Primary Site >> Colorectal Cancer
Gene >> MGMT
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Ref: Transfection of DNA from a chloroethylnitrosourea-resistant tumor cell line (MER+) to a sensitive tumor cell line (MER-) results in a tumor cell line resistant to MNNG and CNU that has increased O-6-methylguanine-DNA methyltransferase levels and reduced l PMID: 3742731 |
Ref: O6-methylguanine-DNA methyltransferase activity in human tumors. PMID: 1394831 Ref: Incision at O6-methylguanine:thymine mispairs in DNA by extracts of human cells. PMID: 1510986 |
Ref: Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro. PMID: 8364924 |
Ref: Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity. PMID: 8044784 |
Ref: Determinants of O6-alkylguanine-DNA alkyltransferase activity in human colon cancer. PMID: 9816011 |
Ref: Activity of the DNA repair protein O6-methylguanine-DNA methyltransferase in human tumor and corresponding normal tissue. PMID: 8706038 |
Ref: O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU. PMID: 9354444 |
Ref: Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. PMID: 10029064 Ref: A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers. PMID: 10078936 Ref: DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts. PMID: 10223735 |
Ref: Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. PMID: 10811111 Ref: Dietary fish oil reduces O6-methylguanine DNA adduct levels in rat colon in part by increasing apoptosis during tumor initiation. PMID: 10952099 |
Ref: Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. PMID: 11221863 Ref: Initiation of strand incision at G:T and O(6)-methylguanine:T base mismatches in DNA by human cell extracts. PMID: 11376160 Ref: Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. PMID: 11406538 Ref: O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer. PMID: 11719438 Ref: DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. PMID: 11751682 Ref: Expression and prognostic significance of O6-methylguanine-DNA methyltransferase in hepatocellular, gastric, and breast cancers. PMID: 11776495 |
Ref: Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability. PMID: 11978509 Ref: Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer. PMID: 12036916 Ref: Emerging concepts in colorectal neoplasia. PMID: 12198712 Ref: Base excision repair as a therapeutic target in colon cancer. PMID: 12231545 Ref: Heterogeneity of O(6)-alkylguanine-DNA alkyltransferase activity in colorectal cancer: implications for treatment. PMID: 12417795 Ref: DNA alkylation and repair in the large bowel: animal and human studies. PMID: 12421880 |
Ref: Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. PMID: 12482974 Ref: Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism. PMID: 12517412 Ref: Associations between tissue-specific DNA alkylation, DNA repair and cell proliferation in the colon and colon tumour yield in mice treated with 1,2-dimethylhydrazine. PMID: 12663514 Ref: Alteration of O6-methylguanine-DNA methyltransferase in colorectal neoplasms in sporadic and familial adenomatous polyposis patients. PMID: 12720298 Ref: Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. PMID: 12810640 Ref: The promoter methylation status of the DNA repair gene O6-methylguanine-DNA methyltransferase in ulcerative colitis. PMID: 12920593 Ref: Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases. PMID: 14614014 Ref: Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. PMID: 14633667 Ref: Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood. PMID: 15068392 |
Ref: Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer. PMID: 15016754 Ref: Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia. PMID: 15122305 Ref: Detection of lymph node micrometastases by gene promoter hypermethylation in samples obtained by endosonography- guided fine-needle aspiration biopsy. PMID: 15240535 Ref: Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer. PMID: 15340260 Ref: Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer. PMID: 15342451 Ref: Repression of MLH1 and MGMT genes in colon mucosa adjacent to implanted cancer in athymic mouse. PMID: 15354418 Ref: Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. PMID: 15386372 Ref: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. PMID: 15476557 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 Ref: Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. PMID: 15542810 |
Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum. PMID: 15389252 Ref: Development and application of a multiplex PCR procedure for the detection of DNA methylation in colorectal cancer. PMID: 15643519 Ref: Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. PMID: 15709190 Ref: Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon. PMID: 15712188 Ref: Methylation profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients. PMID: 15760842 Ref: CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype. PMID: 15760919 Ref: Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation. PMID: 15767794 Ref: Low microsatellite instability is associated with poor prognosis in stage C colon cancer. PMID: 15800322 Ref: Hypermethylation of CpG island in O6-methylguanine-DNA methyltransferase gene was associated with K-ras G to A mutation in colorectal tumor. PMID: 15800999 Ref: Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest. PMID: 15870882 Ref: O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions. PMID: 15888787 Ref: Colorectal cancer "methylator phenotype": fact or artifact? PMID: 15967110 Ref: Serrated adenoma of the colorectum and the DNA-methylator phenotype. PMID: 16130936 Ref: MGMT promoter methylation and field defect in sporadic colorectal cancer. PMID: 16174854 Ref: Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. PMID: 16226712 Ref: Hypermethylation of the putative tumor-suppressor genes DCC, p51/63 and O6-methylguanine-DNA methyltransferase (MGMT) and loss of their expressions in cell lines of hematological malignancies. PMID: 16247226 Ref: DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps. PMID: 16284370 Ref: The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea(ACNU) in gallbladder carcinoma cells. PMID: 16309194 Ref: CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer. PMID: 16336454 |
