Primary Site >> Colorectal Cancer
Gene >> MTOR
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Ref: Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. PMID: 11053255 |
Ref: Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. PMID: 11562278 |
Ref: 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin. PMID: 11847216 Ref: Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture. PMID: 12000755 |
Ref: Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. PMID: 14625550 |
Ref: Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells. PMID: 14729629 |
Ref: The patellazoles inhibit protein synthesis at nanomolar concentrations in human colon tumor cells. PMID: 15846119 Ref: Molecularly targeted therapy for gastrointestinal cancer. PMID: 15892618 Ref: Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyri din-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxami PMID: 15901852 Ref: RAD001 (everolimus) improves the efficacy of replicating adenoviruses that target colon cancer. PMID: 16061672 Ref: Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. PMID: 16127745 Ref: Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954. PMID: 16390278 |
Ref: In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols. PMID: 16506814 Ref: Hepatocyte growth factor installs a survival platform for colorectal cancer cell invasive growth and overcomes p38 MAPK-mediated apoptosis. PMID: 16677802 |
Ref: Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer. PMID: 17175097 Ref: Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis. PMID: 17265080 Ref: Signal-dependent control of autophagy and cell death in colorectal cancer cell: the role of the p38 pathway. PMID: 17495519 Ref: Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. PMID: 17671177 Ref: Exploiting novel molecular targets in gastrointestinal cancers. PMID: 17990350 Ref: [Synergistic effect of rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells]. PMID: 18478925 |
Ref: Defective TGF-beta signaling sensitizes human cancer cells to rapamycin. PMID: 17700525 Ref: Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. PMID: 17993259 Ref: Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer. PMID: 18245553 Ref: Upregulation of colonic ion channels in APC ( Min/+ ) mice. PMID: 18247045 Ref: Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs. PMID: 18319715 Ref: Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. PMID: 18332469 Ref: Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum. PMID: 18351386 Ref: Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy. PMID: 18381446 Ref: Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. PMID: 18470880 Ref: Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer? PMID: 18525343 Ref: Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. PMID: 18768809 Ref: LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. PMID: 18794113 Ref: A novel mTOR inhibitor is efficacious in a murine model of colitis. PMID: 18927209 Ref: Colorectal Cancer Treatment: What's Next? (or: Is There Life After EGFR and VEGF?). PMID: 19343143 |
Ref: Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells. PMID: 18708285 Ref: Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway. PMID: 19148467 Ref: Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer. PMID: 19194827 Ref: Knockin of mutant PIK3CA activates multiple oncogenic pathways. PMID: 19196980 Ref: Combined inhibition of Dnmt and mTOR signaling inhibits formation and growth of colorectal cancer. PMID: 19229543 Ref: Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues. PMID: 19483468 Ref: mTOR signaling pathway is a target for the treatment of colorectal cancer. PMID: 19517193 Ref: Ewing's sarcoma: standard and experimental treatment options. PMID: 19533369 Ref: Repression of protein translation and mTOR signaling by proteasome inhibitor in colon cancer cells. PMID: 19540199 Ref: Rapamycin inhibits hepatectomy-induced stimulation of metastatic tumor growth by reduction of angiogenesis, microvascular blood perfusion, and tumor cell proliferation. PMID: 19551445 Ref: Effective treatment of advanced colorectal cancer by rapamycin and 5-FU/oxaliplatin monitored by TIMP-1. PMID: 19565301 Ref: Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. PMID: 19637312 Ref: Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. PMID: 19661333 Ref: Anti-EGFR therapy in colorectal cancer: how to choose the right patient. PMID: 19663767 Ref: The role of mTORC1 pathway in intestinal tumorigenesis. PMID: 19855161 Ref: Antioxidant and biological properties of bioactive phenolic compounds from Quercus suber L. PMID: 19888728 Ref: A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. PMID: 19909554 Ref: Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer. PMID: 19934294 Ref: The dark side of the moon: the PI3K/PTEN/AKT pathway in colorectal carcinoma. PMID: 20130434 |
Ref: Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell. PMID: 19660860 Ref: Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer. PMID: 19731079 Ref: Translational up-regulation of Aurora-A in EGFR-overexpressed cancer. PMID: 19799648 Ref: Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. PMID: 20080688 Ref: Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. PMID: 20133737 Ref: Suppression of mTOR via Akt-dependent and -independent mechanisms in selenium-treated colon cancer cells: involvement of AMPKalpha1. PMID: 20164123 Ref: Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo. PMID: 20226010 Ref: Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B. PMID: 20299603 Ref: Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells. PMID: 20392997 Ref: Rapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of rapamycin. PMID: 20392999 Ref: Molecular targeted therapy in prevalent tumors: learning from the past and future perspectives. PMID: 20406173 Ref: Molecular target class is predictive of in vitro response profile. PMID: 20406975 Ref: Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice. PMID: 20416302 Ref: Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer. PMID: 20421047 Ref: Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. PMID: 20530489 Ref: The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy. PMID: 20551061 Ref: Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. PMID: 20622004 Ref: Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. PMID: 20639871 Ref: Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer. PMID: 20663899 Ref: Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. PMID: 20664949 Ref: FM19G11: A new modulator of HIF that links mTOR activation with the DNA damage checkpoint pathways. PMID: 20676050 Ref: Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. PMID: 20708588 Ref: Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer. PMID: 20808308 Ref: Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis. PMID: 20971826 Ref: Anthocyanins are novel AMPKalpha1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation. PMID: 21042741 Ref: Significance of p27 as potential biomarker for intracellular oxidative status. PMID: 21103079 Ref: Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer. PMID: 21412012 |
