Primary Site >> Colorectal Cancer
Gene >> PHLPP2
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Ref: The phosphatase PHLPP controls the cellular levels of protein kinase C. PMID: 18162466 |
Ref: Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. PMID: 19079341 |
Ref: mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. PMID: 21177869 |
Ref: Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice. PMID: 23361301 Ref: microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2. PMID: 23846336 |
Ref: PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. PMID: 24530606 Ref: PHLPP2 suppresses the NF-kappaB pathway by inactivating IKKbeta kinase. PMID: 24553260 |
Ref: miR-938 promotes colorectal cancer cell proliferation via targeting tumor suppressor PHLPP2. PMID: 28433657 Ref: Prediction and Validation of Hub Genes Associated with Colorectal Cancer by Integrating PPI Network and Gene Expression Data. PMID: 29209625 |
Ref: Human colorectal cancer initiation is bidirectional, and cell growth, metabolic genes and transporter genes are early drivers of tumorigenesis. PMID: 29885515 |