Primary Site >> Colorectal Cancer
Gene >> MDM2
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Immunohistochemically detectable p53 and mdm-2 oncoprotein expression in colorectal carcinoma: prognostic significance. PMID: 16695968 |
Ref: An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines. PMID: 8631022 Ref: Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells. PMID: 8668331 |
Ref: Biomarkers for predicting response to regional chemo-immunotherapy in liver metastases from colorectal carcinoma. PMID: 9637342 |
Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 Ref: Expression of mdm2 and p53 in epithelial neoplasms of the colorectum. PMID: 9624416 |
Ref: Excess beta-catenin promotes accumulation of transcriptionally active p53. PMID: 10357817 Ref: bcl-2 protein expression is associated with better prognosis in colorectal cancer. PMID: 10564391 |
Ref: MDM2/p53 protein expression in the development of colorectal adenocarcinoma. PMID: 10631371 Ref: Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. PMID: 10646864 Ref: Staining patterns of p53 immunohistochemistry and their biological significance in colorectal cancer. PMID: 10699994 Ref: Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. PMID: 10772681 Ref: p53 gene status and expression of p53, mdm2, and p21Waf1/Cip1 proteins in colorectal cancer. PMID: 11037343 Ref: A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer. PMID: 11072252 |
Ref: Modulation of protein kinase C in antitumor treatment. PMID: 11190577 Ref: Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer. PMID: 11232644 Ref: p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. PMID: 11306450 Ref: Cell differentiation and chemotherapy influence p53 and Mdm2 immunoreactivity in human HT29 colon cancer cells grown in scid mice. PMID: 11311495 Ref: Serous tumors of low malignant potential of the ovary-molecular pathology: part 2. PMID: 11469685 Ref: Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival. PMID: 11523051 |
Ref: Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms. PMID: 11894120 Ref: mdm2-p53 Interaction: lack of correlation with the response to 5-fluorouracil in advanced colorectal cancer. PMID: 12065876 Ref: Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. PMID: 12082636 Ref: Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms. PMID: 12149568 Ref: Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. PMID: 12151395 Ref: The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. PMID: 12174820 |
Ref: Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. PMID: 12589031 Ref: The early response of p53-dependent proteins during radiotherapy in human rectal carcinoma and in adjacent normal tissue. PMID: 14532965 Ref: Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2. PMID: 14614330 |
Ref: Regulation of p53 stability and function in HCT116 colon cancer cells. PMID: 14665630 Ref: Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis. PMID: 15010835 Ref: beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate. PMID: 15073048 Ref: p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. PMID: 15123817 Ref: Altered vegetable intake affects pivotal carcinogenesis pathways in colon mucosa from adenoma patients and controls. PMID: 15271855 Ref: Dysfunction of p53 pathway in human colorectal cancer: analysis of p53 gene mutation and the expression of the p53-associated factors p14ARF, p33ING1, p21WAF1 and MDM2. PMID: 15375540 Ref: Effect of pH on radiation-induced p53 expression. PMID: 15519799 |
Ref: Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. PMID: 15753391 Ref: High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. PMID: 15930362 Ref: Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells. PMID: 15958644 Ref: The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck. PMID: 16141004 Ref: Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. PMID: 16179498 Ref: p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome. PMID: 16203772 Ref: Differential expression of Janus kinase 3 (JAK3), matrix metalloproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays. PMID: 16308103 |
Ref: Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression. PMID: 15921850 Ref: Downregulation of MDM2 expression by RNAi inhibits LoVo human colorectal adenocarcinoma cells growth and the treatment of LoVo cells with mdm2siRNA3 enhances the sensitivity to cisplatin. PMID: 16297858 Ref: Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. PMID: 16478747 Ref: Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis. PMID: 16508011 Ref: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. PMID: 16574813 Ref: cDNA array analysis for prediction of hepatic metastasis of colorectal carcinoma. PMID: 16794795 Ref: Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. PMID: 16797627 Ref: Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors. PMID: 16949053 |
