Primary Site >> Stomach Cancer
Gene >> MTOR
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Ref: The synthesis and anti-proliferative effects of beta-elemene derivatives with mTOR inhibition activity. PMID: 16617020 |
Ref: Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model. PMID: 17230506 Ref: Defibrotide: an endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo. PMID: 17495522 Ref: [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. PMID: 17680526 Ref: Matrine inhibits the activity of translation factor eIF4E through dephosphorylation of 4E-BP1 in gastric MKN45 cells. PMID: 17823871 |
Ref: Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. PMID: 18258606 Ref: Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells. PMID: 18375114 Ref: Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion. PMID: 18381294 Ref: Mammalian target of rapamycin pathway inhibition enhances the effects of 5-aza-dC on suppressing cell proliferation in human gastric cancer cell lines. PMID: 18622747 Ref: mTOR inhibition sensitizes gastric cancer to alkylating chemotherapy in vivo. PMID: 19189667 |
Ref: Obestatin stimulates Akt signalling in gastric cancer cells through beta-arrestin-mediated epidermal growth factor receptor transactivation. PMID: 19153210 Ref: Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer. PMID: 19223493 Ref: Relation between outcomes and localisation of p-mTOR expression in gastric cancer. PMID: 19223902 Ref: Adenovirus-mediated eukaryotic initiation factor 4E binding protein-1 in combination with rapamycin inhibits tumor growth of pancreatic ductal adenocarcinoma in vivo. PMID: 19360336 Ref: Gastric cancer in the era of molecularly targeted agents: current drug development strategies. PMID: 19363621 Ref: Mucosa-associated lymphoid tissue gastric lymphoma regression in a renal transplant patient after conversion of the immunosuppression to sirolimus: a case report. PMID: 19376398 Ref: FDG uptake is a surrogate marker for defining the optimal biological dose of the mTOR inhibitor everolimus in vivo. PMID: 19436299 Ref: Novel investigational drugs for gastric cancer. PMID: 19466878 Ref: mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells. PMID: 19738050 Ref: Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer. PMID: 19764996 Ref: Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy. PMID: 19860903 Ref: The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray. PMID: 20003385 |
Ref: Prognostic role of p-mTOR expression in cancer tissues and metastatic lymph nodes in pT2b gastric cancer. PMID: 19739122 Ref: Rapamycin enhances chemotherapy-induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells. PMID: 19856312 Ref: Esophagogastric cancer: targeted agents. PMID: 20122806 Ref: Effects of vatalanib on tumor growth can be potentiated by mTOR blockade in vivo. PMID: 20404549 Ref: mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric cancer in vivo. PMID: 20471160 Ref: Activation of AMP-activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis. PMID: 20564492 Ref: RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase. PMID: 20727673 Ref: Activated mammalian target of rapamycin is a potential therapeutic target in gastric cancer. PMID: 20929525 |
Ref: Efficacy of RAD001 (everolimus) against advanced gastric cancer with peritoneal dissemination. PMID: 20532589 Ref: Cetuximab enhances the activities of irinotecan on gastric cancer cell lines through downregulating the EGFR pathway upregulated by irinotecan. PMID: 21286718 Ref: Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells. PMID: 21287681 Ref: A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. PMID: 21364753 Ref: beta-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis. PMID: 21595977 Ref: Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling. PMID: 21610320 Ref: Molecularly targeted therapies in unresectable-metastatic gastric cancer: a systematic review. PMID: 21676549 Ref: Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake. PMID: 21712451 Ref: Protective autophagy antagonizes oxaliplatin-induced apoptosis in gastric cancer cells. PMID: 21718595 Ref: Rapamycin inhibits the proliferation and apoptosis of gastric cancer cells by down regulating the expression of survivin. PMID: 21830446 Ref: ERas enhances resistance to CPT-11 in gastric cancer. PMID: 21965746 Ref: Prognostic value of co-expression of STAT3, mTOR and EGFR in gastric cancer. PMID: 22977493 |
