Primary Site >> Colorectal Cancer
Gene >> MLH1
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Ref: Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies. PMID: 4016686 |
Ref: Recognition and treatment of patients with hereditary nonpolyposis colon cancer (Lynch syndromes I and II). PMID: 3632093 |
Ref: Hereditary nonpolyposis colorectal cancer--Lynch syndromes I and II. PMID: 3068137 Ref: Demonstration of altered cellular DNA content distribution in long-term colon epithelial cell lines with colon cancer genotypes. PMID: 3227300 Ref: Differential diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome I and Lynch syndrome II). PMID: 3366037 Ref: Chromosome 18 allele loss at the D18S6 locus in human colorectal carcinomas. PMID: 3415702 |
Ref: Hereditary nonpolyposis colon cancer: (Lynch syndrome I and II). A challenge for the clinician. PMID: 2538763 |
Ref: [Prevention of familial tumor diseases using genetic counseling and early diagnosis]. PMID: 1977199 |
Ref: Hereditary nonpolyposis colorectal cancer (Lynch syndromes I & II). Genetics, pathology, natural history, and cancer control, Part I. PMID: 1648437 |
Ref: The Singapore Polyposis Registry. PMID: 1325751 |
Ref: Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. PMID: 8371783 Ref: Identification of hereditary nonpolyposis colorectal cancer in the general population. The 6-year experience of a population-based registry. PMID: 8387880 Ref: Surveillance in hereditary nonpolyposis colorectal cancer: an international cooperative study of 165 families. The International Collaborative Group on HNPCC. PMID: 8416772 Ref: Familial risk of colo-rectal cancer in a low incidence area in southern Italy. PMID: 8472798 Ref: Lynch Syndrome PMID: 20301390 |
Ref: Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genes. PMID: 7521009 Ref: [Hereditary non-polyposis colorectal cancer: HNPCC]. PMID: 7736246 Ref: [Hereditary non-polyposis colorectal cancer; HNPCC]. PMID: 7837674 Ref: Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes. PMID: 7838728 Ref: [Genes, heredity and colorectal cancer]. PMID: 7878358 Ref: DNA loop repair by human cell extracts. PMID: 7973637 Ref: What is hereditary nonpolyposis colorectal cancer (HNPCC). PMID: 7979195 Ref: 25 years of HNPCC. PMID: 7979196 Ref: Epidemiology of HNPCC. PMID: 7979197 Ref: Genes involved in hereditary nonpolyposis colorectal carcinoma. PMID: 7979203 Ref: The International Collaborative Group on HNPCC. PMID: 7979204 Ref: The inherited component of cancer. PMID: 7987639 Ref: Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. PMID: 8044777 Ref: Endometrial cancer in four sisters: report of a kindred with presumed cancer family syndrome. PMID: 8063241 Ref: Mutation of a mutL homolog in hereditary colon cancer. PMID: 8128251 Ref: Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. PMID: 8145827 |
Ref: Contribution of molecular oncology in the detection of colorectal carcinomas. PMID: 7491839 Ref: Hereditary non-polyposis colorectal cancer (HNPCC or Lynch syndrome) PMID: 7549818 Ref: Monoallelic mutation analysis (MAMA) for identifying germline mutations. PMID: 7550326 Ref: In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer. PMID: 7557107 Ref: Familial aggregation of tumors and detection of hereditary non-polyposis colorectal cancer in 3-year experience of 2 population-based colorectal-cancer registries. PMID: 7558415 Ref: Clinical implications of advances in the molecular genetics of colorectal cancer. PMID: 7571049 Ref: Update on the differential diagnosis, surveillance and management of hereditary non-polyposis colorectal cancer. PMID: 7576988 Ref: Founding mutations and Alu-mediated recombination in hereditary colon cancer. PMID: 7584997 Ref: Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. PMID: 7585634 Ref: Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. PMID: 7585651 Ref: Genetic linkage analysis in hereditary non-polyposis colon cancer syndrome. PMID: 7616541 Ref: Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. PMID: 7641183 Ref: [Heredity and colorectal cancer]. PMID: 7659249 Ref: The molecular basis of Turcot's syndrome. PMID: 7661930 Ref: Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. PMID: 7674315 Ref: Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC) PMID: 7757073 Ref: DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. PMID: 7757980 Ref: A screening clinic for relatives of patients with colorectal cancer in a district general hospital. PMID: 7890243 Ref: Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. PMID: 7892206 Ref: Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. PMID: 8521394 Ref: Mutation screening in the hMLH1 gene in Swedish hereditary nonpolyposis colon cancer families. PMID: 8521398 Ref: Molecular analysis of mutations in mutator colorectal carcinoma cell lines. PMID: 8589681 Ref: Multistep carcinogenesis in colorectal cancers. PMID: 8629105 Ref: Genetics of hereditary colon cancer. PMID: 8825478 |
Ref: Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer. PMID: 8577718 Ref: Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome). PMID: 8600057 Ref: Better survival rates in patients with MLH1-associated hereditary colorectal cancer. PMID: 8608876 Ref: Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. PMID: 8612988 Ref: Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas. PMID: 8622690 Ref: Genetic heterogeneity and unmapped genes for colorectal cancer. PMID: 8640829 Ref: Descriptive epidemiology of hereditary non-polyposis colorectal cancer. PMID: 8644370 Ref: Genetic epidemiology of colorectal cancer. PMID: 8644371 Ref: Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype. PMID: 8649458 Ref: Loss of DNA mismatch repair in acquired resistance to cisplatin. PMID: 8674066 Ref: [Familial cancer and oncogenic factors]. PMID: 8678487 Ref: Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. PMID: 8690195 Ref: Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine. PMID: 8690794 Ref: Mutation of the hMSH2 gene in two families with hereditary nonpolyposis colorectal cancer. PMID: 8723682 Ref: Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers. PMID: 8766523 Ref: DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer. PMID: 8776590 Ref: Microsatellite instability differences between familial and sporadic ovarian cancers. PMID: 8824498 Ref: Genetic basis of tumour development. PMID: 8842841 Ref: Complex genetic predisposition to cancer in an extended HNPCC family with an ancestral hMLH1 mutation. PMID: 8863153 Ref: Recent developments in hereditary nonpolyposis colorectal cancer. PMID: 8865457 Ref: Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. PMID: 8872463 Ref: Mismatch repair defects in human carcinogenesis. PMID: 8875255 Ref: Mutation screening of MSH2 and MLH1 mRNA in hereditary non-polyposis colon cancer syndrome. PMID: 8880570 Ref: Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. PMID: 8895729 Ref: The role of DNA mismatch repair in platinum drug resistance. PMID: 8895738 Ref: The genetic basis of colorectal cancer risk. PMID: 8903598 Ref: [Mutations of hMSH2 gene and hMLH1 gene in human colovectal carcinomas]. PMID: 8920666 Ref: [Genetic steps in colorectal cancer]. PMID: 8920676 Ref: Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability. PMID: 8932328 Ref: Processing of O6-methylguanine by mismatch correction in human cell extracts. PMID: 8939600 Ref: Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer. PMID: 8940269 Ref: Mutations of the transforming growth factor-beta type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. PMID: 8952554 Ref: Familial risk and colorectal cancer. PMID: 8960893 Ref: Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. PMID: 8968088 Ref: Identification of novel germline hMLH1 mutations including a 22 kb Alu-mediated deletion in patients with familial colorectal cancer. PMID: 8971183 Ref: Patterns of mutation in cancer cells. PMID: 8977027 Ref: Mismatch repair and cancer. PMID: 8977028 Ref: Detection of Tn, sialosyl-Tn and T antigens in hereditary nonpolyposis colorectal cancer. PMID: 8982378 Ref: Microsatellite instability in early onset and familial colorectal cancer. PMID: 9004127 Ref: [Microsatellite instability--a new aspects in genetics and molecular biology of hereditary nonpolyposis and sporadic colorectal tumors]. PMID: 9082661 Ref: DNA mismatch repair deficient mice in cancer research. PMID: 9110401 Ref: Novel allele of the hMLH1 gene bearing a TTC deletion in the 3' untranslated region. PMID: 21541571 |
Ref: Characterization of MSH2 and MLH1 mutations in Italian families with hereditary nonpolyposis colorectal cancer. PMID: 8993976 Ref: Mutations in MLH1 are more frequent than in MSH2 in sporadic colorectal cancers with microsatellite instability. PMID: 8993979 Ref: Clinical and molecular features of the hereditary mixed polyposis syndrome. PMID: 9024286 Ref: Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer. PMID: 9032648 Ref: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. PMID: 9041175 Ref: Advances in molecular genetics. PMID: 9046882 Ref: Use of SSCP analysis to identify germline mutations in HNPCC families fulfilling the Amsterdam criteria. PMID: 9048925 Ref: Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled. PMID: 9052445 Ref: Microsatellite instability in cervical and endometrial carcinomas. PMID: 9052745 Ref: Microsatellite instability in human solid tumors. PMID: 9060003 Ref: An update of HNPCC (Lynch syndrome). PMID: 9062584 Ref: Mutational analysis of the hMLH1 gene using an automated two-dimensional DNA typing system. PMID: 9067757 Ref: MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis. PMID: 9087566 Ref: DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load. PMID: 9088350 Ref: [Molecular-pathological problems of genetic diagnosis for colorectal cancer]. PMID: 9101543 Ref: Meat consumption and preparation, and genetic susceptibility in relation to colorectal adenomas. PMID: 9103318 Ref: Mutations predisposing to hereditary nonpolyposis colorectal cancer. PMID: 9111864 Ref: The fragile X CGG repeat shows a marked level of instability in hereditary non-polyposis colorectal cancer patients. PMID: 9195158 Ref: Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair. PMID: 9214593 Ref: Disease expression in Swiss hereditary non-polyposis colorectal cancer (HNPCC) kindreds. PMID: 9221805 Ref: [Molecular etiology of colorectal carcinogenesis, clinical manifestations and therapy]. PMID: 9244653 Ref: Hereditary nonpolyposis colorectal cancer: causative role of a germline missense mutation in the hMLH1 gene confirmed by the independent occurrence of the same somatic mutation in tumour tissue. PMID: 9272156 Ref: Genomic DNA-based hMSH2 and hMLH1 mutation screening