Primary Site >> Colorectal Cancer

Gene >> MRE11

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Ref: Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.
PMID: 10362364
 Ref: Human MRE11 is inactivated in mismatch repair-deficient cancers.
PMID: 11850399
 Ref: The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase.
PMID: 12687013
 Ref: Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.
PMID: 15048091
 Ref: Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells.
PMID: 16127745
 Ref: Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
PMID: 16905549
 Ref: The MRE11/RAD50/NBS1 complex destabilization in Lynch-syndrome patients.
PMID: 17534377
Ref: Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer.
PMID: 18056440
 Ref: A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.
PMID: 18256278
Ref: The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer.
PMID: 18606567
Ref: Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11.
PMID: 18765539
Ref: RAD50/MRE11/NBS1 proteins in relation to tumour development and prognosis in patients with microsatellite stable colorectal cancer.
PMID: 18830935
Ref: Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines.
PMID: 18941461
 Ref: [Tissue microarray (TMA) validated progression markers in colorectal cancer using antibody microarrays].
PMID: 19648079
 Ref: Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study.
PMID: 23050049
 Ref: Effects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases.
PMID: 23065707
Ref: Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.
PMID: 23390603
Ref: Clinicopathological significance of BTF3 expression in colorectal cancer.
PMID: 23532689
Ref: Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells.
PMID: 24039993
Ref: Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue.
PMID: 24062075
 Ref: Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells.
PMID: 24215868
Ref: The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines.
PMID: 24338765
Ref: The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
PMID: 24577941
Ref: MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.
PMID: 25310185
 Ref: Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS status.
PMID: 25685067
Ref: Microsatellite instability: an update.
PMID: 25701956
 Ref: Expression of DNA double-strand break repair proteins predicts the response and prognosis of colorectal cancer patients undergoing oxaliplatin-based chemotherapy.
PMID: 26676960
Ref: Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.
PMID: 26735576
Ref: Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer.
PMID: 27329137
Ref: MRE11 and ATM Expression Levels Predict Rectal Cancer Survival and Their Association with Radiotherapy Response.
PMID: 27930716
 Ref: AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.
PMID: 28967905
Ref: Targeting RAD50 increases sensitivity to radiotherapy in colorectal cancer cells.
PMID: 29322791
Ref: Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis.
PMID: 30176843