Ref: mTOR as a therapeutic target in patients with gastric cancer. PMID: 21898386 Ref: Molecular targeted agents for gastric and gastroesophageal junction cancer. PMID: 22127535 Ref: Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. PMID: 22135232 Ref: NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. PMID: 22159814 Ref: Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer. PMID: 22202059 Ref: E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells. PMID: 22322152 Ref: Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of rapamycin inhibition and 5-fluorouracil in PIK3CA mutant gastric cancer cells. PMID: 22336586 Ref: Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells. PMID: 22337890 Ref: The roles of REIC gene and its encoding product in gastric carcinoma. PMID: 22421143 Ref: Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines. PMID: 22543857 Ref: Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification. PMID: 22614071 Ref: Novel targeted agents for gastric cancer. PMID: 22709792 Ref: Identification of hsa-miR-335 as a prognostic signature in gastric cancer. PMID: 22802949 Ref: Metastatic gastric cancer - focus on targeted therapies. PMID: 22807624 Ref: Immunohistochemical expression of mTOR negatively correlates with PTEN expression in gastric carcinoma. PMID: 23205120 |
Ref: Lactobacillus casei extract induces apoptosis in gastric cancer by inhibiting NF-kappaB and mTOR-mediated signaling. PMID: 22505595 Ref: ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer. PMID: 22907434 Ref: Advanced HER2-positive gastric cancer: current and future targeted therapies. PMID: 23021388 Ref: Therapeutic implications of mTOR inhibitors in the treatment of gastric cancer. PMID: 23215721 Ref: VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. PMID: 23270925 Ref: Phosphorylation of 4E-BP1 predicts sensitivity to everolimus in gastric cancer cells. PMID: 23340172 Ref: Protective role of autophagy in matrineinduced gastric cancer cell death. PMID: 23404079 Ref: Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population. PMID: 23423739 Ref: Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. PMID: 23432957 Ref: A polymorphism (rs2295080) in mTOR promoter region and its association with gastric cancer in a Chinese population. PMID: 23555892 Ref: [Perspectives of the stomach cancer treatment: the introduction of molecular targeted therapy and the hope for cure]. PMID: 23575230 Ref: Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil. PMID: 23684942 Ref: Association between phosphorylated AMP-activated protein kinase and MAPK3/1 expression and prognosis for patients with gastric cancer. PMID: 23860205 Ref: The dual PI3K/mTOR inhibitor NVP-BEZ235 enhances nab-paclitaxel antitumor response in experimental gastric cancer. PMID: 24042258 Ref: Gastric cancer-molecular and clinical dimensions. PMID: 24061039 Ref: Decreased fructose-1,6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells. PMID: 24063558 Ref: MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation. PMID: 24065659 Ref: The Critical Impact of HIF-1a on Gastric Cancer Biology. PMID: 24216696 Ref: Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase/Akt signal transduction in gastric cancer cells. PMID: 24273605 Ref: Akt inhibitors: mechanism of action and implications for anticancer therapeutics. PMID: 24330834 Ref: Transcriptomic changes induced by mycophenolic acid in gastric cancer cells. PMID: 24349619 Ref: Inhibitory effects of water caltrop pericarps on the growth of human gastric cancer cells in vitro. PMID: 24380421 Ref: Combining molecular targeted drugs to inhibit both cancer cells and activated stromal cells in gastric cancer. PMID: 24403861 Ref: The role of miR-18a in gastric cancer angiogenesis. PMID: 24624454 |