in 32 Eastern United States hereditary nonpolyposis colorectal cancer pedigrees. PMID: 9288790 Ref: Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. PMID: 9307272 Ref: Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations. PMID: 9311737 Ref: [Hereditary colorectal cancer (HNPCC or Lynch syndrome)]. PMID: 9312738 Ref: Loss of DNA mismatch repair: effects on the rate of mutation to drug resistance. PMID: 9337351 Ref: Widespread microsatellite instability in sebaceous tumours of patients with the Muir-Torre syndrome. PMID: 9349329 Ref: Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. PMID: 9354436 Ref: Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. PMID: 9371516 Ref: Undectable expression of hMLH1 protein in sporadic colorectal cancer with replication error phenotype. PMID: 9378008 Ref: Tumorigenesis in colorectal tumors from patients with hereditary non-polyposis colorectal cancer. PMID: 9385369 Ref: Germline hMSH2 and hMLH1 gene mutations in incomplete HNPCC families. PMID: 9399661 Ref: Etiology, natural history, management and molecular genetics of hereditary nonpolyposis colorectal cancer (Lynch syndromes): genetic counseling implications. PMID: 9419392 Ref: Identification of concurrent germ-line mutations in hMSH2 and/or hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds. PMID: 9419403 Ref: Drastic genetic instability of tumors and normal tissues in Turcot syndrome. PMID: 9419979 Ref: Molecular biology of colorectal cancer. PMID: 9438104 Ref: Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. PMID: 9491849 Ref: Molecular advances in the etiology and treatment of colorectal cancer. PMID: 9576630 Ref: [Colorectal adenocarcinoma in patients under 40 years of age]. PMID: 9587559 Ref: Cancer genetics in the new era of molecular biology. PMID: 9616736 Ref: [The application of molecular technics in the management of colorectal cancer]. PMID: 9772989 Ref: Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression. PMID: 21590118 |
Ref: Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors. PMID: 9445183 Ref: DNA synthesis, mismatch repair and cancer. PMID: 9458365 Ref: Growth suppression mediated by transfection of wild-type hMLH1 in human cancer cells expressing endogenous truncated hMLH1 protein. PMID: 9472100 Ref: Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. PMID: 9485033 Ref: Possible role of telomerase activation in the cancer predisposition of patients with hereditary nonpolyposis colorectal cancers. PMID: 9486818 Ref: Characterization of MLH1 and MSH2 alternative splicing and its relevance to molecular testing of colorectal cancer susceptibility. PMID: 9490293 Ref: Molecular genetics and clinical-pathology features of hereditary nonpolyposis colorectal carcinoma (Lynch syndrome): historical journey from pedigree anecdote to molecular genetic confirmation. PMID: 9499183 Ref: Genetic identification and management of hereditary nonpolyposis colorectal cancer. PMID: 9499460 Ref: Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. PMID: 9500462 Ref: Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. PMID: 9500552 Ref: Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair. PMID: 9500919 Ref: MLH1 and MSH2 constitutional mutations in colorectal cancer families not meeting the standard criteria for hereditary nonpolyposis colorectal cancer. PMID: 9506527 Ref: A novel missense mutation in the DNA mismatch repair gene hMLH1 present among East Asians but not among Europeans. PMID: 9526167 Ref: Expression of hMSH2 and hMLH1 in colorectal carcinomas with microsatellite instability. PMID: 9542742 Ref: Mismatch repair deficiency leads to a unique mode of colorectal tumorigenesis characterized by intratumoral heterogeneity. PMID: 9546427 Ref: Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population. PMID: 9559626 Ref: Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer. PMID: 9559627 Ref: Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. PMID: 9563488 Ref: Microsatellite instability in human solid tumors. PMID: 9587112 Ref: Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. PMID: 9592192 Ref: Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. PMID: 9593786 Ref: DGGE screening of mutations in mismatch repair genes (hMSH2 and hMLH1) in 34 Swedish families with colorectal cancer. PMID: 9611074 Ref: Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. PMID: 9618505 Ref: Novel germline mutations of hMSH2 in a patient with hereditary nonpolyposis colorectal cancer (HNPCC) and in a patient with six primary cancers. PMID: 9621522 Ref: [Analysis of genomic instability by fluorescence DNA sequencer]. PMID: 9627490 Ref: Functional genetic tests of DNA mismatch repair protein activity in Saccharomyces cerevisiae. PMID: 9630599 Ref: Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria. PMID: 9634524 Ref: Risk factors for endometrial cancer according to familial susceptibility. PMID: 9639390 Ref: Ongoing and unsaid on oxaliplatin: the hope. PMID: 9647613 Ref: Search for chromosome instability in lymphocytes with germ-line mutations in DNA mismatch repair genes. PMID: 9648558 Ref: Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. International Collaborative Group on HNPCC. PMID: 9669805 Ref: Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. PMID: 9671741 Ref: Frequency and type of colorectal tumors in asymptomatic high-risk individuals in families with hereditary nonpolyposis colorectal cancer. PMID: 9681535 Ref: Lack of PMS2 gene-truncating mutations in patients with hereditary colorectal cancer. PMID: 9683794 Ref: [Molecular biological background of FAP and HNPCC, and treatment strategies of both diseases depend upon genetic information]. PMID: 9695069 Ref: Functional analysis of human MLH1 mutations in Saccharomyces cerevisiae. PMID: 9697702 Ref: Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. PMID: 9699680 Ref: Genetics of colonic cancer. PMID: 9705533 Ref: Clinical findings with implications for genetic testing in families with clustering of colorectal cancer. PMID: 9709044 Ref: DNA mismatch repair and colorectal cancer. PMID: 9713337 Ref: Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls. PMID: 9718327 Ref: Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma: different clinical and molecular implications. PMID: 9731891 Ref: Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. PMID: 9736731 Ref: [Molecular cancer disposition diagnosis exemplified by colorectal carcinoma. What is the contribution of pathology?]. PMID: 9746911 Ref: [Val384Asp in hMLH1 gene in Chinese, Japanese and German and its etiological role in colorectal cancer]. PMID: 9758868 Ref: In a resource-poor country, mutation identification has the potential to reduce the cost of family management for hereditary nonpolyposis colorectal cancer. PMID: 9788388 Ref: The impact of molecular diagnosis on familial colorectal cancer. PMID: 9806477 Ref: MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. PMID: 9811473 Ref: TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. PMID: 9822576 Ref: Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer. PMID: 9824623 Ref: I1307K APC and hMLH1 mutations in a non-Jewish family with hereditary non-polyposis colorectal cancer. PMID: 9831355 Ref: Excess of hMLH1 germline mutations in Swiss families with hereditary non-polyposis colorectal cancer. PMID: 9833759 Ref: Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer. PMID: 9834266 Ref: Specificity of mutations in the PMS2-deficient human tumor cell line HEC-1-A. PMID: 9838164 Ref: Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer. PMID: 9841970 Ref: [Germline mutation analysis in hMLH 1 and hMSH 2 genes in hereditary nonpolyposis colorectal cancer and colorectal cancer patients with familial history]. PMID: 9845760 Ref: Reduced COX-2 protein in colorectal cancer with defective mismatch repair. PMID: 9850081 Ref: Allelic losses and DNA methylation at DNA mismatch repair loci in sporadic colorectal cancer. PMID: 9855004 Ref: [Modification of surgical strategy in HNPCC by molecular and clinical aspects]. PMID: 9931896 Ref: [Rectal carcinomas in HNPCC]. PMID: 9931914 Ref: Hereditary Factors in Gynecologic Cancer. PMID: 10388122 Ref: Genetics and colorectal cancer (HNPCC) in adolescence. A case report. PMID: 10436636 Ref: Four new mutations in the DNA mismatch repair gene MLH1 in colorectal cancers with microsatellite instability. Mutations in brief no. 157. Online. PMID: 10627141 Ref: hMLH1 mutations in hereditary nonpolyposis colorectal cancer kindreds. Mutations in brief no. 182. Online. PMID: 10660333 Ref: [The relation between DNA replication error and clinicopathological features of colorectal carcinoma]. PMID: 11245012 Ref: [HNPCC-associated stomach carcinomas display aggressive growth in orthotopic transplantation to the SCID mouse]. PMID: 14518342 Ref: Hereditary nonpolyposis colorectal cancer: an approach to the selection of candidates to genetic testing based on clinical and molecular characteristics. PMID: 15178966 |
Ref: Microsatellite instability in human cancer: a prognostic marker for chemotherapy? PMID: 9882509 Ref: hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. PMID: 9892201 Ref: Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. PMID: 9916805 Ref: Causes and consequences of microsatellite instability in endometrial carcinoma. PMID: 9927063 Ref: Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer. PMID: 9929971 Ref: Survival of patients with hereditary colorectal cancer: comparison of HNPCC and colorectal cancer in FAP patients with sporadic colorectal cancer. PMID: 9935197 Ref: Cancer epigenetics comes of age. PMID: 9988266 Ref: A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer. PMID: 10051005 Ref: Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. PMID: 10070967 Ref: 5'-Cytosine DNA-methyltransferase mRNA levels in hereditary colon carcinoma. PMID: 10071236 Ref: Colorectal cancer and the Muir-Torre syndrome in a Gypsy family: a review. PMID: 10086635 Ref: Cancer risk in mutation carriers of DNA-mismatch-repair genes. PMID: 10188721 Ref: Family history characteristics, tumor microsatellite instability and germline MSH2 and MLH1 mutations in hereditary colorectal cancer. PMID: 10190329 Ref: Mismatch repair gene defects contribute to the genetic basis of double primary cancers of the colorectum and endometrium. PMID: 10196371 Ref: Loci for efficient detection of microsatellite instability in hereditary non-polyposis colorectal cancer. PMID: 10203581 Ref: A century of progress in hereditary nonpolyposis colorectal cancer (Lynch syndrome). PMID: 10211513 Ref: Cooperation between p53 and hMLH1 in a human colocarcinoma cell line in response to DNA damage. PMID: 10213232 Ref: