Primary Site >> Pancreatic Cancer
Gene >> MDM2
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Ref: Increased mdm2 expression and immunoreactivity in human pancreatic ductal adenocarcinoma. PMID: 21559710 |
Ref: [Studies on MDM2 oncogene expression and its effect on pancreatic carcinoma cells]. PMID: 9275659 |
Ref: Accumulation of genetic alterations and their significance in each primary human cancer and cell line. PMID: 9685701 Ref: Inhibiting effect of murine double minute-2 oncogene on apoptosis induced by retroviral-mediated wild-type p53. PMID: 11263374 Ref: [Murine Doube Minute 2 oncogene inhibited apoptosis induced by retroviral-mediated wild-type p53]. PMID: 11717930 |
Ref: Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. PMID: 10445844 |
Ref: Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma. PMID: 10851351 |
Ref: Deregulated expression of cell cycle-associated proteins in solid pseudopapillary tumor of the pancreas. PMID: 11235905 Ref: Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway. PMID: 11287623 |
Ref: p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb. PMID: 11753042 |
Ref: Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor. PMID: 12824895 |
Ref: [Expression of proteins in p53 (p14ARF-mdm2-p53-p21WAF/CIP1) pathway and their significance in exocrine pancreatic carcinoma]. PMID: 15132849 |
Ref: Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. PMID: 15810085 Ref: [Mucinous noncystic (colloid) adenocarcinoma of the pancreas]. PMID: 16251039 Ref: [Expression and clinical significance of P53 pathway-associated proteins in pancreatic carcinoma]. PMID: 16552971 |
Ref: Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer. PMID: 16818496 |
Ref: p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism. PMID: 17630509 |
Ref: Curcumin as "Curecumin": from kitchen to clinic. PMID: 17900536 Ref: MDM2 promoter polymorphism and pancreatic cancer risk and prognosis. PMID: 18559624 |
Ref: Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. PMID: 19020940 Ref: Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells. PMID: 19029954 Ref: Novel ginsenosides 25-OH-PPD and 25-OCH3-PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of action. PMID: 19203832 Ref: Clinicopathological correlations of cyclooxygenase-2, MDM2, and p53 expressions in surgically resectable pancreatic invasive ductal adenocarcinoma. PMID: 19346994 Ref: Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening. PMID: 19424582 |
Ref: Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53. PMID: 19609950 Ref: Spectral karyotypic and comparative genomic analysis of the endocrine pancreatic tumor cell line BON-1. PMID: 19887762 Ref: MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function. PMID: 20156675 Ref: Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy. PMID: 20370686 Ref: MDM2 inhibitors for pancreatic cancer therapy. PMID: 20377522 Ref: Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway. PMID: 20871795 |
Ref: Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. PMID: 21628454 |
Ref: Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. PMID: 22086925 |
Ref: Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death. PMID: 23115126 Ref: Cooperation among Numb, MDM2 and p53 in the development and progression of pancreatic cancer. PMID: 23881403 Ref: [Correlation between Gli1 expression and clinicopathological significance in human pancreatic cancer]. PMID: 24433772 |
Ref: RNA interference against MDM2 suppresses tumor growth and metastasis in pancreatic carcinoma SW1990HM cells. PMID: 22200978 Ref: Overexpression of calreticulin contributes to the development and progression of pancreatic cancer. PMID: 24264800 Ref: The clinicopathological significance and relationship of Gli1, MDM2 and p53 expression in resectable pancreatic cancer. PMID: 24289472 Ref: MDM2 SNP309 is an ethnicity-dependent risk factor for digestive tract cancers. PMID: 24338709 Ref: Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells. PMID: 24415872 Ref: PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines. PMID: 24838627 Ref: Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer. PMID: 24889936 Ref: Netrin-1 promoted pancreatic cancer cell proliferation by upregulation of Mdm2. PMID: 25001177 Ref: Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. PMID: 25016295 Ref: A genetically engineered mouse model developing rapid progressive pancreatic ductal adenocarcinoma. PMID: 25042889 Ref: AKT regulates NPM dependent ARF localization and p53mut stability in tumors. PMID: 25071014 Ref: [The role of Gli1 in the invasion and migration of pancreatic cancer cells]. PMID: 25262609 Ref: [The relationship and clinicopathological significance of Numb,MDM2 and p53 expression in human pancreatic cancer]. PMID: 25410780 Ref: Epithelial cell-derived periostin functions as a tumor suppressor in gastric cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14ARF/Mdm2 signaling pathway. PMID: 25486483 |
Ref: Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. PMID: 26042602 Ref: The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1). PMID: 26228206 Ref: Expression of p53 synergistically augments caspases-mediated apoptosis induced by replication-competent adenoviruses in pancreatic carcinoma cells. PMID: 26251031 |
Ref: Dual inhibition of nuclear factor kappa-B and Mdm2 enhance the antitumor effect of radiation therapy for pancreatic cancer. PMID: 26546875 Ref: CDKN2A mutations with p14 loss predisposing to multiple nerve sheath tumours, melanoma, dysplastic naevi and internal malignancies: a case series and review of the literature. PMID: 26876133 Ref: Metastatic multiple endocrine neoplasia type 1: report of one case. PMID: 28138639 |
Ref: Cooperation of Musashi-2, Numb, MDM2, and P53 in drug resistance and malignant biology of pancreatic cancer. PMID: 28223335 Ref: Association of MDM2 expression with shorter progression-free survival and overall survival in patients with advanced pancreatic cancer treated with gemcitabine-based chemotherapy. PMID: 28678832 Ref: miR-509-5p inhibits cellular proliferation and migration via targeting MDM2 in pancreatic cancer cells. PMID: 28979137 Ref: Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PMID: 29211796 Ref: Caveolin-1 is involved in DNA damage and repair signaling in X-irradiated Chang liver cells. PMID: 29270591 Ref: Synthesis, Biological Evaluation and Modeling Studies of New Pyrido[3,4-b]indole Derivatives as Broad-Spectrum Potent Anticancer Agents. PMID: 29354330 |
Ref: YY1 suppresses proliferation and migration of pancreatic ductal adenocarcinoma by regulating the CDKN3/MdM2/P53/P21 signaling pathway. PMID: 29168185 Ref: Inhibiting beta-Catenin by beta-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy. PMID: 29387014 Ref: Daxx Functions Are p53-Independent In Vivo. PMID: 29903771 Ref: Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals. PMID: 29980405 Ref: Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. PMID: 30069972 Ref: Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy. PMID: 30217928 Ref: Bioselection Reveals miR-99b and miR-485 as Enhancers of Adenoviral Oncolysis in Pancreatic Cancer. PMID: 30341009 |