Primary Site >> Liver Cancer
Gene >> NQO1
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Ref: High levels of expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin. PMID: 1651729 |
Ref: Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C. PMID: 9369485 |
Ref: CB 1954: from the Walker tumor to NQO2 and VDEPT. PMID: 14529407 |
Ref: DT-diaphorase: a target for new anticancer drugs. PMID: 15245776 |
Ref: Hypermethylation of NAD(P)H: quinone oxidoreductase 1 (NQO1) gene in human hepatocellular carcinoma. PMID: 15763338 |
Ref: Analysis of NQO1 polymorphisms and p53 protein expression in patients with hepatocellular carcinoma. PMID: 19688691 |
Ref: Elevation of cell proliferation via generation of reactive oxygen species by piperonyl butoxide contributes to its liver tumor-promoting effects in mice. PMID: 20101389 Ref: No association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and risk of hepatocellular carcinoma development in Turkish subjects. PMID: 21133623 |
Ref: Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats. PMID: 21203749 Ref: Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats. PMID: 21295105 Ref: Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells. PMID: 21843634 |
Ref: Mechanistic study on liver tumor promoting effects of flutamide in rats. PMID: 22076107 Ref: Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies. PMID: 22297691 Ref: Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action. PMID: 22467020 Ref: Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation. PMID: 22528125 Ref: Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells. PMID: 22570534 Ref: Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action. PMID: 22687989 Ref: Threshold dose of liver tumor promoting effect of beta-naphthoflavone in rats. PMID: 22687991 Ref: Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism. PMID: 23026305 Ref: NQO1 expression correlates with cholangiocarcinoma prognosis. PMID: 23480754 |
Ref: A functional NQO1 609C>T polymorphism and risk of hepatocellular carcinoma in a Chinese population. PMID: 22972504 Ref: Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I). PMID: 23289503 Ref: Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells. PMID: 23920313 Ref: Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide. PMID: 24025784 |
Ref: Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital. PMID: 24418717 Ref: Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent. PMID: 25448047 |
Ref: beta-Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy. PMID: 26415823 Ref: Liver expression of Nrf2-related genes in different liver diseases. PMID: 26459724 |
Ref: Quantitative proteomic analysis of anticancer drug RH1 resistance in liver carcinoma. PMID: 26596252 Ref: Ruthenium Complexes Induce HepG2 Human Hepatocellular Carcinoma Cell Apoptosis and Inhibit Cell Migration and Invasion through Regulation of the Nrf2 Pathway. PMID: 27213353 Ref: Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells. PMID: 27749250 |
Ref: Overexpression of NAD(P)H: Quinone Oxidoreductase 1 Inhibits Hepatocellular Carcinoma Cell Proliferation and Induced Apoptosis by Activating AMPK/PGC-1alpha Pathway. PMID: 28191864 |
Ref: Epalrestat Stimulated Oxidative Stress, Inflammation, and Fibrogenesis in Mouse Liver. PMID: 28204799 Ref: Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine. PMID: 29594326 |