Ref: Inhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation. PMID: 24030871 Ref: The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway. PMID: 24416349 Ref: Antibiotic drug tigecycline inhibited cell proliferation and induced autophagy in gastric cancer cells. PMID: 24582751 Ref: Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype. PMID: 24597478 Ref: Prognostic implication of TSC1 and mTOR expression in gastric carcinoma. PMID: 24615476 Ref: Recent advances and future trends in the targeted therapy of metastatic gastric cancer. PMID: 24665840 Ref: Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy. PMID: 24667175 Ref: A GG allele of 3'-side AKT1 SNP is associated with decreased AKT1 activation and better prognosis of gastric cancer. PMID: 24737346 Ref: Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling. PMID: 24799956 Ref: Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. PMID: 24810364 Ref: The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance. PMID: 24844205 Ref: miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2. PMID: 24875127 Ref: MicroRNA-382 induced by HIF-1alpha is an angiogenic miR targeting the tumor suppressor phosphatase and tensin homolog. PMID: 24914051 Ref: Anti-apoptotic and apoptotic pathway analysis of arsenic trioxideinduced apoptosis in human gastric cancer SGC-7901 cells. PMID: 24969414 Ref: [Concurrent association of reirradiation therapy with everolimus for lymph node metastasis of gastroesophageal junction cancer: a case report]. PMID: 24981410 Ref: The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma. PMID: 25003395 Ref: PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. PMID: 25035961 Ref: Mechanisms of GOLPH3 associated with the progression of gastric cancer: a preliminary study. PMID: 25286393 Ref: Reduced miR-126 expression facilitates angiogenesis of gastric cancer through its regulation on VEGF-A. PMID: 25428912 Ref: Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer. PMID: 25597356 Ref: Evaluation of antagonistic effects of metformin with Cisplatin in gastric cancer cells. PMID: 25642303 |
Ref: Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. PMID: 24510342 Ref: An enzymatically fortified ginseng extract inhibits proliferation and induces apoptosis of KATO3 human gastric cancer cells via modulation of Bax, mTOR, PKB and IkappaBalpha. PMID: 25333578 Ref: AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. PMID: 25456211 Ref: Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway. PMID: 25524555 Ref: Insulin-like growth factor 1 promotes growth of gastric cancer by inhibiting foxo1 nuclear retention. PMID: 25596089 Ref: Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells. PMID: 25609923 Ref: Overexpression of CDX2 in gastric cancer cells promotes the development of multidrug resistance. PMID: 25628941 Ref: Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway. PMID: 25701378 Ref: Targeted therapy in gastric cancer. PMID: 25706252 Ref: Silencing profilin-1 inhibits gastric cancer progression via integrin beta1/focal adhesion kinase pathway modulation. PMID: 25741138 Ref: Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and N PMID: 25767376 Ref: Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PMID: 25785838 Ref: Akt signaling is associated with the berberine-induced apoptosis of human gastric cancer cells. PMID: 25837881 Ref: Biologics in combination with chemotherapy for gastric cancer: is this the answer? PMID: 25850442 Ref: Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis. PMID: 25884175 Ref: Successful control of heavily pretreated metastatic gastric cancer with the mTOR inhibitor everolimus (RAD001) in a patient with PIK3CA mutation and pS6 overexpression. PMID: 25886409 Ref: Metformin potentiates rapamycin and cisplatin in gastric cancer in mice. PMID: 25909163 Ref: Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance. PMID: 25956062 Ref: Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. PMID: 25981581 Ref: Emerging kinase inhibitors of the treatment of gastric cancer. PMID: 26021342 Ref: BTG1 expression correlates with pathogenesis, aggressive behaviors and prognosis of gastric cancer: a potential target for gene therapy. PMID: 26050197 Ref: Corosolic acid enhances 5-fluorouracil-induced apoptosis against SNU-620 human gastric carcinoma cells by inhibition of mammalian target of rapamycin. PMID: 26100106 Ref: Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. PMID: 26147886 Ref: Elevated Rictor expression is associated with tumor progression and poor prognosis in patients with gastric cancer. PMID: 26159923 Ref: Protective Macroautophagy Is Involved in Vitamin E Succinate Effects on Human Gastric Carcinoma Cell Line SGC-7901 by Inhibiting mTOR Axis Phosphorylation. PMID: 26168048 Ref: Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. PMID: 26201693 Ref: Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy. PMID: 26267324 