Primary Site >> Colorectal Cancer
Gene >> PHLPP1
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Ref: PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. PMID: 15808505 |
Ref: The phosphatase PHLPP controls the cellular levels of protein kinase C. PMID: 18162466 |
Ref: Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. PMID: 19079341 Ref: Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. PMID: 19661333 Ref: beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. PMID: 19797085 |
Ref: mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. PMID: 21177869 |
Ref: The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. PMID: 22391563 Ref: microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2. PMID: 23846336 Ref: Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells. PMID: 24061475 Ref: WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). PMID: 24145035 |
Ref: PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. PMID: 24530606 |
Ref: MiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1. PMID: 26107137 Ref: Greatwall promotes cell transformation by hyperactivating AKT in human malignancies. PMID: 26613407 |
Ref: PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells. PMID: 28179998 |
Ref: A mutational comparison of adult and adolescent and young adult (AYA) colon cancer. PMID: 29194591 |