Primary Site >> Stomach Cancer
Gene >> MDM2
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Ref: No evidence for functional inactivation of wild-type p53 protein by MDM2 overexpression in gastric carcinogenesis. PMID: 9875138 |
Ref: Molecular alterations in early gastric carcinomas. No apparent correlation with Helicobacter pylori status. PMID: 9930147 Ref: P53-protein accumulation and MDM2-protein overexpression in gastric carcinomas. No apparent correlation with survival. PMID: 10631716 |
Ref: Mdm2 gene amplification in gastric cancer correlation with expression of Mdm2 protein and p53 alterations. PMID: 10874665 Ref: [Gastric cancer and tumor growth regulation. Study of cell proliferation markers and protein complex p53/p21WAF1/CIP1/mdm-2]. PMID: 10962880 |
Ref: MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain. PMID: 12739007 Ref: Alterations of chromosomal copy number during progression of diffuse-type gastric carcinomas: metaphase- and array-based comparative genomic hybridization analyses of multiple samples from individual tumours. PMID: 14595756 |
Ref: [Relationship between gastric cancer and gene amplification of p14 and mdm2]. PMID: 14720371 Ref: [The mechanisms of gastric cancer development produced by the combination of Helicobacter pylori with Sterigmatocystin, a mycotoxin]. PMID: 15283159 |
Ref: Eradication of Helicobacter pylori reduced the immunohistochemical detection of p53 and MDM2 in gastric mucosa. PMID: 15946145 |
Ref: MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis. PMID: 16983111 Ref: Comparative study on cancer cell apoptosis between gastric and intestinal-type human gastric carcinoma. PMID: 17357486 |
Ref: Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanese population. PMID: 17690113 |
Ref: No association of MDM2 T309G polymorphism with susceptibility to Korean gastric cancer patients. PMID: 18348658 Ref: [Impact of PI3K /Akt /mdm2 signaling pathway on the sensitivity of gastric cancer cell line SGC7901 to doxorubicin]. PMID: 19062713 |
Ref: The Expression of Murine Double Minute 2 (MDM2) on Helicobacter pylori-Infected Intestinal Metaplasia and Gastric Cancer. PMID: 19308274 Ref: Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. PMID: 19477214 Ref: The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells. PMID: 19513507 Ref: Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients. PMID: 19751436 |
Ref: Inhibition of the p53-MDM2 interaction by adenovirus delivery of ribosomal protein L23 stabilizes p53 and induces cell cycle arrest and apoptosis in gastric cancer. PMID: 20020415 Ref: [Analysis of the P53 transcriptional activity in gastric cancer]. PMID: 20140870 Ref: [Atypical lipomatous tumors of the stomach. Clinical, morphological and molecular findings]. PMID: 20221763 Ref: PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. PMID: 20506484 Ref: Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. PMID: 20547161 Ref: Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. PMID: 21060154 |
Ref: Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells. PMID: 21205074 Ref: Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis. PMID: 21216524 Ref: Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. PMID: 21431817 Ref: Identification of DNA methylation changes associated with human gastric cancer. PMID: 22133303 Ref: Expression and significance of p53 and mdm2 in atypical intestinal metaplasia and gastric carcinoma. PMID: 22848253 |
Ref: Expression of p53-MDM2 feedback loop related proteins in different gastric pathologies in relation to Helicobacter pylori infection: implications in gastric carcinogenesis. PMID: 22306053 Ref: A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response. PMID: 22588298 Ref: Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways. PMID: 22963678 Ref: MicroRNA-149 inhibits proliferation and cell cycle progression through the targeting of ZBTB2 in human gastric cancer. PMID: 23144691 Ref: Giant gastric lipoma mimicking well-differentiated liposarcoma. PMID: 24834200 |
Ref: miR-17-5p/20a are important markers for gastric cancer and murine double minute 2 participates in their functional regulation. PMID: 23333058 Ref: MDM2 is a useful prognostic biomarker for resectable gastric cancer. PMID: 23347235 Ref: Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy. PMID: 23423487 Ref: MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis. PMID: 23451111 Ref: A functional polymorphism T309G in MDM2 gene promoter, intensified by Helicobacter pylori lipopolysaccharide, is associated with both an increased susceptibility and poor prognosis of gastric carcinoma in Chinese patients. PMID: 23506213 Ref: Association between MDM2 SNP309 T>G and risk of gastric cancer: a meta-analysis. PMID: 23679294 Ref: Somatostatin receptor 1, a novel EBV-associated CpG hypermethylated gene, contributes to the pathogenesis of EBV-associated gastric cancer. PMID: 23722468 Ref: Co-transduction of ribosomal protein L23 enhances the therapeutic efficacy of adenoviral-mediated p53 gene transfer in human gastric cancer. PMID: 23933826 Ref: Helicobacter pylori infection and MDM2 SNP309 association with gastric cancer susceptibility. PMID: 24010568 Ref: PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression. PMID: 24045667 Ref: The utility of immunohistochemistry for providing genetic information on tumors. PMID: 24065374 Ref: HZ08 reverse the aneuploidy-induced cisplatin-resistance in Gastric cancer by modulating the p53 pathway. PMID: 24183976 |
