Primary Site >> Stomach Cancer
Gene >> PIK3CA
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Ref: Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma. PMID: 12569555 |
Ref: Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. PMID: 15289301 |
Ref: PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. PMID: 15608678 Ref: Mutations of PIK3CA in gastric adenocarcinoma. PMID: 15784156 Ref: The prevalence of PIK3CA mutations in gastric and colon cancer. PMID: 15994075 Ref: Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis. PMID: 16086234 Ref: Epithelial-mesenchymal transition in gastric cancer (Review). PMID: 16273224 Ref: ERBB2 kinase domain mutation in a gastric cancer metastasis. PMID: 16309427 |
Ref: Somatic mutations of the ERBB4 kinase domain in human cancers. PMID: 16187281 Ref: Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation. PMID: 16395716 Ref: Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. PMID: 16397024 Ref: Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas. PMID: 17047397 |
Ref: Molecular targets and biological modifiers in gastric cancer. PMID: 19013893 |
Ref: Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen. PMID: 19938198 |
Ref: The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type. PMID: 20398348 Ref: Up-regulation of PIK3CA promotes metastasis in gastric carcinoma. PMID: 20954287 |
Ref: Oncogenic mutations in gastric cancer with microsatellite instability. PMID: 20937558 Ref: Expression of PIK3CA and FOXP1 in gastric and intestinal non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue type. PMID: 21660567 Ref: RNAi knockdown of PIK3CA preferentially inhibits invasion of mutant PIK3CA cells. PMID: 21990951 |
Ref: Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer. PMID: 22292935 Ref: Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of rapamycin inhibition and 5-fluorouracil in PIK3CA mutant gastric cancer cells. PMID: 22336586 Ref: Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells. PMID: 22337890 Ref: Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. PMID: 22484628 Ref: Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines. PMID: 22543857 Ref: Detection of kinase amplifications in gastric cancer archives using fluorescence in situ hybridization. PMID: 22691185 Ref: High-throughput mutation profiling identifies frequent somatic mutations in advanced gastric adenocarcinoma. PMID: 22723903 Ref: Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models. PMID: 22935382 Ref: [Genetic and epigenetic alterations in gastric carcinogenesis]. PMID: 23198549 Ref: Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer. PMID: 23236232 |
Ref: A clinical-biological risk stratification model for resected gastric cancer: prognostic impact of Her2, Fhit, and APC expression status. PMID: 23131390 Ref: Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. PMID: 23196062 Ref: An alpha-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. PMID: 23208944 Ref: VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. PMID: 23270925 Ref: Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer. PMID: 23813545 Ref: Towards the goal of personalized medicine in gastric cancer--time to move beyond HER2 inhibition. Part I: Targeting receptor tyrosine kinase gene amplification. PMID: 23819947 Ref: Prognostic and putative predictive biomarkers of gastric cancer for personalized medicine. PMID: 23846438 Ref: Towards the goal of personalized medicine in gastric cancer--time to move beyond HER2 inhibition. Part II: Targeting gene mutations and gene amplifications and the angiogenesis pathway. PMID: 23911227 Ref: Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110alpha inhibitor potently blocks PI3K signaling and growth of HER2+ breast cancers. PMID: 23918797 Ref: Phase I study of everolimus and mitomycin C for patients with metastatic esophagogastric adenocarcinoma. PMID: 23930209 Ref: Concomitant PIK3CA amplification and RASSF1A or PAX6 hypermethylation predict worse survival in gastric cancer. PMID: 24513424 |
Ref: Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: meta-analysis, co-occurrence and ethnic variation. PMID: 23960014 Ref: TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer. PMID: 24178904 Ref: The forkhead transcription factor FOXO1 mediates cisplatin resistance in gastric cancer cells by activating phosphoinositide 3-kinase/Akt pathway. PMID: 24202965 Ref: HER2 expression and PI3K-Akt pathway alterations in gastric cancer. PMID: 24458107 Ref: SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review. PMID: 24503755 Ref: Concomitant PIK3CA amplification and RASSF1A or PAX6 hypermethylation predict worse survival in gastric cancer. PMID: 24505629 Ref: Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype. PMID: 24597478 Ref: Cancers of the upper gastro-intestinal tract: a review of somatic mutation distributions. PMID: 24724606 Ref: A GG allele of 3'-side AKT1 SNP is associated with decreased AKT1 activation and better prognosis of gastric cancer. PMID: 24737346 Ref: Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer. PMID: 24774510 Ref: MiRNA-34a inhibits EGFR-signaling-dependent MMP7 activation in gastric cancer. PMID: 24981249 Ref: The mutational burdens and evolutionary ages of early gastric cancers are comparable to those of advanced gastric cancers. PMID: 25042771 Ref: [Chitosan/PIK3CA siRNA nanoparticle-mediated PIK3CA gene interference decreases the invasive capacity of gastric cancer cells in vitro]. PMID: 25345950 Ref: High-throughput sequencing and copy number variation detection using formalin fixed embedded tissue in metastatic gastric cancer. PMID: 25372287 Ref: Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer. PMID: 25771729 |
