Primary Site >> Colorectal Cancer
Gene >> PAK4
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Ref: Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. PMID: 11668177 |
Ref: MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells. PMID: 22766504 |
Ref: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling. PMID: 23233484 Ref: Tumor-suppressive microRNA-145 targets catenin delta-1 to regulate Wnt/beta-catenin signaling in human colon cancer cells. PMID: 23499891 |
Ref: SH3RF2 functions as an oncogene by mediating PAK4 protein stability. PMID: 24130170 Ref: The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4. PMID: 24829151 |
Ref: P21-activated kinase 1 and 4 were associated with colorectal cancer metastasis and infiltration. PMID: 25791829 |
Ref: MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway. PMID: 28440035 Ref: PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth. PMID: 28542136 |