Primary Site >> Colorectal Cancer
Gene >> PARP1
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Ref: A new ADP-ribosyltransferase in human serum: significance in cancer. PMID: 3132517 |
Ref: Hydrogen peroxide induced adenosine diphosphate ribosyl transferase (ADPRT) response in patients with inflammatory bowel disease. PMID: 3146530 |
Ref: Abrogation of c-Raf expression induces apoptosis in tumor cells. PMID: 9583688 Ref: Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancer. PMID: 9635838 Ref: The stress-response proteins poly(ADP-ribose) polymerase and NF-kappaB protect against bile salt-induced apoptosis. PMID: 10200517 |
Ref: Prevention of oxidant-induced cell death in Caco-2 colon carcinoma cells after inhibition of poly(ADP-ribose) polymerase and Ca2+ chelation: involvement of a common mechanism. PMID: 9920281 Ref: Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness. PMID: 10100720 Ref: Novel 19-nor-hexafluoride vitamin D3 analog (Ro 25-6760) inhibits human colon cancer in vitro via apoptosis. PMID: 10200351 Ref: Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP). PMID: 10467346 Ref: Aspirin induces cell death and caspase-dependent phosphatidylserine externalization in HT-29 human colon adenocarcinoma cells. PMID: 10496355 Ref: Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents. PMID: 10537360 Ref: Antitumor activity and induction of apoptosis by water-soluble derivatives of 7 beta-hydroxycholesterol in human colon carcinoma cell lines. PMID: 10628383 |
Ref: Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice. PMID: 10815928 Ref: Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs. PMID: 10855553 Ref: Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. PMID: 10864208 |
Ref: Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. PMID: 11323103 Ref: Prodigiosin-induced apoptosis in human colon cancer cells. PMID: 11388704 Ref: Induction of apoptosis in human colon carcinoma cells HT29 by sublethal cryo-injury: mediation by cytochrome c release. PMID: 11477556 Ref: 4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release. PMID: 11511183 Ref: Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo. PMID: 11593056 |
Ref: Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. PMID: 11821946 Ref: Phenylbutyrate-induced apoptosis is associated with inactivation of NF-kappaB IN HT-29 colon cancer cells. PMID: 11855750 Ref: C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells. PMID: 11961668 Ref: Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. PMID: 12097652 Ref: Tumor necrosis factor-alpha induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells. PMID: 12168847 Ref: Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status. PMID: 12209584 Ref: Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. PMID: 12507932 Ref: Retinoic Acid Enhances Drug-Induced Cell Death in Anticancer Drug-Resistant Cell Lines. PMID: 26680865 |
Ref: Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondrial dysfunction. PMID: 12471619 Ref: Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine. PMID: 12473386 Ref: Apoptosis induction in human cancer cells by sungucine from Strychnos icaja root. PMID: 12644898 Ref: Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. PMID: 12700281 Ref: Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. PMID: 12851702 Ref: Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. PMID: 12855651 Ref: Direct effects of octreotide, galanin and serotonin on human colon cancer cells. PMID: 14534685 Ref: Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. PMID: 14556662 Ref: [Suppression of HCT116 growth of cells by Gadd45]. PMID: 14642075 Ref: Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. PMID: 14750023 |
Ref: Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. PMID: 14578157 Ref: Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis. PMID: 14604899 Ref: Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells. PMID: 14648715 Ref: Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathway. PMID: 14729063 Ref: Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors. PMID: 15109627 Ref: LIGHT sensitizes IFN-gamma-mediated apoptosis of HT-29 human carcinoma cells through both death receptor and mitochondria pathways. PMID: 15115612 Ref: Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production. PMID: 15163544 Ref: Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. PMID: 15177310 Ref: Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. PMID: 15289867 Ref: Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. PMID: 15308587 Ref: Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells. PMID: 15340841 Ref: Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. PMID: 15453709 Ref: EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo. PMID: 15517892 |