The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells. PMID: 10213489 Ref: Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. PMID: 10232580 Ref: Mutated gene-specific phenotypes of dinucleotide repeat instability in human colorectal carcinoma cell lines deficient in DNA mismatch repair. PMID: 10321739 Ref: Microsatellite instability-a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer. PMID: 10323887 Ref: Germline hMSH2 and differential somatic mutations in patients with Turcot's syndrome. PMID: 10337989 Ref: Public health perspectives on testing for colorectal cancer susceptibility genes. PMID: 10343885 Ref: CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. PMID: 10344733 Ref: Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. PMID: 10348818 Ref: Establishment and characterization of 12 human colorectal-carcinoma cell lines. PMID: 10362137 Ref: Immunocytochemical detection of hMSH2 and hMLH1 expression in oral SCC. PMID: 10368636 Ref: Hereditary colorectal cancer in the general population: from cancer registration to molecular diagnosis. PMID: 10369701 Ref: Influence of selection criteria on mutation detection in patients with hereditary nonpolyposis colorectal cancer. PMID: 10375096 Ref: Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis. PMID: 10378593 Ref: Histologic comparison of hereditary nonpolyposis colorectal cancer associated with MSH2 and MLH1 and colorectal cancer from the general population. PMID: 10378595 Ref: Epidemiologic and genetic factor in colorectal cancer: development of cancer in dizygotic twins in a family with Lynch syndrome. PMID: 10379484 Ref: Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects. PMID: 10382540 Ref: Novel hMLH1 and hMSH2 germline mutations in African Americans with colorectal cancer. PMID: 10386556 Ref: [Genetics of colorectal cancer. I. Non-polyposis and polyposis forms of hereditary colorectal cancer]. PMID: 10389534 Ref: Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours. PMID: 10389971 Ref: Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds. PMID: 10404063 Ref: Epidemiology of digestive tract cancers in India. V. Large and small bowel. PMID: 10407566 Ref: Mutations in Bcl10 are very rare in colorectal cancer. PMID: 10408399 Ref: [Familial cancer: recent advances]. PMID: 10410140 Ref: CpG island methylator phenotype in colorectal cancer. PMID: 10411935 Ref: Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer. PMID: 10413423 Ref: Screening for colorectal cancer and other GI cancers. PMID: 10416884 Ref: Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error. PMID: 10418831 Ref: BAT-26 identifies sporadic colorectal cancers with mutator phenotype: a correlative study with clinico-pathological features and mutations in mismatch repair genes. PMID: 10419591 Ref: Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. PMID: 10419916 Ref: Microsatellite instability and expression of MLH1 and MSH2 in normal and malignant endometrial and ovarian epithelium in hereditary nonpolyposis colorectal cancer family members. PMID: 10432927 Ref: Rectal cancer in a 13-year-old boy without a detectable germline mutation in FAP and HNPCC genes. PMID: 10433009 Ref: Choice of management strategy for colorectal cancer based on a diagnostic immunohistochemical test for defective mismatch repair. PMID: 10446111 Ref: Evaluation of the replication error phenotype in relation to molecular and clinicopathological features in hereditary and early onset colorectal cancer. PMID: 10448273 Ref: Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1. PMID: 10468602 Ref: Replication error in colorectal carcinoma: association with loss of heterozygosity at mismatch repair loci and clinicopathological variables. PMID: 10470121 Ref: DNA methylation analysis using bisulfite treatment and PCR-single-strand conformation polymorphism in colorectal cancer showing microsatellite instability. PMID: 10471384 Ref: hMLH1, hMSH2 and hMSH6 mutations in hereditary non-polyposis colorectal cancer families from southern Sweden. PMID: 10471527 Ref: Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer. PMID: 10480359 Ref: Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. PMID: 10495421 Ref: Various mutation screening techniques in the DNA mismatch repair genes hMSH2 and hMLH1. PMID: 10495924 Ref: Microsatellite alterations in serum DNA of patients with colorectal cancer. PMID: 10496533 Ref: Mouse models for colorectal cancer. PMID: 10498885 Ref: Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer. PMID: 10507723 Ref: Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination. PMID: 10523644 Ref: Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors. PMID: 10524526 Ref: Microsatellite instability is rare in rectal carcinomas and signifies hereditary cancer. PMID: 10533476 Ref: Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers. PMID: 10535979 Ref: Germ-line msh6 mutations in colorectal cancer families. PMID: 10537275 Ref: Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents. PMID: 10537360 Ref: Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. PMID: 10542278 Ref: Genetic susceptibility to non-polyposis colorectal cancer. PMID: 10544223 Ref: Strategies for screening for hereditary non-polyposis colorectal cancer. PMID: 10544224 Ref: CpG island methylator phenotypes in aging and cancer. PMID: 10547343 Ref: Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. PMID: 10554013 Ref: [HNPCC syndrome, microsatellite instability and NF1 gene alteration]. PMID: 10572231 Ref: Assessment of pathogenicity criteria for constitutional missense mutations of the hereditary nonpolyposis colorectal cancer genes MLH1 and MSH2. PMID: 10573010 Ref: 1998 Runme Shaw Memorial Lecture: somatic evolution of cancer. 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PMID: 15709190 Ref: Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon. PMID: 15712188 Ref: Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer. PMID: 15713769 Ref: Critical issues in the identification and management of patients with hereditary non-polyposis colorectal cancer. PMID: 15716656 Ref: Epigenetics, mismatch repair genes and colorectal cancer. PMID: 15720901 Ref: [Hereditary colorectal cancer]. PMID: 15725711 Ref: Expression of the hMLH1 and hMSH2 proteins in normal tissues: relationship to cancer predisposition in hereditary non-polyposis colon cancer. PMID: 15735976 Ref: Hypersensitivity in DNA mismatch repair-deficient colon carcinoma cells to DNA polymerase reaction inhibitors. PMID: 15737691 Ref: Detection of occult high graded microsatellite instabilities in MMR gene mutation negative HNPCC tumors by addition of complementary marker analysis. PMID: 15737950 Ref: Hereditary nonpolyposis colorectal cancer (Lynch syndrome): criteria for identification and management. PMID: 15745097 Ref: The mechanism of microsatellite instability is different in synchronous and metachronous colorectal cancer. PMID: 15749592 Ref: CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype. PMID: 15760919 Ref: Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation. PMID: 15767794 Ref: Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency. PMID: 15770215 Ref: Clinical phenotype and prevalence of hereditary nonpolyposis colorectal cancer syndrome in Chinese population. PMID: 15770724 Ref: Evidence for genetic anticipation in hereditary non-polyposis colorectal cancer. PMID: 15772852 Ref: Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability. PMID: 15778432 Ref: BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes. PMID: 15782118 Ref: Clinicopathological and molecular genetic analysis of HNPCC in China. PMID: 15786548 Ref: Microsatellite instability testing in colorectal carcinoma: choice of markers affects sensitivity of detection of mismatch repair-deficient tumors. PMID: 15788665 Ref: No MSH6 germline mutations in breast cancer families with colorectal and/or endometrial cancer. PMID: 15805151 Ref: Modulation of CDK2-AP1 (p12(DOC-1)) expression in human colorectal cancer. PMID: 15806176 Ref: Correlation between hMLH1/hMSH2 and p53 protein expression in sporadic colorectal cancer. PMID: 15816455 Ref: Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice. PMID: 15818612 Ref: Accuracy of MSI testing in predicting germline mutations of MSH2 and MLH1: a case study in Bayesian meta-analysis of diagnostic tests without a gold standard. PMID: 15831578 Ref: Association between family history and mismatch repair in colorectal cancer. PMID: 15831908 Ref: Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? PMID: 15837969 Ref: Cigarette smoking and colorectal cancer: APC mutations, hMLH1 expression, and GSTM1 and GSTT1 polymorphisms. PMID: 15840612 Ref: Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines. PMID: 15842591 Ref: Adenomas in young patients: what is the optimal evaluation? PMID: 15842592 Ref: [Mutation detection of mismatch repair genes in hereditary nonpolyposis colorectal cancer by denaturing high-performance liquid chromatography]. PMID: 15842942 Ref: Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma. PMID: 15845562 Ref: Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer. PMID: 15849733 Ref: Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. PMID: 15855432 Ref: Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. PMID: 15856472 Ref: TGFBR1*6A may contribute to hereditary colorectal cancer. PMID: 15860866 Ref: Identification of predictive factors for the occurrence of predisposing MLH1 and MSH2 germline mutations among Sardinian patients with colorectal carcinoma. PMID: 15862756 Ref: Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest. PMID: 15870882 Ref: Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). PMID: 15872200 Ref: Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer. PMID: 15887099 Ref: A novel missense germline mutation in exon 2 of the hMSH2 gene in a HNPCC family from Southern Italy. PMID: 15896463 Ref: [Activity of the National Oncology R&D Consortium in 2004]. PMID: 15902326 Ref: Expression of tumour necrosis factor-related apoptosis-inducing ligand death receptors in sporadic and hereditary colorectal tumours: potential targets for apoptosis induction. PMID: 15911244 Ref: Spectrum of germ-line MLH1 and MSH2 mutations in Austrian patients with hereditary nonpolyposis colorectal cancer. PMID: 15926618 Ref: High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. PMID: 15930362 Ref: Molecular markers that predict response to colon cancer therapy. PMID: 15934813 Ref: Risk of colorectal and endometrial cancer for carriers of mutations of the hMLH1 and hMSH2 gene: correction for ascertainment. PMID: 15937084 Ref: Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC). PMID: 15942939 Ref: Germline mutations in the MYH gene in Swedish