Primary Site >> Biliary tract Cancer
Gene >> MGMT
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Ref: Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. PMID: 11986189 Ref: Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. PMID: 12213730 |
Ref: Mutation analysis of K-ras and beta-catenin genes related to O6-methylguanin-DNA methyltransferase and mismatch repair protein status in human gallbladder carcinoma. PMID: 12469220 Ref: Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas. PMID: 12730870 |
Ref: Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. PMID: 15467712 Ref: Cisplatin represses transcriptional activity from the minimal promoter of the O6-methylguanine methyltransferase gene and increases sensitivity of human gallbladder cancer cells to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-2-chloroethyl)-3-nitrosourea. PMID: 15809756 Ref: Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest. PMID: 15870882 Ref: Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers. PMID: 15915369 Ref: The effect of o6-methylguanine-DNA methyltransferase (MGMT) and mismatch repair gene (hMLH1) status on the sensitivity to alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea(ACNU) in gallbladder carcinoma cells. PMID: 16309194 |
Ref: Methylation profiles of multiple CpG island loci in extrahepatic cholangiocarcinoma versus those of intrahepatic cholangiocarcinomas. PMID: 17550320 Ref: Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. PMID: 18158568 |
Ref: Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China. PMID: 18708406 |
Ref: Promoter methylation profile in preneoplastic and neoplastic gallbladder lesions. PMID: 18543280 |
Ref: Intrahepatic cholangiocarcinoma and gallbladder cancer: distinguishing molecular profiles to guide potential therapy. PMID: 26374242 |