Ref: mTOR signaling is involved in indomethacin and nimesulide suppression of colorectal cancer cell growth via a COX-2 independent pathway. PMID: 20803081 Ref: Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1alpha translational pathway in colorectal cancer cells. PMID: 20857420 Ref: Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo. PMID: 20890178 Ref: Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death. PMID: 20930850 Ref: Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab. PMID: 20956938 Ref: Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. PMID: 21035469 Ref: Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. PMID: 21089180 Ref: The role of short-chain fatty acids in orchestrating two types of programmed cell death in colon cancer. PMID: 21160278 Ref: mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. PMID: 21177869 Ref: PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors. PMID: 21216929 Ref: Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. PMID: 21233335 Ref: Cetuximab enhances the activities of irinotecan on gastric cancer cell lines through downregulating the EGFR pathway upregulated by irinotecan. PMID: 21286718 Ref: Adiponectin supports cell survival in glucose deprivation through enhancement of autophagic response in colorectal cancer cells. PMID: 21299716 Ref: mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. PMID: 21430067 Ref: Diosgenin suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition by down-regulation of Mdm2 and vimentin. PMID: 21504235 Ref: Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. PMID: 21531761 Ref: Evaluation of the effects of the flavonoid apigenin on apoptotic pathway gene expression on the colon cancer cell line (HT29). PMID: 21548803 Ref: Antitumor effects of a novel benzonaphthofurandione derivative (8e) on the human colon cancer cells in vitro and in vivo through cell cycle arrest accompanied with the modulation of EGFR and mTOR signaling. PMID: 21600193 Ref: Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells. PMID: 21622897 Ref: Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. PMID: 21673091 Ref: Role of reactive oxygen species (ROS) in CDDO-Me-mediated growth inhibition and apoptosis in colorectal cancer cells. PMID: 21699019 Ref: AMPK regulates metabolism and survival in response to ionizing radiation. PMID: 21715037 Ref: Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway. PMID: 21782788 Ref: The cytostatic effects of lovastatin on ACC-MESO-1 cells. PMID: 21816418 Ref: PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers. PMID: 21829508 Ref: (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo. PMID: 21885813 Ref: Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. PMID: 21946537 Ref: The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. PMID: 21949739 Ref: Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells. PMID: 21963494 Ref: The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. PMID: 21966435 Ref: Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment. PMID: 21999454 Ref: Deoxyribose protects against rapamycin-induced cytotoxicity in colorectal cancer cells in vitro. PMID: 22132975 Ref: Clinical significance of mTOR and p-mTOR protein expression in human colorectal carcinomas. PMID: 22320958 Ref: [RAD001 reverses radio-resistance and exerts synergistic tumor inhibition with 5-fluorouracil]. PMID: 22321888 Ref: [Expression of mammalian target of rapamycin in colon cancer and its effect on proliferation and apoptosis of human colon cancer HT-29 cells]. PMID: 22333609 |
Ref: The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy. PMID: 22154651 Ref: Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. PMID: 22173549 Ref: 5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer. PMID: 22187071 Ref: Selenite-induced apoptosis and autophagy in colon cancer cells. PMID: 22200533 Ref: Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways. PMID: 22213051 Ref: Consumption of high-fat diet induces tumor progression and epithelial-mesenchymal transition of colorectal cancer in a mouse xenograft model. PMID: 22221675 Ref: Role of oncogenic pathways and KRAS/BRAF mutations in the behavior of colon adenocarcinoma in renal transplant patients. PMID: 22245873 Ref: The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer. PMID: 22261800 Ref: mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors. PMID: 22262166 Ref: Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. PMID: 22270257 Ref: Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055). PMID: 22271687 Ref: Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells. PMID: 22285861 Ref: Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway. PMID: 22357207 Ref: Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon. PMID: 22363130 Ref: Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas. PMID: 22392911 Ref: Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells. PMID: 22401294 Ref: Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. PMID: 22406476 Ref: The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition. PMID: 22415236 Ref: Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine. PMID: 22419878 Ref: Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition. PMID: 22422922 Ref: Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. PMID: 22443173 Ref: Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines. PMID: 22543857 Ref: Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells. PMID: 22552366 Ref: [Expression of leptin and p-mTOR and their clinicopathological significance in human colon carcinoma]. PMID: 22561505 Ref: Differential response to EGFR- and VEGF-targeted therapies in patient-derived tumor tissue xenograft models of colon carcinoma and related metastases. PMID: 22581265 Ref: Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3beta pathway in colon cancer. PMID: 22581840 Ref: Pharmacological control of autophagy: therapeutic perspectives in inflammatory bowel disease and colorectal cancer. PMID: 22632751 Ref: KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors. PMID: 22675430 Ref: Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells. PMID: 22679478 Ref: Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer. PMID: 22682314 Ref: Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA. PMID: 22696593 Ref: Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials. PMID: 22723336 Ref: Cancer chemotherapy reduces plasma total polyphenols and total antioxidants capacity in colorectal cancer patients. PMID: 22772457 Ref: Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer. PMID: 22828149 Ref: The rectal cancer microRNAome--microRNA expression in rectal cancer and matched normal mucosa. PMID: 22850566 Ref: HRT, Herbal Formula, Induces G(2)/M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells. PMID: 22899960 Ref: The promise of mTOR inhibitors in the treatment of colorectal cancer. PMID: 22978346 Ref: Downregulation of miR-144 is associated with colorectal cancer progression via activation of mTOR signaling pathway. PMID: 22983984 Ref: Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. PMID: 22992293 Ref: Cyclosporin A inhibits colon cancer cell growth independently of the calcineurin pathway. PMID: 22992618 Ref: Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules. PMID: 23033949 Ref: Cytosolic malic enzyme 1 (ME1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice. PMID: 23056418 Ref: Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells. PMID: 23056575 Ref: [Predictive biomarkers for anti-EGFR antibodies]. PMID: 23152013 Ref: Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer. PMID: 23241148 Ref: Alternative dosing of dual PI3K and MEK inhibition in cancer therapy. PMID: 23259591 Ref: Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. PMID: 23272949 Ref: Future of targeted agents in metastatic colorectal cancer. PMID: 24273599 |