Ref: Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population. PMID: 26287940 Ref: Association of MTOR and AKT Gene Polymorphisms with Susceptibility and Survival of Gastric Cancer. PMID: 26317520 Ref: Anticancer activities of self-assembled molecular bowls containing a phenanthrene-based donor and Ru(II) acceptors. PMID: 26347134 Ref: Auraptene, a Major Compound of Supercritical Fluid Extract of Phalsak (Citrus Hassaku Hort ex Tanaka), Induces Apoptosis through the Suppression of mTOR Pathways in Human Gastric Cancer SNU-1 Cells. PMID: 26351512 Ref: The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis. PMID: 26366097 Ref: The JAK/STAT signaling cascade in gastric carcinoma (Review). PMID: 26398764 Ref: Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer. PMID: 26500453 Ref: LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway. PMID: 26540343 Ref: Dual PI3K/mTOR inhibitor BEZ235 exerts extensive antitumor activity in HER2-positive gastric cancer. PMID: 26560145 Ref: Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? PMID: 26604635 Ref: MMP2 and MMP7 at the invasive front of gastric cancer are not associated with mTOR expression. PMID: 26652716 Ref: [Effect of evodiamine in inducing apoptosis of gastric cancer SGC-7901 cells through mTOR signal pathway]. PMID: 26790304 |
Ref: miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway. PMID: 26458815 Ref: Reciprocal expression of p-AMPKa and p-S6 is strongly associated with the prognosis of gastric cancer. PMID: 26520441 Ref: Systemic therapy beyond first-line in advanced gastric cancer: An overview of the main randomized clinical trials. PMID: 26697987 Ref: Targeted therapy for gastric cancer: Current status and future directions (Review). PMID: 26718131 Ref: Molecular targeted therapy for the treatment of gastric cancer. PMID: 26728266 Ref: The Transcription Factor p8 Regulates Autophagy in Response to Palmitic Acid Stress via a Mammalian Target of Rapamycin (mTOR)-independent Signaling Pathway. PMID: 26733200 Ref: Mefloquine effectively targets gastric cancer cells through phosphatase-dependent inhibition of PI3K/Akt/mTOR signaling pathway. PMID: 26780727 Ref: Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways. PMID: 26859571 Ref: Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus. PMID: 26859683 Ref: Targeted therapies in gastric cancer treatment: where we are and where we are going. PMID: 26873643 Ref: Current Molecular Targeted Therapy in Advanced Gastric Cancer: A Comprehensive Review of Therapeutic Mechanism, Clinical Trials, and Practical Application. PMID: 26880889 Ref: Long Noncoding RNA H19-Derived miR-675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells. PMID: 26931432 Ref: The potential of deferasirox as a novel therapeutic modality in gastric cancer. PMID: 26965928 Ref: miR-196b regulates gastric cancer cell proliferation and invasion via PI3K/AKT/mTOR signaling pathway. PMID: 26998071 Ref: Huaier aqueous extract sensitizes cells to rapamycin and cisplatin through activating mTOR signaling. PMID: 27045863 Ref: Oleanolic acid induces autophagic death in human gastric cancer cells in vitro and in vivo. PMID: 27079177 Ref: DT-13, a saponin monomer of dwarf lilyturf tuber, induces autophagy and potentiates anti-cancer effect of nutrient deprivation. PMID: 27079642 Ref: PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells. PMID: 27147579 Ref: The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines. PMID: 27156070 Ref: High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial. PMID: 27179038 Ref: Recent updates of precision therapy for gastric cancer: Towards optimal tailored management. PMID: 27217696 Ref: Autophagic death induced by thermochemotherapy in gastric cancer cells results from the reactive oxygen species pathway. PMID: 27277337 Ref: Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. PMID: 27277844 Ref: Comprehensive mutation profiling of mucinous gastric carcinoma. PMID: 27313181 Ref: Autophagy regulation and its role in gastric cancer and colorectal cancer. PMID: 27314289 Ref: MicroRNA-224 aggrevates tumor growth and progression by targeting mTOR in gastric cancer. PMID: 27315344 Ref: Linifanib (ABT-869) Potentiates the Efficacy of Chemotherapeutic Agents through the Suppression of Receptor Tyrosine Kinase-Mediated AKT/mTOR Signaling Pathways in Gastric Cancer. PMID: 27387652 Ref: URI promotes gastric cancer cell motility, survival, and