaling pathways by regulating phosphorylation levels of Aurora-A. PMID: 28260026 Ref: FGF7/FGFR2 signal promotes invasion and migration in human gastric cancer through upregulation of thrombospondin-1. PMID: 28339036 Ref: Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3beta activation. PMID: 28345638 Ref: Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer. PMID: 28460635 Ref: Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer. PMID: 28476678 Ref: miR-200b inhibits CD133(+) glioma cells by targeting the AKT pathway. PMID: 28599471 Ref: MicroRNA-630 Suppresses Epithelial-to-Mesenchymal Transition by Regulating FoxM1 in Gastric Cancer Cells. PMID: 28601080 Ref: The Wnt/beta-catenin and PI3K/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation. PMID: 28671020 Ref: Research on the mechanism of HP mediated PI3K/AKT/GSK3beta pathways in gastric cancer. PMID: 28745795 Ref: Luteolin induces apoptosis in vitro through suppressing the MAPK and PI3K signaling pathways in gastric cancer. PMID: 28789432 Ref: Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1/PI3K/Akt signaling pathway. PMID: 28847482 Ref: AKT inhibition is an effective treatment strategy in ARID1A-deficient gastric cancer cells. PMID: 28860825 Ref: ERp29 controls invasion and metastasis of gastric carcinoma by inhibition of epithelial-mesenchymal transition via PI3K/Aktsignaling pathway. PMID: 28874138 Ref: Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway. PMID: 28881639 Ref: Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN. PMID: 28950928 Ref: PTEN Gene Induces Cell Invasion and Migration via Regulating AKT/GSK-3beta/beta-Catenin Signaling Pathway in Human Gastric Cancer. PMID: 29030742 Ref: MiR-129 inhibits cell proliferation and metastasis by targeting ETS1 via PI3K/AKT/mTOR pathway in prostate cancer. PMID: 29035829 Ref: Mcl-1 stabilization confers resistance to taxol in human gastric cancer. PMID: 29137317 Ref: Expression of the beta3 subunit of Na(+)/K(+)-ATPase is increased in gastric cancer and regulates gastric cancer cell progression and prognosis via the PI3/AKT pathway. PMID: 29137423 Ref: Enhancing conventional chemotherapy drug cisplatin-induced anti-tumor effects on human gastric cancer cells both in vitro and in vivo by Thymoquinone targeting PTEN gene. PMID: 29156767 Ref: Prognostic implications of phosphatidylinositol 3-kinase/AKT signaling pathway activation in gastric carcinomas. PMID: 29181056 Ref: DNA Methylation-Mediated Silencing of Regenerating Protein 1 Alpha (REG1A) Affects Gastric Cancer Prognosis. PMID: 29222406 Ref: Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway. PMID: 29229873 Ref: Long non-coding RNA CRNDE is a novel tumor promoter by modulating PI3K/AKT signal pathways in human gastric cancer. PMID: 29243780 Ref: LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway. PMID: 29282102 Ref: Imperatorin shows selective antitumor effects in SGC-7901 human gastric adenocarcinoma cells by inducing apoptosis, cell cycle arrest and targeting PI3K/Akt/m-TOR signalling pathway. PMID: 29332340 Ref: CD133 mediates the TGF-beta1-induced activation of the PI3K/ERK/P70S6K signaling pathway in gastric cancer cells. PMID: 29344155 Ref: Combination of cecropinXJ and LY294002 induces synergistic cytotoxicity, and apoptosis in human gastric cancer cells via inhibition of the PI3K/Akt signaling pathway. PMID: 29344198 |