Ref: Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells. PMID: 16825434 Ref: MDM2 SNP309 T>G alone or in combination with the TP53 R72P polymorphism does not appear to influence disease expression and age of diagnosis of colorectal cancer in HNPCC patients. PMID: 17096342 Ref: Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner. PMID: 17135250 Ref: Microsatellite instability in Ewing tumor is not associated with loss of mismatch repair protein expression. PMID: 17530287 Ref: p21 (CDKN1A) is a negative regulator of p53 stability. PMID: 17585201 Ref: MDM2 SNP309 and cancer risk: a combined analysis. PMID: 17827408 Ref: A proteomics analysis of cell signaling alterations in colorectal cancer. PMID: 17848589 Ref: p53 and mdm2 expression in colorectal carcinoma: a correlative analysis with clinical staging and histological parameters. PMID: 17913939 Ref: Cyclin-dependent kinase inhibitors sensitize tumor cells to nutlin-induced apoptosis: a potent drug combination. PMID: 18025259 Ref: Hsp27 modulates p53 signaling and suppresses cellular senescence. PMID: 18089808 |
Ref: Potential role of apoptosis and apoptotic regulatory proteins in colorectal neoplasia: correlations with clinico-pathological parameters and survival. PMID: 17562177 Ref: Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. PMID: 17620308 Ref: Curcumin as "Curecumin": from kitchen to clinic. PMID: 17900536 Ref: Abberant crypt foci -- importance in colorectal carcinogenesis and expression of p53 and mdm2: a changing concept. PMID: 18080767 Ref: Regulation of MDMX expression by mitogenic signaling. PMID: 18172009 Ref: IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells. PMID: 18294957 Ref: MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers. PMID: 18314481 Ref: Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer. PMID: 18381604 Ref: A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model. PMID: 18418047 Ref: Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity. PMID: 18442038 Ref: E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. PMID: 18521084 Ref: Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer. PMID: 18566224 Ref: MDM2 mRNA expression in the p53 pathway may predict the potential of invasion and liver metastasis in colorectal cancer. PMID: 18607552 Ref: Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. PMID: 18677110 Ref: Full-length hdmX transcripts decrease following genotoxic stress. PMID: 18711402 Ref: [Genetic polymorphism in MDM2 is associated with susceptibility to colorectal cancer in a Chinese population]. PMID: 18953830 Ref: Statistical strategies to improve the efficiency of molecular studies of colorectal cancer prognosis. PMID: 19018265 |
Ref: Genotyping of single nucleotide polymorphism in MDM2 genes by universal fluorescence primer PCR and capillary electrophoresis. PMID: 19015838 Ref: Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening. PMID: 19424582 Ref: Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. PMID: 19690970 Ref: Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. PMID: 19846903 |
Ref: Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells. PMID: 19577358 Ref: DNA damage response to the Mdm2 inhibitor nutlin-3. PMID: 19788889 Ref: A novel E1B-55kD-deleted oncolytic adenovirus carrying mutant KRAS-regulated hdm2 transgene exerts specific antitumor efficacy on colorectal cancer cells. PMID: 20124454 Ref: Recent patents and advances in genomic biomarker discovery for colorectal cancers. PMID: 20426761 Ref: MDM2 gene amplification in colorectal cancer is associated with disease progression at the primary site, but inversely correlated with distant metastasis. PMID: 20461754 Ref: Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. PMID: 21060154 Ref: Molecular prognostic factors in rectal cancer treated by preoperative chemoradiotherapy. PMID: 22966250 |
