Primary Site >> Colorectal Cancer
Gene >> MSH3
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Ref: MutS homologs in mammalian cells. PMID: 9024626 Ref: DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. PMID: 9294177 Ref: Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. PMID: 9307272 Ref: Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype. PMID: 9331106 Ref: Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas. PMID: 9401011 Ref: Drastic genetic instability of tumors and normal tissues in Turcot syndrome. PMID: 9419979 |
Ref: Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability. PMID: 9485005 Ref: RER phenotype and its associated mutations in familial gastric cancer. PMID: 9498272 Ref: Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. PMID: 9500462 Ref: Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. PMID: 9677427 Ref: Microsatellite instability in young patients with colorectal cancer. PMID: 9736405 Ref: Allelic losses and DNA methylation at DNA mismatch repair loci in sporadic colorectal cancer. PMID: 9855004 Ref: Hereditary Factors in Gynecologic Cancer. PMID: 10388122 |
Ref: Causes and consequences of microsatellite instability in endometrial carcinoma. PMID: 9927063 Ref: Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer. PMID: 9929971 Ref: Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. PMID: 10348818 Ref: Regional reproducibility of microsatellite instability in sporadic colorectal cancer. PMID: 10469448 Ref: Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination. PMID: 10523644 Ref: HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. PMID: 10545954 Ref: Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability. PMID: 10597289 Ref: Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. PMID: 10637515 Ref: Frameshift mutations and a length polymorphism in the hMSH3 gene and the spectrum of microsatellite instability in sporadic colon cancer. PMID: 10665647 Ref: Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines. PMID: 10674020 Ref: Analysis of microsatellite instability in cervical cancer. PMID: 11240745 |
Ref: The effect of mismatch repair deficiency on tumourigenesis; microsatellite instability affecting genes containing short repeated sequences. PMID: 10601558 Ref: Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. PMID: 10607839 Ref: Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium. PMID: 10717241 Ref: Atypical clustering of gynecologic malignancies: A family study including molecular analysis of candidate genes. PMID: 10739686 Ref: Mismatch repair defects in cancer. PMID: 10753784 Ref: HMSH6 alterations in patients with microsatellite instability-low colorectal cancer. PMID: 10786688 Ref: DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. PMID: 10861262 Ref: Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. PMID: 10861263 Ref: Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation. PMID: 10918391 Ref: Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer. PMID: 10934138 Ref: Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability. PMID: 10944853 Ref: Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity. PMID: 10959092 Ref: Genetic alterations of sporadic colorectal cancer with microsatellite instability, especially characteristics of primary multiple colorectal cancers. PMID: 10962455 Ref: [Response of metastatic colorectal cancers to treatment with CPT11 (irinotecan): implications of the mismatched base repair system]. PMID: 11084429 Ref: High throughput genetic screening for the detection of hereditary non-polyposis colon cancer (HNPCC) using capillary electrophoresis. PMID: 11121520 |
Ref: Evolution of instability at coding and non-coding repeat sequences in human MSI-H colorectal cancers. PMID: 11181575 Ref: MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer. PMID: 11245474 Ref: Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer. PMID: 11290569 Ref: Infrequent frameshift mutations in the simple repeat sequences of hMLH3 in hereditary nonpolyposis colorectal cancers. PMID: 11302343 Ref: Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype. PMID: 11470537 Ref: Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1. PMID: 11498787 Ref: Relationship between grade of microsatellite instability and target genes of mismatch repair pathways in sporadic colorectal carcinoma. PMID: 11508658 Ref: PTEN gene mutations in colorectal cancers displaying microsatellite instability. PMID: 11689295 |
Ref: Mismatch repair and the hereditary non-polyposis colorectal cancer syndrome (HNPCC). PMID: 11852992 Ref: Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer. PMID: 11996796 Ref: Functional analysis of MSH6 mutations linked to kindreds with putative hereditary non-polyposis colorectal cancer syndrome. PMID: 12019211 Ref: A hMLH1 genomic mutation and associated novel mRNA defects in a hereditary non-polyposis colorectal cancer family. PMID: 12052501 Ref: Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. PMID: 12057899 Ref: The activity profile of the hexacyclic camptothecin derivative DX-8951f in experimental human colon cancer and ovarian cancer. PMID: 12234607 Ref: Analysis of mismatch repair defects in the familial occurrence of lymphoma and colorectal cancer. PMID: 12400605 Ref: Frequent microsatellite instability in sporadic tumors of the upper urinary tract. PMID: 12460887 |
Ref: Combined deficiency of hMLH1, hMSH2, hMSH3 and hMSH6 is an independent prognostic factor in colorectal cancer. PMID: 12469183 Ref: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-based detection of microsatellite instabilities in coding DNA sequences: a novel approach to identify DNA-mismatch repair-deficient cancer cells. PMID: 12651806 Ref: Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability. PMID: 12712438 Ref: Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene. PMID: 12792735 Ref: Microsatellite instability and mutations in DNA mismatch repair genes in sporadic colorectal cancers. PMID: 12907901 Ref: Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. PMID: 14522894 Ref: Genetic analysis of radiation-associated rectal cancer. PMID: 14714259 |