Ref: p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. PMID: 15386430 Ref: Effects of triple therapy with octreotide, galanin and serotonin on a human colon cancer cell line implanted in mice: comparison between different routes of administration. PMID: 15578418 Ref: Assessment of apoptosis by immunohistochemical markers compared to cellular morphology in ex vivo-stressed colonic mucosa. PMID: 15684335 Ref: Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53. PMID: 15710360 Ref: Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. PMID: 15940627 Ref: Induction of apoptosis by Panduratin A isolated from Kaempferia pandurata in human colon cancer HT-29 cells. PMID: 15971119 Ref: Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway. PMID: 15995977 Ref: The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells. PMID: 16039951 Ref: TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death. PMID: 16157217 Ref: Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation. PMID: 16294035 Ref: Caspase-3 activation and induction of PARP cleavage by cyclic dipeptide cyclo(Phe-Pro) in HT-29 cells. PMID: 16309216 |
Ref: A role for cyclic-GMP dependent protein kinase in anoikis. PMID: 16139477 Ref: Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents. PMID: 16343908 Ref: Characterization of four clones derived from human adenocarcinoma cell line, HT29, and analysis of their response to sodium butyrate. PMID: 16391813 Ref: Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells. PMID: 16497702 Ref: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. PMID: 16500682 Ref: Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. PMID: 16715131 Ref: An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. PMID: 16777983 Ref: Discovery and structure-activity relationship of 2-phenyl-oxazole-4-carboxamide derivatives as potent apoptosis inducers. PMID: 16784854 Ref: Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest. PMID: 16886631 Ref: EMAP-II-dependent lymphocyte killing is associated with hypoxia in colorectal cancer. PMID: 16929248 Ref: Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway? PMID: 17202837 |
Ref: The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo. PMID: 17124594 Ref: Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis. PMID: 17191116 Ref: Effect of hyperthermia on TRAIL-induced apoptotic death in human colon cancer cells: development of a novel strategy for regional therapy. PMID: 17212362 Ref: Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. PMID: 17258704 Ref: Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice. PMID: 17260186 Ref: Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma. PMID: 17283177 Ref: Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. PMID: 17395984 Ref: Celecoxib attenuates 5-fluorouracil-induced apoptosis in HCT-15 and HT-29 human colon cancer cells. PMID: 17461495 Ref: p53 dependent and independent sensitivity to oxaliplatin of colon cancer cells. PMID: 17559811 Ref: [Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29]. PMID: 17562258 Ref: Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. PMID: 17597109 Ref: Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. PMID: 17673978 Ref: Soluble CD44 secretion contributes to the acquisition of aggressive tumor phenotype in human colon cancer cells. PMID: 17945213 Ref: Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. PMID: 17950073 Ref: DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. PMID: 18006925 |
Ref: Cell death in response to antimetabolites directed at thymidylate synthase. PMID: 17396263 Ref: Effect of hyperthermia and chemotherapeutic agents on TRAIL-induced cell death in human colon cancer cells. PMID: 17520700 Ref: In vitro cytotoxic potential of Polyalthia longifolia on human cancer cell lines and induction of apoptosis through mitochondrial-dependent pathway in HL-60 cells. PMID: 17935706 Ref: Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. PMID: 18026951 Ref: Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts. PMID: 18189352 Ref: Irinotecan pharmacogenetics: influence of pharmacodynamic genes. PMID: 18347181 Ref: Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner. PMID: 18423603 Ref: Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. PMID: 18455702 Ref: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. PMID: 18460448 Ref: PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. PMID: 18544567 Ref: Herbal isoprenols induce apoptosis in human colon cancer cells through transcriptional activation of PPARgamma. PMID: 18608213 Ref: Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent. PMID: 18665601 Ref: Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil: Mechanistic basis. PMID: 18787402 Ref: [Overcoming acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand by Bcl-XL small interfering RNA in human colon cancer]. PMID: 18788624 |
