Primary Site >> Colorectal Cancer
Gene >> MBD4
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Ref: Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. PMID: 10637515 |
Ref: Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer. PMID: 10934138 |
Ref: Alterations of repeated sequences in 5' upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome. PMID: 11526511 |
Ref: Frameshift mutations in the MBD4/MED1 gene in primary gastric cancer with high-frequency microsatellite instability. PMID: 12430186 |
Ref: Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer. PMID: 12591727 Ref: Microsatellite instability and MBD4 mutation in unselected colorectal cancer. PMID: 12926109 |
Ref: Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer. PMID: 16421660 Ref: Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH. PMID: 16831587 |
Ref: A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells. PMID: 17285135 |
Ref: Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer. PMID: 18097604 Ref: Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. PMID: 18162445 |
Ref: Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer. PMID: 19127118 Ref: The Glu346Lys polymorphism and frameshift mutations of the Methyl-CpG Binding Domain 4 gene in gastrointestinal cancer. PMID: 19469655 Ref: Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer. PMID: 19787250 |
Ref: Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency. PMID: 22608206 |
Ref: Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity. PMID: 23643670 |
Ref: Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. PMID: 26503472 |
Ref: The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury. PMID: 27086921 Ref: Production of truncated MBD4 protein by frameshift mutation in DNA mismatch repair-deficient cells enhances 5-fluorouracil sensitivity that is independent of hMLH1 status. PMID: 27115207 |
Ref: MBD4 frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cells. PMID: 29545913 |