Primary Site >> Liver Cancer
Gene >> MAT1A
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance. PMID: 8903381 |
Ref: Structure of the rat methionine adenosyltransferase 2A gene and its promoter. PMID: 9461287 |
Ref: Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. PMID: 9537246 |
Ref: Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat. PMID: 10216131 |
Ref: Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation. PMID: 10627284 Ref: Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 1A gene. PMID: 10677369 Ref: Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. PMID: 11131452 |
Ref: Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. PMID: 11208539 Ref: The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma. PMID: 11427482 |
Ref: Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. PMID: 12060674 |
Ref: Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine. PMID: 12631701 Ref: Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. PMID: 12671891 Ref: Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1. PMID: 14530285 |
Ref: Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. PMID: 15033934 Ref: Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. PMID: 15067322 Ref: WITHDRAWN: Silencing of human methionine adenosyltransferase 1A expression by methylation of the coding region. PMID: 15590672 |
Ref: Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis. PMID: 15498786 Ref: Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. PMID: 16054984 Ref: Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis. PMID: 16252306 |
Ref: Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases. PMID: 16602702 Ref: S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. PMID: 16614071 |
Ref: Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. PMID: 17154373 Ref: Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells. PMID: 17441811 Ref: Dissection of signal transduction pathways as a tool for the development of targeted therapies of hepatocellular carcinoma. PMID: 18474008 |
Ref: Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta. PMID: 18041713 Ref: Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells. PMID: 18045590 Ref: Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. PMID: 18167064 Ref: S-Adenosylmethionine in cell growth, apoptosis and liver cancer. PMID: 18336669 Ref: S-adenosylmethionine and proliferation: new pathways, new targets. PMID: 18793149 |
Ref: S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis. PMID: 18983843 Ref: CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. PMID: 19115422 |
Ref: HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. PMID: 20102719 Ref: Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. PMID: 20363925 Ref: Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. PMID: 20815019 Ref: Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. PMID: 20890892 |
Ref: The X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production. PMID: 21247894 |
Ref: Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation. PMID: 21678410 Ref: Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine. PMID: 22270009 Ref: Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. PMID: 22318685 Ref: S-adenosylmethionine in liver health, injury, and cancer. PMID: 23073625 |
Ref: Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer. PMID: 23588207 Ref: Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. PMID: 23665184 Ref: MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth. PMID: 24098708 Ref: 5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production. PMID: 24377546 |
Ref: Structure and function study of the complex that synthesizes S-adenosylmethionine. PMID: 25075345 Ref: New insights on the role of epigenetic alterations in hepatocellular carcinoma. PMID: 27508177 |
Ref: Deregulated methionine adenosyltransferase alpha1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(double dagger). PMID: 26969892 |
Ref: Prohibitin 1 suppresses liver cancer tumorigenesis in mice and human hepatocellular and cholangiocarcinoma cells. PMID: 27981602 Ref: Tumor-suppressive effect of S-adenosylmethionine supplementation in a murine model of inflammation-mediated hepatocarcinogenesis is dependent on treatment longevity. PMID: 29285212 |
Ref: Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy. PMID: 29141455 Ref: Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma. PMID: 29448301 Ref: Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. PMID: 29733835 Ref: A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis. PMID: 29749642 Ref: SNHG6 Acts as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297-Mediated S-Adenosylmethionine-Dependent Positive Feedback Loops. PMID: 29844127 Ref: Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma. PMID: 30050996 |