Ref: MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis. PMID: 20503107 Ref: Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. PMID: 20812030 Ref: TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. PMID: 21051533 Ref: MDM2 gene amplification and protein expressions in colon carcinoma: is targeting MDM2 a new therapeutic option? PMID: 21113617 Ref: Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. PMID: 21317874 Ref: A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. PMID: 21338495 Ref: LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression. PMID: 21491996 Ref: Rare MDM4 gene amplification in colorectal cancer: The principle of a mutually exclusive relationship between MDM alteration and TP53 inactivation is not applicable. PMID: 21503588 Ref: Diosgenin suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition by down-regulation of Mdm2 and vimentin. PMID: 21504235 Ref: Synchronized release of Doxil and Nutlin-3 by remote degradation of polysaccharide matrices and its possible use in the local treatment of colorectal cancer. PMID: 22082104 Ref: Cancer: Mdm2-regulated stabilization of HuR by neddylation in HCC and colon cancer--a possible target for therapy. PMID: 22158377 Ref: Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. PMID: 22195963 |
Ref: Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells. PMID: 21557332 Ref: Identification of spliced variants of the proto-oncogene HDM2 in colorectal cancer. PMID: 21761395 Ref: MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis. PMID: 21770737 Ref: MDM2 SNP309 polymorphism and colorectal cancer risk: appraisal of a recent meta-analysis. PMID: 22066579 Ref: Expression of SPRR3 is associated with tumor cell proliferation in less advanced stages of breast cancer. PMID: 22076481 Ref: Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. PMID: 22086925 Ref: Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. PMID: 22095636 Ref: Abrogation of Gli3 expression suppresses the growth of colon cancer cells via activation of p53. PMID: 22227409 Ref: MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PMID: 22235338 Ref: Impact of MDM2 polymorphism: increased risk of developing colorectal cancer and a poor prognosis in the Tunisian population. PMID: 22266832 Ref: Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma. PMID: 22438068 Ref: Hypermethylation of the 5' CpG island of the p14ARF flanking exon 1beta in human colorectal cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression. PMID: 22703554 Ref: Cross-regulation of protein stability by p53 and nuclear receptor SHP. PMID: 22737255 Ref: Polymorphisms in TP53 and MDM2 contribute to higher risk of colorectal cancer in Chinese population: a hospital-based, case-control study. PMID: 22744426 Ref: Study of the Murine Double Minute 2 status in patients with gastric and colorectal carcinomas and its correlation with prognostic factors. PMID: 22771642 Ref: MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame. PMID: 22870278 Ref: Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines. PMID: 22895844 Ref: Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer. PMID: 22912557 Ref: Identification of HEXIM1 as a positive regulator of p53. PMID: 22948151 |
Ref: A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. PMID: 22292771 Ref: Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population. PMID: 22914606 Ref: Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway. PMID: 23246487 Ref: Synthesis and evaluation of an imidazole derivative-fluorescein conjugate. PMID: 23477941 Ref: Do CDKN2 p16 540 C>G, CDKN2 p16 580 C>T, and MDM2 SNP309 T>G gene variants act on colorectal cancer development or progression? PMID: 23777425 Ref: Regulation of hypoxia-inducible factor 1alpha (HIF-1alpha) by lysophosphatidic acid is dependent on interplay between p53 and Kruppel-like factor 5. PMID: 23880760 Ref: Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk. PMID: 23912932 Ref: An updated meta-analysis on the association of MDM2 SNP309 polymorphism with colorectal cancer risk. PMID: 24098760 Ref: Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress. PMID: 24225777 Ref: PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context. PMID: 24336083 Ref: [Application of genome-wide genechip for screening and identifying genes related to CD133(+)CD200(+) colorectal cancer stem cells]. PMID: 24369246 |