Ref: Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression. PMID: 14871813 Ref: [Transforming growth factor beta receptor II mutations in RER positive colorectal cancers]. PMID: 14989920 Ref: Multiple epithelial and nonepithelial tumors in hereditary nonpolyposis colorectal cancer: characterization of germline and somatic mutations of the MSH2 gene and heterogeneity of replication error phenotypes. PMID: 15350299 |
Ref: Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers. PMID: 16000315 |
Ref: The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1. PMID: 16288223 Ref: Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. PMID: 16421660 |
Ref: Mismatch repair polymorphisms and the risk of colorectal cancer. PMID: 17205513 |
Ref: Common variants in mismatch repair genes and risk of colorectal cancer. PMID: 18364438 Ref: Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. PMID: 18922920 |
Ref: Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer. PMID: 19115210 Ref: Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer. PMID: 19787250 |
Ref: Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability. PMID: 20565851 Ref: MMR gene expression pattern in sporadic colorectal cancer. PMID: 20593048 Ref: Microsatellite alterations at selected tetranucleotide repeats are associated with morphologies of colorectal neoplasias. PMID: 20708618 Ref: Relationship of EMAST and microsatellite instability among patients with rectal cancer. PMID: 20844976 Ref: Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin. PMID: 20979647 Ref: Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability. PMID: 21209843 |
Ref: Evidence for an hMSH3 defect in familial hamartomatous polyps. PMID: 20845481 Ref: Association of low-risk MSH3 and MSH2 variant alleles with Lynch syndrome: probability of synergistic effects. PMID: 21128252 Ref: MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin, and a poly(ADP-ribose) polymerase inhibitor. PMID: 21285347 Ref: Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I. PMID: 21726567 Ref: An MSI tumor specific frameshift mutation in a coding microsatellite of MSH3 encodes for HLA-A0201-restricted CD8+ cytotoxic T cell epitopes. PMID: 22110587 Ref: Alterations of copy number of methylation pattern in mismatch repair genes by methylation specific-multiplex ligation-dependent probe amplification in cases of colon cancer. PMID: 24052709 |
Ref: Candidate driver genes in microsatellite-unstable colorectal cancer. PMID: 21544814 Ref: DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome. PMID: 21974800 Ref: Aberrant protein expression and frequent allelic loss of MSH3 in colorectal cancer with low-level microsatellite instability. PMID: 22249440 Ref: Down-regulation of MutS homolog 3 by hypoxia in human colorectal cancer. PMID: 22343000 Ref: Comprehensive molecular characterization of human colon and rectal cancer. PMID: 22810696 Ref: Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells. PMID: 23226332 |
Ref: MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination. PMID: 23636450 Ref: Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity. PMID: 23643670 Ref: MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells. PMID: 23724141 Ref: Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study. PMID: 24065530 |
Ref: Mismatch repair deficiency in ovarian cancer -- molecular characteristics and clinical implications. PMID: 24333356 Ref: Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients. PMID: 24484585 Ref: Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. PMID: 24755471 |
Ref: Comprehensive screening for mutations associated with colorectal cancer in unselected cases reveals penetrant and nonpenetrant mutations. PMID: 25142776 Ref: Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells. PMID: 25461668 Ref: Interactions between meat intake and genetic variation in relation to colorectal cancer. PMID: 25491747 Ref: Microsatellite instability: an update. PMID: 25701956 Ref: EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression. PMID: 25836926 Ref: EMAST is associated with a poor prognosis in microsatellite instable metastatic colorectal cancer. PMID: 25884216 Ref: Prospective derivation of a living organoid biobank of colorectal cancer patients. PMID: 25957691 Ref: Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer. PMID: 25996601 Ref: Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation. PMID: 26247575 Ref: MSH3 rs26279 polymorphism increases cancer risk: a meta-analysis. PMID: 26617824 |
Ref: Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway. PMID: 26510091 Ref: Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis. PMID: 26752111 Ref: Serrated polyposis associated with a family history of colorectal cancer and/or polyps: The preferential location of polyps in the colon and rectum defines two molecular entities. PMID: 27430658 Ref: Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. PMID: 27476653 Ref: Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) and Microsatellite Instability in Patients with Colorectal Cancer and Its Clinical Features. PMID: 27889996 Ref: HEREDITARY, SPORADIC AND METASTATIC COLORECTAL CANCER ARE COMMONLY DRIVEN BY SPECIFIC SPECTRUMS OF DEFECTIVE DNA MISMATCH REPAIR COMPONENTS. PMID: 28066040 |
Ref: Expanding the genotype-phenotype spectrum in hereditary colorectal cancer by gene panel testing. PMID: 27696107 Ref: Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer. PMID: 28002797 Ref: Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648. PMID: 28224663 Ref: Schizosaccharomyces pombe MutSalpha and MutLalpha Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats. PMID: 28341698 Ref: Loss of MSH2 and MSH6 due to heterozygous germline defects in MSH3 and MSH6. PMID: 28528517 Ref: DNA mismatch repair deficiency in lung and oral cavity carcinomas: the role of histogenetic origin. PMID: 28730763 Ref: Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort. PMID: 29212164 Ref: Distinctive DNA mismatch repair and APC rare variants in African Americans with colorectal neoplasia. PMID: 29245953 |
Ref: Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer. PMID: 29375743 Ref: Novel MSH2 splice-site mutation in a young patient with Lynch syndrome. PMID: 29568967 Ref: Fusobacterium nucleatum Infection in Colorectal Cancer: Linking Inflammation, DNA Mismatch Repair and Genetic and Epigenetic Alterations. PMID: 30116794 |