Primary Site >> Colorectal Cancer
Gene >> NFKBIA
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Ref: Nuclear factor - kappaB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug. PMID: 9528861 |
Ref: A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. PMID: 10449430 |
Ref: IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling. PMID: 10638662 Ref: Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. PMID: 10766192 Ref: Activation of NF-kappaB determines the sensitivity of human colon cancer cells to TNFalpha-induced apoptosis. PMID: 10784420 Ref: Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation. PMID: 10811101 Ref: Activation of NF-kappaB binding in HT-29 colon cancer cells by inhibition of phosphatidylinositol 3-kinase. PMID: 10891336 Ref: IkappaBbeta-related proteins in normal and transformed colonic epithelial cells. PMID: 11020244 |
Ref: Assessment of tumor necrosis factor receptor and Fas signaling pathways by transcriptional profiling. PMID: 11212226 Ref: Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. PMID: 11316563 Ref: IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. PMID: 11359792 |
Ref: 5-Fluorouracil inhibits nitric oxide production through the inactivation of IkappaB kinase in stomach cancer cells. PMID: 12417257 |
Ref: NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. PMID: 12527911 Ref: Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. PMID: 12584750 Ref: Adenovirus-mediated gene transduction of truncated I kappa B alpha enhances radiosensitivity in human colon cancer cells. PMID: 12901803 Ref: NF-kappaB-independent actions of sulfasalazine dissociate the CD95L- and Apo2L/TRAIL-dependent death signaling pathways in human malignant glioma cells. PMID: 12934082 |
Ref: [Deoxycholic acid-induced signal transduction in HT-29 cells: role of NF-kappa B and interleukin-8]. PMID: 15034288 Ref: NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling. PMID: 15047705 Ref: Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. PMID: 15139523 Ref: Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells. PMID: 15172114 Ref: Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis. PMID: 15188000 Ref: Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer. PMID: 15234211 Ref: Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer. PMID: 15292388 |
Ref: Mapping of the critical region of mitogene-inducible gene-6 for NF-kappaB activation. PMID: 15706420 Ref: Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency. PMID: 15770215 Ref: Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors. PMID: 15824729 Ref: HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha. PMID: 15950952 Ref: Diclofenac attenuates Wnt/beta-catenin signaling in colon cancer cells by activation of NF-kappaB. PMID: 16051228 Ref: Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. PMID: 16199534 |
Ref: PKCdelta-mediated regulation of FLIP expression in human colon cancer cells. PMID: 16052516 Ref: Ursodeoxycholic acid inhibits interleukin 1 beta [corrected] and deoxycholic acid-induced activation of NF-kappaB and AP-1 in human colon cancer cells. PMID: 16106402 Ref: Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. PMID: 16360644 Ref: Rac1, but not Rac1B, stimulates RelB-mediated gene transcription in colorectal cancer cells. PMID: 16551621 Ref: Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines. PMID: 16733051 Ref: Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes. PMID: 16800774 Ref: The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene. PMID: 16841079 Ref: Intracellular expression of toll-like receptor 4 in neuroblastoma cells and their unresponsiveness to lipopolysaccharide. PMID: 17156435 |
Ref: Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. PMID: 17132819 Ref: Triptolide suppresses IL-1beta-induced chemokine and stromelysin-1 gene expression in human colonic subepithelial myofibroblasts. PMID: 17184586 Ref: Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations. PMID: 17354114 Ref: Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NF kappa B signalling. PMID: 17521736 Ref: [Inhibitory effects of cordyceps extract on growth of colon cancer cells]. PMID: 17634040 Ref: Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B. PMID: 17671195 Ref: Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. PMID: 17671207 Ref: NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases. PMID: 17701919 Ref: EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. PMID: 18032824 |
Ref: The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB. PMID: 18059344 Ref: Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. PMID: 18485277 Ref: Lithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cells. PMID: 18515093 Ref: Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway. PMID: 18570457 Ref: Sulindac enhances arsenic trioxide-mediated apoptosis by inhibition of NF-kappaB in HCT116 colon cancer cells. PMID: 18575716 Ref: The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression. PMID: 18830563 Ref: Evaluation of the expression of transcriptional factor NF-kappaB induced by phytic acid in colon cancer cells. PMID: 19172851 |
