Primary Site >> Liver Cancer
Gene >> NOTCH1
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Ref: Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. PMID: 14678992 |
Ref: Deregulated expression of Notch receptors in human hepatocellular carcinoma. PMID: 17920003 Ref: Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling. PMID: 18418214 |
Ref: Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. PMID: 18942116 Ref: Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanism. PMID: 19304334 Ref: Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. PMID: 19376776 Ref: Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma. PMID: 19728763 Ref: Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma. PMID: 19956448 |
Ref: RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells. PMID: 19800882 Ref: Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage. PMID: 20578140 |
Ref: The epigenetic regulation of stem cell factors in hepatic stellate cells. PMID: 21219128 Ref: Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular carcinoma. PMID: 21480340 Ref: Late SV40 factor: a key mediator of Notch signaling in human hepatocarcinogenesis. PMID: 21876634 Ref: Cooperation of deregulated Notch signaling and Ras pathway in human hepatocarcinogenesis. PMID: 21892768 Ref: Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. PMID: 22128911 |
Ref: Notch1-Snail1-E-cadherin pathway in metastatic hepatocellular carcinoma. PMID: 22052196 Ref: IKKalpha activation of NOTCH links tumorigenesis via FOXA2 suppression. PMID: 22196886 Ref: Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study. PMID: 22511905 Ref: beta,beta-Dimethylacrylshikonin exerts antitumor activity via Notch-1 signaling pathway in vitro and in vivo. PMID: 22634048 Ref: CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma. PMID: 22705236 Ref: Notch1 activation contributes to tumor cell growth and proliferation in human hepatocellular carcinoma HepG2 and SMMC7721 cells. PMID: 22922832 Ref: Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. PMID: 22974708 Ref: [Expression and clinical significance of Notch1 in human hepatocellular carcinoma]. PMID: 23227533 Ref: Analysis of Notch and TGF-beta Signaling Expression in Different Stages of Disease Progression During Hepatitis B Virus Infection. PMID: 23238065 |
Ref: Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells. PMID: 22986536 Ref: The Notch1/cyclooxygenase-2/Snail/E-cadherin pathway is associated with hypoxia-induced hepatocellular carcinoma cell invasion and migration. PMID: 23124652 Ref: Associations between high levels of Notch1 expression and high invasion and poor overall survival in hepatocellular carcinoma. PMID: 23179396 Ref: The hepatitis B virus X protein downregulates NF-kappaB signaling pathways through decreasing the Notch signaling pathway in HBx-transformed L02 cells. PMID: 23450368 Ref: The significance of Notch1 compared with Notch3 in high metastasis and poor overall survival in hepatocellular carcinoma. PMID: 23468978 Ref: [Relationship between glypican-3 and Notch1 expressions in hepatocellular carcinoma]. PMID: 23644127 Ref: Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma. PMID: 23742774 Ref: Elevated expression of notch1 is associated with metastasis of human malignancies. PMID: 23883974 Ref: Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PMID: 24386256 |
Ref: Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma. PMID: 24336972 Ref: Notch1 increases Snail expression under high reactive oxygen species conditions in hepatocellular carcinoma cells. PMID: 24684482 Ref: Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/beta-catenin pathway. PMID: 25017705 Ref: Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma. PMID: 25031748 Ref: Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling. PMID: 25107841 Ref: Downregulation of Notch1 inhibits the invasion of human hepatocellular carcinoma HepG2 and MHCC97H cells through the regulation of PTEN and FAK. PMID: 25110169 Ref: Spatial localization of