Ref: Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. PMID: 16118624 Ref: DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients. PMID: 16152625 Ref: Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. PMID: 16369045 Ref: Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma. PMID: 16374457 Ref: Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer. PMID: 16436636 Ref: The prognostic impact of O6-Methylguanine-DNA Methyltransferase (MGMT) promotor hypermethylation in esophageal adenocarcinoma. PMID: 16477636 Ref: Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. PMID: 16609022 Ref: O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States). PMID: 16633920 Ref: Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. PMID: 16645205 Ref: Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. PMID: 16645207 Ref: Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis. PMID: 16699497 Ref: CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. PMID: 16708352 Ref: Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer. PMID: 16819711 Ref: Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas. PMID: 16820927 Ref: Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer. PMID: 16879389 Ref: Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors. PMID: 16886601 Ref: Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas. PMID: 16902913 Ref: Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis. PMID: 16929496 Ref: Genetic instability on chromosome 17 in the epithelium of non-polypoid colorectal carcinomas compared to polypoid lesions. PMID: 17032312 Ref: Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients. PMID: 17108212 Ref: Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. PMID: 17122504 Ref: Types of colorectal adenoma. PMID: 17867575 |
Ref: Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. PMID: 17088260 Ref: Colorectal serrated adenocarcinoma. PMID: 17204027 Ref: Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas. PMID: 17278092 Ref: Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. PMID: 17289753 Ref: Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. PMID: 17339237 Ref: Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. PMID: 17352030 Ref: CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. PMID: 17372756 Ref: Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. PMID: 17378912 Ref: Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias. PMID: 17408633 Ref: Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic value. PMID: 17451198 Ref: [Stem cell theory of colorectal cancer and its connection with molecular-biological data]. PMID: 17452307 Ref: Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines. PMID: 17487405 Ref: Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells. PMID: 17597106 Ref: MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. PMID: 17621591 Ref: Promoter methylation status of multiple genes in uveal melanoma. PMID: 17898258 Ref: Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways. PMID: 17908962 Ref: DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. PMID: 18006925 Ref: Promoter hypermethylation of tumor-related genes in sporadic colorectal cancer in young patients. PMID: 18365548 |
Ref: Detailed methylation patterns and protein expression profiles of MGMT in colorectal carcinoma surgical margins. PMID: 18028895 Ref: Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. PMID: 18048385 Ref: Combination of O6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy. PMID: 18068349 Ref: CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. PMID: 18204436 Ref: A novel method to quantify local CpG methylation density by regional methylation elongation assay on microarray. PMID: 18237388 Ref: Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. PMID: 18240147 Ref: Large-scale evaluation of genetic variants in candidate genes for colorectal cancer risk in the Nurses' Health Study and the Health Professionals' Follow-up Study. PMID: 18268114 Ref: Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy. PMID: 18271923 Ref: CpG island methylation in familial colorectal cancer patients not fulfilling the Amsterdam criteria. PMID: 18437011 Ref: Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. PMID: 18451217 Ref: Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics. PMID: 18486467 Ref: Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. PMID: 18509181 Ref: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. PMID: 18516290 Ref: Distinct CpG island methylation profiles and BRAF mutation status in serrated and adenomatous colorectal polyps. PMID: 18798261 Ref: Methylation of the MGMT and p16 genes in sporadic colorectal carcinoma and corresponding normal colonic mucosa. PMID: 18830187 Ref: Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions. PMID: 18938072 Ref: Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PMID: 19002263 Ref: Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. PMID: 19117505 |
