Primary Site >> Colorectal Cancer
Gene >> NR4A1
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Ref: Effects of steroid hormone therapy on primarily xenotransplanted human colorectal adenocarcinomas. PMID: 6511808 |
Ref: The efficacy of 5-fluorouracil in human colorectal cancer is not enhanced by thymidylate synthetase inhibition with CB3717 (N10-propargyl-5,8 dideazafolic acid). PMID: 3166908 Ref: Phase II study of the thymidylate synthetase inhibitor CB3717 (N10-propargyl-5,8-dideazafolic acid) in colorectal cancer. PMID: 3408648 |
Ref: Folate-based thymidylate synthase inhibitors as anticancer drugs. PMID: 8624289 |
Ref: Transcriptional induction of Nur77 by indomethacin that results in apoptosis of colon cancer cells. PMID: 10919358 Ref: Tezacitabine Hoechst Marion Roussel. PMID: 11249589 |
Ref: Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer. PMID: 12027413 |
Ref: Impact of pretreatment thrombocytosis on survival in primary breast cancer. PMID: 12783124 Ref: TR3/Nur77 in colon cancer cell apoptosis. PMID: 14500374 Ref: High p27Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin. PMID: 14512390 |
Ref: Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: the Austrian Breast and Colorectal Cancer Study Group. PMID: 15718312 |
Ref: Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. PMID: 17234778 |
Ref: 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. PMID: 17957723 Ref: Exemestane as primary systemic treatment for hormone receptor positive post-menopausal breast cancer patients: a phase II trial of the Austrian Breast and Colorectal Cancer Study Group (ABCSG-17). PMID: 18158620 Ref: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. PMID: 18460448 Ref: Bcl-B expression in human epithelial and nonepithelial malignancies. PMID: 18483366 Ref: Is long-term adjuvant treatment of breast cancer with anastrozole indicated? PMID: 18518790 Ref: American Society of Clinical Oncology/National Comprehensive Cancer Network Quality Measures. PMID: 18640941 |
Ref: Low p27 expression predicts early relapse and death in postmenopausal hormone receptor-positive breast cancer patients receiving adjuvant tamoxifen therapy. PMID: 19723645 Ref: Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. PMID: 19773552 |
Ref: Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells. PMID: 19823826 Ref: Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. PMID: 20068171 |
Ref: Regulation of Nur77 expression by beta-catenin and its mitogenic effect in colon cancer cells. PMID: 20847229 Ref: Inflammation: a role for NR4A orphan nuclear receptors? PMID: 21428963 Ref: Nuclear orphan receptor NR4A2 modulates fatty acid oxidation pathways in colorectal cancer. PMID: 21757690 |
Ref: The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling. PMID: 21873734 Ref: Inhibition of beta-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. PMID: 21986938 Ref: Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis. PMID: 22159226 |
Ref: Hypoxia triggers a Nur77-beta-catenin feed-forward loop to promote the invasive growth of colon cancer cells. PMID: 24423919 Ref: Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9 and E-cadherin. PMID: 25064356 Ref: Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. PMID: 25099012 |
Ref: Bile acids regulate nuclear receptor (Nur77) expression and intracellular location to control proliferation and apoptosis. PMID: 25232032 Ref: Non-genomic effects of the NR4A1/Nur77/TR3/NGFIB orphan nuclear receptor. PMID: 25555471 Ref: The Role of Ovarian Suppression in Premenopausal Women With Hormone Receptor-Positive Early-Stage Breast Cancer. PMID: 26178334 Ref: Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy. PMID: 26229035 |
Ref: gamma-Aminobutyric acid inhibits the proliferation and increases oxaliplatin sensitivity in human colon cancer cells. PMID: 27644246 |
Ref: The nuclear orphan receptor NR4A1 regulates beta1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. PMID: 28418095 Ref: Possible role of diet in cancer: systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk. PMID: 28969358 |
Ref: RARbeta acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells. PMID: 30252536 Ref: [Contraception and cancer: CNGOF Contraception Guidelines]. PMID: 30385358 |