Primary Site >> Colorectal Cancer

Gene >> NTRK2

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Ref: The trk family of oncogenes and neurotrophin receptors.
PMID: 1844238
Ref: Absence of tyrosine kinase mutations in Japanese colorectal cancer patients.
PMID: 17016444
Ref: Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin-1.
PMID: 18691385
Ref: Overexpression of TrkB promotes the progression of colon cancer.
PMID: 20132184
Ref: BDNF/TrkB content and interaction with gastrin-releasing peptide receptor blockade in colorectal cancer.
PMID: 21474968
Ref: Functional characterization of human cancer-derived TRKB mutations.
PMID: 21379385
Ref: Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival.
PMID: 21966426
Ref: BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition.
PMID: 22842573
Ref: A tissue-based comparative effectiveness analysis of biomarkers for early detection of colorectal tumors.
PMID: 23324654
Ref: Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker in colorectal carcinoma.
PMID: 23332094
Ref: Tropomyosin-related kinase B promotes distant metastasis of colorectal cancer through protein kinase B-mediated anoikis suppression and correlates with poor prognosis.
PMID: 24549576
Ref: Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer.
PMID: 24801982
Ref: Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro.
PMID: 25054037
Ref: Tyrosine kinase receptor B (TrkB) expression in colorectal cancers highlights anoikis resistance as a survival mechanism of tumour budding cells.
PMID: 25382057
Ref: Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer.
PMID: 26811602
Ref: Targeting TRK family proteins in cancer.
PMID: 28174090
Ref: BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations.
PMID: 28591715
Ref: Dual inhibition of BDNF/TrkB and autophagy: a promising therapeutic approach for colorectal cancer.
PMID: 28597984
Ref: Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing.
PMID: 28714374