Ref: Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cells. PMID: 18729103 Ref: Oncogene functions of FHL2 are independent from NF-kappaBIalpha in gastrointestinal cancer. PMID: 18752053 Ref: Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. PMID: 19056378 Ref: Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling. PMID: 19159619 Ref: Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway. PMID: 19472191 Ref: An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation. PMID: 19616541 Ref: Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway. PMID: 19722233 |
Ref: Association between activation of atypical NF-kappaB1 p105 signaling pathway and nuclear beta-catenin accumulation in colorectal carcinoma. PMID: 20027638 Ref: Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells. PMID: 20060025 Ref: Bifidobacterium lactis inhibits NF-kappaB in intestinal epithelial cells and prevents acute colitis and colitis-associated colon cancer in mice. PMID: 20310012 Ref: Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. PMID: 20360625 Ref: An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-kappaB pathway in a mouse model of colitis-associated colon cancer. PMID: 20400476 Ref: Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin. PMID: 20424169 Ref: Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products. PMID: 20460401 Ref: Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. PMID: 20509140 Ref: Quantitative evaluation of transcriptional activation of NF-kappaB p65 and p50 subunits and IkappaBalpha encoding genes in colon cancer cells by Desulfovibrio desulfuricans endotoxin. PMID: 21253915 Ref: Polymorphism in the promoter region of the NFKBIA gene is rare in Swedish and Chinese colorectal cancer patients and controls. PMID: 21472202 |
Ref: Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. PMID: 21098643 Ref: Sage components enhance cell death through nuclear factor kappa-B signaling. PMID: 21196321 Ref: Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}. PMID: 21205744 Ref: p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. PMID: 21353507 Ref: Fluoxetine inhibits NF-kappaB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice. PMID: 21436313 Ref: Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-alpha-stimulated HT-29 cells. PMID: 21462331 Ref: 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma. PMID: 21544861 Ref: c-Src dependency of NSAID-induced effects on NF-kappaB-mediated apoptosis in colorectal cancer cells. PMID: 21551129 Ref: Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity. PMID: 21586136 Ref: NF-kappaB activation by peroxynitrite through IkappaBalpha-dependent phosphorylation versus nitration in colon cancer cells. PMID: 21617217 Ref: An IkappaBalpha phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-kappaB-independent mechanism. PMID: 21620964 Ref: Involvement of ERK1/2/NF-kappaB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620. PMID: 21625939 Ref: NFkappaB1 and NFkappaBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population. PMID: 21738780 Ref: Differential expression of TNF-alpha signaling molecules and ERK1 in distal and proximal colonic tumors associated with obesity. PMID: 21761118 Ref: C086, a novel analog of curcumin, induces growth inhibition and down-regulation of NFkappaB in colon cancer cells and xenograft tumors. PMID: 21900746 Ref: [Role of NF-kappaB in factor VIIa-induced proliferation and migration of colon cancer cell line SW620 cells]. PMID: 22340043 |
Ref: Calpain 2-dependent IkappaBalpha degradation mediates CPT-11 secondary resistance in colorectal cancer xenografts. PMID: 22069124 Ref: Mutated in colorectal cancer protein modulates the NFkappaB pathway. PMID: 22213290 Ref: NF-kappaB activity is downregulated by KRAS knockdown in SW620 cells via the RAS-ERK-IkappaBalpha pathway. PMID: 22327383 Ref: The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response. PMID: 22342343 Ref: Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway. PMID: 22461522 Ref: Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. PMID: 22465936 Ref: Effect of silencing PARG in human colon carcinoma LoVo cells on the ability of HUVEC migration and proliferation. PMID: 22918473 |
Ref: Effect of silibinin in human colorectal cancer cells: targeting the activation of NF-kappaB signaling. PMID: 22086675 Ref: Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1alpha. PMID: 23368925 Ref: Secreted heat shock protein 90alpha (HSP90alpha) induces nuclear factor-kappaB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion. PMID: 23386606 Ref: The detergent-soluble cytoplasmic pool of survivin suppresses anoikis and its expression is associated with metastatic disease of human colon cancer. PMID: 23405201 Ref: Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways. PMID: 23451189 Ref: Positional mapping and candidate gene analysis of the mouse Ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer. PMID: 23516545 Ref: Epigenetic control of NF-kappaB-dependent FAS gene transcription during progression of myelodysplastic syndromes. PMID: 23604035 Ref: Nimbolide, a limonoid triterpene, inhibits growth of human colorectal cancer xenografts by suppressing the proinflammatory microenvironment. PMID: 