the JAG1/Notch1/osteopontin cascade modulates extrahepatic metastasis in hepatocellular carcinoma. PMID: 25176314 Ref: [Effect of siRNA-mediated silencing of Notch2 on proliferation of the HepG2 human hepatocellular carcinoma cells]. PMID: 25180870 Ref: miR-429 represses cell proliferation and induces apoptosis in HBV-related HCC. PMID: 25312821 Ref: Association of Notch1 with vasculogenic mimicry in human hepatocellular carcinoma cell lines. PMID: 25337219 Ref: Recurrent genetic alterations in hepatitis C-associated hepatocellular carcinoma detected by genomic microarray: a genetic, clinical and pathological correlation study. PMID: 25469175 |
Ref: Differential effects of targeting Notch receptors in a mouse model of liver cancer. PMID: 25311838 Ref: Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma. PMID: 25333354 Ref: Simvastatin induces growth inhibition and apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells via upregulation of Notch1 expression. PMID: 25412322 Ref: Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. PMID: 25671302 Ref: Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b. PMID: 25889022 Ref: Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway. PMID: 25955618 Ref: Xanthohumol inhibits Notch signaling and induces apoptosis in hepatocellular carcinoma. PMID: 26011160 Ref: NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells. PMID: 26252838 Ref: Co-delivery of platinum drug and siNotch1 with micelleplex for enhanced hepatocellular carcinoma therapy. PMID: 26302232 Ref: The Histone Deacetylase Inhibitor Vaproic Acid Induces Cell Growth Arrest in Hepatocellular Carcinoma Cells via Suppressing Notch Signaling. PMID: 26366213 Ref: Loss of function of Notch1 identifies a poor prognosis group of early stage hepatocellular carcinoma following hepatectomy. PMID: 26398566 Ref: Interferon-alpha2b gene-modified human bone marrow mesenchymal stem cells inhibit hepatocellular carcinoma by reducing the Notch1 levels. PMID: 26518164 Ref: KRT6B, a key mediator of notch signaling in honokiol-induced human hepatoma cell apoptosis. PMID: 26629239 |
Ref: LTbetaR signalling preferentially accelerates oncogenic AKT-initiated liver tumours. PMID: 26206664 Ref: TGF-beta1 pathway affects the protein expression of many signaling pathways, markers of liver cancer stem cells, cytokeratins, and TERT in liver cancer HepG2 cells. PMID: 26462837 Ref: Inhibition of perillyl alcohol on cell invasion and migration depends on the Notch signaling pathway in hepatoma cells. PMID: 26475687 Ref: Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma. PMID: 26530164 Ref: CD24 promotes HCC progression via triggering Notch-related EMT and modulation of tumor microenvironment. PMID: 26608371 Ref: Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition. PMID: 26698646 Ref: Notch and Wnt/beta-catenin signaling pathway play important roles in activating liver cancer stem cells. PMID: 26735577 Ref: Hepatitis B Virus HBx Activates Notch Signaling via Delta-Like 4/Notch1 in Hepatocellular Carcinoma. PMID: 26766040 Ref: Role of Akt inhibition on Notch1 expression in hepatocellular carcinoma: potential role for dual targeted therapy. PMID: 26850133 Ref: Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice. PMID: 26877611 Ref: Corilagin suppresses cholangiocarcinoma progression through Notch signaling pathway in vitro and in vivo. PMID: 26935808 Ref: Corrigendum. PMID: 27038038 Ref: Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma. PMID: 27167202 Ref: A systems biology pipeline identifies new immune and disease related molecular signatures and networks in human cells during microgravity exposure. PMID: 27185415 Ref: Astragalus polysaccharide induces the apoptosis of human hepatocellular carcinoma cells by decreasing the expression of Notch1. PMID: 27279598 Ref: NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling. PMID: 27634758 Ref: Vasculogenic mimicry in hepatocellular carcinoma contributes to portal vein invasion. PMID: 27793002 Ref: Hepatitis B virus X protein promotes interleukin-7 receptor expression via NF-kappaB and Notch1 pathway to facilitate proliferation and migration of hepatitis B virus-related hepatoma cells. PMID: 27821177 Ref: A personalized approach identifies disturbed pathways and key genes in hepatitis C virus-cirrhosis with hepatocellular carcinoma. PMID: 27831648 |