Ref: Biological significance of promoter hypermethylation of p14/ARF gene: relationships to p53 mutational status in Tunisian population with colorectal carcinoma. PMID: 24065196 Ref: p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors. PMID: 24281001 Ref: Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. PMID: 24481553 Ref: Prospective virtual screening for novel p53-MDM2 inhibitors using ultrafast shape recognition. PMID: 24554192 Ref: Swietenia macrophylla King induces mitochondrial-mediated apoptosis through p53 upregulation in HCT116 colorectal carcinoma cells. PMID: 24613274 Ref: Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma. PMID: 24621249 Ref: Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. PMID: 24643130 Ref: MDM2 SNP309 polymorphism is associated with colorectal cancer risk. PMID: 24797837 Ref: Synergistic cooperation of MDM2 and E2F1 contributes to TAp73 transcriptional activity. PMID: 24845566 Ref: Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction. PMID: 24852275 Ref: SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. PMID: 25145672 Ref: MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling. PMID: 25193859 Ref: LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. PMID: 25323535 Ref: Gene expression profile of peripheral blood in colorectal cancer. PMID: 25339833 Ref: Pokemon enhances proliferation, cell cycle progression and anti-apoptosis activity of colorectal cancer independently of p14ARF-MDM2-p53 pathway. PMID: 25367850 Ref: Novel roles for p53 in the genesis and targeting of tetraploid cancer cells. PMID: 25380055 Ref: Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. PMID: 25384157 Ref: FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX. PMID: 25512388 |
Ref: L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells. PMID: 25168242 Ref: A novel pyrido-thieno-pyrimidine derivative activates p53 through induction of phosphorylation and acetylation in colorectal cancer cells. PMID: 25338966 Ref: Identification of antipsychotic drug fluspirilene as a potential p53-MDM2 inhibitor: a combined computational and experimental study. PMID: 25377899 Ref: UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop. PMID: 25382750 Ref: Impact of the Mdm2(SNP309-G) allele on a murine model of colorectal cancer. PMID: 25435368 Ref: TP53 Arg 72Pro and MDM2 SNP309 polymorphisms and colorectal cancer risk: a west Algerian population study. PMID: 25537146 Ref: MiR-194, commonly repressed in colorectal cancer, suppresses tumor growth by regulating the MAP4K4/c-Jun/MDM2 signaling pathway. PMID: 25602366 Ref: Modulation of intracellular calcium levels by calcium lactate affects colon cancer cell motility through calcium-dependent calpain. PMID: 25629974 Ref: RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal cancer cell to docetaxel. PMID: 25638156 Ref: CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo. PMID: 25663456 Ref: Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients. PMID: 25742468 Ref: SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation. PMID: 25871776 Ref: The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning. PMID: 25955646 Ref: Growth inhibitory effect of adenovirus-mediated tissue-targeted expression of ribosomal protein L23 on human colorectal carcinoma cells. PMID: 26044651 Ref: miRNA-26b Overexpression in Ulcerative Colitis-associated Carcinogenesis. PMID: 26083618 Ref: LIF is a new p53 negative regulator. PMID: 26161442 Ref: A Thiol-Ene Coupling Approach to Native Peptide Stapling and Macrocyclization. PMID: 26189498 Ref: Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. PMID: 26294215 Ref: Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets. PMID: 26446703 Ref: Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy. PMID: 26462020 Ref: p53 Configures the G2/M Arrest Response of Nucleostemin-Deficient Cells. PMID: 26835157 |
Ref: The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer. PMID: 25408419 Ref: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. PMID: 26152521 Ref: CRISPR-Cas9-based target validation for p53-reactivating model compounds. PMID: 26595461 Ref: Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53. PMID: 26636733 Ref: Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex. PMID: 26726742 Ref: Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells by PML and p53. PMID: 26795951 Ref: microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. PMID: 26840028 Ref: Piperlongumine exerts cytotoxic effects against cancer cells with mutant p53 proteins at least in part by restoring the biological functions of the tumor suppressor. PMID: 26848023 Ref: Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity. PMID: 26864072 Ref: Prospective evaluation of 64 serum autoantibodies as biomarkers for early detection of colorectal cancer in a true screening setting. PMID: 26909861 Ref: Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation. PMID: 26957954 Ref: Design, synthesis and biological evaluation of novel benzimidazole-2-substituted phenyl or pyridine propyl ketene derivatives as antitumour agents. PMID: 27017265 Ref: Modeling the Etiology of p53-mutated Cancer Cells. PMID: 27022024 Ref: Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate. PMID: 27081698 Ref: Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases. PMID: 27218826 Ref: Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer. PMID: 27417709 Ref: Crocodile blood extract induces the apoptosis of lung cancer cells through PTEN activity. PMID: 27431918 Ref: MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer. PMID: 27624283 Ref: Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. PMID: 27634879 Ref: Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. PMID: 27748879 Ref: Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53. PMID: 28008906 |