Ref: Combined treatment of Caco-2 cells with butyrate and mesalazine inhibits cell proliferation and reduces Survivin protein level. PMID: 18774638 Ref: Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon carcinoma CT26 cells. PMID: 18989759 Ref: Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells. PMID: 19067737 Ref: Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells. PMID: 19116755 Ref: Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23. PMID: 19118525 Ref: Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. PMID: 19148542 Ref: Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. PMID: 19154411 Ref: Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. PMID: 19229860 Ref: Fermentation products of inulin-type fructans reduce proliferation and induce apoptosis in human colon tumour cells of different stages of carcinogenesis. PMID: 19250571 Ref: Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin. PMID: 19264955 Ref: New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. PMID: 19331692 Ref: Study of the effects of a new pyrazolecarboxamide: changes in mitochondria and induction of apoptosis. PMID: 19379827 Ref: A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene. PMID: 19384947 Ref: Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells. PMID: 19462692 Ref: Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells. PMID: 19468250 Ref: Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon. PMID: 19479993 Ref: Effects of omega-3 and omega-6 fatty acids on IGF-I receptor signalling in colorectal cancer cells. PMID: 19480565 Ref: Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate. PMID: 19507186 Ref: Ethyl pyruvate administration inhibits hepatic tumor growth. PMID: 19584311 Ref: 2,3',4,4',5'-Pentamethoxy-trans-stilbene, a resveratrol derivative, is a potent inducer of apoptosis in colon cancer cells via targeting microtubules. PMID: 19591809 Ref: Novel functional profiling approach combining reverse phase protein microarrays and human 3-D ex vivo tissue cultures: expression of apoptosis-related proteins in human colon cancer. PMID: 19609961 Ref: Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signaling pathway at low-dose H2O2. PMID: 19723101 Ref: GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells. PMID: 19755849 Ref: Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells. PMID: 19801840 Ref: [Detection of apoptosis in vivo: comparison of different methods in histological sections of subcutaneous xenografts of HT29 human colon adenocarcinoma]. PMID: 20004835 Ref: Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. PMID: 20024169 Ref: Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. PMID: 20559012 |
Ref: Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. PMID: 20056314 Ref: Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53. PMID: 20200495 Ref: Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. PMID: 20228137 Ref: RasV12 induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance. PMID: 20362665 Ref: Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells. PMID: 20392997 Ref: Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. PMID: 20397199 Ref: 3,3',4,5,5'-Pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress. PMID: 20399769 Ref: LA-12 overcomes confluence-dependent resistance of HT-29 colon cancer cells to Pt (II) compounds. PMID: 20530425 Ref: Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors. PMID: 20544795 Ref: Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa. PMID: 20600805 Ref: A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells. PMID: 20615460 Ref: Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. PMID: 20633624 Ref: In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201. PMID: 20633731 Ref: Inhibition of cell growth and potentiation of tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells. PMID: 20674553 Ref: Oxaliplatin resistance induced by ERCC1 up-regulation is abrogated by siRNA-mediated gene silencing in human colorectal cancer cells. PMID: 20682979 Ref: Fucoidan present in brown algae induces apoptosis of human colon cancer cells. PMID: 20727207 Ref: Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities. PMID: 20951582 Ref: Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. PMID: 21037106 Ref: Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts. PMID: 21042746 Ref: Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species. PMID: 21311680 Ref: 20(S)-Ginsenoside Rg3-induced apoptosis in HT-29 colon cancer cells is associated with AMPK signaling pathway. PMID: 21472321 Ref: Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. PMID: 21614182 |