familial and sporadic colorectal cancer. PMID: 15943555 Ref: [The first molecular analysis of a Hungarian HNPCC family: a novel MSH2 germline mutation]. PMID: 15945244 Ref: Large genomic aberrations in MSH2 and MLH1 genes are frequent in Chinese colorectal cancer. PMID: 15949572 Ref: The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families. PMID: 15951971 Ref: Frequency of hereditary non-polyposis colorectal cancer among Uruguayan patients with colorectal cancer. PMID: 15952990 Ref: Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer. PMID: 15955785 Ref: One-milliliter wet-digestion for inductively coupled plasma mass spectrometry (ICP-MS): determination of platinum-DNA adducts in cells treated with platinum(II) complexes. PMID: 15959768 Ref: Hereditary nonpolyposis colorectal cancer identification and surveillance of high-risk families. PMID: 15962087 Ref: Colorectal cancer "methylator phenotype": fact or artifact? PMID: 15967110 Ref: Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients. PMID: 15991064 Ref: Hereditary breast cancer syndromes in a Turkish population. Results of molecular germline analysis. PMID: 15993273 Ref: Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia. PMID: 15996210 Ref: A homozygous mutation in MSH6 causes Turcot syndrome. PMID: 16000562 Ref: [Evaluation of outpatient management in HNPCC]. PMID: 16001346 Ref: Genomic rearrangements in MSH2 and MLH1 are rare mutational events in Spanish patients with hereditary nonpolyposis colorectal cancer. PMID: 16003840 Ref: Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer. PMID: 16007118 Ref: Risk stratification for colorectal cancer and implications for screening. PMID: 16013642 Ref: BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors. PMID: 16015629 Ref: Fruits, vegetables, and hMLH1 protein-deficient and -proficient colon cancer: The Netherlands cohort study. PMID: 16030092 Ref: Screening for genomic fragments that are methylated specifically in colorectal carcinoma with a methylated MLH1 promoter. PMID: 16033773 Ref: Functional consequences of DNA mismatch repair missense mutations in murine models and their impact on cancer predisposition. PMID: 16042575 Ref: Phenotype associated with recessively inherited mutations in DNA mismatch repair (MMR) genes. PMID: 16042583 Ref: DNA mismatch repair status may influence anti-neoplastic effects of butyrate. PMID: 16042586 Ref: ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States). PMID: 16049814 Ref: Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study. PMID: 16054567 Ref: Aberrant CpG island methylation in early-onset sporadic gastric carcinoma. PMID: 16075282 Ref: Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1. PMID: 16083711 Ref: Novel genomic insertion-- deletion in MLH1: possible mechanistic role for non-homologous end-joining DNA repair. PMID: 16098012 Ref: The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers. PMID: 16106253 Ref: Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer. PMID: 16116158 Ref: Preoperative serum levels of the carcinoembryonic antigen in hereditary non-polyposis colorectal cancer compared to levels in sporadic colorectal cancer. PMID: 16122885 Ref: Serrated adenoma of the colorectum and the DNA-methylator phenotype. PMID: 16130936 Ref: Evolution of the nomenclature for the hereditary colorectal cancer syndromes. PMID: 16136380 Ref: Gynecologic Cancers in Lynch Syndrome/HNPCC. PMID: 16136386 Ref: Value of microsatellite instability typing in detecting hereditary non-polyposis colorectal cancer. A prospective multicentric study by the Association Aquitaine Gastro. PMID: 16142001 Ref: Family history of colorectal cancer in Iran. PMID: 16143045 Ref: Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. PMID: 16143123 Ref: Who takes the lead in the development of ulcerative colitis-associated colorectal cancers: mutator, suppressor, or methylator pathway? PMID: 16157203 Ref: An alternative to prophylactic colectomy for colon cancer prevention in HNPCC syndrome. PMID: 16162958 Ref: Isolated loss of PMS2 expression in colorectal cancers: frequency, patient age, and familial aggregation. PMID: 16166421 Ref: Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified. PMID: 16175654 Ref: Morphology and microsatellite instability in sporadic serrated and non-serrated colorectal cancer. PMID: 16177963 Ref: Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer. PMID: 16181380 Ref: Molecular genetic alterations and clinical features in early-onset colorectal carcinomas and their role for the recognition of hereditary cancer syndromes. PMID: 16181381 Ref: Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). PMID: 16184469 Ref: The HNPCC associated MSH2*1906G-->C founder mutation probably originated between 1440 CE and 1715 CE in the Ashkenazi Jewish population. PMID: 16199548 Ref: The p53 codon 72 variation is associated with the age of onset of hereditary non-polyposis colorectal cancer (HNPCC). PMID: 16199549 Ref: Numbers of mutations to different types of colorectal cancer. PMID: 16202134 Ref: High frequency of hereditary colorectal cancer in Newfoundland likely involves novel susceptibility genes. PMID: 16203774 Ref: Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. PMID: 16204034 Ref: Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway. PMID: 16243801 Ref: Testing for defective DNA mismatch repair in colorectal carcinoma: a practical guide. PMID: 16253016 Ref: Performance of the revised Bethesda guidelines for identification of colorectal carcinomas with a high level of microsatellite instability. PMID: 16253017 Ref: [Hereditary predispositions to gynaecological cancers]. PMID: 16256400 Ref: [Hereditary colorectal cancer]. PMID: 16266567 Ref: [Follow-up of patients after curative surgery for colorectal cancer]. PMID: 16266577 Ref: Microsatellite instability in sporadic and inherited colon adenocarcinomas from Greek patients: correlation with several clinicopathological characteristics. PMID: 16268414 Ref: Low prevalence of germline hMSH6 mutations in colorectal cancer families from Spain. PMID: 16270383 Ref: [Detection mutations in the DNA mismatch repair genes of hMLH1 and hMSH2 genes in Colombian families with suspicion of hereditary non-polyposis colorectal carcinoma (Lynch syndrome)]. PMID: 16276679 Ref: Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome. PMID: 16283884 Ref: [Prophylactic surgery for hereditary non-polyposis colorectal cancer]. PMID: 16292564 Ref: Microsatellite instability caused by hMLH1 promoter methylation increases with tumor progression in right-sided sporadic colorectal cancer. PMID: 16293975 Ref: The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea(ACNU) in gallbladder carcinoma cells. PMID: 16309194 Ref: Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair. PMID: 16322221 Ref: [Hereditary predisposition of colorectal cancer and prevalence of hereditary nonpolyposis colorectal cancer in general population of colorectal cancer patients in China]. PMID: 16324388 Ref: The analysis for identifying large DNA fragment aberrations of MSH2 and MLH1 genes from familial colorectal cancer in China. PMID: 16331552 Ref: CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer. PMID: 16336454 Ref: Mutational analysis of hMsh6 in Israeli HNPCC and HNPCC-like families. PMID: 16341805 Ref: Long term follow-up of HNPCC gene mutation carriers: compliance with screening and satisfaction with counseling and screening procedures. PMID: 16341806 Ref: Survival of patients with ovarian cancer due to a mismatch repair defect. PMID: 16341807 Ref: Syndrome of early onset colon cancers, hematologic malignancies & features of neurofibromatosis in HNPCC families with homozygous mismatch repair gene mutations. PMID: 16341812 Ref: Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. PMID: 16356174 Ref: Mechanisms of microsatellite instability in colorectal cancer patients in different age groups. PMID: 16374936 Ref: Impact of genetic counseling and DNA testing on individuals with colorectal cancer with a positive family history: a population-based study. PMID: 16379545 Ref: [Hereditary non polyposis colon cancer--basic principle and ethical considerations]. PMID: 16396368 Ref: Detection of germline mutations of hMLH1 and hMSH2 based on cDNA sequencing in China. PMID: 16425354 Ref: Is colonoscopy sufficient for colorectal cancer surveillance in all HNPCC patients? PMID: 16437731 Ref: A comparison of multi-layer neural network and logistic regression in hereditary non-polyposis colorectal cancer risk assessment. PMID: 17282725 Ref: Deletion Mutations in an Australian Series of HNPCC Patients. PMID: 20223028 Ref: Case report: familial gastric cancer and chordoma in the same family. PMID: 20223035 Ref: Hereditary colorectal cancer in china. PMID: 20223042 Ref: Organization and running of the first comprehensive hereditary cancer clinic in India. PMID: 20223043 |
Ref: Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. PMID: 16118624 Ref: DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients. PMID: 16152625 Ref: Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability. PMID: 16247484 Ref: Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. PMID: 16299036 Ref: Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma. PMID: 16323174 Ref: N-acetyltransferase (NAT) 2 acetylator status and age of onset in patients with hereditary nonpolyposis colorectal cancer (HNPCC). PMID: 16337339 Ref: Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. PMID: 16356838 Ref: Methylation analysis of hMLH1 gene promoter by a bisulfite-sensitive single-strand conformation polymorphism-capillary electrophoresis method. PMID: 16358356 Ref: A novel MSH2 germline mutation in homozygous state in two brothers with colorectal cancers diagnosed at the age of 11 and 12 years. PMID: 16372347 Ref: CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. PMID: 16407376 Ref: Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor. PMID: 16418736 Ref: DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. PMID: 16421593 Ref: Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers. PMID: 16423994 Ref: Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue. PMID: 16426447 Ref: Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance. PMID: 16426742 Ref: Mismatch repair genes in renal cortical neoplasms. PMID: 16426918 Ref: The genetics of HNPCC: application to diagnosis and screening. PMID: 16434208 Ref: Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer. PMID: 16436636 Ref: Germline MSH2 and MLH1 mutational spectrum including large rearrangements in HNPCC families from Poland (update study). PMID: 16451135 Ref: Mismatch repair, p53 and chromosomal aberrations in primary colorectal