Ref: Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. PMID: 24510342 Ref: PTEN deficiency as a predictive biomarker of resistance to HER2-targeted therapy in advanced gastric cancer. PMID: 25300346 Ref: Genomic assays for Epstein-Barr virus-positive gastric adenocarcinoma. PMID: 25613731 Ref: Update on Epstein-Barr virus and gastric cancer (review). PMID: 25633561 Ref: Tumor profiling of gastric and esophageal carcinoma reveal different treatment options. PMID: 25778705 Ref: Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer. PMID: 25815786 Ref: Prospective comprehensive genomic profiling of advanced gastric carcinoma cases reveals frequent clinically relevant genomic alterations and new routes for targeted therapies. PMID: 25882375 Ref: Successful control of heavily pretreated metastatic gastric cancer with the mTOR inhibitor everolimus (RAD001) in a patient with PIK3CA mutation and pS6 overexpression. PMID: 25886409 Ref: alpha-Fetoprotein-Producing Hepatoid Gastric Adenocarcinoma With Osteoclast-Like Giant Cells and Neuroendocrine Differentiation: A Case Study With Molecular Profiling. PMID: 26009570 Ref: Downregulation of miR203 induces overexpression of PIK3CA and predicts poor prognosis of gastric cancer patients. PMID: 26213461 Ref: Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer. PMID: 26334097 Ref: Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell Machineries and Somatic Gene Mutations. PMID: 26337667 Ref: Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer. PMID: 26401016 Ref: Overexpression of PI3K p110alpha contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts. PMID: 26543351 Ref: Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? PMID: 26604635 |
Ref: MET in gastric cancer--discarding a 10% cutoff rule. PMID: 26033401 Ref: Clinicopathological characteristics of RHOA mutations in a Central European gastric cancer cohort. PMID: 26251521 Ref: Comprehensive analyses using next-generation sequencing and immunohistochemistry enable precise treatment in advanced gastric cancer. PMID: 26489445 Ref: Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers. PMID: 26701847 Ref: Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites. PMID: 26811494 Ref: Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus. PMID: 26859683 Ref: Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems. PMID: 26955870 Ref: Comprehensive molecular portrait using next generation sequencing of resected intestinal-type gastric cancer patients dichotomized according to prognosis. PMID: 26961069 Ref: Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus-associated gastric carcinoma. PMID: 26980034 Ref: PD-L1 is an independent prognostic predictor in gastric cancer of Western patients. PMID: 27009855 Ref: The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines. PMID: 27156070 Ref: The Inositide Signaling Pathway As a Target for Treating Gastric Cancer and Colorectal Cancer. PMID: 27242542 Ref: Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1. PMID: 27323812 Ref: [New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "a la carte" treatment?]. PMID: 27345450 Ref: Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review. PMID: 27388016 Ref: Clinicopathological Significance of Elevated PIK3CA Expression in Gastric Cancer. PMID: 27433393 |
Ref: Epstein-Barr Virus-associated Gastric Cancer and Potential Mechanisms of Oncogenesis. PMID: 27677953 Ref: Discordance of Somatic Mutations Between Asian and Caucasian Patient Populations with Gastric Cancer. PMID: 28039579 Ref: Epstein-Barr virus-associated gastric cancer reveals intratumoral heterogeneity of PIK3CA mutations. PMID: 28453696 Ref: Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers. PMID: 28522256 Ref: Expression of Phosphoinositide 3-Kinase p110alpha and p110beta Subunits and PIK3CA Mutation in Patients With Advanced Gastric Carcinoma. PMID: 28549032 Ref: KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer. PMID: 28581513 Ref: Genomic Profiling of Small-Bowel Adenocarcinoma. PMID: 28617917 Ref: Distribution of somatic mutations of cancer-related genes according to microsatellite instability status in Korean gastric cancer. PMID: 28640116 Ref: Pilot study of sirolimus in patients with PIK3CA mutant/amplified refractory solid cancer. PMID: 28685070 Ref: Genomic alterations in advanced gastric cancer endoscopic biopsy samples using targeted next-generation sequencing. PMID: 28744403 Ref: PIK3CA mutations are associated with increased tumor aggressiveness and Akt activation in gastric cancer. PMID: 29207615 Ref: Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis. PMID: 29237412 Ref: Correlation between MEK signature and Ras gene alteration in advanced gastric cancer. PMID: 29296181 Ref: Study on the association between PI3K/AKT/mTOR signaling pathway gene polymorphism and susceptibility to gastric cancer. PMID: 29332342 |
Ref: Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis. PMID: 27779515 Ref: Association between telomere length and PIK3CA amplification in gastric cancer. PMID: 28584918 Ref: Gastric poorly cohesive carcinoma: a correlative study of mutational signatures and prognostic significance based on histopathological subtypes. PMID: 28873240 Ref: Gastric Carcinomas With Lymphoid Stroma: An Evaluation of the Histopathologic and Molecular Features. PMID: 29438172 Ref: Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status. PMID: 29468422 Ref: Association between PIK3CA alteration and prognosis of gastric cancer patients: a meta-analysis. PMID: 29484141 Ref: REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway. PMID: 29512686 Ref: PIK3CA Mutation Analysis in Iranian Patients with Gastric Cancer PMID: 29704890 Ref: Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer. PMID: 29725898 Ref: Clinical Importance of Epstein(-)Barr Virus-Associated Gastric Cancer. PMID: 29843478 Ref: Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. PMID: 29853970 Ref: Gastritis-Infection-Cancer Sequence of Epstein-Barr Virus-Associated Gastric Cancer. PMID: 29896679 Ref: MiR-152-5p as a microRNA passenger strand special functions in human gastric cancer cells. PMID: 29904279 Ref: PIK3CA mutation in gastric cancer and the role of microsatellite instability status in mutations of exons 9 and 20 of the PIK3CA gene. PMID: 29905413 Ref: What Will We Expect From Novel Therapies to Esophageal and Gastric Malignancies? PMID: 30231398 Ref: Somatic mutational profiles of stage II and III gastric cancer according to tumor microenvironment immune type. PMID: 30239046 Ref: Landscape of somatic mutations in gastric cancer assessed using next-generation sequencing analysis. PMID: 30250552 |