Ref: Investigation of the extracts from Bidens pilosa Linn. var. radiata Sch. Bip. for antioxidant activities and cytotoxicity against human tumor cells. PMID: 22382861 Ref: Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation. PMID: 22458846 Ref: SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway. PMID: 23017388 Ref: Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells. PMID: 23188704 Ref: Involvement of heregulin/HER3 in the primary culture of human urothelial cancer. PMID: 23313199 Ref: Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells. PMID: 23316499 Ref: Free radical scavenging property and antiproliferative activity of Rhodiola imbricata Edgew extracts in HT-29 human colon cancer cells. PMID: 23317880 Ref: The mTOR Pathway and the Role of Energy Balance Throughout Life in Colorectal Cancer Etiology and Prognosis: Unravelling Mechanisms Through a Multidimensional Molecular Epidemiologic Approach. PMID: 23396869 Ref: In vitro biological activity of essential oils and isolated furanosesquiterpenes from the neglected vegetable Smyrnium olusatrum L. (Apiaceae). PMID: 23411181 Ref: Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growth. PMID: 23427297 Ref: Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries. PMID: 23445752 Ref: Coexistent mutations of KRAS and PIK3CA affect the efficacy of NVP-BEZ235, a dual PI3K/MTOR inhibitor, in regulating the PI3K/MTOR pathway in colorectal cancer. PMID: 23475782 Ref: miR-30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma. PMID: 23486085 Ref: Utilization of quantitative in vivo pharmacology approaches to assess combination effects of everolimus and irinotecan in mouse xenograft models of colorectal cancer. PMID: 23520486 Ref: Involvement of PI3K-AKT-mTOR pathway in protein kinase CKII inhibition-mediated senescence in human colon cancer cells. PMID: 23523798 Ref: Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. PMID: 23549875 Ref: Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells. PMID: 23558291 Ref: Digestive neuroendocrine tumors (DNET): the era of targeted therapies. PMID: 23562338 Ref: Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways. PMID: 23581408 Ref: Altered cardiac muscle mTOR regulation during the progression of cancer cachexia in the ApcMin/+ mouse. PMID: 23589074 Ref: Activation of AMP-Activated Protein Kinase alpha and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells. PMID: 23589723 Ref: mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers. PMID: 23593290 Ref: Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells. PMID: 23629727 Ref: Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells. PMID: 23677180 Ref: Evaluation of antiproliferative and antioxidant activities of the organic extract and its polar fractions from the Mediterranean gorgonian Eunicella singularis. PMID: 23712134 Ref: Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways. PMID: 23725112 Ref: Epithelial-specific deletion of 11beta-HSD2 hinders Apcmin/+ mouse tumorigenesis. PMID: 23741059 Ref: Phase II study of everolimus in patients with metastatic colorectal adenocarcinoma previously treated with bevacizumab-, fluoropyrimidine-, oxaliplatin-, and irinotecan-based regimens. PMID: 23743569 Ref: 13,14-bis(cis-3,5-dimethyl-1-piperazinyl)-beta-elemene, a novel beta-elemene derivative, shows potent antitumor activities via inhibition of mTOR in human breast cancer cells. PMID: 23761818 Ref: Clinical impacts of mammalian target of rapamycin expression in human colorectal cancers. PMID: 23773481 Ref: Molecular biomarkers of resistance to anti-EGFR treatment in metastatic colorectal cancer, from classical to innovation. PMID: 23806981 Ref: Overexpression of peptide deformylase in breast, colon, and lung cancers. PMID: 23815882 Ref: Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation. PMID: 23826249 Ref: Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression. PMID: 23827854 Ref: Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. PMID: 23848206 Ref: Combining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling. PMID: 23852390 Ref: PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy. PMID: 23887393 Ref: Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. PMID: 23899692 Ref: Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway. PMID: 23905676 Ref: Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab. PMID: 23930204 Ref: Genotype directed therapy in murine mismatch repair deficient tumors. PMID: 23935891 Ref: Phase I clinical trial of lenalidomide in combination with temsirolimus in patients with advanced cancer. PMID: 23982248 Ref: Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma. PMID: 23991179 Ref: Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR. PMID: 23996930 Ref: Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells. PMID: 24061475 Ref: Target-based therapeutic matching in early-phase clinical trials in patients with advanced colorectal cancer and PIK3CA mutations. PMID: 24092809 Ref: Chemical composition and biological activities of the essential oil of Athanasia brownii Hochr. (Asteraceae) endemic to Madagascar. PMID: 24130030 Ref: [Metformin, an antidiabetic molecule with anti-cancer properties]. PMID: 24180199 Ref: Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1. PMID: 24185040 Ref: Toward a Molecular Classification of Colorectal Cancer: The Role of BRAF. PMID: 24298448 Ref: Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers. PMID: 24349411 Ref: Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells. PMID: 25337554 |
Ref: Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. PMID: 23542178 Ref: MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer. PMID: 23899558 Ref: Significance of mTOR signaling and its inhibitor against cancer stem-like cells in colorectal cancer. PMID: 23907312 Ref: CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation. PMID: 23995790 Ref: mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. PMID: 24163374 Ref: CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. PMID: 24184209 Ref: Cancer usurps skeletal muscle as an energy repository. PMID: 24197136 Ref: Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53. PMID: 24247721 Ref: Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014. PMID: 24309100 Ref: Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation. PMID: 24363449 Ref: mTOR pathway in colorectal cancer: an update. PMID: 24393708 Ref: Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway. PMID: 24462916 Ref: OSU-CG5, a novel energy restriction mimetic agent, targets human colorectal cancer cells in vitro. PMID: 24464048 Ref: Signal transducer and activator of transcription 3 - a promising target in colitis-associated cancer. PMID: 24568457 Ref: A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells. PMID: 24573549 Ref: FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors. PMID: 24586741 Ref: Determining eligibility for and preparation to kidney transplantation of a patient with Lynch syndrome--a case report and literature review. PMID: 24614524 Ref: Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells. PMID: 24619662 Ref: Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation. PMID: 24667661 Ref: BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737. PMID: 24709422 Ref: Target identification of grape seed extract in colorectal cancer using drug affinity responsive target stability (DARTS) technique: role of endoplasmic reticulum stress response proteins. PMID: 24724981 Ref: Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability. PMID: 24743574 Ref: Moguntinones--new selective inhibitors for the treatment of human colorectal cancer. PMID: 24743703 Ref: Targeting mTOR network in colorectal cancer therapy. PMID: 24764656 Ref: Genetic variations in STK11, PRKAA1, and TSC1 associated with prognosis for patients with colorectal cancer. PMID: 24770722 Ref: ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. PMID: 24810758 Ref: Sequence-selective molecular recognition of the C-terminal CaaX-boxes of Rheb and related Ras-proteins by synthetic receptors. PMID: 24856002 Ref: Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. PMID: 24858802 Ref: Combination of gefitinib and DNA methylation inhibitor decitabine exerts synergistic anti-cancer activity in colon cancer cells. PMID: 24874286 Ref: LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. PMID: 24879590 Ref: Dichloroacetate induces autophagy in colorectal cancer cells and tumours. PMID: 24892448 Ref: Alpha-2-glycoprotein 1(AZGP1) regulates biological behaviors of LoVo cells by down-regulating mTOR signaling pathway and endogenous fatty acid synthesis. PMID: 24918753 Ref: Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway. PMID: 24932287 Ref: Activation of the PI3K/Akt/mTOR/p70S6K pathway is involved in S100A4-induced viability and migration in colorectal cancer cells. 