Ref: CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. PMID: 18832519 Ref: Absence of MGMT promoter methylation in endometrial cancer. PMID: 18973931 Ref: Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins. PMID: 19029948 Ref: Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters. PMID: 19060925 Ref: JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. PMID: 19107235 Ref: NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer. PMID: 19107910 Ref: Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B. PMID: 19147861 Ref: MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events. PMID: 19164452 Ref: High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis. PMID: 19179456 Ref: Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation. PMID: 19302287 Ref: The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients. PMID: 19309276 Ref: Promoter hypermethylation of tumor-related genes in peritoneal lavage and the prognosis of patients with colorectal cancer. PMID: 19384904 Ref: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 19430421 Ref: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. PMID: 19470733 Ref: Pathologic features and biologic importance of colorectal serrated polyps. PMID: 19550369 Ref: Stool methylation-specific polymerase chain reaction assay for the detection of colorectal neoplasia in Korean patients. PMID: 19617759 Ref: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. PMID: 19686742 Ref: MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. PMID: 19734844 Ref: Concordant DNA methylation in synchronous colorectal carcinomas. PMID: 19737982 Ref: Methylation in p14(ARF) is frequently observed in colorectal cancer with low-level microsatellite instability. PMID: 19761686 Ref: Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer. PMID: 19773381 Ref: Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism. PMID: 19789298 Ref: Methylation of the MGMT gene is frequently detected in advanced gastric carcinoma. PMID: 20044616 Ref: Effects of amino acid substitution polymorphisms of two DNA methyltransferases on susceptibility to sporadic colorectal cancer. PMID: 20192566 Ref: MGMT gene is aberrantly methylated from the early stages of colorectal cancers. PMID: 20214209 |
Ref: Intramedullary solitary fibrous tumor of dorsal spinal cord. PMID: 19751244 Ref: Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. PMID: 19777566 Ref: Effects of O6-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis. PMID: 19892775 Ref: CpG island methylation of BNIP3 predicts resistance against S-1/CPT-11 combined therapy in colorectal cancer patients. PMID: 19956881 Ref: A phase I trial of lomeguatrib and irinotecan in metastatic colorectal cancer. PMID: 20039040 Ref: Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. PMID: 20051376 Ref: Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. PMID: 20068091 Ref: Promoter methylation of specific genes is associated with the phenotype and progression of colorectal adenocarcinomas. PMID: 20077021 Ref: MGMT -535G>T polymorphism is associated with prognosis for patients with metastatic colorectal cancer treated with oxaliplatin-based chemotherapy. PMID: 20091185 Ref: MGMT Ile143Val polymorphism, dietary factors and the risk of breast, colorectal and prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study. PMID: 20096652 Ref: Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. PMID: 20098741 Ref: Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. PMID: 20572039 Ref: Novel methylation panel for the early detection of colorectal tumors in stool DNA. PMID: 20643622 Ref: Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas. PMID: 20653064 Ref: Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer. PMID: 20682398 Ref: Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis. PMID: 20732909 Ref: Effects of X-ray irradiation on methylation levels of p16, MGMT and APC genes in sporadic colorectal carcinoma and corresponding normal colonic mucosa. PMID: 20885350 Ref: Epigenetic drivers of genetic alterations. PMID: 20920753 Ref: Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers. PMID: 20947886 Ref: An MLH1 mutation links BACH1/FANCJ to colon cancer, signaling, and insight toward directed therapy. PMID: 20978114 Ref: Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. PMID: 21037082 |
Ref: Hierarchical clustering analysis of pathologic and molecular data identifies prognostically and biologically distinct groups of colorectal carcinomas. PMID: 20852594 Ref: SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study. PMID: 21075068 Ref: Tissue sampling for mutation analysis in colorectal cancer: K-ras is homogeneously distributed throughout the tumor tissue. PMID: 21109984 Ref: MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. PMID: 21140203 Ref: Histologic characteristics of non-microsatellite-instable colon adenomas correlate with distinct molecular patterns. PMID: 21238786 Ref: [Gene methylation in stool for the screening of colorectal cancer and pre-malignant lesions]. PMID: 21271382 Ref: Promoter hypermethylation of RASSF1A, MGMT, and HIC-1 genes in benign and malignant colorectal tumors. PMID: 21274674 Ref: A novel case of rhabdoid colon carcinoma associated with a positive CpG island methylator phenotype and BRAF mutation. PMID: 21315413 Ref: The effect of radiation quality on genomic DNA methylation profiles in irradiated human cell lines. PMID: 21375360 Ref: Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis. PMID: 21406167 Ref: Folate receptor-alpha expression in resectable hepatic colorectal cancer metastases: patterns and significance. PMID: 21572402 Ref: Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features. PMID: 21660972 Ref: Hypermethylation of promoter regions of the APC1A and p16INK4a genes in relation to prognosis and tumor characteristics in cervical cancer patients. PMID: 21674126 Ref: Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence. PMID: 21706233 Ref: Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair. PMID: 21720182 Ref: B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). PMID: 21738611 Ref: The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy. PMID: 21827707 Ref: Familial colorectal cancer type X syndrome: two distinct molecular entities? PMID: 21837511 Ref: DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. PMID: 22132162 Ref: Alterations of copy number of methylation pattern in mismatch repair genes by methylation specific-multiplex ligation-dependent probe amplification in cases of colon cancer. PMID: 24052709 |
