Primary Site >> Pancreatic Cancer
Gene >> MST1R
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Ref: Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression. PMID: 15289319 |
Ref: Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member. PMID: 16982759 |
Ref: Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target. PMID: 17311308 |
Ref: Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells. PMID: 18310076 |
Ref: In memoriam: Great 21st century physician 'One Health' leader dies - Ronald M. Davis, MD, Past President, American Medical Association. PMID: 20391399 |
Ref: Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. PMID: 20103639 Ref: The RON tyrosine kinase receptor regulates vascular endothelial growth factor production in pancreatic cancer cells. PMID: 20358644 Ref: Inhibition of MSP-RON signaling pathway in cancer cells by a novel soluble form of RON comprising the entire sema sequence. PMID: 20428780 Ref: Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy. PMID: 20694025 |
Ref: IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migration. PMID: 21565828 Ref: Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein. PMID: 21619683 Ref: Sustained expression of the RON receptor tyrosine kinase by pancreatic cancer stem cells as a potential targeting moiety for antibody-directed chemotherapeutics. PMID: 22014215 |
Ref: Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors. PMID: 22287729 Ref: RON is not a prognostic marker for resectable pancreatic cancer. PMID: 22958871 |
Ref: Synergistic activities of MET/RON inhibitor BMS-777607 and mTOR inhibitor AZD8055 to polyploid cells derived from pancreatic cancer and cancer stem cells. PMID: 24233399 Ref: The RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapies. PMID: 24518495 |
Ref: A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. PMID: 26477314 Ref: Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment. PMID: 27293990 Ref: Analogs of the hepatocyte growth factor and macrophage-stimulating protein hinge regions act as Met and Ron dual inhibitors in pancreatic cancer cells. PMID: 27314431 |
Ref: A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts. PMID: 27602776 Ref: Identification of candidate genes related to pancreatic cancer based on analysis of gene co-expression and protein-protein interaction network. PMID: 29050346 |
Ref: Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase. PMID: 29944378 |