Primary Site >> Liver Cancer
Gene >> NOX4
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|
|
Ref: Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion. PMID: 18371937 Ref: Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. PMID: 18845355 |
Ref: Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells. PMID: 19406930 Ref: Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. PMID: 19773433 |
Ref: Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth. PMID: 20583212 Ref: Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection. PMID: 20844152 |
Ref: Dissecting the effect of targeting the epidermal growth factor receptor on TGF-beta-induced-apoptosis in human hepatocellular carcinoma cells. PMID: 21147185 Ref: NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy. PMID: 21915726 |
Ref: The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice. PMID: 22711600 |
Ref: The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression. PMID: 24509161 Ref: Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma. PMID: 24816297 |
Ref: Dihydromyricetin induces mouse hepatoma Hepal-6 cell apoptosis via the transforming growth factor-beta pathway. PMID: 25376731 Ref: Transforming growth factor beta-interacting factor-induced malignant progression of hepatocellular carcinoma cells depends on superoxide production from Nox4. PMID: 25841779 Ref: {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acet ic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3. PMID: 25961022 |
Ref: NADPH Oxidase 1 and NADPH Oxidase 4 Have Opposite Prognostic Effects for Patients with Hepatocellular Carcinoma after Hepatectomy. PMID: 27282266 Ref: Differential transcriptional regulation of hypoxia-inducible factor-1alpha by arsenite under normoxia and hypoxia: involvement of Nrf2. PMID: 27286880 |
Ref: The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination. PMID: 27941881 Ref: Gene expression of NOX family members and their clinical significance in hepatocellular carcinoma. PMID: 28894215 Ref: The level of caveolin-1 expression determines response to TGF-beta as a tumour suppressor in hepatocellular carcinoma cells. PMID: 29022911 Ref: Does Hypoxia Cause Carcinogenic Iron Accumulation in Alcoholic Liver Disease (ALD)? PMID: 29068390 Ref: NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4. PMID: 29085012 Ref: Hypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling. PMID: 29237157 |
Ref: A natural small molecule inhibitor corilagin blocks HCV replication and modulates oxidative stress to reduce liver damage. PMID: 29224736 |