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PMID: 24970817 Ref: NF-kappaB signaling inhibition and anticancer activities of LLDT-246 on human colorectal cancer HCT-116 cells in vitro. PMID: 24986326 Ref: ATG4B promotes colorectal cancer growth independent of autophagic flux. PMID: 24991826 Ref: The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. PMID: 25023051 Ref: Differential protein expression and novel biomarkers related to 5-FU resistance in a 3D colorectal adenocarcinoma model. PMID: 25050539 Ref: Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice. PMID: 25057912 Ref: Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways. PMID: 25075187 Ref: The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor. PMID: 25107843 Ref: Clinical significance of aberrant mammalian target of rapamycin expression in stage IIIB colon cancer. PMID: 25120661 Ref: A combination of eicosapentaenoic acid-free fatty acid, epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal cancer cells. PMID: 25123131 Ref: PGE2-induced colon cancer growth is mediated by mTORC1. PMID: 25128827 Ref: 3'-Deoxy-3'-[18F]-Fluorothymidine PET imaging reflects PI3K-mTOR-mediated pro-survival response to targeted therapy in colorectal cancer. PMID: 25247710 Ref: Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies. PMID: 25277205 Ref: A parallel-arm phase I trial of the humanised anti-IGF-1R antibody dalotuzumab in combination with the AKT inhibitor MK-2206, the mTOR inhibitor ridaforolimus, or the NOTCH inhibitor MK-0752, in patients with advanced solid tumours. PMID: 25290091 Ref: Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression. PMID: 25347473 Ref: Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer. PMID: 25356873 Ref: Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation. PMID: 25379021 Ref: Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR. PMID: 25389372 Ref: Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors. PMID: 25389774 Ref: Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer. PMID: 25401499 Ref: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer. PMID: 25443414 Ref: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors. 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Ref: Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies. PMID: 24791855 Ref: Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice. PMID: 24838344 Ref: An exploratory biomarker study in metastatic tumors from colorectal cancer patients treated with bevacizumab. PMID: 24980447 Ref: Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. PMID: 25123959 Ref: Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway. PMID: 25216025 Ref: Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF and matrix metallopeptidase-9. PMID: 25326806 Ref: mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. PMID: 25383520 Ref: Hypothesis: cell signalling influences age-related risk of colorectal cancer. PMID: 25388238 Ref: GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. PMID: 25402767 Ref: Combined use of vitamin D3 and metformin exhibits synergistic chemopreventive effects on colorectal neoplasia in rats and mice. PMID: 25416412 Ref: mTOR and PDGF pathway blockade inhibits liver metastasis of colorectal cancer by modulating the tumor microenvironment. PMID: 25478811 Ref: Targeted therapy of colorectal neoplasia with rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles. PMID: 25483425 Ref: Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer. PMID: 25497009 Ref: Sann-Joong-Kuey-Jian-Tang decreases the protein expression of mammalian target of rapamycin but increases microtubule associated protein II light chain 3 expression to inhibit human BxPC3 pancreatic carcinoma cells. PMID: 25516264 Ref: Cancer: mTOR inhibition curbs colorectal cancer. PMID: 25549586 Ref: Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer. PMID: 25569743 Ref: Augmented pentose phosphate pathway plays critical roles in colorectal carcinomas. PMID: 25591719 Ref: Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer. PMID: 25637165 Ref: Cross-resistance to clinically used tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib. PMID: 25665527 Ref: The tumor-suppressor gene LZTS1 suppresses colorectal cancer proliferation through inhibition of the AKT-mTOR signaling pathway. PMID: 25667121 Ref: AZD-4547 exerts potent cytostatic and cytotoxic activities against fibroblast growth factor receptor (FGFR)-expressing colorectal cancer cells. PMID: 25691251 Ref: Tumor suppression by resistant maltodextrin, Fibersol-2. PMID: 25692338 Ref: The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent. PMID: 25692620 Ref: Biomarker signatures correlate with clinical outcome in refractory metastatic colorectal cancer patients receiving bevacizumab and everolimus. PMID: 25695956 Ref: Nexavar/Stivarga and viagra interact to kill tumor cells. PMID: 25704960 Ref: AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants. PMID: 25714871 Ref: miR-218 inhibits the invasion and migration of colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway. PMID: 25760926 Ref: Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies. PMID: 25773992 Ref: Frameshift mutations in mammalian target of rapamycin pathway genes and their regional heterogeneity in sporadic colorectal cancers. PMID: 25776026 Ref: Functional promoter rs2295080 T>G variant in MTOR gene is associated with risk of colorectal cancer in a Chinese population. PMID: 25776475 Ref: Nitrogen permease regulator-like 2 enhances sensitivity to oxaliplatin in colon cancer cells. PMID: 25777765 Ref: Differential regulation of autophagy and cell viability by ceramide species. PMID: 25803131 Ref: Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect. PMID: 25807077 Ref: Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy. PMID: 25809873 Ref: Oxaliplatin analogues with carboxy derivatives of boldine with enhanced antioxidant activity. PMID: 25814916 Ref: HGUE-C-1 is an atypical and novel colon carcinoma cell line. PMID: 25885658 Ref: Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines. PMID: 25893829 Ref: Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. PMID: 25895029 Ref: IL13 Receptor alpha2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis. PMID: 25896327 Ref: mLST8 Promotes mTOR-Mediated Tumor Progression. PMID: 25906254 Ref: Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer. PMID: 25911689 Ref: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer. PMID: 25934076 Ref: The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death. PMID: 25935480 Ref: Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway. PMID: 25936523 Ref: AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis. PMID: 25961827 Ref: Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathways. PMID: 25998232 Ref: Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation. PMID: 26017929 Ref: Obesity and Obese-related Chronic Low-grade Inflammation in Promotion of Colorectal Cancer Development. PMID: 26028066 Ref: Expression and clinical significances of Beclin1, LC3 and mTOR in colorectal cancer. PMID: 26097572 Ref: The Mendelian colorectal cancer syndromes. PMID: 26169059 Ref: Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue. PMID: 26171014 Ref: Assessment of the In Vivo Activity of PI3K and MEK Inhibitors in Genetically Defined Models of Colorectal Cancer. PMID: 26206338 Ref: Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of thymidylate synthase in human colon carcinoma cells. PMID: 26208739 Ref: Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. PMID: 26223300 Ref: Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy. PMID: 26229035 Ref: A phase I-II study on the combination of rapamycin and short course radiotherapy in rectal cancer. PMID: 26253949 Ref: miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR. PMID: 26259252 Ref: Expression of phospho-mTOR kinase is abundant in colorectal cancer and associated with left-sided tumor localization. PMID: 26261591 Ref: AdipoRon: a possible drug for colorectal cancer prevention? PMID: 26282004 Ref: Diacylglycerol kinase-zeta regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1. PMID: 26302180 Ref: Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma. PMID: 26306675 Ref: Autophagy-related genes Raptor, Rictor, and Beclin1 expression and relationship with multidrug resistance in colorectal carcinoma. PMID: 26363527 Ref: Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis. PMID: 26378024 Ref: DNA-PKcs interference