Primary Site >> Colorectal Cancer
Gene >> MAPK8
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Ref: In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. PMID: 9352861 Ref: Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells. PMID: 9354428 Ref: ErbB kinases and NDF signaling in human prostate cancer cells. PMID: 9400997 |
Ref: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. PMID: 9622070 Ref: Analysis of signaling protein kinases in human colon or colorectal carcinomas. PMID: 9690379 |
Ref: Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells. PMID: 10086335 Ref: Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells. PMID: 10344756 Ref: 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation. PMID: 10585423 |
Ref: Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. PMID: 10864208 Ref: Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades. PMID: 11085935 |
Ref: PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics. PMID: 11156952 Ref: Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis. PMID: 11159738 Ref: Butyric acid induces apoptosis by up-regulating Bax expression via stimulation of the c-Jun N-terminal kinase/activation protein-1 pathway in human colon cancer cells. PMID: 11208715 Ref: Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1. PMID: 11278263 Ref: NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps. PMID: 11314016 Ref: Alterations of MAPK activities associated with intestinal cell differentiation. PMID: 11394874 Ref: DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells. PMID: 11494044 Ref: Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway. PMID: 11806247 |
Ref: Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. PMID: 11706006 Ref: Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. PMID: 11894124 Ref: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. PMID: 11910351 Ref: Molecular cloning and characterization of WRCH2 on human chromosome 15q15. PMID: 11956592 Ref: Frequent up-regulation of WNT5A mRNA in primary gastric cancer. PMID: 11956659 Ref: The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. PMID: 11992399 Ref: Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells. PMID: 12203364 Ref: Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice. PMID: 12207005 Ref: Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. PMID: 12221076 Ref: Red wine polyphenols inhibit the growth of colon carcinoma cells and modulate the activation pattern of mitogen-activated protein kinases. PMID: 12221251 Ref: Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. PMID: 12239632 Ref: Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation. PMID: 12383707 Ref: Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. PMID: 12417302 Ref: Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A. PMID: 12450255 |
Ref: Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. PMID: 12759338 Ref: Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. PMID: 12819184 Ref: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. PMID: 12819185 Ref: Enhanced sensitivity to cis-diamminedichloroplatinum(II) of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21(WAF1) expression. PMID: 12824923 Ref: Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling. PMID: 14506233 Ref: MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2. PMID: 14511767 Ref: Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. PMID: 14556662 Ref: Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. PMID: 14583480 Ref: The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines. PMID: 14608117 |
Ref: Quantitative effects on c-Jun N-terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines. PMID: 14722256 Ref: Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death. PMID: 14749540 Ref: Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line. PMID: 15139522 Ref: Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. PMID: 15177310 Ref: C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression. PMID: 15205382 Ref: Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. PMID: 15256484 Ref: Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease. PMID: 15275879 Ref: Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-g PMID: 15289320 Ref: Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells. PMID: 15298620 Ref: Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or wounding. PMID: 15331629 Ref: Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. PMID: 15334063 Ref: [Complex forms of immune insufficiency to some cytokines (TNF-alpha, interferons) in colorectal cancers as exemplified by the COLO 205 cell line. Mechanism of resistance with special reference to signaling proteins and cytokines]. PMID: 15577750 |
Ref: The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. PMID: 15592505 Ref: Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK. PMID: 15611081 Ref: Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells. PMID: 15655348 Ref: TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation. PMID: 15665513 Ref: Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53. PMID: 15710360 Ref: Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. PMID: 15735759 Ref: Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. PMID: 15743787 Ref: Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade. PMID: 15774489 Ref: Butyrate-induced differentiation of colon cancer cells is PKC and JNK dependent. PMID: 15810631 Ref: Wnt signaling in lung cancer. PMID: 15837535 Ref: Role of intracellular glutathione in cell sensitivity to the apoptosis induced by tumor necrosis factor {alpha}-related apoptosis-inducing ligand/anticancer drug combinations. PMID: 15837763 Ref: (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. PMID: 15860507 Ref: The MAPK signalling pathways and colorectal cancer. PMID: 15863380 Ref: Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells. PMID: 15918186 Ref: Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway. PMID: 15956247 Ref: Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells. PMID: 16024641 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation. PMID: 16125170 Ref: JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells. PMID: 16179969 Ref: 4-hydroxynonenal and TGF-beta1 concur in inducing antiproliferative effects on the CaCo-2 human colon adenocarcinoma cell line. PMID: 16403984 |