Ref: p53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers. PMID: 21557216 Ref: Oncogenic PIK3CA mutations in colorectal cancers and polyps. PMID: 21932420 Ref: Why do results conflict regarding the prognostic value of the methylation status in colon cancers? The role of the preservation method. PMID: 22243995 Ref: Colorectal serrated adenocarcinoma shows a different profile of oncogene mutations, MSI status and DNA repair protein expression compared to conventional and sporadic MSI-H carcinomas. PMID: 22287190 Ref: Epigenetic markers of early tumor development. PMID: 22359284 Ref: Evaluation of the expression of the MGMT gene in normal and neoplastic tissue of patients with colorectal cancer. PMID: 22481706 Ref: Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer. PMID: 22655257 Ref: The impact of CpG island methylator phenotype and microsatellite instability on tumour budding in colorectal cancer. PMID: 22803799 Ref: Methylation of the polycomb group target genes is a possible biomarker for favorable prognosis in colorectal cancer. PMID: 23010642 Ref: Expression profiling of archival tumors for long-term health studies. PMID: 23136189 Ref: Analysis of O6-methylguanine-DNA methyltransferase methylation status in sporadic colon polyps. PMID: 24376999 |
Ref: Molecular patterns in the evolution of serrated lesion of the colorectum. PMID: 23011871 Ref: DNA methylation of the p14ARF, RASSF1A and APC1A genes as an independent prognostic factor in colorectal cancer patients. PMID: 23128528 Ref: Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer. PMID: 23271133 Ref: Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma. PMID: 23310950 Ref: Human metastable epiallele candidates link to common disorders. PMID: 23321599 Ref: Role of conventional chemosensitivity test and tissue biomarker expression in predicting response to treatment of peritoneal carcinomatosis from colon cancer. PMID: 23332421 Ref: The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase. PMID: 23335782 Ref: Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features. PMID: 23348904 Ref: Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer. PMID: 23422094 Ref: A phase II study of temozolomide in patients with advanced aerodigestive tract and colorectal cancers and methylation of the O6-methylguanine-DNA methyltransferase promoter. PMID: 23443801 Ref: Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population. PMID: 23573237 Ref: Evaluation of methylation of MGMT (O(6)-methylguanine-DNA methyltransferase) gene promoter in sporadic colorectal cancer. PMID: 23705976 Ref: PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival. PMID: 23785428 Ref: O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer. PMID: 23929436 Ref: Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study. PMID: 24065530 Ref: MGMT Leu84Phe polymorphism contributes to cancer susceptibility: evidence from 44 case-control studies. PMID: 24086516 Ref: The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia. PMID: 24108782 Ref: Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis. PMID: 24140386 Ref: Toward a Molecular Classification of Colorectal Cancer: The Role of MGMT. PMID: 24151575 Ref: Correlation of MLH1 and MGMT methylation levels between peripheral blood leukocytes and colorectal tissue DNA samples in colorectal cancer patients. PMID: 24179526 |
Ref: Tumor-associated mutations in O(6) -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality. PMID: 23065697 Ref: Two DNA repair gene polymorphisms on the risk of gastrointestinal cancers: a meta-analysis. PMID: 24203816 Ref: The role of plasma cell-free DNA detection in predicting preoperative chemoradiotherapy response in rectal cancer patients. PMID: 24378613 Ref: Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation. PMID: 24379162 Ref: Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism. PMID: 24500500 Ref: Association between six genetic polymorphisms and colorectal cancer: a meta-analysis. PMID: 24552298 Ref: Distinct profile of HIF1alpha, PTCH, EphB2, or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma. PMID: 24612059 Ref: Review of current best practice and priorities for research in radiation oncology for elderly patients with cancer: the International Society of Geriatric Oncology (SIOG) task force. PMID: 24625455 Ref: Deletion of the MGMT gene in familial melanoma. PMID: 24801985 Ref: Prognostic and predictive value of CpG island methylator phenotype in patients with locally advanced nonmetastatic sporadic colorectal cancer. PMID: 24822060 Ref: Prognostic impact of MGMT promoter methylation and MGMT and CD133 expression in colorectal adenocarcinoma. PMID: 25015560 Ref: Molecular markers of carcinogenesis for risk stratification of individuals with colorectal polyps: a case-control study. PMID: 25092825 Ref: IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. PMID: 25110432 Ref: CpG island methylator phenotype and prognosis of colorectal cancer in Northeast China. PMID: 25243122 Ref: Role of MGMT as biomarker in colorectal cancer. PMID: 25516857 Ref: Role of Red Meat and Resistant Starch in Promutagenic Adduct Formation, MGMT Repair, Thymic Lymphoma and Intestinal Tumourigenesis in Msh2 -Deficient Mice. PMID: 26022687 |
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