Primary Site >> Colorectal Cancer
Gene >> NBN
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Ref: Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. PMID: 10362364 |
Ref: Allelic imbalance at NBS1 is frequent in both proximal and distal colorectal carcinoma. PMID: 10671697 |
Ref: Human MRE11 is inactivated in mismatch repair-deficient cancers. PMID: 11850399 Ref: Nijmegen breakage syndrome gene (NBS1) is not the tumor suppressor gene at 8q21.3 involved in colorectal carcinoma. PMID: 12066197 |
Ref: Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. PMID: 15048091 Ref: Increased cancer risk of heterozygotes with NBS1 germline mutations in Poland. PMID: 15185344 Ref: ATM-dependent CHK2 activation induced by anticancer agent, irofulven. PMID: 15269203 |
Ref: Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas. PMID: 16025146 |
Ref: [Mutations in tumor suppressor gene NBS1 in adult patients with malignancies]. PMID: 16634478 Ref: Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. PMID: 16905549 |
Ref: Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. PMID: 17218778 Ref: The MRE11/RAD50/NBS1 complex destabilization in Lynch-syndrome patients. PMID: 17534377 Ref: Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer. PMID: 18056440 |
Ref: Heterozygous carriers of the I171V mutation of the NBS1 gene have a significantly increased risk of solid malignant tumours. PMID: 18280732 Ref: The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer. PMID: 18606567 Ref: RAD50/MRE11/NBS1 proteins in relation to tumour development and prognosis in patients with microsatellite stable colorectal cancer. PMID: 18830935 Ref: NBS1 Heterozygosity and Cancer Risk. PMID: 19452044 |
Ref: NBN 657del5 heterozygous mutations and colorectal cancer risk in the Czech Republic. PMID: 19393249 |
Ref: Expression profile of significant immortalization genes in colon cancer. PMID: 20127035 Ref: Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. PMID: 20720310 Ref: Novel somatic frameshift mutations of genes related to cell cycle and DNA damage response in gastric and colorectal cancers with microsatellite instability. PMID: 21388066 |
Ref: Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis. PMID: 21390062 Ref: [Heterozygous carriers of Slavic mutation 657del5 of NBN gene in patients with colorectal cancer]. PMID: 21560448 |
Ref: Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancer. PMID: 23097684 |
Ref: Clinicopathological significance of BTF3 expression in colorectal cancer. PMID: 23532689 Ref: The influence of XPD, APE1, XRCC1, and NBS1 polymorphic variants on DNA repair in cells exposed to X-rays. PMID: 23669291 |
Ref: Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer. PMID: 23681918 Ref: Distinct DNA damage determines differential phosphorylation of Chk2. PMID: 25535901 |
Ref: Associations between NBS1 Polymorphisms and Colorectal Cancer in Chinese Population. PMID: 26186548 |
Ref: rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk. PMID: 27845421 |
Ref: AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. PMID: 28967905 Ref: Targeting RAD50 increases sensitivity to radiotherapy in colorectal cancer cells. PMID: 29322791 Ref: Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing. PMID: 29844865 Ref: Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis. PMID: 30176843 |