Ref: Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation. PMID: 16169935 Ref: p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. PMID: 16170570 Ref: Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. PMID: 16215992 Ref: Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers. PMID: 16337741 Ref: TAK1-mediated stress signaling pathways are essential for TNF-alpha-promoted pulmonary metastasis of murine colon cancer cells. PMID: 16385569 Ref: Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways. PMID: 16442704 Ref: Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. PMID: 16449643 Ref: Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. PMID: 16475687 Ref: Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells. PMID: 16497702 Ref: Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells. PMID: 16501251 Ref: Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis. PMID: 16528675 Ref: Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways. PMID: 16546990 Ref: Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. PMID: 16715131 Ref: c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-beta1 and 4-hydroxynonenal in colon mucosa. PMID: 16843825 Ref: 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation. PMID: 17085668 Ref: TGF-beta during human colorectal carcinogenesis: the shift from epithelial to mesenchymal signaling. PMID: 17093904 Ref: Modulation of the cell cycle and induction of apoptosis in human cancer cells by synthetic bile acids. PMID: 17168673 |
Ref: The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. PMID: 16912864 Ref: Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells. PMID: 17049495 Ref: Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis. PMID: 17191116 Ref: NF-kappaB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells. PMID: 17226769 Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo. PMID: 17292881 Ref: A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. PMID: 17296806 Ref: TNF potentiates anticancer activity of bortezomib (Velcade) through reduced expression of proteasome subunits and dysregulation of unfolded protein response. PMID: 17373661 Ref: Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. PMID: 17390031 Ref: Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase. PMID: 17465197 Ref: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. PMID: 17478078 Ref: Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells. PMID: 17510397 Ref: Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6. PMID: 17519236 Ref: c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. PMID: 17591974 Ref: Bone morphogenetic protein-4 inhibits heat-induced apoptosis by modulating MAPK pathways in human colon cancer HCT116 cells. PMID: 17640799 Ref: Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. PMID: 17656449 Ref: Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. PMID: 17671748 Ref: Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. PMID: 17673978 Ref: Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition. PMID: 17699782 Ref: The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro. PMID: 17936921 Ref: [Regulation of promatrilysin expression by tissue factor/actived coagulation factor VII complex in LoVo colon cancer cell line]. PMID: 17940558 Ref: Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion. PMID: 17982677 |
Ref: Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells. PMID: 17657594 Ref: Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events. PMID: 18032477 Ref: Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/beta-catenin pathway. PMID: 18037152 Ref: Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells. PMID: 18043130 Ref: Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells. PMID: 18045590 Ref: Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29). PMID: 18084318 Ref: A sensitive flow cytometry-based nucleotide excision repair assay unexpectedly reveals that mitogen-activated protein kinase signaling does not regulate the removal of UV-induced DNA damage in human cells. PMID: 18093981 Ref: Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G. PMID: 18163459 Ref: Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. PMID: 18172863 Ref: Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (--)-epigallocatechin against HCT116 colorectal carcinoma cells. PMID: 18175946 Ref: Disruption of signaling through SEK1 and MKK7 yields differential responses in hypoxic colon cancer cells treated with oxaliplatin. PMID: 18436711 Ref: Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism. PMID: 18451518 Ref: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. PMID: 18460448 Ref: Involvement of Smad3 phosphoisoform-mediated signaling in the development of colonic cancer in IL-10-deficient mice. PMID: 18497983 Ref: Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. PMID: 18520051 Ref: JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase. PMID: 18535619 Ref: Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. PMID: 18594007 Ref: Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. PMID: 18596194 Ref: Pyrazino[1,2-b]isoquinolines: synthesis and study of their cytostatic and cytotoxic properties. PMID: 18799316 Ref: Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells. PMID: 18929641 Ref: Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin. PMID: 19112505 |
Ref: Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain. PMID: 19014919 Ref: Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways. PMID: 19038304 Ref: N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1. PMID: 19058178 Ref: p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047. PMID: 19138820 Ref: Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. PMID: 19232820 Ref: Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. PMID: 19289106 Ref: Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells. PMID: 19290007 Ref: MAP kinases in proliferating human colon cancer Caco-2 cells. PMID: 19301097 Ref: Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines. PMID: 19352384 Ref: Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancer. PMID: 19396842 Ref: Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. PMID: 19423215 Ref: NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer. PMID: 19499154 Ref: Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer. PMID: 19531654 Ref: Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620. PMID: 19563859 Ref: Suppression of dendritic cells by HMGB1 is associated with lymph node metastasis of human colon cancer. PMID: 19571604 Ref: 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. PMID: 19690198 Ref: Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway. PMID: 19735099 Ref: Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. PMID: 19773752 Ref: TNF-alpha downregulates E-cadherin and sensitizes response to gamma-irradiation in Caco-2 cells. PMID: 19809566 Ref: Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line. PMID: 19836435 Ref: Inhibitory effects of the ethanol extract of Gleditsia sinensis thorns on human colon cancer HCT116 cells in vitro and in vivo. PMID: 19885606 |
