Primary Site >> Pancreatic Cancer
Gene >> NFKBIA
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Ref: The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. PMID: 9918209 Ref: Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer cells. PMID: 10210643 Ref: Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. PMID: 10467400 |
Ref: Evidence that de novo protein synthesis is dispensable for anti-apoptotic effects of NF-kappaB. PMID: 10822373 Ref: Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma. PMID: 11096450 |
Ref: Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. PMID: 11314019 Ref: Inhibitor of nuclear factor-kappaB induction by cAMP antagonizes interleukin-1-induced human macrophage-colony-stimulating-factor expression. PMID: 11368781 Ref: PI-3' kinase and NF-kappaB cross-signaling in human pancreatic cancer cells. PMID: 12086898 |
Ref: Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines. PMID: 11830551 Ref: Selective targeting of the nuclear factor-kappaB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death. PMID: 12219002 Ref: [Expression of NF-kappa B in human bladder cancer and its clinical significance]. PMID: 12452071 |
Ref: Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis. PMID: 12618762 Ref: Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. PMID: 12761494 Ref: Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer. PMID: 12767057 Ref: Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor. PMID: 12824895 |
Ref: NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. PMID: 14639600 Ref: Increased expression of NF-kappa B subunits in human pancreatic cancer cells. PMID: 15093710 Ref: N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts. PMID: 15375156 |
Ref: Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells. PMID: 15827332 |
Ref: GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability. PMID: 16353139 Ref: Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells. PMID: 16985059 Ref: Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells. PMID: 17050666 |
Ref: Keratinocyte growth factor/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-kappaB transcription factors. PMID: 17200110 Ref: Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death. PMID: 17410536 Ref: Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B. PMID: 17671195 |
Ref: IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model. PMID: 19010928 Ref: Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-kappa B-dependent pathway. PMID: 19050262 |
Ref: N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression. PMID: 19491262 Ref: Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB. PMID: 19670328 Ref: Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway. PMID: 19722233 |
Ref: TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells. PMID: 19940030 Ref: miR-146a suppresses invasion of pancreatic cancer cells. PMID: 20124483 Ref: NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. PMID: 20350779 Ref: Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway. PMID: 20367887 Ref: Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. PMID: 20416281 Ref: Gemcitabine combined with gum mastic causes potent growth inhibition and apoptosis of pancreatic cancer cells. PMID: 20523344 Ref: Gemcitabine resistance induced by interaction between alternatively spliced segment of tenascin-C and annexin A2 in pancreatic cancer cells. PMID: 20686216 Ref: Anti-tumor effect by inhibition of NF-kappaB activation using nafamostat mesilate for pancreatic cancer in a mouse model. PMID: 20811662 Ref: Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer. PMID: 20959520 Ref: Up-regulation of miR-146a contributes to the inhibition of invasion of pancreatic cancer cells. PMID: 25242818 |
Ref: Altered intracellular calcium fluxes in pancreatic cancer induced diabetes mellitus: Relevance of the S100A8 N-terminal peptide (NT-S100A8). PMID: 20717964 Ref: PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKalpha and sustained activation of the NF-kappaB pathway. PMID: 21376459 Ref: Nafamostat mesilate can prevent adhesion, invasion and peritoneal dissemination of pancreatic cancer thorough nuclear factor kappa-B inhibition. PMID: 21484229 Ref: Requirement of nuclear factor kappaB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis. PMID: 22241962 Ref: PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKalpha and sustained activation of the NF-kappaB pathway. PMID: 26904954 |
Ref: Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells. PMID: 22618517 Ref: CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor kappaB: implications for bidirectional tumor-stromal interactions. PMID: 22995914 |
Ref: Concurrent chemotherapy inhibits herpes simplex virus-1 replication and oncolysis. PMID: 23348635 Ref: Combination chemotherapy of serine protease inhibitor nafamostat mesilate with oxaliplatin targeting NF-kappaB activation for pancreatic cancer. PMID: 23348695 Ref: Targeting the NF-kappaB and mTOR pathways with a quinoxaline urea analog that inhibits IKKbeta for pancreas cancer therapy. PMID: 23444213 Ref: An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor kappaB- and hypoxia-inducible factor 1alpha-mediated up-regulation of CXCR4. PMID: 23740244 Ref: Digitoflavone inhibits IkappaBalpha kinase and enhances apoptosis induced by TNFalpha through downregulation of expression of nuclear factor kappaB-regulated gene products in human pancreatic cancer cells. PMID: 24146961 |
Ref: MiR-196a promotes pancreatic cancer progression by targeting nuclear factor kappa-B-inhibitor alpha. PMID: 24504166 Ref: S100P antibody-mediated therapy as a new promising strategy for the treatment of pancreatic cancer. PMID: 24637492 Ref: Differential activity of GSK-3 isoforms regulates NF-kappaB and TRAIL- or TNFalpha induced apoptosis in pancreatic cancer cells. PMID: 24675460 Ref: Apoptosis induced by microwave radiation in pancreatic cancer JF305 cells. PMID: 24708215 Ref: p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-kappaB pathway. PMID: 25238288 |
Ref: Targeted nuclear factor-kappaB suppression enhances gemcitabine response in human pancreatic tumor cell line murine xenografts. PMID: 26209568 |
Ref: Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating nuclear factor-kappaB activation. PMID: 26445000 Ref: RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. PMID: 27181206 Ref: Inhibition of the NF-kappaB pathway by nafamostat mesilate suppresses colorectal cancer growth and metastasis. PMID: 27322737 Ref: A liposomal formulation of the synthetic curcumin analog EF24 (Lipo-EF24) inhibits pancreatic cancer progression: towards future combination therapies. PMID: 27401816 Ref: Negative control of TRAIL-R1 signaling by transforming growth factor beta1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1. PMID: 27492861 Ref: Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Human Cancer Cells through Reactive Oxygen Species-Mediated NF-kappaB Activations. PMID: 27791350 |
Ref: RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells. PMID: 28234980 Ref: Sporamin induces apoptosis and inhibits NF-kappaB activation in human pancreatic cancer cells. PMID: 28714369 Ref: Centrosomal protein 55 activates NF-kappaB signalling and promotes pancreatic cancer cells aggressiveness. PMID: 28724890 |
Ref: SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer. PMID: 29059173 Ref: Matrine inhibiting pancreatic cells epithelial-mesenchymal transition and invasion through ROS/NF-kappaB/MMPs pathway. PMID: 29155301 |