Primary Site >> Biliary tract Cancer
Gene >> PIK3CD
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Ref: The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines. PMID: 16525641 |
Ref: Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion. PMID: 17461449 |
Ref: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. PMID: 19445727 |
Ref: Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion. PMID: 20135719 Ref: Induction of MKP-1 prevents the cytotoxic effects of PI3K inhibition in hilar cholangiocarcinoma cells. PMID: 20145951 |
Ref: Periostin activates integrin alpha5beta1 through a PI3K/AKTdependent pathway in invasion of cholangiocarcinoma. PMID: 22735632 Ref: Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability. PMID: 22762308 |
Ref: Regional differences in gallbladder cancer pathogenesis: insights from a comparison of cell cycle-regulatory, PI3K, and pro-angiogenic protein expression. PMID: 23212762 Ref: Genetic and epigenetic alterations are involved in the regulation of TPM1 in cholangiocarcinoma. PMID: 23254774 Ref: Contribution of the PI3K/MMPs/Ln-5gamma2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas. PMID: 23588386 Ref: Suppression of cholangiocarcinoma cell growth by human umbilical cord mesenchymal stem cells: a possible role of Wnt and Akt signaling. PMID: 23646150 Ref: Down-regulation of Gab1 inhibits cell proliferation and migration in hilar cholangiocarcinoma. PMID: 24312291 |
Ref: Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5gamma2 signaling pathway. PMID: 24628713 Ref: Role of aberrant PI3K pathway activation in gallbladder tumorigenesis. PMID: 24658595 Ref: Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma. PMID: 24796583 |
Ref: Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy. PMID: 25639632 Ref: Gab1 regulates proliferation and migration through the PI3K/Akt signaling pathway in intrahepatic cholangiocarcinoma. PMID: 26014518 Ref: Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer. PMID: 26294099 Ref: Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway. PMID: 26823715 |
Ref: LTbetaR signalling preferentially accelerates oncogenic AKT-initiated liver tumours. PMID: 26206664 Ref: Somatic Mutations of PI3K in Early and Advanced Gallbladder Cancer: Additional Options for an Orphan Cancer. PMID: 26947513 Ref: A novel PI3K/AKT signaling axis mediates Nectin-4-induced gallbladder cancer cell proliferation, metastasis and tumor growth. PMID: 26949052 Ref: Corrigendum to PMID: 27125425 Ref: Knockdown of Sall4 inhibits intrahepatic cholangiocarcinoma cell migration and invasion in ICC-9810 cells. PMID: 27601921 Ref: Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway. PMID: 27655691 Ref: Upregulation of long non-coding RNA LINC00152 by SP1 contributes to gallbladder cancer cell growth and tumor metastasis via PI3K/AKT pathway. PMID: 27829993 |
Ref: Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities. PMID: 27811010 Ref: Signaling pathways as therapeutic targets in biliary tract cancer. PMID: 28282502 Ref: TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. PMID: 28423362 Ref: Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling. PMID: 28656003 Ref: Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway. PMID: 28766687 Ref: Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma. PMID: 28902342 |
Ref: Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway. PMID: 29170841 Ref: STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma. PMID: 29413947 Ref: miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma. PMID: 29416013 Ref: PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay. PMID: 29474549 Ref: Knockdown of TRIM31 suppresses proliferation and invasion of gallbladder cancer cells by down-regulating MMP2/9 through the PI3K/Akt signaling pathway. PMID: 29864908 Ref: CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K/Akt pathway in gallbladder cancer. PMID: 30276551 Ref: Targeting phosphoinositide-3-kinase pathway in biliary tract cancers: A remedial route? PMID: 30370571 |