resistance to adriamycin in vitro. PMID: 27429854 Ref: Sinularin Induces Apoptosis through Mitochondria Dysfunction and Inactivation of the pI3K/Akt/mTOR Pathway in Gastric Carcinoma Cells. PMID: 27472346 Ref: Upregulation of microRNA-370 promotes cell apoptosis and inhibits proliferation by targeting PTEN in human gastric cancer. PMID: 27499479 Ref: Oncogenic NanogP8 expression regulates cell proliferation and migration through the Akt/mTOR signaling pathway in human gastric cancer - SGC-7901cell line. PMID: 27563247 Ref: RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer. PMID: 27572296 Ref: Cancer stem cell marker CD90 inhibits ovarian cancer formation via beta3 integrin. PMID: 27633757 Ref: Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer. PMID: 27697670 Ref: Knockdown of Rap1b Enhances Apoptosis and Autophagy in Gastric Cancer Cells via the PI3K/Akt/mTOR Pathway. PMID: 27712585 Ref: [Research status quo and progression in targeted therapy for advanced gastric cancer]. PMID: 27781258 Ref: Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling. PMID: 27863387 Ref: Autophagy Protects from Raddeanin A-Induced Apoptosis in SGC-7901 Human Gastric Cancer Cells. PMID: 27974905 Ref: To Excavate Biomarkers Predictive of the Response for Capecitabine plus RAD001 through Nanostring-Based Multigene Assay in Advanced Gastric Cancer Patients. PMID: 27994652 Ref: Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer. PMID: 28005970 Ref: CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line. PMID: 28281969 |
Ref: Akt/AMPK/mTOR pathway was involved in the autophagy induced by vitamin E succinate in human gastric cancer SGC-7901 cells. PMID: 27796683 Ref: Fabrication of self-assembled chitosan-dispersed LDL nanoparticles for drug delivery with a one-step green method. PMID: 27845214 Ref: Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition. PMID: 28028034 Ref: Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma. PMID: 28188923 Ref: DDX5 promotes gastric cancer cell proliferation in vitro and in vivo through mTOR signaling pathway. PMID: 28216662 Ref: MicroRNA-134 suppresses cell proliferation in gastric cancer cells via targeting of GOLPH3. PMID: 28260021 Ref: Gastric cancer management: Kinases as a target therapy. PMID: 28271563 Ref: Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells. PMID: 28299464 Ref: FGF7/FGFR2 signal promotes invasion and migration in human gastric cancer through upregulation of thrombospondin-1. PMID: 28339036 Ref: Chalcone flavokawain B induces autophagic-cell death via reactive oxygen species-mediated signaling pathways in human gastric carcinoma and suppresses tumor growth in nude mice. PMID: 28374157 Ref: Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1alpha to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells. PMID: 28401064 Ref: Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer. PMID: 28446188 Ref: Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer. PMID: 28460635 Ref: Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer. PMID: 28476678 Ref: Efficacy and safety of different molecular targeted agents based on chemotherapy for gastric cancer patients treatment: a network meta-analysis. PMID: 28477027 Ref: Anticancer activities of harmine by inducing a pro-death autophagy and apoptosis in human gastric cancer cells. PMID: 28478808 Ref: In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies. PMID: 28484222 Ref: Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells. PMID: 28498433 Ref: MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway. PMID: 28498460 Ref: Inhibition of cell proliferation and induction of autophagy by KDM2B/FBXL10 knockdown in gastric cancer cells. PMID: 28506929 Ref: Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistance. PMID: 28507275 Ref: Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors. PMID: 28594907 Ref: Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death. PMID: 28613975 Ref: MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer. PMID: 28632723 Ref: Knockdown of ARK5 Expression Suppresses Invasion and Metastasis of Gastric Cancer. PMID: 28662499 Ref: miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR. PMID: 28693382 Ref: Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling. PMID: 28713919 Ref: [Curcumin induces apoptosis and protective autophagy in human gastric cancer cells with different