Ref: Complement C5a/C5aR pathway potentiates the pathogenesis of gastric cancer by down-regulating p21 expression. PMID: 29031586 Ref: Knockdown of long non-coding RNA HOTAIR inhibits cisplatin resistance of gastric cancer cells through inhibiting the PI3K/Akt and Wnt/beta-catenin signaling pathways by up-regulating miR-34a. PMID: 29080815 Ref: The screening and analysis of protein signatures and signaling associated with chemoresistance based on Protein Pathway Array technology in gastric cancer. PMID: 29115543 Ref: Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k-Akt signaling pathway. PMID: 29143985 Ref: Nectin-4 promotes gastric cancer progression via the PI3K/AKT signaling pathway. PMID: 29208564 Ref: NES1/KLK10 promotes trastuzumab resistance via activation of PI3K/AKT signaling pathway in gastric cancer. PMID: 29231994 Ref: MicroRNA-28 promotes cell proliferation and invasion in gastric cancer via the PTEN/PI3K/AKT signalling pathway. PMID: 29257342 Ref: F-box protein 11 promotes the growth and metastasis of gastric cancer via PI3K/AKT pathway-mediated EMT. PMID: 29278851 Ref: Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway. PMID: 29374144 Ref: Association of mast cell infiltration with gastric cancer progression. PMID: 29422964 Ref: Clinical value of CagA, c-Met, PI3K and Beclin-1 expressed in gastric cancer and their association with prognosis. PMID: 29422968 Ref: Effect of silencing colon cancer-associated transcript 2 on the proliferation, apoptosis and autophagy of gastric cancer BGC-823 cells. PMID: 29435046 Ref: MiR-361-5p suppresses chemoresistance of gastric cancer cells by targeting FOXM1 via the PI3K/Akt/mTOR pathway. PMID: 29435149 Ref: Astragaloside IV inhibits TGF-beta1-induced epithelial-mesenchymal transition through inhibition of the PI3K/Akt/NF-kappaB pathway in gastric cancer cells. PMID: 29480652 Ref: Osthole inhibits gastric cancer cell proliferation through regulation of PI3K/AKT. PMID: 29590128 Ref: ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway. PMID: 29620274 Ref: Genomic Profiling of HER2-Positive Gastric Cancer: PI3K/Akt/mTOR Pathway as Predictor of Outcomes in HER2-Positive Advanced Gastric Cancer Treated with Trastuzumab. PMID: 29700210 Ref: miR-1236-3p inhibits invasion and metastasis in gastric cancer by targeting MTA2. PMID: 29743816 Ref: Combined treatment with PI3K inhibitor BKM120 and PARP inhibitor olaparib is effective in inhibiting the gastric cancer cells with ARID1A deficiency. PMID: 29767248 Ref: High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer. PMID: 29767389 Ref: Inhibitor of growth 3 induces cell death by regulating cell proliferation, apoptosis and cell cycle arrest by blocking the PI3K/AKT pathway. PMID: 29855536 Ref: Downregulation of HIF-1alpha inhibits the proliferation, migration and invasion of gastric cancer by inhibiting PI3K/AKT pathway and VEGF expression. PMID: 29899167 Ref: Overexpression of retinoblastomabinding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3kinase/protein kinase B pathway suppression. PMID: 29901205 Ref: HGF derived from cancerassociated fibroblasts promotes vascularization in gastric cancer via PI3K/AKT and ERK1/2 signaling. PMID: 29917165 Ref: IL-1beta promotes the nuclear translocaiton of S100A4 protein in gastric cancer cells MGC803 and the cell's stem-like properties through PI3K pathway. PMID: 29932233 Ref: PKG II inhibits PDGF-BB triggered biological activities by phosphorylating PDGFRbeta in gastric cancer cells. PMID: 29935031 Ref: Anticancer effect of YWHAZ silencing via inducing apoptosis and autophagy in gastric cancer cells. PMID: 29940752 Ref: Aclidinium bromide inhibits the growth and metastasis of gastric cancer MKN28 cells via the PI3K signaling pathway. PMID: 29956761 Ref: Vasodilator-stimulated phosphoprotein (VASP), a novel