Ref: Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis. PMID: 20974518 Ref: Apoptotic effect of eugenol in human colon cancer cell lines. PMID: 21044050 Ref: Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells. PMID: 21057529 Ref: Apoptosis-inducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines. PMID: 21122037 Ref: High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer. PMID: 21214291 Ref: Translational research in pancreatic cancer. Highlights from the "2011 ASCO Gastrointestinal Cancers Symposium". San Francisco, CA, USA. January 20-22, 2011. PMID: 21386635 Ref: Functional characterization of peroxisome proliferator-activated receptor-beta/delta expression in colon cancer. PMID: 21400612 Ref: The p53-, Bax- and p21-dependent inhibition of colon cancer cell growth by 5-hydroxy polymethoxyflavones. PMID: 21462329 Ref: Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1. PMID: 21570414 Ref: Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity. PMID: 21586136 Ref: DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response. PMID: 21636528 Ref: Role of reactive oxygen species (ROS) in CDDO-Me-mediated growth inhibition and apoptosis in colorectal cancer cells. PMID: 21699019 Ref: Enormous influence of TNIK knockdown on intracellular signals and cell survival. PMID: 21710359 Ref: Photolon --photosensitization induces apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes. PMID: 21725591 Ref: Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells. PMID: 21737934 Ref: A novel non-aromatic B-ring flavonoid: isolation, structure elucidation and its induction of apoptosis in human colon HT-29 tumor cell via the reactive oxygen species-mitochondrial dysfunction and MAPK activation. PMID: 21741427 Ref: Drug therapy for hereditary cancers. PMID: 21819606 Ref: Proteomic analysis of 1alpha,25-dihydroxyvitamin D3 action on human colon cancer cells reveals a link to splicing regulation. PMID: 21864731 Ref: An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro. PMID: 21875034 Ref: Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells. PMID: 21963494 Ref: Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. PMID: 22110202 Ref: Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PMID: 22194930 Ref: Rapamycin synergizes with low-dose oxaliplatin in the HCT116 colon cancer cell line by inducing enhanced apoptosis. PMID: 22848242 |
Ref: Silencing Poly (ADP-Ribose) glycohydrolase (PARG) expression inhibits growth of human colon cancer cells in vitro via PI3K/Akt/NFkappa-B pathway. PMID: 21713600 Ref: Knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells. PMID: 21901254 Ref: Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway. PMID: 22050790 Ref: Synthetic lethality-based therapeutics: perspectives for applications in colorectal cancer. PMID: 22385509 Ref: DNA damage response pathways and cell cycle checkpoints in colorectal cancer: current concepts and future perspectives for targeted treatment. PMID: 22385513 Ref: Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis. PMID: 22395735 Ref: Tumor growth is suppressed in mice expressing a truncated XRCC1 protein. PMID: 22432057 Ref: RNA interference of PARG could inhibit the metastatic potency of colon carcinoma cells via PI3-kinase/Akt pathway. PMID: 22508044 Ref: The combination of olaparib and camptothecin for effective radiosensitization. PMID: 22524618 Ref: Down-regulation of p110beta expression increases chemosensitivity of colon cancer cell lines to oxaliplatin. PMID: 22528234 Ref: Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PMID: 22574158 Ref: The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells. PMID: 22617025 Ref: SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than gemcitabine. PMID: 22617428 Ref: Protein kinase Calpha protects against multidrug resistance in human colon cancer cells. PMID: 22639047 Ref: AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells. PMID: 22674626 Ref: Inhibition of GSK-3beta reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells. PMID: 22683934 Ref: Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro. PMID: 22728232 Ref: MLH1-deficient HCT116 colon tumor cells exhibit resistance to the cytostatic and cytotoxic effect of the poly(A) polymerase inhibitor cordycepin (3'-deoxyadenosine) in vitro. PMID: 22740928 Ref: DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets. PMID: 22788763 Ref: (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a cembrenolide diterpene from soft coral Lobophytum sp., inhibits growth and induces apoptosis in human colon cancer cells through reactive oxygen species generation. PMID: 22791152 Ref: A novel steroidal saponin glycoside from Fagonia indica induces cell-selective apoptosis or necrosis in cancer cells. PMID: 22800968 Ref: Enhanced chemosensitivity to CPT-11 in colorectal carcinoma xenografts by small hairpin RNA interference targeting PLK1. PMID: 22862168 Ref: Colorectal cancers differ in respect of PARP-1 protein expression. PMID: 22864776 Ref: Effect of silencing PARG in human colon carcinoma LoVo cells on the ability of HUVEC migration and proliferation. PMID: 22918473 Ref: Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells. PMID: 22948973 Ref: Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas. PMID: 22966016 Ref: Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis. PMID: 22971663 Ref: DAPK plays an important role in panobinostat-induced autophagy and commits cells to apoptosis under autophagy deficient conditions. PMID: 23011180 Ref: PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development. PMID: 23042038 Ref: Cytotoxic caffeic acid derivatives from the rhizomes of Cimicifuga heracleifolia. PMID: 23054712 Ref: Sophoridine exerts an anti-colorectal carcinoma effect through apoptosis induction in vitro and in vivo. PMID: 23069582 Ref: Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism. PMID: 23193914 Ref: Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer. PMID: 23241148 |
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Ref: New dibutyltin(IV) ladders: Syntheses, structures and, optimization and evaluation of cytotoxic potential employing A375 (melanoma) and HCT116 (colon carcinoma) cell lines in vitro. PMID: 27815980 Ref: Gen-27, a newly synthesized flavonoid, inhibits glycolysis and induces cell apoptosis via suppression of hexokinase II in human breast cancer cells. PMID: 27818240 Ref: Oblongifolin C and guttiferone K extracted from Garcinia yunnanensis fruit synergistically induce apoptosis in human colorectal cancer cells in vitro. PMID: 27840412 Ref: Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-kappaB/iNOS signaling pathways. PMID: 27865009 Ref: 2'-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression. PMID: 27922674 Ref: Carboxamide analog ITR-284 evokes apoptosis and inhibits migration ability in human lung adenocarcinoma A549 cells. PMID: 28098885 Ref: Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-kappaB Activation. PMID: 28108625 Ref: Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. PMID: 28173629 Ref: ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib. PMID: 28182994 Ref: Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma. PMID: 28188923 Ref: Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2. PMID: 28219770 Ref: A novel cycloartane triterpenoid from Cimicifuga induces apoptotic and autophagic cell death in human colon cancer HT-29 cells. PMID: 28260002 Ref: Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement. PMID: 28302009 Ref: Antiproliferative Activity of Egg Yolk Peptides in Human Colon Cancer Cells. PMID: 28323499 Ref: In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor. PMID: 28442322 Ref: HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer. PMID: 28457970 Ref: Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells. PMID: 28458622 Ref: Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line. PMID: 28472978 Ref: PARP inhibitors and chemoradiation for rectal cancer. PMID: 28497749 Ref: [Knock-down of cadherin 17 inhibits proliferation and promote apoptosis in noscapine-resistant human SW480 colon cancer cells]. PMID: 28502297 Ref: Mammea longifolia Planch. and Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53. PMID: 28504908 Ref: Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. PMID: 28551635 Ref: Genome-wide network-based pathway analysis of CSF t-tau/Abeta1-42 ratio in the ADNI cohort. PMID: 28558704 Ref: mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer. PMID: 28615517 Ref: 18 beta-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration. PMID: 28656212 Ref: Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. PMID: 28659575 Ref: Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II. PMID: 28683851 Ref: Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells. PMID: 28706417 Ref: Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway. PMID: 28713983 Ref: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling. PMID: 28726723 Ref: MHY451 induces cell cycle arrest and apoptosis by ROS generation in HCT116 human colorectal cancer cells. PMID: 28731136 Ref: Predictive and prognostic biomarkers in personalized gastrointestinal cancer treatment. PMID: 28736628 Ref: The Association of Low-Penetrance Variants in DNA Repair Genes with Colorectal Cancer: A Systematic Review and Meta-Analysis. PMID: 28749454 Ref: Antitumor activity of beta-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. PMID: 28782499 Ref: Knockdown of tripartite motif-59 inhibits the malignant processes in human colorectal cancer cells. PMID: 28849218 Ref: Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy. PMID: 28903334 Ref: In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells. PMID: 28923355 Ref: Inhibitory Effects of Culinary Herbs and Spices on the Growth of HCA-7 Colorectal Cancer Cells and Their COX-2 Expression. PMID: 28934138 Ref: Targeting progastrin enhances radiosensitization of colorectal cancer cells. PMID: 28938581 Ref: Identification of 7-(4'-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells. PMID: 28963527 Ref: Improved chemoradiation treatment using trifluridine in human colorectal cancer cells in vitro. PMID: 29024630 Ref: MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis. PMID: 29048575 Ref: In vivo and in vitro induction of the apoptotic effects of oxysophoridine on colorectal cancer cells via the Bcl-2/Bax/caspase-3 signaling pathway. PMID: 29344242 Ref: Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression. PMID: 29383150 |