sensitizes colorectal cancer cells to a mTOR kinase inhibitor WAY-600. PMID: 26381179 Ref: Se-Allylselenocysteine induces autophagy by modulating the AMPK/mTOR signaling pathway and epigenetic regulation of PCDH17 in human colorectal adenocarcinoma cells. PMID: 26395119 Ref: PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells. PMID: 26399781 Ref: Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers. PMID: 26404261 Ref: Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors. PMID: 26418718 Ref: Mechanism of Chemoprevention against Colon Cancer Cells Using Combined Gelam Honey and Ginger Extract via mTOR and Wnt/beta-catenin Pathways. PMID: 26434873 Ref: Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy. PMID: 26457069 Ref: Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PMID: 26469692 Ref: Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro. PMID: 26497930 Ref: Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway. PMID: 26503559 Ref: Mutational profiling of colorectal cancers with microsatellite instability. PMID: 26517354 Ref: Neuroendocrine differentiation: The mysterious fellow of colorectal cancer. PMID: 26556999 Ref: Combination of cetuximab and PP242 synergistically suppress the progression of wild-type KRAS colorectal carcinoma. PMID: 26586952 Ref: Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1alpha and Induces Apoptosis in Human Colorectal Cancer Cells. PMID: 26610526 Ref: Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. PMID: 26678268 Ref: Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells. PMID: 26729093 Ref: Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway. PMID: 26735435 Ref: Functional mechanism of the enhancement of 5-fluorouracil sensitivity by TUSC4 in colon cancer cells. PMID: 26788191 Ref: PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. PMID: 26844273 Ref: Rapamycin-Mediated mTOR Inhibition Reverses Drug Resistance to Adriamycin in Colon Cancer Cells. PMID: 26902021 Ref: PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. PMID: 28958491 |
Ref: Hinokitiol induces autophagy in murine breast and colorectal cancer cells. PMID: 25044443 Ref: Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy. PMID: 25594310 Ref: PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition. PMID: 25641341 Ref: The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer. PMID: 25720497 Ref: mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation. PMID: 25867072 Ref: BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling. PMID: 26033966 Ref: Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway. PMID: 26109148 Ref: New Wnt/beta-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals. PMID: 26156959 Ref: Tankyrase Inhibition Blocks Wnt/beta-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. PMID: 26224873 Ref: Antioxidant and antiproliferative properties of 3-deoxyanthocyanidins. PMID: 26304331 Ref: Anticancer effect of rapamycin on MCF-7 via downregulation of VEGF expression. PMID: 26427711 Ref: Combination therapy with zoledronic acid and cetuximab effectively suppresses growth of colorectal cancer cells regardless of KRAS status. PMID: 26437179 Ref: mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition. PMID: 26471831 Ref: A Novel Bioavailable BH3 Mimetic Efficiently Inhibits Colon Cancer via Cascade Effects of Mitochondria. PMID: 26515494 Ref: A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells. PMID: 26615871 Ref: Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6. PMID: 26657850 Ref: Pristimerin demonstrates anticancer potential in colorectal cancer cells by inducing G1 phase arrest and apoptosis and suppressing various pro-survival signaling proteins. PMID: 26718323 Ref: Arginine starvation in colorectal carcinoma cells: Sensing, impact on translation control and cell cycle distribution. PMID: 26751966 Ref: Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice. PMID: 26774139 Ref: Effective targeting of colorectal cancer cells using TORC1/2 kinase inhibitors in vitro and in vivo. PMID: 26776341 Ref: BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. PMID: 26802026 Ref: KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis. PMID: 26839262 Ref: Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment. PMID: 26840292 Ref: Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K. PMID: 26863299 Ref: Ghrelin induces colon cancer cell proliferation through the GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways. PMID: 26879868 Ref: Mesenchymal stem cells promote colorectal cancer progression through AMPK/mTOR-mediated NF-kappaB activation. PMID: 26892992 Ref: In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line. PMID: 26915414 Ref: AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin. PMID: 26918349 Ref: Palmitoylethanolamide Exerts Antiproliferative Effect and Downregulates VEGF Signaling in Caco-2 Human Colon Carcinoma Cell Line Through a Selective PPAR-alpha-Dependent Inhibition of Akt/mTOR Pathway. PMID: 26929026 Ref: Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. PMID: 26936429 Ref: Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation. PMID: 26955235 Ref: Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model. PMID: 26970558 Ref: Autophagy inhibition sensitizes WYE-354-induced anti-colon cancer activity in vitro and in vivo. PMID: 27020593 Ref: Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. PMID: 27028006 Ref: Lentivirus-mediated somatic recombination and development of a novel mouse model for sporadic colorectal cancer. PMID: 27037682 Ref: Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells. PMID: 27044819 Ref: [Expression of Rictor and mTOR in colorectal cancer and their clinical significance]. PMID: 27063170 Ref: Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells. PMID: 27064730 Ref: Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells. PMID: 27078027 Ref: Silencing homeobox C6 inhibits colorectal cancer cell proliferation. PMID: 27081081 Ref: Aerobic and resistance training dependent skeletal muscle plasticity in the colon-26 murine model of cancer cachexia. PMID: 27085776 Ref: miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling. PMID: 27095166 Ref: Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-kappaB and mTOR signaling. PMID: 27106148 Ref: Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway. PMID: 27144580 Ref: Houttuynia cordata Thunb reverses oxaliplatin-induced neuropathic pain in rat by regulating Th17/Treg balance. PMID: 27186286 Ref: Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC. PMID: 27197306 Ref: Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma. PMID: 27210058 Ref: Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule. PMID: 27224913 Ref: Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/mTOR dual inhibitor BEZ235 through apoptosis. PMID: 27226714 Ref: [Roles of glucose-regulated protein 78 in proliferation and migration of human colorectal carcinoma cell line RKO]. PMID: 27256049 Ref: Rifaximin, a non-absorbable antibiotic, inhibits the release of pro-angiogenic mediators in colon cancer cells through a pregnane X receptor-dependent pathway. PMID: 27279570 Ref: Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells. PMID: 27294206 Ref: PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study. PMID: 27296289 Ref: Autophagy regulation and its role in gastric cancer and colorectal cancer. PMID: 27314289 Ref: Autophagy inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235. PMID: 27347108 Ref: BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. PMID: 27351224 Ref: Tounong Powder () extracts induce G1 cell cycle arrest and apoptosis in LoVo cells. PMID: 27358203 Ref: Engineering of caveolae-specific self-micellizing anticancer lipid nanoparticles to enhance the chemotherapeutic efficacy of oxaliplatin in colorectal cancer cells. PMID: 27395829 Ref: Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma. PMID: 27401611 Ref: A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway. PMID: 27460008 Ref: Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells. PMID: 27461218 Ref: ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments. PMID: 27462398 Ref: Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer. PMID: 27529512 Ref: Cytotoxic and targeted therapy for hereditary cancers. PMID: 27555886 Ref: Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells. PMID: 27557491 Ref: mTOR inhibition sensitizes ONC201-induced anti-colorectal cancer cell activity. PMID: 27565731 Ref: A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration. PMID: 27611801 Ref: Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer. PMID: 27626684 Ref: GOLPH3 overexpression correlates with poor response to neoadjuvant therapy and prognosis in locally advanced rectal cancer. PMID: 27634904 Ref: MEK and TAK1 Regulate Apoptosis in Colon Cancer Cells with KRAS-Dependent Activation of Proinflammatory Signaling. PMID: 27655129 Ref: Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer. PMID: 27657889 Ref: Oxymatrine synergistically enhances antitumor activity of oxaliplatin in colon carcinoma through PI3K/AKT/mTOR pathway. PMID: 27671687 Ref: Curcumin targets the TFEB-lysosome pathway for induction of autophagy. PMID: 27689333 Ref: Anti-inflammatory and Antitumor Activity of a Triple Therapy for a Colitis-Related Colorectal Cancer. PMID: 27698900 Ref: Differential effects of peptidoglycan on colorectal tumors and intestinal tissue post-pelvic radiotherapy. PMID: 27708223 Ref: DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up. PMID: 27709558 Ref: 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells. PMID: 27710830 Ref: Salidroside induces apoptosis and autophagy in human colorectal cancer cells through inhibition of PI3K/Akt/mTOR pathway. PMID: 27748934 Ref: Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase. PMID: 27764698 Ref: Probing the PI3K/Akt/mTor pathway using (31)P-NMR spectroscopy: routes to glycogen synthase kinase 3. PMID: 27811956 Ref: Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells. PMID: 27895729 Ref: [Inhibitory effect of jianpi-jiedu prescription-contained serum on colorectal cancer SW48 cell proliferation by mTOR-P53-P21 signalling pathway]. PMID: 27932756 Ref: NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. PMID: 27951586 Ref: Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study. PMID: 28050146 Ref: [Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer]. PMID: 28070042 Ref: Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. PMID: 28087713 Ref: In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation. PMID: 28101119 |
Ref: PTRF suppresses the progression of colorectal cancers. PMID: 27203393 Ref: BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression. PMID: 27354468 Ref: Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells. PMID: 27416805 Ref: PI3K/Akt/mTOR Signaling and Plasma Membrane Proteins Are Implicated in Responsiveness to Adjuvant Dendritic Cell Vaccination for Metastatic Colorectal Cancer. PMID: 27435399 Ref: Protective effect of metformin in an aberrant crypt foci model induced by 1,2-dimethylhydrazine: Modulation of oxidative stress and inflammatory process. PMID: 27585117 Ref: A proteomics approach to identifying novel protein targets involved in erinacine A-mediated inhibition of colorectal cancer cells' aggressiveness. PMID: 27709782 Ref: Colorectal carcinomas with submucosal invasion (pT1): analysis of histopathological and molecular factors predicting lymph node metastasis. PMID: 27713420 Ref: mTOR activity and its prognostic significance in human colorectal carcinoma depending on C1 and C2 complex-related protein expression. PMID: 27729429 Ref: Smith-Kingsmore syndrome: A third family with the MTOR mutation c.5395G>A p.(Glu1799Lys) and evidence for paternal gonadal mosaicism. PMID: 27753196 Ref: Non-Invasive Glutamine PET Reflects Pharmacological Inhibition of BRAF(V600E) In Vivo. PMID: 27770401 Ref: Metformin suppresses CRC growth by inducing apoptosis via ADORA1. PMID: 27814614 Ref: Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity. PMID: 27833053 Ref: Koelreuteria Formosana Extract Induces Growth Inhibition and Cell Death in Human Colon Carcinoma Cells via G2/M Arrest and LC3-II Activation-Dependent Autophagy. PMID: 27880045 Ref: FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma. PMID: 27916606 Ref: Is Metformin a Therapeutic Paradigm for Colorectal Cancer: Insight into the Molecular Pathway? PMID: 27919208 Ref: Ketogenesis contributes to intestinal cell differentiation. PMID: 27935584 Ref: alpha-enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer. PMID: 27996156 Ref: Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells. PMID: 28031534 Ref: Downregulation of microRNA-100/microRNA-125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion. PMID: 28032929 Ref: Tumour immunology: NLRC3 inhibits mTOR in colorectal cancer. PMID: 28044056 Ref: Taspine derivative 12k suppressed A549 cell migration through the Wnt/beta-catenin and EphrinB2 signaling pathway. PMID: 28049091 Ref: Activation of the mTOR Pathway by Oxaliplatin in the Treatment of Colorectal Cancer Liver Metastasis. PMID: 28060954 Ref: Current Status and Perspectives Regarding the Therapeutic Potential of Targeting EGFR Pathway by Curcumin in Lung Cancer. PMID: 28117012 Ref: Increased serum leptin level in overweight patients with colon carcinoma: A cross-sectional and prospective study. PMID: 28123733 Ref: Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin. PMID: 28143584 Ref: Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer. PMID: 28153010 Ref: Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine. PMID: 28159918 Ref: Whole-exome sequencing identified mutational profiles of high-grade colon adenomas. PMID: 28179590 Ref: Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations. PMID: 28184015 Ref: Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma. PMID: 28188923 Ref: The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1alpha Levels and Colorectal Cancer Cell Survival under Hypoxia. PMID: 28199842 Ref: The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target. PMID: 28223542 Ref: Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways. PMID: 28241877 Ref: Angiogenesis and Oxidative Stress in Metastatic Tumor Progression: Pathogenesis and Novel Therapeutic Approach of Colon Cancer. PMID: 28245762 Ref: Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PMID: 28273117 Ref: Cancer with low cathepsin D levels is susceptible to vacuolar (H(+) )-ATPase inhibition. PMID: 28317223 Ref: Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer. PMID: 28323034 Ref: Apigenin-induced lysosomal degradation of beta-catenin in Wnt/beta-catenin signaling. PMID: 28337019 Ref: Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1alpha via the mTOR/p70S6K/4E-BP1 and MAPK pathways. PMID: 28341244 Ref: Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. PMID: 28392376 Ref: The suppressing effects of BTG3 expression on aggressive behaviors and phenotypes of colorectal cancer: An in vitro and vivo study. PMID: 28407690 Ref: A Dose-finding and Biomarker Evaluation Phase Ib Study of Everolimus in Association With 5-Fluorouracil and Pelvic Radiotherapy as Neoadjuvant Treatment of Locally Advanced Rectal Cancer (E-LARC Study). PMID: 28410832 Ref: Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells. PMID: 28412728 Ref: Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy. PMID: 28416456 Ref: Down-regulation of long non-coding RNA RP11-708H21.4 is associated with poor prognosis for colorectal cancer and promotes tumorigenesis through regulating AKT/mTOR pathway. PMID: 28427191 Ref: Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer? PMID: 28465145 Ref: Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways. PMID: 28496003 Ref: Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia. PMID: 28524162 Ref: An Oncolytic Adenovirus Expressing SNORD44 and GAS5 Exhibits Antitumor Effect in Colorectal Cancer Cells. PMID: 28530127 Ref: FOXQ1 promotes cancer metastasis by PI3K/AKT signaling regulation in colorectal carcinoma. PMID: 28559972 Ref: The identification and validation of Trichosstatin A as a potential inhibitor of