Primary Site >> Stomach Cancer
Gene >> MAPK3
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Ref: Gastrin and phorbol 12-myristate 13-acetate regulate the human histidine decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric cancer cells. PMID: 9341140 |
Ref: Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells. PMID: 11413105 Ref: Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C-mediated mechanism. PMID: 11709203 |
Ref: ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas. PMID: 12204060 Ref: Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth. PMID: 12387866 Ref: [Inhibition of activator protein-1 on the growth of gastric cancer by octreotide]. PMID: 12478891 Ref: MAPK signaling is involved in camptothecin-induced cell death. PMID: 12521296 |
Ref: Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements. PMID: 12509426 Ref: Effect of inhibition of extracellular signal-regulated kinase 1 and 2 pathway on apoptosis and bcl-2 expression in Helicobacter pylori-infected AGS cells. PMID: 12540563 Ref: Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells. PMID: 12618892 Ref: P38 MAPK pathway is involved in the urokinase plasminogen activator expression in human gastric SNU-638 cells. PMID: 12883725 Ref: Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. PMID: 12907645 Ref: Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. PMID: 14531897 Ref: TGFbeta1 activates c-Jun and Erk1 via alphaVbeta6 integrin. PMID: 14572313 Ref: [Roles of ERK1/2 MAPK in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells]. PMID: 14963907 |
Ref: TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity. PMID: 14720123 Ref: Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended, but not in adherent, gastric carcinoma cells. PMID: 15067346 Ref: Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells. PMID: 15208668 Ref: Blockage of HSP 90 modulates Helicobacter pylori-induced IL-8 productions through the inactivation of transcriptional factors of AP-1 and NF-kappaB. PMID: 15240121 |
Ref: Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer. PMID: 15655810 Ref: Helicobacter pylori-dependent NF-kappa B activation in newly established Mongolian gerbil gastric cancer cell lines. PMID: 15771620 Ref: Transformed immortalized gastric epithelial cells by virulence factor CagA of Helicobacter pylori through Erk mitogen-activated protein kinase pathway. PMID: 15856031 Ref: Extracellular signal-regulated kinase and AP-1 pathways are involved in reactive oxygen species-induced urokinase plasminogen activator receptor expression in human gastric cancer cells. PMID: 15870884 Ref: Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells. PMID: 16230373 Ref: Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells. PMID: 16393120 |
Ref: Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3. PMID: 16472776 Ref: Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells. PMID: 16527552 Ref: Helicobacter pylori extract induces nuclear factor-kappa B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells. PMID: 16627221 Ref: Erk is involved in the differentiation induced by diallyl disulfide in the human gastric cancer cell line MGC803. PMID: 16874458 Ref: Cellular prion protein promotes invasion and metastasis of gastric cancer. PMID: 16877520 Ref: Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha. PMID: 16918998 Ref: Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis. PMID: 17088902 |
Ref: alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner. PMID: 16839662 Ref: Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines. PMID: 17001321 Ref: Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. PMID: 17003101 Ref: Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. PMID: 17214962 Ref: Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. PMID: 17363505 Ref: Hypoxia induced overexpression of PrP(C) in gastric cancer cell lines. PMID: 17387271 Ref: Involvement of MGr1-Ag/37LRP in the vincristine-induced HIF-1 expression in gastric cancer cells. PMID: 17476462 Ref: Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression. PMID: 17724739 Ref: Matrine inhibits the activity of translation factor eIF4E through dephosphorylation of 4E-BP1 in gastric MKN45 cells. PMID: 17823871 Ref: Triptolide inhibits tumor promoter-induced uPAR expression via blocking NF-kappaB signaling in human gastric AGS cells. PMID: 17970088 Ref: Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2. PMID: 18025257 Ref: Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin. PMID: 18365868 |
Ref: 12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway. PMID: 17522976 Ref: Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells. PMID: 17991709 Ref: Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. PMID: 18081943 Ref: Blockage of intracellular proton extrusion with proton extrusions with proton pump inhibitor induces apoptosis in gastric cancer. PMID: 18224727 Ref: Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. PMID: 18258606 Ref: CPT21, a novel compound with anti-proliferative effect against gastric cancer cell SGC7901. PMID: 18283417 Ref: Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion. PMID: 18381294 Ref: The effect of polysaccharide extracted from the marine alga Capsosiphon fulvescens on ethanol administration. PMID: 18524446 Ref: Constitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma. PMID: 18570890 Ref: EGF stimulates uPAR expression and cell invasiveness through ERK, AP-1, and NF-kappaB signaling in human gastric carcinoma cells. PMID: 19020743 Ref: Role of TMPRSS4 during cancer progression. PMID: 19034347 |