Ref: Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis. PMID: 27617574 Ref: Novel mouse model recapitulates genome and transcriptome alterations in human colorectal carcinomas. PMID: 27750367 Ref: ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1. PMID: 27965283 Ref: BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer. PMID: 28073006 Ref: Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells. PMID: 28103302 Ref: MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk. PMID: 28158999 Ref: USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. PMID: 28216017 Ref: NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway. PMID: 28418896 Ref: Apoptosis-induced effects of extract from Artemisia annua Linne by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. PMID: 28454566 Ref: PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth. PMID: 28542136 Ref: PNC27 anticancer peptide as targeting ligand significantly improved antitumor efficacy of Doxil in HDM2-expressing cells. PMID: 28565974 Ref: Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10. PMID: 28587923 Ref: Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients. PMID: 28692053 Ref: Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers. PMID: 28783173 Ref: In vitro targeting of colon cancer cells using spiropyrazoline oxindoles. PMID: 28800455 Ref: Primary colonic well-differentiated / dedifferentiated liposarcoma of the ascending colon: a case report. PMID: 28856628 Ref: Colorectal carcinoma with osseous metaplasia. PMID: 29029440 Ref: A Proteomics Analysis Reveals 9 Up-Regulated Proteins Associated with Altered Cell Signaling in Colon Cancer Patients. PMID: 29128960 Ref: LRP6 targeting suppresses gastric tumorigenesis via P14(ARF)-Mdm2-P53-dependent cellular senescence. PMID: 29340077 Ref: Analysis of 12 variants in the development of gastric and colorectal cancers. PMID: 29358861 |
Ref: Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis. PMID: 28960612 Ref: Simvastatin enhances the radiosensitivity of p53deficient cells via inhibition of mouse double minute 2 homolog. PMID: 29115437 Ref: DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. PMID: 29394130 Ref: Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment. PMID: 29631612 Ref: TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma. PMID: 29653964 Ref: Cyclophilin B induces chemoresistance by degrading wild-type p53 via interaction with MDM2 in colorectal cancer. PMID: 29876924 Ref: LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation. PMID: 29899406 Ref: Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity. PMID: 30041135 Ref: Bevacizumab-enhanced antitumor effect of 5-fluorouracil via upregulation of thymidine phosphorylase through vascular endothelial growth factor A/vascular endothelial growth factor receptor 2-specificity protein 1 pathway. PMID: 30151975 Ref: HMGA2 promotes intestinal tumorigenesis by facilitating MDM2-mediated ubiquitination and degradation of p53. PMID: 30175854 Ref: Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan. PMID: 30194081 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 Ref: RASSF1A suppresses colorectal tumor cell growth through p53-dependent p21(WAF1) activation. PMID: 30226276 Ref: The Study of MDM2 rs937283 Variant and Cancer Susceptibility in a Central Chinese Population. PMID: 30244662 Ref: Role of screening colonoscopy for colorectal tumors in Helicobacter pylori-related chronic gastritis with MDM2 SNP309 G/G homozygous: A prospective cross-sectional study in Thailand. PMID: 30260777 Ref: Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5. PMID: 30271790 Ref: PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis. PMID: 30334411 Ref: Induction of Apoptosis and Cell-Cycle Arrest in Human Colon-Cancer Cells by Whole-Grain Alkylresorcinols via Activation of the p53 Pathway. PMID: 30354111 Ref: UBA2 promotes proliferation of colorectal cancer. PMID: 30387828 |