Ref: HDM2 regulation by AURKA promotes cell survival in gastric cancer. PMID: 24240108 Ref: MDM2 SNP309 is an ethnicity-dependent risk factor for digestive tract cancers. PMID: 24338709 Ref: Meta-analysis of the MDM2 T309G polymorphism and gastric cancer risk. PMID: 24377582 Ref: Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization. PMID: 24491355 Ref: Meta-analysis of associations between MDM2 SNP309 polymorphism and gastric cancer risk. PMID: 24649079 Ref: Genomic profile analysis of diffuse-type gastric cancers. PMID: 24690483 Ref: MDM2 oncogene, E3 ubiquitin protein ligase T309G polymorphism and risk of oesophageal or gastric cancer: meta-analysis of 15 studies. PMID: 25070969 Ref: MicroRNA-410 suppresses migration and invasion by targeting MDM2 in gastric cancer. PMID: 25136862 Ref: Effects of p53 codon 72 and MDM2 SNP309 polymorphisms on gastric cancer risk among the Iranian population. PMID: 25227851 Ref: Triptolide induces apoptosis of gastric cancer cells via inhibiting the overexpression of MDM2. PMID: 25280518 Ref: Role of p53 in the progression of gastric cancer. PMID: 25427447 Ref: Epithelial cell-derived periostin functions as a tumor suppressor in gastric cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14ARF/Mdm2 signaling pathway. PMID: 25486483 |
Ref: Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. PMID: 25080447 Ref: A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. PMID: 25307786 Ref: UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop. PMID: 25382750 Ref: Genetic association of single nucleotide polymorphisms in P53 pathway with gastric cancer risk in a Chinese Han population. PMID: 25479941 Ref: Arsenic sulfide, the main component of realgar, a traditional Chinese medicine, induces apoptosis of gastric cancer cells in vitro and in vivo. PMID: 25565771 Ref: Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. PMID: 25605238 Ref: Correction: HDM2 Regulation by AURKA Promotes Cell Survival in Gastric Cancer. PMID: 25646184 Ref: Semi-comprehensive analysis of gene amplification in gastric cancers using multiplex ligation-dependent probe amplification and fluorescence in situ hybridization. PMID: 25743022 Ref: Role of Delta133p53 in Tumor Necrosis Factor-induced survival of p53 functions in MKN45 gastric cancer cell line. PMID: 26214777 Ref: Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer. PMID: 26330014 Ref: Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China). PMID: 26373042 Ref: Genetic Polymorphism of MDM2 SNP309 in Patients with Helicobacter Pylori-Associated Gastritis. PMID: 26514489 Ref: Correlation between Patterns of Mdm2 SNIP 309 and Histopathological Severity of Helicobacter pylori Associated Gastritis in Thailand. PMID: 26625797 |
Ref: Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand. PMID: 27042174 Ref: MicroRNA-610 is downregulated in glioma cells, and inhibits proliferation and motility by directly targeting MDM2. PMID: 27485527 Ref: Upregulation of microRNA-370 promotes cell apoptosis and inhibits proliferation by targeting PTEN in human gastric cancer. PMID: 27499479 Ref: p53, a potential predictor of Helicobacter pylori infection-associated gastric carcinogenesis? PMID: 27556187 Ref: Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway. PMID: 27659528 |
Ref: hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation. PMID: 26370108 Ref: 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis. PMID: 28017829 Ref: Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib. PMID: 28417568 Ref: CMIP is oncogenic in human gastric cancer cells. PMID: 28944848 Ref: Identification of a novel YAP-14-3-3zeta negative feedback loop in gastric cancer. PMID: 29069755 Ref: Investigation of the association between the MDM2 T309G polymorphism and gastric cancer. PMID: 29181159 Ref: LRP6 targeting suppresses gastric tumorigenesis via P14(ARF)-Mdm2-P53-dependent cellular senescence. PMID: 29340077 Ref: Analysis of 12 variants in the development of gastric and colorectal cancers. PMID: 29358861 |
Ref: [Spindle-cell osteosclerotic bone lesion with MDM2 amplification]. PMID: 29209796 Ref: HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5-FU resistance by a p53-dependent pathway. PMID: 29436749 Ref: Inhibition of IAP's and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with Scutellarein. PMID: 29464049 Ref: Melatonin induces the apoptosis and inhibits the proliferation of human gastric cancer cells via blockade of the AKT/MDM2 pathway. PMID: 29484412 Ref: Prader-Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p. PMID: 29535266 Ref: A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma. PMID: 29716622 Ref: The MDM2 rs937283 A > G variant significantly increases the risk of lung and gastric cancer in Chinese population. PMID: 29777315 Ref: Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2. PMID: 29793321 Ref: Lifestyle chemical carcinogens associated with mutations in cell cycle regulatory genes increases the susceptibility to gastric cancer risk. PMID: 30209766 Ref: Using a panel of multiple tumor-associated antigens to enhance autoantibody detection for immunodiagnosis of gastric cancer. PMID: 30221047 Ref: Double amplifications of CDK4 and MDM2 in a gastric inflammatory myofibroblastic tumor mimicking cancer with local invasion of the spleen and diaphragm. PMID: 30252584 Ref: Role of screening colonoscopy for colorectal tumors in Helicobacter pylori-related chronic gastritis with MDM2 SNP309 G/G homozygous: A prospective cross-sectional study in Thailand. PMID: 30260777 Ref: PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis. PMID: 30334411 |