Primary Site >> Colorectal Cancer

Gene >> NLRP3

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Ref: Arginase isoenzymes in human cirrhotic liver.
PMID: 19636440
 Ref: IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation.
PMID: 20855874
 Ref: The Nlrp3 inflammasome: contributions to intestinal homeostasis.
PMID: 21388882
 Ref: Genetic variation and alterations of genes involved in NFkappaB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer.
PMID: 22843550
Ref: IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
PMID: 23075849
 Ref: Targeting the unfolded protein response, XBP1, and the NLRP3 inflammasome in fibrosis and cancer.
PMID: 24496016
Ref: NLRPs, microbiota, and gut homeostasis: unravelling the connection.
PMID: 24740681
Ref: [Impact of chemotherapies on immunosuppression and discovery of new therapeutic targets].
PMID: 24899072
Ref: Liver X receptor beta activation induces pyroptosis of human and murine colon cancer cells.
PMID: 25124554
 Ref: Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components.
PMID: 26378020
Ref: The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity.
PMID: 26384545
Ref: NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans.
PMID: 26535712
 Ref: Dietary cholesterol promotes AOM-induced colorectal cancer through activating the NLRP3 inflammasome.
PMID: 26921636
Ref: Inflammasome-independent NLRP3 is required for epithelial-mesenchymal transition in colon cancer cells.
PMID: 26968633
 Ref: The multifaceted roles of inflammasome proteins in cancer.
PMID: 27875342
Ref: Redox signaling in the gastrointestinal tract.
PMID: 28062361
Ref: Inflammasomes and Cancer.
PMID: 28093447
Ref: NLRP3 Inhibitors as Potential Therapeutic Agents for Treatment of Inflammatory Bowel Disease.
PMID: 28155620
Ref: The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation.
PMID: 28472897
Ref: Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.
PMID: 29196621
Ref: Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.
PMID: 29296531
 Ref: Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development.
PMID: 30064198
Ref: NLRP3 inflammasome in colitis and colitis-associated colorectal cancer.
PMID: 30206651
Ref: Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis.
PMID: 30339173