carcinomas. PMID: 16464797 Ref: Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome). PMID: 16472587 Ref: Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1. PMID: 16473673 Ref: Occult endometrial cancer and decision making for prophylactic hysterectomy in hereditary nonpolyposis colorectal cancer patients. PMID: 16476474 Ref: Low colonic glutathione detoxification capacity in patients at risk for colon cancer. PMID: 16506964 Ref: PMS2 mutations in childhood cancer. PMID: 16507833 Ref: First report of a de novo germline mutation in the MLH1 gene. PMID: 16521201 Ref: Polyposis and early cancer in a patient with low penetrant mutations in MSH6 and APC: hereditary colorectal cancer as a polygenic trait. PMID: 16525781 Ref: The value of multi-modal gene screening in HNPCC in Quebec: three mutations in mismatch repair genes that would have not been correctly identified by genomic DNA sequencing alone. PMID: 16528605 Ref: Hypermethylation of the MLH1 promoter with concomitant absence of transcript and protein occurs in small patches of crypt cells in unaffected mucosa from sporadic colorectal carcinoma. PMID: 16531764 Ref: Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. PMID: 16533773 Ref: Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer. PMID: 16534870 Ref: Immunohistochemical mismatch repair proteins expression in colorectal cancer. PMID: 16540729 Ref: Optimization of antibodies for detection of the mismatch repair proteins MLH1, MSH2, MSH6, and PMS2 using a biotin-free visualization system. PMID: 16540742 Ref: A genetic model for determining MSH2 and MLH1 carrier probabilities based on family history and tumor microsatellite instability. PMID: 16542391 Ref: HMLH1 and HMSH2 germline mutations in Greek families with hereditary non-polyposis colorectal cancer. PMID: 16542397 Ref: Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency. PMID: 16551850 Ref: RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas. PMID: 16557577 Ref: [Current concepts in the genetics of hereditary and sporadic colorectal cancer and the role of genetics in patient management. Hereditary colorectal cancers]. PMID: 16579336 Ref: Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. PMID: 16585178 Ref: Cancer genetics: colorectal cancer as a model. PMID: 16596323 Ref: Economic evaluation of the familial cancer programme in Western Australia: predictive genetic testing for familial adenomatous polyposis and hereditary non-polyposis colorectal carcinoma. PMID: 16612060 Ref: Cancer risks for mismatch repair gene mutation carriers: a population-based early onset case-family study. PMID: 16616355 Ref: Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC. PMID: 16623753 Ref: Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer. PMID: 16636019 Ref: Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. PMID: 16645207 Ref: Thymidylate synthase expression in colon carcinomas with microsatellite instability. PMID: 16675565 Ref: [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas]. PMID: 16677780 Ref: Immunohistochemistry detects mismatch repair gene defects in colorectal cancer. PMID: 16684085 Ref: A cost-effective algorithm for hereditary nonpolyposis colorectal cancer detection. PMID: 16690480 Ref: Birt-Hogg-Dube gene mutations in human endometrial carcinomas with microsatellite instability. PMID: 16691634 Ref: Clinical performance of original and revised Bethesda guidelines for the identification of MSH2/MLH1 gene carriers in patients with newly diagnosed colorectal cancer: proposal of a new and simpler set of recommendations. PMID: 16696788 Ref: Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis. PMID: 16699497 Ref: CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. PMID: 16708352 Ref: Immunohistochemical test for MLH1 and MSH2 expression predicts clinical outcome in stage II and III colorectal cancer patients. PMID: 16710035 Ref: Prognostic factors and analysis of microsatellite instability in resected pulmonary metastases from colorectal carcinoma. PMID: 16731121 Ref: Germline mutations of the hMLH1 and hMSH2 mismatch repair genes in Belgian hereditary nonpolyposis colon cancer (HNPCC) patients. PMID: 16736289 Ref: A 'nonsense' mutation leads to aberrant splicing of hMLH1 in a German hereditary non-polyposis colorectal cancer family. PMID: 16736291 Ref: RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis. PMID: 16737913 Ref: Predominance of younger age, advanced stage, poorly-differentiated and mucinous histology in Israeli Arab patients with colorectal cancer. PMID: 16739315 Ref: Microarray-based molecular margin methylation pattern analysis in colorectal carcinoma. PMID: 16756932 Ref: Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin. PMID: 16760302 Ref: Elevated microsatellite instability at selected tetranucleotide repeats does not correlate with clinicopathologic features of bladder cancer. PMID: 16762487 Ref: Overexpression of the receptor for hyaluronic acid mediated motility is an independent adverse prognostic factor in colorectal cancer. PMID: 16763611 Ref: Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years. PMID: 16765042 Ref: Mutations in the DNA mismatch repair gene MLH1 associated with early-onset colon cancer. PMID: 16769400 Ref: Mismatch repair polymorphisms and colorectal polyps: hMLH1-93G>A variant modifies risk associated with smoking. PMID: 16771955 Ref: Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer. PMID: 16773493 Ref: Histologic features distinguish microsatellite-high from microsatellite-low and microsatellite-stable colorectal carcinomas, but do not differentiate germline mutations from methylation of the MLH1 promoter. PMID: 16784982 Ref: Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum. PMID: 16786121 Ref: CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. PMID: 16804544 Ref: Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer. PMID: 16807412 Ref: Clinical and genetic characteristics of Chinese hereditary nonpolyposis colorectal cancer families. PMID: 16810763 Ref: The added value of PMS2 immunostaining in the diagnosis of hereditary nonpolyposis colorectal cancer. PMID: 16817031 Ref: Genetic predisposition to colorectal cancer: new pieces in the pediatric puzzle. PMID: 16819371 Ref: Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer. PMID: 16819711 Ref: Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 16820091 Ref: Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas. PMID: 16820927 Ref: DNA mismatch repair and Lynch syndrome. PMID: 16821093 Ref: Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas. PMID: 16826164 Ref: Survival from colorectal carcinoma in HNPCC families as compared to the general population in Lithuania--initial results. PMID: 16826317 Ref: Novel and recurrent germline alterations in the MLH1 and MSH2 genes identified in hereditary nonpolyposis colorectal cancer patients in Slovakia. PMID: 16830052 Ref: [Morphological and immunohistogenetical features of colon cancer in children]. PMID: 16830623 Ref: [Turcot's syndrome confirmed by molecular biological tests]. PMID: 16840983 Ref: Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 16850502 Ref: Inverse effects of mucin on survival of matched hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer patients. PMID: 16857798 Ref: Prognostic significance of histological features and biological parameters in stage I (pT1 and pT2) colorectal adenocarcinoma. PMID: 16860493 Ref: Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in colorectal cancer-a tissue microarray-based approach. PMID: 16867865 Ref: Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking. PMID: 16874859 Ref: MLH3 mutation in endometrial cancer. PMID: 16885347 Ref: Immunohistochemical expression of MYH protein can be used to identify patients with MYH-associated polyposis. PMID: 16890597 Ref: Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas. PMID: 16902913 Ref: Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. PMID: 16906516 Ref: Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium. PMID: 16908935 Ref: DNA methylation profiles of female steroid hormone-driven human malignancies. PMID: 16909910 Ref: [Handling of hereditary intestinal cancer]. PMID: 16915319 Ref: Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis. PMID: 16929496 Ref: Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. PMID: 16931963 Ref: Role of detection of microsatellite instability in Chinese with hereditary nonpolyposis colorectal cancer or ordinary hereditary colorectal cancer. PMID: 16937450 Ref: Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act". PMID: 16938659 Ref: MSH6 germline mutations in early-onset colorectal cancer patients without family history of the disease. PMID: 16940983 Ref: DNA repair pathway profiling and microsatellite instability in colorectal cancer. PMID: 16951227 Ref: Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer. PMID: 16951683 Ref: Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients. PMID: 16952542 Ref: A de novo MLH1 germ line mutation in a 31-year-old colorectal cancer patient. PMID: 16955466 Ref: Identification of germline MLH1 alterations in familial prostate cancer. PMID: 16963262 Ref: Assessing the predictive accuracy of hMLH1 and hMSH2 mutation probability models. PMID: 16969708 Ref: A novel mutation detection approach of hMLH1 and hMSH2 genes for screening of colorectal cancer. PMID: 16971051 Ref: APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer. PMID: 16981189 Ref: Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma. PMID: 16984616 Ref: Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene. PMID: 16996571 Ref: Prediction of MLH1 and MSH2 mutations in Lynch syndrome. PMID: 17003395 Ref: Variations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal cancer in a Chinese population. PMID: 17011982 Ref: Correlation of microsatellite status, proliferation, apoptotic and selected immunohistochemical markers in colorectal carcinoma studied with tissue microarray. PMID: 17019973 Ref: Microsatellite instability accounts for tumor site-related differences in clinicopathologic variables and prognosis in human colon cancers. PMID: 17026563 Ref: Inherited association of breast and colorectal cancer: limited role of CHEK2 compared with high-penetrance genes. PMID: 17026620 Ref: The role of MYH and microsatellite instability in the development of sporadic colorectal cancer. PMID: 17031395 Ref: Genetic instability on chromosome 17 in the epithelium of non-polypoid colorectal carcinomas compared to polypoid lesions. PMID: 17032312 Ref: Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer. PMID: 17054581 Ref: Genetics of hereditary nonpolyposis colorectal cancer. PMID: 17061614 