target of miR-4455, promotes gastric cancer cell proliferation, migration, and invasion, through activating the PI3K/AKT signaling pathway. PMID: 30002604 Ref: miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop. PMID: 30012200 Ref: DcR3 induces proliferation, migration, invasion, and EMT in gastric cancer cells via the PI3K/AKT/GSK-3beta/beta-catenin signaling pathway. PMID: 30050309 Ref: NOX4, A New Genetic Target for Anti-cancer Therapy in Digestive System Cancer. PMID: 30058122 Ref: Neogenin-1 Promotes Cell Proliferation, Motility, and Adhesion by Up-Regulation of Zinc Finger E-Box Binding Homeobox 1 Via Activating the Rac1/PI3K/AKT Pathway in Gastric Cancer Cells. PMID: 30064133 Ref: E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function. PMID: 30066183 Ref: Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. PMID: 30066879 Ref: Down-regulation of lncRNA ADAMTS9-AS2 contributes to gastric cancer development via activation of PI3K/Akt pathway. PMID: 30089248 Ref: [Wogonoside reverses cisplatin resistance in SGC7901/cDDP cells through inhibition of PI3K/Akt/Nrf2/ARE signaling pathway]. PMID: 30112565 Ref: Anticancer effect of resibufogenin on gastric carcinoma cells through the phosphoinositide 3-kinase/protein kinase B/glycogen synthase kinase 3beta signaling pathway. PMID: 30127928 Ref: Knockdown of long noncoding RNA urothelial carcinoma-associated 1 inhibits cell viability, migration, and invasion by regulating microRNA-182 in gastric carcinoma. PMID: 30129054 Ref: High miR-718 Suppresses Phosphatase and Tensin Homolog (PTEN) Expression and Correlates to Unfavorable Prognosis in Gastric Cancer. PMID: 30131483 Ref: Sh-MARCH8 Inhibits Tumorigenesis via PI3K Pathway in Gastric Cancer. PMID: 30138931 Ref: Knockdown of TMPRSS3 inhibits gastric cancer cell proliferation, invasion and EMT via regulation of the ERK1/2 and PI3K/Akt pathways. PMID: 30142546 Ref: Bacillomycin D-C16 triggers apoptosis of gastric cancer cells through the PI3K/Akt and FoxO3a signaling pathways. PMID: 30169424 Ref: Geniposide suppresses growth, migration and invasion of MKN45 cells by down-regulation of lncRNA HULC. PMID: 30176223 Ref: Knockdown of CEACAM19 suppresses human gastric cancer through inhibition of PI3K/Akt and NF-kappaB. PMID: 30217308 Ref: Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling. PMID: 30246429 Ref: Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in gastric cancer. PMID: 30250639 Ref: F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway. PMID: 30257389 Ref: MicroRNA495 regulates human gastric cancer cell apoptosis and migration through Akt and mTOR signaling. PMID: 30272336 Ref: Dual inhibitor of PI3K and mTOR (NVP-BEZ235) augments the efficacy of fluorouracil on gastric cancer chemotherapy. PMID: 30275715 Ref: Downregulation of microRNA-4295 enhances cisplatin-induced gastric cancer cell apoptosis through the EGFR/PI3K/Akt signaling pathway by targeting LRIG1. PMID: 30320337 Ref: Methionine enkephalin (MENK) inhibits human gastric cancer through regulating tumor associated macrophages (TAMs) and PI3K/AKT/mTOR signaling pathway inside cancer cells. PMID: 30343258 Ref: Analysis of correlation between HP infection and activation of PI3K/Akt pathway in mucosal tissues of gastric cancer and precancerous lesions. PMID: 30344716 Ref: Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1alpha signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo. PMID: 30349304 Ref: NUCKS1 promotes gastric cancer cell aggressiveness by upregulating IGF-1R and subsequently activating the PI3K/Akt/mTOR signaling pathway. PMID: 30371738 |