Ref: Inhibition of MEK blocks GRP78 up-regulation and enhances apoptosis induced by ER stress in gastric cancer cells. PMID: 18829155 Ref: Proliferative effects of gamma-aminobutyric acid on the gastric cancer cell line are associated with extracellular signal-regulated kinase 1/2 activation. PMID: 19032445 Ref: Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer. PMID: 19142899 Ref: Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. PMID: 19148483 Ref: Midkine positively regulates the proliferation of human gastric cancer cells. PMID: 19250738 Ref: Local angiotensin II-generation in human gastric cancer: correlation with tumor progression through the activation of ERK1/2, NF-kappaB and survivin. PMID: 19424575 Ref: Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. PMID: 19477214 |
Ref: Rapamycin enhances chemotherapy-induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells. PMID: 19856312 Ref: Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells. PMID: 20348091 Ref: Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines. PMID: 20428833 Ref: gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line. PMID: 20452389 Ref: Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells. PMID: 20460732 Ref: Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways. PMID: 20651362 Ref: Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. PMID: 20804754 Ref: Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. PMID: 20876799 Ref: CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation. PMID: 21047770 Ref: Mycoplasma hyorhinis infection in gastric carcinoma and its effects on the malignant phenotypes of gastric cancer cells. PMID: 21062494 |
Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways. PMID: 20498032 Ref: Arsenic trioxide induces apoptosis through JNK and ERK in human mesothelioma cells. PMID: 20799280 Ref: MSP-induced RON activation upregulates uPAR expression and cell invasiveness via MAPK, AP-1 and NF-kappaB signals in gastric cancer cells. PMID: 21081472 Ref: Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells. PMID: 21312237 Ref: 15-hydroxyprostaglandin dehydrogenase is downregulated and exhibits tumor suppressor activity in gastric cancer. PMID: 21469975 Ref: Human gastrin mRNA expression up-regulated by Helicobacter pylori CagA through MEK/ERK and JAK2-signaling pathways in gastric cancer cells. PMID: 21509655 Ref: Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells. PMID: 21672207 Ref: Interferon-alpha sensitizes human gastric cancer cells to TRAIL-induced apoptosis via activation of the c-CBL-dependent MAPK/ERK pathway. PMID: 21725207 Ref: Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cells. PMID: 21751384 Ref: Anti-tumor activity of the proteasome inhibitor bortezomib in gastric cancer. PMID: 21785822 |
Ref: Lymphatic endothelial cell-secreted CXCL1 stimulates lymphangiogenesis and metastasis of gastric cancer. PMID: 21387301 Ref: PTP1B expression contributes to gastric cancer progression. PMID: 21442314 Ref: LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. PMID: 22085492 Ref: Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. PMID: 22135232 Ref: Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P. PMID: 22142694 Ref: Multi-parametric approach to identify coffee components that regulate mechanisms of gastric acid secretion. PMID: 22147653 Ref: Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. PMID: 22198711 Ref: E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells. PMID: 22322152 Ref: Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. PMID: 22634261 Ref: Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer. PMID: 22672288 Ref: Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway. PMID: 22736399 Ref: ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-kappaB-dependent and Notch-independent mechanism. PMID: 22781708 Ref: ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer. PMID: 22799764 Ref: Pro-apoptotic role of the MEK/ERK pathway in ursodeoxycholic acid-induced apoptosis in SNU601 gastric cancer cells. PMID: 22824956 Ref: The proliferative effects of ghrelin on human gastric cancer AGS cells. PMID: 22908970 Ref: [Mechanisms of (2-methyl-n-butyl) shikonin induced apoptosis of gastric cancer SGC-7901 cells]. PMID: 22919733 Ref: Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells. PMID: 22941376 Ref: Prostaglandin reductase 2 modulates ROS-mediated cell death and tumor transformation of gastric cancer cells and is associated with higher mortality in gastric cancer patients. PMID: 22998775 Ref: [Mig-7 enhances vasculogenic mimicry in gastric cancer cells]. PMID: 23127401 |
