Primary Site >> Biliary tract Cancer
Gene >> NRAS
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Ref: ras-family gene mutations in neoplasia of the ampulla of Vater. PMID: 7927901 |
Ref: Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas. PMID: 9923922 |
Ref: Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. PMID: 19440799 |
Ref: Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma. PMID: 21303542 |
Ref: Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. PMID: 22180306 |
Ref: Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions. PMID: 23391413 |
Ref: High throughput molecular profiling reveals differential mutation patterns in intrahepatic cholangiocarcinomas arising in chronic advanced liver diseases. PMID: 24186137 Ref: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. PMID: 24563076 Ref: Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets. PMID: 24889489 |
Ref: Microsatellite instability in gallbladder carcinoma. PMID: 25680569 Ref: Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of ERBB2 (HER2). PMID: 25975284 Ref: Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing. PMID: 26189129 |
Ref: Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets. PMID: 26500333 Ref: Cholangiocarcinoma Heterogeneity Revealed by Multigene Mutational Profiling: Clinical and Prognostic Relevance in Surgically Resected Patients. PMID: 26717940 Ref: Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing. PMID: 27267833 |
Ref: Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components. PMID: 28698100 Ref: Mutational frequency of KRAS, NRAS, IDH2, PIK3CA, and EGFR in North Indian gallbladder cancer patients. PMID: 28900470 Ref: The construction of intrahepatic cholangiocarcinoma model in zebrafish. PMID: 29042681 |
Ref: Phase 1b investigation of the MEK inhibitor binimetinib in patients with advanced or metastatic biliary tract cancer. PMID: 29785570 |