colon tumorigenesis and colon cancer stem-like cells. PMID: 28560069 Ref: The novel hypoxia-inducible factor-1alpha inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth. PMID: 28569777 Ref: Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1alpha and VEGF receptors. PMID: 28594907 Ref: Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor. PMID: 28596013 Ref: NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer. PMID: 28598238 Ref: Transcription factor EB is involved in autophagy-mediated chemoresistance to doxorubicin in human cancer cells. PMID: 28603284 Ref: A Combined ULBP2 and SEMA5A Expression Signature as a Prognostic and Predictive Biomarker for Colon Cancer. PMID: 28607584 Ref: Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death. PMID: 28613975 Ref: mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer. PMID: 28615517 Ref: SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner. PMID: 28618450 Ref: Portal branch ligation does not counteract the inhibiting effect of temsirolimus on extrahepatic colorectal metastatic growth. PMID: 28631253 Ref: Angiomotin Family Members: Oncogenes or Tumor Suppressors? PMID: 28656002 Ref: Identification of RING-box 2 as a potential target for combating colorectal cancer growth and metastasis. PMID: 28670488 Ref: Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and mitochondrial apoptosis. PMID: 28675857 Ref: Feedback autophagy activation as a key resistance factor of Ku-0060648 in colorectal cancer cells. PMID: 28676397 Ref: Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1alpha signaling. PMID: 28684144 Ref: Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment. PMID: 28708103 Ref: Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. PMID: 28737825 Ref: miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. PMID: 28739727 Ref: M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway. PMID: 28751160 Ref: Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma. PMID: 28759045 Ref: A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis. PMID: 28775144 Ref: Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. PMID: 28776332 Ref: The phytochemical and bioactivity profiles of wild Asparagus albus L. plant. PMID: 28784537 Ref: Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes? PMID: 28799785 Ref: Fibroblast-derived CXCL12/SDF-1alpha promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer. PMID: 28811711 Ref: CENPH Inhibits Rapamycin Sensitivity by Regulating GOLPH3-dependent mTOR Signaling Pathway in Colorectal Cancer. PMID: 28819418 Ref: Immuno-Matrix-Assisted Laser Desorption/Ionization Assays for Quantifying AKT1 and AKT2 in Breast and Colorectal Cancer Cell Lines and Tumors. PMID: 28853539 Ref: miR-625-3p is upregulated in CD8+ T cells during early immune reconstitution after allogeneic stem cell transplantation. PMID: 28854245 Ref: Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis. PMID: 28881576 Ref: Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells. PMID: 28881770 Ref: A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. PMID: 28899863 Ref: Rhus coriaria increases protein ubiquitination, proteasomal degradation and triggers non-canonical Beclin-1-independent autophagy and apoptotic cell death in colon cancer cells. PMID: 28912474 Ref: miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin. PMID: 28928082 Ref: The Impact of Cetuximab Plus AKT- or mTOR- Inhibitor in a Patient-Derived Colon Cancer Cell Model with Wild-Type RAS and PIK3CA Mutation. PMID: 28928860 Ref: TRAIL enhances quinacrine-mediated apoptosis in breast cancer cells through induction of autophagy via modulation of p21 and DR5 interactions. PMID: 28936683 Ref: Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival. PMID: 28936799 Ref: MicroRNA212 inhibits colorectal cancer cell viability and invasion by directly targeting PIK3R3. PMID: 28944887 Ref: Identification of 7-(4'-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells. PMID: 28963527 Ref: Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway. PMID: 28972559 Ref: Augmented O-GlcNAcylation of AMP-activated kinase promotes the proliferation of LoVo cells, a colon cancer cell line. PMID: 28973823 Ref: Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer. PMID: 28978118 Ref: Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer. PMID: 28979133 Ref: Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells. PMID: 28981110 Ref: Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells. PMID: 28986187 Ref: MiR-129 inhibits cell proliferation and metastasis by targeting ETS1 via PI3K/AKT/mTOR pathway in prostate cancer. PMID: 29035829 Ref: Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b. PMID: 29036788 Ref: Phosphoinositide-specific phospholipase Cgamma1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells. PMID: 29066806 Ref: A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer. PMID: 29067643 Ref: Apatinib has anti-tumor effects and induces autophagy in colon cancer cells. PMID: 29085592 Ref: The Impact of Diet-Induced Weight Loss on Biomarkers for Colorectal Cancer: An Exploratory Study (INTERCEPT). PMID: 29086510 Ref: Invitro Evaluation of Torin2 and 2, 6-Dihydroxyacetophenone in Colorectal Cancer Therapy. PMID: 29103204 Ref: Gene expression profiling demonstrates WNT/beta-catenin pathway genes alteration in Mexican patients with colorectal cancer and diabetes mellitus. PMID: 29135090 Ref: Tumor-biopsy stratification based on mTOR-pathway activity and functional mutations in the upstream genes PIK3CA and PTEN. PMID: 29137436 Ref: Uncoupling TORC2 from AGC kinases inhibits tumour growth. PMID: 29156676 Ref: Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production. PMID: 29167573 Ref: Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death. PMID: 29179457 Ref: miRNA-495 suppresses proliferation and migration of colorectal cancer cells by targeting FAM83D. PMID: 29221726 Ref: Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer. PMID: 29246220 Ref: Separation of low and high grade colon and rectum carcinoma by eukaryotic translation initiation factors 1, 5 and 6. PMID: 29254159 Ref: Therapeutic effects of the euglenoid ichthyotoxin, euglenophycin, in colon cancer. PMID: 29262645 Ref: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. PMID: 29273065 Ref: L-type amino acid transporter 1 expression is upregulated and associated with cellular proliferation in colorectal cancer. PMID: 29344181 |
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PMID: 29041842 Ref: Long non-coding RNA-422 acts as a tumor suppressor in colorectal cancer. PMID: 29050940 Ref: Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human gammadeltaT cells against colon cancer. PMID: 29104081 Ref: RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer. PMID: 29196555 Ref: MicroRNA-411 inhibits malignant biological behaviours of colorectal cancer cells by directly targeting PIK3R3. PMID: 29207180 Ref: Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation. PMID: 29217764 Ref: TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting beta-CATENIN and AKT Signaling in Colorectal Cancer. PMID: 29222171 Ref: Hyperthermia enhances radiosensitivity of colorectal cancer cells through ROS inducing autophagic cell death. PMID: 29240246 Ref: Rational Approaches for Combination Therapy Strategies Targeting the MAP Kinase Pathway in Solid Tumors. PMID: 29295962 Ref: Autophagy-mediated upregulation of cytoplasmic claudin 1 stimulates the degradation of SQSTM1/p62 under starvation. PMID: 29307823 Ref: miR1273g3p promotes proliferation, migration and invasion of LoVo cells via cannabinoid receptor 1 through activation of ERBB4/PIK3R3/mTOR/S6K2 signaling pathway. PMID: 29328379 Ref: Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3. PMID: 29338072 Ref: Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway. PMID: 29344654 Ref: Ginkgolic acid induces interplay between apoptosis and autophagy regulated by ROS generation in colon cancer. PMID: 29353042 Ref: NF-kappaB-induced WIP1 expression promotes colorectal cancer cell proliferation through mTOR signaling. PMID: 29367109 