Ref: Thymol Elicits HCT-116 Colorectal Carcinoma Cell Death Through Induction of Oxidative Stress. PMID: 28356011 Ref: CB002, a novel p53 tumor suppressor pathway-restoring small molecule induces tumor cell death through the pro-apoptotic protein NOXA. PMID: 28749203 Ref: NAMPT Is a Potent Oncogene in Colon Cancer Progression that Modulates Cancer Stem Cell Properties and Resistance to Therapy through Sirt1 and PARP. PMID: 29203587 Ref: Acylated and unacylated ghrelin inhibit apoptosis in myoblasts cocultured with colon carcinoma cells. PMID: 29328480 Ref: Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents. PMID: 29335212 Ref: Loss of ABCB4 attenuates the caspase-dependent apoptosis regulating resistance to 5-Fu in colorectal cancer. PMID: 29371412 Ref: Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways. PMID: 29389802 Ref: Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen). PMID: 29464799 Ref: A silyl andrographolide analogue suppresses Wnt/beta-catenin signaling pathway in colon cancer. PMID: 29501763 Ref: Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer. PMID: 29512707 Ref: Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum. PMID: 29538328 Ref: Food Additive Sodium Benzoate (NaB) Activates NFkappaB and Induces Apoptosis in HCT116 Cells. PMID: 29565269 Ref: Anticancer effect of fermented Insampaedok-san in human colon cancer cells: a pilot study. PMID: 29611024 Ref: PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. PMID: 29632181 Ref: Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells. PMID: 29684585 Ref: Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells. PMID: 29724012 Ref: Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol. PMID: 29771951 Ref: Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK. PMID: 29783958 Ref: The anti-cancer activity of an andrographolide analogue functions through a GSK-3beta-independent Wnt/beta-catenin signaling pathway in colorectal cancer cells. PMID: 29784906 Ref: Reactive oxygen species-mediated phosphorylation of p38 signaling is critically involved in apoptotic effect of Tanshinone I in colon cancer cells. PMID: 29876988 Ref: MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors. PMID: 29880585 Ref: Pea lectin inhibits cell growth by inducing apoptosis in SW480 and SW48 cell lines. PMID: 29885391 Ref: Artesunate induces apoptosis and autophagy in HCT116 colon cancer cells, and autophagy inhibition enhances the artesunateinduced apoptosis. PMID: 29901098 Ref: Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo. PMID: 29970185 Ref: Novel cinnamaldehyde-based aspirin derivatives for the treatment of colorectal cancer. PMID: 30037494 Ref: Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1. PMID: 30046848 Ref: Lysosomal permeabilization and endoplasmic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic zinc(II) phthalocyanine. PMID: 30130653 Ref: Terpenes from essential oils and hydrolate of Teucrium alopecurus triggered apoptotic events dependent on caspases activation and PARP cleavage in human colon cancer cells through decreased protein expressions. PMID: 30190788 Ref: In silico insights on Tankyrase protein: a potential target for colorectal cancer. PMID: 30204055 Ref: Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells. PMID: 30211553 Ref: MPT0B169 and MPT0B002, New Tubulin Inhibitors, Induce Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis in Human Colorectal Cancer Cells. PMID: 30227438 Ref: MACROD2 deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer. PMID: 30237848 Ref: Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity. PMID: 30266650 Ref: PTBP1 promotes tumorigenesis by regulating apoptosis and cell cycle in colon cancer. PMID: 30309622 Ref: Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1. PMID: 30342037 Ref: PARP inhibition sensitizes colorectal cancer-initiating cells to chemotherapy. PMID: 30353615 Ref: Galla Rhois water extract inhibits lung metastasis by inducing AMPKmediated apoptosis and suppressing metastatic properties of colorectal cancer cells. PMID: 30365120 Ref: ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells. PMID: 30384048 |