Primary Site >> Colorectal Cancer
Gene >> MDM4
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Ref: Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status. PMID: 11239498 Ref: Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. PMID: 11587480 |
Ref: Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors. PMID: 12606785 Ref: Molecular modes of action of artesunate in tumor cell lines. PMID: 12869643 |
Ref: Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. PMID: 17262809 |
Ref: Regulation of MDMX expression by mitogenic signaling. PMID: 18172009 Ref: Full-length hdmX transcripts decrease following genotoxic stress. PMID: 18711402 |
Ref: Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. PMID: 20176655 |
Ref: Rare MDM4 gene amplification in colorectal cancer: The principle of a mutually exclusive relationship between MDM alteration and TP53 inactivation is not applicable. PMID: 21503588 |
Ref: MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame. PMID: 22870278 |
Ref: JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PMID: 24667498 Ref: FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX. PMID: 25512388 |
Ref: Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer. PMID: 25675144 |
Ref: Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex. PMID: 26726742 Ref: Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation. PMID: 26957954 |
Ref: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. PMID: 28280620 Ref: The suppressing effects of BTG3 expression on aggressive behaviors and phenotypes of colorectal cancer: An in vitro and vivo study. PMID: 28407690 |
Ref: MiR-370 promotes apoptosis in colon cancer by directly targeting MDM4. PMID: 29434862 Ref: Improving anticancer activity towards colon cancer cells with a new p53-activating agent. PMID: 30076608 |