degree of differentiation]. PMID: 28728293 Ref: Biologic therapy in esophageal and gastric malignancies: current therapies and future directions. PMID: 28736629 Ref: Angiogenesis inhibitors in early development for gastric cancer. PMID: 28770623 Ref: Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death. PMID: 28789388 Ref: CISD2 enhances the chemosensitivity of gastric cancer through the enhancement of 5-FU-induced apoptosis and the inhibition of autophagy by AKT/mTOR pathway. PMID: 28857517 Ref: Targeting mTORC2 component rictor inhibits cell proliferation and promotes apoptosis in gastric cancer. PMID: 28979705 Ref: MiR-129 inhibits cell proliferation and metastasis by targeting ETS1 via PI3K/AKT/mTOR pathway in prostate cancer. PMID: 29035829 Ref: Profiling cancer-associated genetic alterations and molecular classification of cancer in Korean gastric cancer patients. PMID: 29050249 Ref: Apatinib has anti-tumor effects and induces autophagy in colon cancer cells. PMID: 29085592 Ref: Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer. PMID: 29094049 Ref: The GAS5/miR-222 Axis Regulates Proliferation of Gastric Cancer Cells Through the PTEN/Akt/mTOR Pathway. PMID: 29098549 Ref: Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor development in vitro and in vivo. PMID: 29100325 Ref: Prognostic implications of phosphatidylinositol 3-kinase/AKT signaling pathway activation in gastric carcinomas. PMID: 29181056 Ref: Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway. PMID: 29212166 Ref: Mangiferin prevents the growth of gastric carcinoma by blocking the PI3K-Akt signalling pathway. PMID: 29215373 Ref: Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway. PMID: 29229873 Ref: Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients. PMID: 29233126 Ref: [Checkpoint Inhibitors in the Treatment of Upper Gastrointestinal Tract Tumors]. PMID: 29239193 Ref: Study on the association between PI3K/AKT/mTOR signaling pathway gene polymorphism and susceptibility to gastric cancer. PMID: 29332342 |
Ref: Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling. PMID: 28926094 Ref: Enhanced gastric cancer growth potential of mesenchymal stem cells derived from gastric cancer tissues educated by CD4(+) T cells. PMID: 29057538 Ref: Increased T-helper 17 cell differentiation mediated by exosome-mediated microRNA-451 redistribution in gastric cancer infiltrated T cells. PMID: 29059496 Ref: miR-21 Inhibitors Modulate Biological Functions of Gastric Cancer Cells via PTEN/PI3K/mTOR Pathway. PMID: 29185784 Ref: Suppression of eEF-2K-mediated autophagy enhances the cytotoxicity of raddeanin A against human breast cancer cells in vitro. PMID: 29239350 Ref: EGFR and AKT1 overexpression are mutually exclusive and associated with a poor survival in resected gastric adenocarcinomas. PMID: 29278885 Ref: Correlation of Gli1 and HER2 expression in gastric cancer: Identification of novel target. PMID: 29321573 Ref: STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy. PMID: 29329543 Ref: ESCO2 knockdown inhibits cell proliferation and induces apoptosis in human gastric cancer cells. PMID: 29330052 Ref: Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway. PMID: 29374144 Ref: TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling. PMID: 29423269 Ref: Characterization and validation of potential therapeutic targets based on the molecular signature of patient-derived xenografts in gastric cancer. PMID: 29433585 Ref: Effect of silencing colon cancer-associated transcript 2 on the proliferation, apoptosis and autophagy of gastric cancer BGC-823 cells. PMID: 29435046 Ref: MiR-361-5p suppresses chemoresistance of gastric cancer cells by targeting FOXM1 via the PI3K/Akt/mTOR pathway. PMID: 29435149 Ref: LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3beta signaling. PMID: 29436606 Ref: Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin-EGFR crosstalk. PMID: 29468433 Ref: Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. PMID: 29483523 Ref: Autophagy flux inhibition augments gastric cancer resistance to the anti-human epidermal growth factor receptor 2 antibody trastuzumab. PMID: 29541179 Ref: Acquired Resistance to a MET Antibody In Vivo Can Be Overcome by the MET Antibody Mixture Sym015. PMID: 29545332 Ref: [Corrigendum] RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer. 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