Primary Site >> Colorectal Cancer

Gene >> NEDD8

  • 2012
  • 2013
  • 2014
  • 2015
  • 2016
  • 2017
  • 2018
Ref: Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.
PMID: 22095636
Ref: A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924.
PMID: 22832224
 Ref: Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.
PMID: 23100467
 Ref: The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
PMID: 24821572
 Ref: Molecular dynamics simulation on the low sensitivity of mutants of NEDD-8 activating enzyme for MLN4924 inhibitor as a cancer drug.
PMID: 26807320
 Ref: Radiosensitization of Human Colorectal Cancer Cells by MLN4924: An Inhibitor of NEDD8-Activating Enzyme.
PMID: 26082455
 Ref: Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.
PMID: 27771609
Ref: Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening.
PMID: 28388520
Ref: Neural precursor cell expressed, developmentally downregulated 8activating enzyme inhibitor MLN4924 sensitizes colorectal cancer cells to oxaliplatin by inducing DNA damage, G2 cell cycle arrest and apoptosis.
PMID: 28447739
 Ref: Construction and characterization of regulated cycle inhibiting factors induced upon Tet-On system in human colon cancer cell lines.
PMID: 29923895