Ref: MicroRNA-204 Inhibits the Growth and Motility of Colorectal Cancer Cells by Downregulation of CXCL8. PMID: 29402343 Ref: Human epidermal receptor family inhibitors in patients with ERBB3 mutated cancers: Entering the back door. PMID: 29413684 Ref: Fyn knockdown inhibits migration and invasion in cholangiocarcinoma through the activated AMPK/mTOR signaling pathway. PMID: 29434909 Ref: Effect of silencing colon cancer-associated transcript 2 on the proliferation, apoptosis and autophagy of gastric cancer BGC-823 cells. PMID: 29435046 Ref: Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors. PMID: 29440231 Ref: Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer. PMID: 29442390 Ref: Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling. PMID: 29448085 Ref: AZD8055 Exerts Antitumor Effects on Colon Cancer Cells by Inhibiting mTOR and Cell-cycle Progression. PMID: 29491070 Ref: Functional Anthocyanin-Rich Sausages Diminish Colorectal Cancer in an Animal Model and Reduce Pro-Inflammatory Bacteria in the Intestinal Microbiota. PMID: 29494510 Ref: Colorectal cancer cell-derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway. PMID: 29496262 Ref: The Immunome of Colon Cancer: Functional In Silico Analysis of Antigenic Proteins Deduced from IgG Microarray Profiling. PMID: 29505855 Ref: Cross regulation between mTOR signaling and O-GlcNAcylation. PMID: 29524020 Ref: Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K/AKT/mTOR/p70S6K signaling pathway. PMID: 29541215 Ref: Expression of factors and key components associated with the PI3K signaling pathway in colon cancer. PMID: 29552187 Ref: Celastrol inhibits colorectal cancer cell proliferation and migration through suppression of MMP3 and MMP7 by the PI3K/AKT signaling pathway. PMID: 29553945 Ref: Cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the Akt pathway. PMID: 29560517 Ref: Berberine decelerates glucose metabolism via suppression of mTORdependent HIF1alpha protein synthesis in colon cancer cells. PMID: 29565467 Ref: Deciphering the molecular mechanism and apoptosis underlying the in-vitro and in-vivo chemotherapeutic efficacy of vanadium luteolin complex in colon cancer. PMID: 29574863 Ref: TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [(18)F] fluorodeoxyglucose ((18)F-FDG PET). PMID: 29581845 Ref: Deptor Is a Novel Target of Wnt/beta-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth. PMID: 29666061 Ref: MiR-490-3p Functions As a Tumor Suppressor by Inhibiting Oncogene VDAC1 Expression in Colorectal Cancer. PMID: 29675103 Ref: Mitochondrial DNA content reduction induces aerobic glycolysis and reversible resistance to drug-induced apoptosis in SW480 colorectal cancer cells. PMID: 29684851 Ref: Knockdown of long noncoding RNA PVT1 reverses multidrug resistance in colorectal cancer cells. PMID: 29693171 Ref: Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis. PMID: 29730197 Ref: Over-activation of AKT signaling leading to 5-Fluorouracil resistance in SNU-C5/5-FU cells. PMID: 29731993 Ref: Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer. PMID: 29777330 Ref: Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells. PMID: 29805556 Ref: Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-kappaB and microRNA-127 in human glioma U87MG cells. PMID: 29805677 Ref: Metformin in cancer. PMID: 29807101 Ref: Dual mTOR/PI3K inhibitor NVPBEZ235 arrests colorectal cancer cell growth and displays differential inhibition of 4EBP1. PMID: 29845289 Ref: Jianpi Jiedu decoction, a traditional Chinese medicine formula, inhibits tumorigenesis, metastasis, and angiogenesis through the mTOR/HIF-1alpha/VEGF pathway. PMID: 29852266 Ref: Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer. PMID: 29867114 Ref: Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer. PMID: 29871814 Ref: The Effects of Different mTOR Inhibitors in EGFR Inhibitor Resistant Colon Carcinoma Cells. PMID: 29882195 Ref: The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes. PMID: 29884818 Ref: Chrysin Attenuates Cell Viability of Human Colorectal Cancer Cells through Autophagy Induction Unlike 5-Fluorouracil/Oxaliplatin. PMID: 29899208 Ref: Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations. PMID: 29907857 Ref: Effects of immune suppression for transplantation on inflammatory colorectal cancer progression. PMID: 29915171 Ref: Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells. PMID: 29921474 Ref: Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy. PMID: 29921885 Ref: Cancer-associated fibroblasts enhance cell proliferation and metastasis of colorectal cancer SW480 cells by provoking long noncoding RNA UCA1. PMID: 29948578 Ref: Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling. PMID: 29957460 Ref: Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression. PMID: 29970122 Ref: Activation of WNT/beta-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations. PMID: 29978469 Ref: [Polymorphisms of mTORC1 genes and risk of primary colorectal adenocarcinoma in Chinese populations]. PMID: 29996312 Ref: STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer. PMID: 29996891 Ref: Anticancer activity of safranal against colon carcinoma is due to induction of apoptosis and G2/M cell cycle arrest mediated by suppression of mTOR/PI3K/Akt pathway. PMID: 30003721 Ref: Active fraction of clove induces apoptosis via PI3K/Akt/mTOR-mediated autophagy in human colorectal cancer HCT-116 cells. PMID: 30015913 Ref: miR-212 and mTOR form a regulation loop to modulate autophagy in colorectal adenoma HT-29 cells. PMID: 30021100 Ref: Combination of BEZ235 and Metformin Has Synergistic Effect on Cell Viability in Colorectal Cancer Cells. PMID: 30023463 Ref: KT2 and RT2 modified antimicrobial peptides derived from Crocodylus siamensis Leucrocin I show activity against human colon cancer HCT-116 cells. PMID: 30031283 Ref: Discovery of an Orally Bioavailable Dual PI3K/mTOR Inhibitor Based on Sulfonyl-Substituted Morpholinopyrimidines. PMID: 30034607 Ref: Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1alpha mediated signal pathway. PMID: 30036603 Ref: Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. PMID: 30056083 Ref: Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells. PMID: 30071226 Ref: Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation. PMID: 30087121 Ref: Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells. PMID: 30103008 Ref: Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes. PMID: 30111296 Ref: Tim-4 promotes the growth of colorectal cancer by activating angiogenesis and recruiting tumor-associated macrophages via the PI3K/AKT/mTOR signaling pathway. PMID: 30118845 Ref: The influence of aberrant expression of GLI1/p-S6K on colorectal cancer. PMID: 30143258 Ref: Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition. PMID: 30201826 Ref: Neratinib augments the lethality of [regorafenib + sildenafil]. PMID: 30203445 Ref: Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK-1-eIF4G-eIF4E signaling. PMID: 30221473 Ref: MicroRNA-7 inhibits colorectal cancer cell proliferation, migration and invasion via TYRO3 and phosphoinositide 3-kinase/protein B kinase/mammalian target of rapamycin pathway suppression. PMID: 30226533 Ref: SP1-induced lncRNA-ZFAS1 contributes to colorectal cancer progression via the miR-150-5p/VEGFA axis. PMID: 30250022 Ref: F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway. PMID: 30257389 Ref: Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/beta-Catenin Pathway. PMID: 30257507 Ref: (+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer. PMID: 30298093 Ref: Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial-mesenchymal transition in human colon cancer cells. PMID: 30308035 Ref: Silencing of FOXO6 inhibits the proliferation, invasion, and glycolysis in colorectal cancer cells. PMID: 30321450 Ref: Knockdown of long noncoding RNA urothelial carcinoma associated 1 inhibits colorectal cancer cell proliferation and promotes apoptosis via modulating autophagy. PMID: 30362538 Ref: Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1alpha nuclear translocation. PMID: 30388517 |