23766363 Ref: A mechanistic study of the proapoptotic effect of tolfenamic acid: involvement of NF-kappaB activation. PMID: 23784084 Ref: Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells. PMID: 23794454 Ref: Reactive oxygen species mediate tolfenamic acid-induced apoptosis in human colorectal cancer cells. PMID: 23896517 Ref: Gender-specific association of NFKBIA promoter polymorphisms with the risk of sporadic colorectal cancer. PMID: 23996241 Ref: Sulindac activates NF-kappaB signaling in colon cancer cells. PMID: 24083678 Ref: Epigenetic silencing of CXCL14 induced colorectal cancer migration and invasion. PMID: 24099668 Ref: ART1 silencing enhances apoptosis of mouse CT26 cells via the PI3K/Akt/NF-kappaB pathway. PMID: 24335275 Ref: Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer. PMID: 24367615 |
Ref: Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-kappaB signaling. PMID: 22949302 Ref: Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer. PMID: 24716225 |
Ref: Tolfenamic Acid Suppresses Inflammatory Stimuli-Mediated Activation of NF-kappaB Signaling. PMID: 25593642 Ref: Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFkappaB signaling. PMID: 25704885 Ref: Tetraarsenic hexoxide demonstrates anticancer activity at least in part through suppression of NF-kappaB activity in SW620 human colon cancer cells. PMID: 25845556 Ref: Hypoxia attenuates the proinflammatory response in colon cancer cells by regulating IkappaB. PMID: 25978030 Ref: Resveratrol induces AMPK-dependent MDR1 inhibition in colorectal cancer HCT116/L-OHP cells by preventing activation of NF-kappaB signaling and suppressing cAMP-responsive element transcriptional activity. PMID: 26124005 Ref: Parthenolide induces apoptosis in colitis-associated colon cancer, inhibiting NF-kappaB signaling. PMID: 26137027 Ref: Crosstalk between the TNF and IGF pathways enhances NF-kappaB activation and signaling in cancer cells. PMID: 26239406 Ref: Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. PMID: 26310874 Ref: Chemosensitization by diverging modulation by short-term and long-term TNF-alpha action on ABCB1 expression and NF-kappaB signaling in colon cancer. PMID: 26463665 Ref: [Qinghuachang Decoction Inhibited NF-kappaB Activation in LPS-induced Human Enterocytes]. PMID: 26775485 |
Ref: Combination treatment with flavonoid morin and telomerase inhibitor MST312 reduces cancer stem cell traits by targeting STAT3 and telomerase. PMID: 27279256 Ref: Inhibition of the NF-kappaB pathway by nafamostat mesilate suppresses colorectal cancer growth and metastasis. PMID: 27322737 Ref: Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer. PMID: 27472952 Ref: Knockdown of RPL9 expression inhibits colorectal carcinoma growth via the inactivation of Id-1/NF-kappaB signaling axis. PMID: 27633352 Ref: Novel Synthetic Oxazines Target NF-kappaB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo. PMID: 27685808 Ref: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model. PMID: 27729020 Ref: The methanol-ethyl acetate partitioned fraction from Chinese olive fruits inhibits cancer cell proliferation and tumor growth by promoting apoptosis through the suppression of the NF-kappaB signaling pathway. PMID: 27869910 |
Ref: Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-kappaB/iNOS signaling pathways. PMID: 27865009 Ref: Knockdown of NIK and IKKbeta-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-kappaBeta Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK. PMID: 28125661 Ref: Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer. PMID: 28476123 Ref: microRNA-335 inhibits colorectal cancer HCT116 cells growth and epithelial-mesenchymal transition (EMT) process by targeting Twist1. PMID: 29441907 |
Ref: DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in colorectal cancer. PMID: 29277893 Ref: Codonopis bulleynana Forest ex Diels inhibits autophagy and induces apoptosis of colon cancer cells by activating the NF-kappaB signaling pathway. PMID: 29286074 Ref: Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. PMID: 29382334 Ref: Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice. PMID: 29439531 Ref: Loss of NDRG2 in liver microenvironment inhibits cancer liver metastasis by regulating tumor associate macrophages polarization. PMID: 29445150 Ref: Antimalarial drug mefloquine inhibits nuclear factor kappa B signaling and induces apoptosis in colorectal cancer cells. PMID: 29453896 Ref: Co-inhibition of BET proteins and NF-kappaB as a potential therapy for colorectal cancer through synergistic inhibiting MYC and FOXM1 expressions. PMID: 29472532 Ref: Andrographolide derivative CX-10 ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: Involvement of NF-kappaB and MAPK signalling pathways. PMID: 29475099 Ref: Single nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer. PMID: 29564065 Ref: Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer. PMID: 29879413 Ref: Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice. PMID: 30359174 Ref: alpha-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-kappaB Signaling in Colon Cancer Cells. PMID: 30363706 Ref: Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling. PMID: 30378164 |