Ref: Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology. PMID: 17065421 Ref: CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. PMID: 17065427 Ref: Single-nucleotide polymorphisms of mismatch repair genes in healthy Chinese individuals and sporadic colorectal cancer patients. PMID: 17074586 Ref: The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer. PMID: 17080293 Ref: Frequency of hereditary non-polyposis colorectal cancer among unselected patients with colorectal cancer in Germany. PMID: 17095871 Ref: Frequency of immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan. PMID: 17106811 Ref: Dietary folate and APC mutations in sporadic colorectal cancer. PMID: 17116713 Ref: Very low prevalence of germline MSH6 mutations in hereditary non-polyposis colorectal cancer suspected patients with colorectal cancer without microsatellite instability. PMID: 17117178 Ref: Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. PMID: 17122504 Ref: Loss of p27 expression and microsatellite instability in sporadic colorectal cancer. PMID: 17123889 Ref: [Hyperplastic colorectal polyposis]. PMID: 17125656 Ref: [Hereditary colorectal cancer: Molecular analysis of APC and MLH1 genes]. PMID: 17130966 Ref: Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer. PMID: 17148775 Ref: Promoter methylation precedes chromosomal alterations in colorectal cancer development. PMID: 17167178 Ref: Increased risk for abnormalities on perioperative colon screening in patients with microsatellite instability-positive endometrial carcinoma. PMID: 17177835 Ref: [Microsatellite instability among patients with colorectal cancer]. PMID: 17186090 Ref: Methylation of serum DNA is an independent prognostic marker in colorectal cancer. PMID: 17189406 Ref: Two germline alterations in mismatch repair genes found in a HNPCC patient with poor family history. PMID: 17189986 Ref: New aspects in molecular diagnosis of Lynch syndrome (HNPCC). PMID: 17192058 Ref: Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family. PMID: 17203532 Ref: [Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium]. PMID: 17216011 Ref: Gene symbol: MLH1. Disease: colorectal cancer, non-polyposis. PMID: 17230646 Ref: Early genetic instability of both epithelial and stromal cells in esophageal squamous cell carcinomas, contrasted with Barrett's adenocarcinomas. PMID: 17287898 Ref: Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice. PMID: 17347588 Ref: [Fenotypical diversity of hereditary non-polyposis colorectal carcinoma. Pedigree and genetical analysis of two mutation carrier patients]. PMID: 17432081 Ref: Types of colorectal adenoma. PMID: 17867575 Ref: [A new quantitative DNA-methylation analysis of MSI colorectal cancers helps to separate sporadic colorectal cancers from HNPCC-candidates]. PMID: 17867602 Ref: Proportionate increase in incidence of colorectal cancer at an age below 40 years: an observation. PMID: 17998686 Ref: MUTYH Mutations Do Not Cause HNPCC or Late Onset Familial Colorectal Cancer. PMID: 20223013 Ref: The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria. 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Ref: Colorectal cancer in a population with endemic Schistosoma mansoni: is this an at-risk population? PMID: 16786317 Ref: Prognostic significance of mucins in colorectal cancer with different DNA mismatch-repair status. PMID: 16816167 Ref: Genomic rearrangements in MSH2, MLH1 or MSH6 are rare in HNPCC patients carrying point mutations. PMID: 16837128 Ref: Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer. PMID: 16902769 Ref: Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis. PMID: 17021745 Ref: No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer. PMID: 17043646 Ref: Persistent mismatch repair deficiency following targeted correction of hMLH1. PMID: 17082796 Ref: Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP. PMID: 17086168 Ref: The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. PMID: 17087942 Ref: Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. PMID: 17088260 Ref: Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer. PMID: 17096326 Ref: Assessment of microsatellite instability in colorectal carcinoma at an Indian center. PMID: 17160686 Ref: A missense germline mutation in exon 7 of the MSH2 gene in a HNPCC family from center-Italy. PMID: 17165155 Ref: Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repair. PMID: 17178418 Ref: Alterations in cell proliferation and apoptosis in colon cancers with microsatellite instability. PMID: 17187355 Ref: Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer. PMID: 17195912 Ref: Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. PMID: 17200375 Ref: Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC. PMID: 17203173 Ref: Colorectal serrated adenocarcinoma. PMID: 17204027 Ref: Mismatch repair polymorphisms and the risk of colorectal cancer. PMID: 17205513 Ref: The effect of genetic background on the function of Saccharomyces cerevisiae mlh1 alleles that correspond to HNPCC missense mutations. PMID: 17210669 Ref: A procedure for the detection of linkage with high density SNP arrays in a large pedigree with colorectal cancer. PMID: 17222328 Ref: The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1. PMID: 17224235 Ref: Evidence for heritable predisposition to epigenetic silencing of MLH1. PMID: 17230510 Ref: Cost-effectiveness of surveillance programs for families at high and moderate risk of hereditary non-polyposis colorectal cancer. PMID: 17234021 Ref: Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data. PMID: 17237905 Ref: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. PMID: 17239930 Ref: 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. 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PMID: 17278092 Ref: Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors. PMID: 17284719 Ref: [Lynch syndrome and gynaecologic's cancer: follow-up recommendations]. PMID: 17293255 Ref: MLH1 germline epimutations in selected patients with early-onset non-polyposis colorectal cancer. PMID: 17309645 Ref: Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. PMID: 17312306 Ref: Alcohol consumption and distinct molecular pathways to colorectal cancer. PMID: 17313702 Ref: Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma. PMID: 17316416 Ref: HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression. PMID: 17316446 Ref: DNA mismatch repair initiates 6-thioguanine--induced autophagy through p53 activation in human tumor cells. PMID: 17317843 Ref: Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). PMID: 17327285 Ref: A novel MSH2 mutation in a Chinese family with hereditary non-polyposis colorectal cancer. PMID: 17333219 Ref: Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. PMID: 17339237 Ref: Cancer genetics clinics and the surgeon: a valuable role for family history screening. PMID: 17346404 Ref: A new variant database for mismatch repair genes associated with Lynch syndrome. PMID: 17347989 Ref: Nationwide study of clinical and molecular features of hereditary non-polyposis colorectal cancer (HNPCC) in Latvia. PMID: 17348456 Ref: Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 17350669 Ref: Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer. PMID: 17350821 Ref: MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer. PMID: 17350979 Ref: From cancer families to HNPCC: Henry Lynch and the transformations of hereditary cancer, 1975-1999. PMID: 17369671 Ref: CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. PMID: 17372756 Ref: Beta2-microglobulin mutations in microsatellite unstable colorectal tumors. PMID: 17373663 Ref: MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer. PMID: 17374836 Ref: Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. PMID: 17378912 Ref: Turcot syndrome confirmed with molecular analysis. PMID: 17389002 Ref: Genetic testing in colorectal cancer: who, when, how and why. PMID: 17392593 Ref: Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias. PMID: 17408633 Ref: Is surveillance of the small bowel indicated for Lynch syndrome families? PMID: 17409122 Ref: Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management. PMID: 17414604 Ref: Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer. PMID: 17417778 Ref: Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis. PMID: 17427169 Ref: Immunohistochemical staining for mismatch repair proteins, and its relevance in the diagnosis of hereditary non-polyposis colorectal cancer. PMID: 17440950 Ref: Prognostic and predictive value of baseline and posttreatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. PMID: 17445998 Ref: Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: a tissue microarray-based analysis. PMID: 17448021 Ref: Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. PMID: 17449906 Ref: [Stem cell theory of colorectal cancer and its connection with molecular-biological data]. PMID: 17452307 Ref: Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer. PMID: 17453358 Ref: No difference in the occurrence of mismatch repair defects and APC and CTNNB1 genes mutation in a multi-racial colorectal carcinoma patient cohort. PMID: 17454753 Ref: Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma. PMID: 17460459 Ref: Clinical and molecular analysis of hereditary non-polyposis colorectal cancer in Chinese colorectal cancer patients. PMID: 17461458 Ref: Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1. PMID: 17465256 Ref: Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancer. PMID: 17465465 Ref: Detection of metachronous neoplasms in colorectal cancer patients: identification of risk factors. PMID: 17468913 Ref: A mononucleotide markers panel to identify hMLH1/hMSH2 germline mutations. PMID: 17473388 Ref: Estimating cancer risk in HNPCC by the GRL method. PMID: 17473834 Ref: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. PMID: 17474983 Ref: LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PMID: 17476321 Ref: Microsatellite instability markers for identifying early-onset colorectal cancers caused by germ-line mutations in DNA mismatch repair genes. PMID: 17504984 Ref: Genotype-phenotype correlations in individuals with a founder mutation in the MLH1 gene and hereditary non-polyposis colorectal cancer. PMID: 17505997 Ref: Microsatellite instability in Ewing tumor is not associated with loss of mismatch repair protein expression. PMID: 17530287 Ref: Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. PMID: 17545526 Ref: [Mismatch repair (MMR) efficiency and MSH2 gene mutation in human colorectal carcinoma cell line COLO320HSR]. PMID: 17555131 Ref: Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing. PMID: 17569143 Ref: High proportion of large genomic rearrangements