Primary Site >> Colorectal Cancer
Gene >> PIK3CB
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Ref: A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon. PMID: 9822674 |
Ref: A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. PMID: 11042696 |
Ref: TGF-beta inhibits Akt-induced transformation in intestinal epithelial cells. PMID: 16904986 |
Ref: Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B. PMID: 17671195 |
Ref: PTEN-deficient cancers depend on PIK3CB. PMID: 18755892 Ref: The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion. PMID: 18837901 |
Ref: The p110alpha and p110beta isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells. PMID: 20953381 |
Ref: Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. PMID: 21673091 |
Ref: Studies on the expression patterns of class I PI3K catalytic subunits and its prognostic significance in colorectal cancer. PMID: 21910030 Ref: Down-regulation of p110beta expression increases chemosensitivity of colon cancer cell lines to oxaliplatin. PMID: 22528234 |
Ref: TLR4 activates the beta-catenin pathway to cause intestinal neoplasia. PMID: 23691015 |
Ref: WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear beta-Catenin depend on active PI3K signaling. PMID: 24930890 Ref: Phosphatidylinositol 3-kinase CB association with preoperative radiotherapy response in rectal adenocarcinoma. PMID: 25473181 Ref: PIK3CA and PIK3CB expression and relationship with multidrug resistance in colorectal carcinoma. PMID: 25550888 |
Ref: Frameshift mutations in mammalian target of rapamycin pathway genes and their regional heterogeneity in sporadic colorectal cancers. PMID: 25776026 |
Ref: Bioinformatic analyses revealed underlying biological functions correlated with oxaliplatin responsiveness. PMID: 26232912 Ref: PIK3CA and PIK3CB silencing by RNAi reverse MDR and inhibit tumorigenic properties in human colorectal carcinoma. PMID: 26747178 Ref: Gankyrin sustains PI3K/GSK-3beta/beta-catenin signal activation and promotes colorectal cancer aggressiveness and progression. PMID: 27835604 |
Ref: Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway. PMID: 28107519 Ref: Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/beta-Catenin and PI3K/Akt Signaling. PMID: 28939743 |