Primary Site >> Colorectal Cancer
Gene >> PDE4A
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Ref: Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. PMID: 11358813 |
Ref: Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. PMID: 17545604 |
Ref: Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model. PMID: 22830422 |
Ref: Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells. PMID: 24215890 |
Ref: Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies. PMID: 24985336 Ref: Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture. PMID: 25075098 |
Ref: Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia. PMID: 27927168 |
Ref: Roflumilast, type 4 phosphodiesterase inhibitor, attenuates inflammation in rats with ulcerative colitis via down-regulation of iNOS and elevation of cAMP. PMID: 29331766 |