in hMSH2 in hereditary nonpolyposis colorectal cancer (HNPCC) families of the Basque Country. PMID: 17582678 Ref: [Microsatellite analysis and hMLH1/hMSH2 expression detection in young patients with colorectal cancer: value in screening hereditary nonpolyposis colorectal cancer]. PMID: 17584637 Ref: Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. PMID: 17591929 Ref: Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer. PMID: 17606714 Ref: Surgical outcomes for colon and rectal cancer over a decade: results from a consecutive monocentric experience in 902 unselected patients. PMID: 17610720 Ref: TGF-beta signaling alterations and susceptibility to colorectal cancer. PMID: 17613544 Ref: Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players. PMID: 17613548 Ref: MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. PMID: 17621591 Ref: Understanding Lynch syndrome: implications for nursing. PMID: 17623626 Ref: Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genes. PMID: 17636402 Ref: Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa. PMID: 17640302 Ref: Heterogeneous staining for mismatch repair proteins during population-based prescreening for hereditary nonpolyposis colorectal cancer. PMID: 17652638 Ref: Uterine carcinosarcoma associated with hereditary nonpolyposis colorectal cancer. PMID: 17666659 Ref: The role of clinical criteria, genetic and epigenetic alterations in Lynch-syndrome diagnosis. PMID: 17688369 Ref: A single nucleotide substitution (-107C-->G) in the hMLH1 promoter found in colorectal cancer population reduces transcriptional activity. PMID: 17690979 Ref: Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 17710160 Ref: Rectal carcinoma after radiotherapy for cervical carcinoma in patients with a family history of colorectal carcinoma: report of two cases. PMID: 17713103 Ref: Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer. PMID: 17717427 Ref: Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer. PMID: 17724798 Ref: Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas. PMID: 17726263 Ref: Hereditary nonpolyposis colorectal cancer: diagnostic strategies and their implications. PMID: 17764220 Ref: [Screening the hereditary nonpolyposis colorectal cancer by revised Bethesda guideline: a cohort study of 110 cases]. PMID: 17785078 Ref: [A new oncogenetic service of counseling and diagnosing for hereditary non-polyposis colorectal cancer (HNPCC)]. PMID: 17803162 Ref: Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families. PMID: 17854147 Ref: Germline hMSH2 promoter mutation in a Chinese HNPCC kindred: evidence for dual role of LOH. PMID: 17894833 Ref: Re: MLH1 93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer. PMID: 17895478 Ref: Muir-Torre syndrome. PMID: 17902735 Ref: Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer. PMID: 17909015 Ref: Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis. PMID: 17914558 Ref: Decreased expression of hMLH1 correlates with reduced 5-fluorouracil-mediated apoptosis in colon cancer cells. PMID: 17914563 Ref: Familial colorectal cancer syndrome X. PMID: 17920898 Ref: Methylation of estrogen receptor alpha and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia. PMID: 17921385 Ref: Clinicopathological characteristics of colorectal cancer with family history: an evaluation of family history as a predictive factor for microsatellite instability. PMID: 17923762 Ref: Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer. PMID: 17925543 Ref: Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy. PMID: 17947473 Ref: Prevention of colorectal cancer in high-risk populations: the increasing role for endoscopy and chemoprevention in FAP and HNPCC. PMID: 17947820 Ref: Data reduction for prediction: a case study on robust coding of age and family history for the risk of having a genetic mutation. PMID: 17948867 Ref: Similar colorectal cancer risk in patients with monoallelic and biallelic mutations in the MYH gene identified in a population with adenomatous polyposis. PMID: 17949294 Ref: Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. PMID: 17950381 Ref: Molecular testing for microsatellite instability and DNA mismatch repair defects in hereditary and sporadic colorectal cancers--ready for prime time? PMID: 17962726 Ref: Methylation-induced silencing of ASC/TMS1, a pro-apoptotic gene, is a late-stage event in colorectal cancer. PMID: 17986858 Ref: SNP-Array genotyping and spectral karyotyping reveal uniparental disomy as early mutational event in MSS- and MSI-colorectal cancer cell lines. PMID: 18000373 Ref: Frequency of defective DNA mismatch repair in colorectal cancer among the Alaska Native people. PMID: 18006922 Ref: Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells. PMID: 18029474 Ref: Humanizing mismatch repair in yeast: towards effective identification of hereditary non-polyposis colorectal cancer alleles. PMID: 18031259 Ref: Two novel germline mutations of MLH1 and investigation of their pathobiology in hereditary non-polyposis colorectal cancer families in China. PMID: 18069769 Ref: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. PMID: 18084616 Ref: hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. PMID: 18214062 Ref: Piroxicam increases colon tumorigenesis and promotes apoptosis in Mlh1 +/- /Apc1638(N/+) mice. PMID: 18225536 Ref: MSI is frequently recognized among gastric cancer patients with a family history of cancer. PMID: 18265677 Ref: [Colorectal serrated adenoma: diagnostic criteria and clinical implications]. PMID: 18314605 Ref: [Need of new clinical criteria for the identification of genetic Lynch syndrome]. PMID: 18331697 Ref: Promoter hypermethylation of tumor-related genes in sporadic colorectal cancer in young patients. PMID: 18365548 Ref: [How and when to search for microsatellite instability in colorectal cancer in 2008?]. PMID: 18554553 Ref: Epigenetic changes (aberrant DNA methylation) in colorectal neoplasia. PMID: 20485652 |
Ref: Correlation between patient weight and defects in DNA mismatch repair: is this the link between an increased risk of previous cancer in thinner women with endometrial cancer? PMID: 17466051 Ref: Pathology of the hereditary colorectal carcinoma. PMID: 17564815 Ref: A novel MSH2 germline mutation in a Druze HNPCC family. PMID: 17661183 Ref: Homozygous PMS2 germline mutations in two families with early-onset haematological malignancy, brain tumours, HNPCC-associated tumours, and signs of neurofibromatosis type 1. PMID: 17851451 Ref: Strategy in clinical practice for classification of unselected colorectal tumours based on mismatch repair deficiency. PMID: 17868408 Ref: Sessile serrated polyps of the colorectum are rare in patients with Lynch syndrome and in familial colorectal cancer families. PMID: 17929199 Ref: Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). PMID: 17939062 Ref: Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases. PMID: 17943475 Ref: Clustering of Lynch syndrome malignancies with no evidence for a role of DNA mismatch repair. PMID: 18022218 Ref: Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. PMID: 18027856 Ref: Classification of ambiguous mutations in DNA mismatch repair genes identified in a population-based study of colorectal cancer. PMID: 18033691 Ref: Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. PMID: 18048385 Ref: The extracolonic cancer spectrum in females with the common 'South African' hMLH1 c.C1528T mutation. PMID: 18049911 Ref: Validation and extension of the PREMM1,2 model in a population-based cohort of colorectal cancer patients. PMID: 18061181 Ref: WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18084250 Ref: A prospective, multicenter, population-based study of BRAF mutational analysis for Lynch syndrome screening. PMID: 18096441 Ref: Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms. PMID: 18097574 Ref: Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. PMID: 18162445 Ref: Working through a diagnostic challenge: colonic polyposis, Amsterdam criteria, and a mismatch repair mutation. PMID: 18176851 Ref: Detection of hMSH2 and hMLH1 mutations in Chinese hereditary non-polyposis colorectal cancer kindreds. PMID: 18186571 Ref: CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. PMID: 18204436 Ref: [Clinical and molecular consequences of microsatellite instability in human cancers]. PMID: 18230578 Ref: A novel method to quantify local CpG methylation density by regional methylation elongation assay on microarray. PMID: 18237388 Ref: Detection of mismatch repair gene germline mutation carrier among Chinese population with colorectal cancer. PMID: 18257912 Ref: Detection of microsatellite instability in colorectal cancer using an alternative multiplex assay of quasi-monomorphic mononucleotide markers. PMID: 18258928 Ref: Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy. PMID: 18271923 Ref: Tumor histology helps to identify Lynch syndrome among colorectal cancer patients. PMID: 18283560 Ref: Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. PMID: 18299982 Ref: No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients. PMID: 18301448 Ref: Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features. PMID: 18301950 Ref: Clinical features and mismatch repair genes analyses of Chinese suspected hereditary non-polyposis colorectal cancer: a cost-effective screening strategy proposal. PMID: 18307539 Ref: Immunoexpression of hMSH2 and hMLH1 in oral squamous cell carcinoma and its relationship to histological grades of malignancy. PMID: 18331286 Ref: Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis. PMID: 18337503 Ref: Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer. PMID: 18339680 Ref: Common variants in mismatch repair genes and risk of colorectal cancer. PMID: 18364438 Ref: LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 18366060 Ref: Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy. PMID: 18381446 Ref: Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. PMID: 18384130 Ref: Screening for urinary tract cancer with urine cytology in Lynch syndrome and familial colorectal cancer. PMID: 18389386 Ref: Mutation spectrum in HNPCC in the Israeli population. PMID: 18389388 Ref: The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. PMID: 18398828 Ref: The CpG island methylator phenotype correlates with long-range epigenetic silencing in colorectal cancer. PMID: 18403637 Ref: A novel missense MSH2 gene mutation in a patient of a Korean family with hereditary nonpolyposis colorectal cancer. PMID: 18406877 Ref: Compound heterozygosity for two MSH6 mutations in a patient with early onset colorectal cancer, vitiligo and systemic lupus erythematosus. PMID: 18409202 Ref: Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas. PMID: 