Primary Site >> Colorectal Cancer
Gene >> NCK1
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Ref: The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism. PMID: 12149262 |
Ref: Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. PMID: 15788770 |
Ref: Compartmentalized DCC signalling is distinct from DCC localized to lipid rafts. PMID: 18616430 |
Ref: NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits. PMID: 25913325 |
Ref: Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis. PMID: 28455144 |