Ref: Notch1 promotes vasculogenic mimicry in hepatocellular carcinoma by inducing EMT signaling. PMID: 27705934 Ref: Hepatitis B virus X protein and hypoxiainducible factor-1alpha stimulate Notch gene expression in liver cancer cells. PMID: 27840976 Ref: Increased FNDC5/Irisin expression in human hepatocellular carcinoma. PMID: 28012856 Ref: MicroRNA-34a regulates liver regeneration and the development of liver cancer in rats by targeting Notch signaling pathway. PMID: 28129650 Ref: NOR1 promotes hepatocellular carcinoma cell proliferation and migration through modulating the Notch signaling pathway. PMID: 28232113 Ref: Activated Notch signaling augments cell growth in hepatocellular carcinoma via up-regulating the nuclear receptor NR4A2. PMID: 28423575 Ref: Notch1 regulates the JNK signaling pathway and increases apoptosis in hepatocellular carcinoma. PMID: 28507277 Ref: Notch Inhibitor PF-03084014 Inhibits Hepatocellular Carcinoma Growth and Metastasis via Suppression of Cancer Stemness due to Reduced Activation of Notch1-Stat3. PMID: 28522590 Ref: Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma. PMID: 28574502 Ref: COE inhibits vasculogenic mimicry in hepatocellular carcinoma via suppressing Notch1 signaling. PMID: 28694103 Ref: Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis. PMID: 28794048 Ref: The role of Jagged1/Notch pathway-mediated angiogenesis of hepatocarcinoma cells in vitro, and the effects of the spleen-invigorating and blood stasis-removing recipe. PMID: 28927121 Ref: Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer. PMID: 28939741 Ref: Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells. PMID: 28974890 Ref: Regulation of ERK and AKT pathways by hepatitis B virus X protein via the Notch1 pathway in hepatocellular carcinoma. PMID: 29048612 Ref: Lidamycin decreases CD133 expression in hepatocellular carcinoma via the Notch signaling pathway. PMID: 29344233 |
Ref: Notch Signalling Pathways and Their Importance in the Treatment of Cancers. PMID: 28294046 Ref: Hepatic leukemia-associated macrophages exhibit a pro-inflammatory phenotype in Notch1-induced acute T cell leukemia. PMID: 29030004 Ref: MiR-199-3p replacement affects E-cadherin expression through Notch1 targeting in hepatocellular carcinoma. PMID: 29249451 Ref: LINC00261 suppresses cell proliferation, invasion and Notch signaling pathway in hepatocellular carcinoma. PMID: 29278875 Ref: Long non-coding RNA CCAL promotes papillary thyroid cancer progression by activation of NOTCH1 pathway. PMID: 29471887 Ref: Cancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6/STAT3/Notch signaling. PMID: 29511600 Ref: Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. PMID: 29545603 Ref: Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a. PMID: 29895332 Ref: ADAM17 promotes cell migration and invasion through the integrin beta1 pathway in hepatocellular carcinoma. PMID: 29966664 Ref: MicroRNA-760 Inhibits Doxorubicin Resistance in Hepatocellular Carcinoma through Regulating Notch1/Hes1-PTEN/Akt Signaling Pathway. PMID: 29968951 Ref: Modification of alpha2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway. PMID: 29981167 Ref: Combined antitumor effects of 1,25dihydroxy vitamin D3 and Notch inhibitor in liver cancer. PMID: 30015939 Ref: Mutations in NOTCH1 and nucleotide excision repair genes are correlated with prognosis of hepatitis B virus-associated hepatocellular carcinoma. PMID: 30087708 Ref: iNOS promotes CD24(+)CD133(+) liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway. PMID: 30297396 Ref: Regulation of periostin expression by Notch signaling in hepatocytes and liver cancer cell lines. PMID: 30384995 |