18415027 Ref: Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. PMID: 18435933 Ref: CpG island methylation in familial colorectal cancer patients not fulfilling the Amsterdam criteria. PMID: 18437011 Ref: Proximal colon cancer in patients aged 51-60 years of age should be tested for microsatellites instability. A comment on the Revised Bethesda Guidelines. PMID: 18446350 Ref: Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. PMID: 18451217 Ref: Cost analysis of biomarker testing for mismatch repair deficiency in node-positive colorectal cancer. PMID: 18457354 Ref: Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency. PMID: 18464258 Ref: Hypermethylation of the DNA mismatch repair gene hMLH1 and its association with lymph node metastasis and T1799A BRAF mutation in patients with papillary thyroid cancer. PMID: 18470905 Ref: Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses. PMID: 18480061 Ref: Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes. PMID: 18481196 Ref: Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer. PMID: 18497967 Ref: Contribution of common monoallelic MUTYH gene variants in German patients with familial colorectal cancer. PMID: 18503156 Ref: Inherited cancer predisposition syndromes in Greece. PMID: 18505076 Ref: Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. PMID: 18509181 Ref: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. PMID: 18516290 Ref: The first functional study of MLH3 mutations found in cancer patients. PMID: 18521850 Ref: Association of family history with cancer recurrence and survival among patients with stage III colon cancer. PMID: 18523220 Ref: [Comparison of clinical and genetic phenotypes between Chinese and Korean hereditary nonpolyposis colorectal cancer families]. PMID: 18543228 Ref: Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway. PMID: 18546042 Ref: The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population. PMID: 18547406 Ref: Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. PMID: 18551179 Ref: Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part II. The utility of microsatellite instability testing. PMID: 18556776 Ref: Epigenetic signatures of familial cancer are characteristic of tumor type and family category. PMID: 18559504 Ref: Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers. PMID: 18581137 Ref: Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study Group. PMID: 18594845 Ref: Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status. PMID: 18595133 Ref: Comparison of predictive models, clinical criteria and molecular tumour screening for the identification of patients with Lynch syndrome in a population-based cohort of colorectal cancer patients. PMID: 18603628 Ref: The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer. PMID: 18615680 Ref: Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients. 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PMID: 29442399 Ref: Comprehensive analysis of the MLH1 promoter region in 480 patients with colorectal cancer and 1150 controls reveals new variants including one with a heritable constitutional MLH1 epimutation. PMID: 29472279 Ref: MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques. PMID: 29490919 Ref: [Small intestine neoplasms]. PMID: 29498365 Ref: Evaluation of MLH1 variants of unclear significance. PMID: 29520894 Ref: MBD4 frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cells. PMID: 29545913 Ref: Novel MSH2 splice-site mutation in a young patient with Lynch syndrome. PMID: 29568967 Ref: Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. 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PMID: 29666172 Ref: Tumor development in Japanese patients with Lynch syndrome. PMID: 29672549 Ref: The prognostic impact of CDX2 correlates with the underlying mismatch repair status and BRAF mutational status but not with distant metastasis in colorectal cancer. PMID: 29675807 Ref: Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer. PMID: 29701748 Ref: Specific features of colorectal cancer in patients with metabolic syndrome: a matched case-control analysis of 772 patients. PMID: 29704123 Ref: Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome. PMID: 29723603 Ref: Mismatch repair-deficient status associates with favorable prognosis of Eastern Chinese population with sporadic colorectal cancer. PMID: 29725427 Ref: Immunohistochemical and genetic characteristics of a colorectal mucin-rich variant of traditional serrated adenoma. PMID: 29729192 Ref: Current clinical topics of Lynch syndrome. PMID: 29744602 Ref: Universal screening of both endometrial and colon cancers increases the detection of Lynch syndrome. PMID: 29750335 Ref: TumorNext-Lynch-MMR: a comprehensive next generation sequencing assay for the detection of germline and somatic mutations in genes associated with mismatch repair deficiency and Lynch syndrome. PMID: 29755653 Ref: Molecular Background of Colorectal Tumors From Patients With Lynch Syndrome Associated With Germline Variants in PMS2. PMID: 29758216 Ref: A novel MLH1 intronic variant in a young Japanese patient with Lynch syndrome. PMID: 29760937 Ref: Molecular Diagnostics in Colorectal Carcinoma: Advances and Applications for 2018. PMID: 29776633 Ref: Association of patient navigation with care coordination in an Lynch syndrome screening program. PMID: 29800403 Ref: Molecular subtypes in early colorectal cancer associated with clinical features and patient prognosis. 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PMID: 29872454 Ref: Disruption of a -35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells. PMID: 29898989 Ref: A Chinese family affected by lynch syndrome caused by MLH1 mutation. PMID: 29929473 Ref: Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans. PMID: 29930328 Ref: Muir-Torre Syndrome: A Case Report in a Woman Without Personal Cancer History. PMID: 29933315 Ref: [Genetic variations in MLH3 and MSH2 genes are associated with the sensitivity and prognosis in locally advanced rectal cancer patients receiving preoperative chemoradiotherapy]. PMID: 29936769 Ref: Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease-Associated Colorectal Cancers. PMID: 29950348 Ref: Assessing colorectal cancer mismatch repair status in the modern era: a survey of current practices and re-evaluation of the role of microsatellite instability testing. PMID: 29955148 Ref: Investigation of GHSR and GHRL methylation in colorectal cancer. PMID: 29963901 Ref: Optimization of the diagnosis of inherited colorectal cancer using NGS and capture of exonic and intronic sequences of panel genes. PMID: 29967336 Ref: Promoter methylation of human mutL homolog 1 and colorectal cancer risk: A meta-analysis. PMID: 29970664 Ref: Frequency of Mismatch Repair Protein Deficiency in a Puerto Rican Population with Colonic Adenoma and Adenocarcinoma. PMID: 29976631 Ref: Advantage of HSP110 (T17) marker inclusion for microsatellite instability (MSI) detection in colorectal cancer patients. PMID: 29983889 Ref: Colorectal Cancer Stratification in the Routine Clinical Pathway: A District General Hospital Experience. PMID: 29985199 Ref: The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. PMID: 30010450 Ref: The First Molecular Screening of MLH1 and MSH2 Genes in Moroccan Colorectal Cancer Patients Shows a Relatively High Mutational Prevalence. PMID: 30044143 Ref: Sigmoid Colon Adenocarcinoma with Isolated Loss of PMS2 Presenting in a Patient with Synchronous Prostate Cancer with Intact MMR: Diagnosis and Analysis of the Family Pedigree. PMID: 30061258 Ref: No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies. PMID: 30063918 Ref: Routine molecular analysis for Lynch syndrome among adenomas or colorectal cancer within a national screening program. PMID: 30063919 Ref: Molecular characteristics of colorectal cancer in a Middle Eastern population in a single institution. PMID: 30078023 Ref: A novel MLH1 mutation in a Japanese family with Lynch syndrome associated with small bowel cancer. PMID: 30083359 Ref: Development of patient-derived orthotopic xenografts from metastatic colorectal cancer in nude mice. PMID: 30088428 Ref: A cancer vaccine approach for personalized treatment of Lynch Syndrome. PMID: 30108227 Ref: Mismatch repair gene mutations lead to lynch syndrome colorectal cancer in rhesus macaques. PMID: 30108684 Ref: DNA damage response genes mark the early transition from colitis to neoplasia in colitis-associated colon cancer. PMID: 30121380 Ref: Universal Lynch Syndrome Screening Should be Performed in All Upper Tract Urothelial Carcinomas. PMID: 30148743 Ref: EXOSC4 functions as a potential oncogene in development and progression of colorectal cancer. PMID: 30155936 Ref: Cancer Risks for PMS2-Associated Lynch Syndrome. PMID: 30161022 Ref: Prevalence and clinicopathological characteristics of mismatch repair-deficient colorectal carcinoma in early onset cases as compared with late-onset cases: a retrospective cross-sectional study in Northeastern Iran. PMID: 30166308 Ref: Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas. PMID: 30166615 Ref: Immune environment in serrated lesions of the Colon: intraepithelial lymphocyte density, PD-1, and PD-L1 expression correlate with serrated neoplasia pathway progression. PMID: 30172913 Ref: DNA mismatch repair and CD133-marked cancer stem cells in colorectal carcinoma. PMID: 30221090 Ref: Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition. PMID: 30256826 Ref: Molecular and presymptomatic analysis of a Moroccan Lynch syndrome family revealed a novel frameshift MLH1 germline mutation. PMID: 30289396 Ref: Mullerian carcinosarcoma in the colon of a patient with history of endometrial carcinoma: A case report and insight into possible pathogenesis. PMID: 30294656 Ref: Current mismatch repair deficiency tumor testing practices and capabilities: A survey of Australian pathology providers. PMID: 30294856 Ref: Prevalence estimation of microsatellite instability in colorectal cancers using tissue microarray based methods - A tertiary care center experience. PMID: 30303141 Ref: From colorectal cancer pattern to the characterization of individuals at risk: picture for genetic research in Latin America. PMID: 30303536 Ref: Identification of Lynch syndrome risk variants in the Romanian population. PMID: 30324682 Ref: Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer. PMID: 30376427 Ref: Punctate MLH1 mismatch repair immunostaining in colorectal cancer. PMID: 30379344 Ref: DNA mismatch repair deficiency but not ARID1A loss is associated with prognosis in small intestinal adenocarcinoma. PMID: 30381262 Ref: Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation. PMID: 30387329 |