Ref: HSP70 interacts with TRAF2 and differentially regulates TNFalpha signalling in human colon cancer cells. PMID: 19243468 Ref: Butyrate-stimulated H2S production in colon cancer cells. PMID: 19803745 Ref: c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. PMID: 19833164 Ref: Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. PMID: 19882352 Ref: The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells. PMID: 19949342 Ref: Hypertonic environment elicits cyclooxygenase-2-driven prostaglandin E2 generation by colon cancer cells: role of cytosolic phospholipase A2-alpha and kinase signaling pathways. PMID: 20004562 Ref: Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1. PMID: 20017136 Ref: HMGB1 attenuates anti-metastatic defence of the liver in colorectal cancer. PMID: 20018503 Ref: Deoxycholic acid and selenium metabolite methylselenol exert common and distinct effects on cell cycle, apoptosis, and MAP kinase pathway in HCT116 human colon cancer cells. PMID: 20043263 Ref: Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection. PMID: 20111723 Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. PMID: 20136087 Ref: Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation. PMID: 20198313 Ref: Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. PMID: 20198339 Ref: AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma. PMID: 20220132 Ref: Inhibition of TNFalpha-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-kappaB- and MAPK-dependent mechanisms. PMID: 20224909 Ref: Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells. PMID: 20346929 Ref: PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. PMID: 20348951 Ref: 17beta-estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells. PMID: 20446020 Ref: ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. PMID: 20512919 Ref: Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors. PMID: 20544795 Ref: Signal transduction pathways associated with ATP-induced proliferation of colon adenocarcinoma cells. PMID: 20562007 Ref: Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M-phase cell cycle arrest and p53 expression. PMID: 20564491 Ref: Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways. PMID: 20581861 Ref: Phytate hydrolysate induces circumferential F-actin ring formation at cell-cell contacts by a Rho-associated kinase-dependent mechanism in colorectal cancer HT-29 cells. PMID: 20626001 Ref: JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative. PMID: 20683666 Ref: Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules. PMID: 20803769 Ref: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 20837473 Ref: Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells. PMID: 20859756 Ref: Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells. PMID: 20863062 Ref: GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells. PMID: 20888181 Ref: Enteric bacteria and cancer stem cells. PMID: 21297903 Ref: Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. PMID: 21614182 |
Ref: Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells--involvement of ROS generation and polyamine depletion. PMID: 20940027 Ref: Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. PMID: 21156789 Ref: Decursin and decursinol from Angelica gigas inhibit the lung metastasis of murine colon carcinoma. PMID: 21170925 Ref: c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex. PMID: 21196933 Ref: COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer. PMID: 21296766 Ref: JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Delta716) mice. PMID: 21320501 Ref: Targeting the JNK signaling pathway potentiates the antiproliferative efficacy of rapamycin in LS174T colon cancer cells. PMID: 21324487 Ref: RNA interference (RNAi) of Ufd1 protein can sensitize a hydroxycamptothecin-resistant colon cancer cell line SW1116/HCPT to hydroxycamptothecin. PMID: 21401896 Ref: Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression. PMID: 21418393 Ref: Involvement of ROS in Curcumin-induced Autophagic Cell Death. PMID: 21461234 Ref: Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells. PMID: 21467134 Ref: Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells. PMID: 21519792 Ref: The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. PMID: 21524306 Ref: Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53. PMID: 21557998 Ref: [Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms]. PMID: 21575515 Ref: Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation. PMID: 21653830 Ref: The Drosophila Netrin receptor frazzled/DCC functions as an invasive tumor suppressor. PMID: 21672235 Ref: Oxaliplatin sensitizes human colon cancer cells to TRAIL through JNK-dependent phosphorylation of Bcl-xL. PMID: 21683075 Ref: Downregulation of discoidin domain receptor 2 in A375 human melanoma cells reduces its experimental liver metastasis ability. PMID: 21701781 Ref: Enormous influence of TNIK knockdown on intracellular signals and cell survival. PMID: 21710359 Ref: Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. PMID: 21763418 Ref: Dimerumic acid inhibits SW620 cell invasion by attenuating H(2)O(2)-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner. PMID: 21814482 Ref: RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. PMID: 21834757 Ref: Cancer selective metallocenedicarboxylates of the fungal cytotoxin illudin M. PMID: 21848340 Ref: An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression. PMID: 21853123 Ref: JNK suppression is essential for 17beta-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. PMID: 21859479 Ref: 5-fluorouracil increases the chemopreventive potentials of resveratrol through DNA damage and MAPK signaling pathway in human colorectal cancer cells. PMID: 21936401 Ref: Tumor necrosis factor-related genes and colon and rectal cancer. PMID: 22199996 |
Ref: Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-kappaB in colon cancer cells. PMID: 21678498 Ref: The protective role of polymorphism MKK4-1304 T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus' infection status. PMID: 21702039 Ref: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. PMID: 21919080 Ref: Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. PMID: 21941373 Ref: Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. PMID: 21983885 Ref: Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. PMID: 22109108 Ref: Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells. PMID: 22134768 Ref: Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel. PMID: 22158036 Ref: Selenite-induced apoptosis and autophagy in colon cancer cells. PMID: 22200533 Ref: PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation. PMID: 22252525 Ref: p38alpha MAPK mediates 17beta-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells. PMID: 22377968 Ref: p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors. 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