Ref: Fas signaling promotes motility and metastasis through epithelial-mesenchymal transition in gastrointestinal cancer. PMID: 22508480 Ref: Proliferative and apoptotic effects of gastric epithelial cells induced by coccoid Helicobacter pylori. PMID: 22581720 Ref: Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9. PMID: 22821546 Ref: CCDC134 is down-regulated in gastric cancer and its silencing promotes cell migration and invasion of GES-1 and AGS cells via the MAPK pathway. PMID: 23070808 Ref: Tumor-suppressive effects of 1, 25-dihydroxyvitamin D3 in gastric cancer cells. PMID: 23298900 Ref: Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion. PMID: 23354307 Ref: Down-regulation of dual-specificity phosphatase 5 in gastric cancer by promoter CpG island hypermethylation and its potential role in carcinogenesis. PMID: 23402999 Ref: Expression of C-X-C chemokine receptor types 1/2 in patients with gastric carcinoma: Clinicopathological correlations and significance. PMID: 23420470 Ref: RNAimediated knockdown of PRL3 inhibits cell invasion and downregulates ERK 1/2 expression in the human gastric cancer cell line, SGC7901. PMID: 23589069 Ref: MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation. PMID: 23637748 Ref: Periostin mediates the increased pro-angiogenic activity of gastric cancer cells under hypoxic conditions. PMID: 23728938 Ref: Combination treatment of PD98059 and DAPT in gastric cancer through induction of apoptosis and downregulation of WNT/beta-catenin. PMID: 23792588 Ref: GPR48, a poor prognostic factor, promotes tumor metastasis and activates beta-catenin/TCF signaling in colorectal cancer. PMID: 23803691 Ref: ERK1/2 signalling pathway is involved in CD147-mediated gastric cancer cell line SGC7901 proliferation and invasion. PMID: 23828593 Ref: Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells. PMID: 23840737 Ref: Association between phosphorylated AMP-activated protein kinase and MAPK3/1 expression and prognosis for patients with gastric cancer. PMID: 23860205 Ref: Anticancer effects of AcPheLysPABCdoxorubicin via mitochondriacentered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC803 cells. PMID: 23877402 Ref: The expression of TMPRSS4 and Erk1 correlates with metastasis and poor prognosis in Chinese patients with gastric cancer. PMID: 23922976 Ref: Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells. PMID: 23924923 Ref: Expression and prognostic significance of Livin in gastric cancer. PMID: 24008725 Ref: Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine. PMID: 24063987 Ref: Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling. PMID: 24159347 Ref: A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway. PMID: 24241351 Ref: Hypermethylation and clinicopathological significance of RASAL1 gene in gastric cancer. PMID: 24377515 |
Ref: MicroRNA-296-5p increases proliferation in gastric cancer through repression of Caudal-related homeobox 1. PMID: 23353818 Ref: CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer. PMID: 24131472 Ref: ERK1/2 inhibition enhances apoptosis induced by JAK2 silencing in human gastric cancer SGC7901 cells. PMID: 24178240 Ref: Increased serum chemerin level promotes cellular invasiveness in gastric cancer: a clinical and experimental study. PMID: 24274970 Ref: Inhibition of MEK sensitizes gastric cancer cells to TRAIL-induced apoptosis. PMID: 24299309 Ref: Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells. PMID: 24337453 Ref: Overexpression of GNAO1 correlates with poor prognosis in patients with gastric cancer and plays a role in gastric cancer cell proliferation and apoptosis. PMID: 24366063 Ref: Cholesterol induces autophagic and apoptotic death in gastric carcinoma cells. PMID: 24399152 Ref: RASAL1 influences the proliferation and invasion of gastric cancer cells by regulating the RAS/ERK signaling pathway. PMID: 24531877 Ref: The role of leptin in gastric cancer: clinicopathologic features and molecular mechanisms. PMID: 24569072 Ref: SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells. PMID: 24676680 Ref: MicroRNA-338 inhibits growth, invasion and metastasis of gastric cancer by targeting NRP1 expression. PMID: 24736504 Ref: The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression. PMID: 24946088 Ref: CDX2 can be regulated through the signalling pathways activated by IL-6 in gastric cells. PMID: 24953186 Ref: Association of CXCR1 and 2 expressions with gastric cancer metastasis in ex vivo and tumor cell invasion in vitro. PMID: 25022956 Ref: Cadmium induces urokinase-type plasminogen activator receptor expression and the cell invasiveness of human gastric cancer cells via the ERK-1/2, NF-kappaB, and AP-1 signaling pathways. PMID: 25069788 Ref: Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via downregulation of MMP7 and MMP13. PMID: 25085584 Ref: Analysis of T4SS-induced signaling by H. pylori using quantitative phosphoproteomics. PMID: 25101063 Ref: Annexin A2 is implicated in multi-drug-resistance in gastric cancer through p38MAPK and AKT pathway. PMID: 25150310 Ref: Rabeprazole exhibits antiproliferative effects on human gastric cancer cell lines. PMID: 25202402 Ref: MEK inhibitor for gastric cancer with MEK1 gene mutations. PMID: 25253779 Ref: GNAS mutation as an alternative mechanism of activation of the Wnt/beta-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type. PMID: 25288233 Ref: An increase in integrin-linked kinase non-canonically confers NF-kappaB-mediated growth advantages to gastric cancer cells by activating ERK1/2. PMID: 25398317 Ref: Reduced miR-126 expression facilitates angiogenesis of gastric cancer through its regulation on VEGF-A. PMID: 25428912 |
Ref: Pb2+ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells. PMID: 23765435 Ref: The human epididymis protein 4 acts as a prognostic factor and promotes progression of gastric cancer. PMID: 25432133 Ref: NAIF1 inhibits gastric cancer cells migration and invasion via the MAPK pathways. PMID: 25432142 Ref: 1-butyltryptophan inhibits cell proliferation, migration, and invasion through the Akt pathway in human gastric cancer cells. PMID: 25433499 Ref: Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway. PMID: 25515760 Ref: The therapeutic potential of a novel non-ATP-competitive fibroblast growth factor receptor 1 inhibitor on gastric cancer. PMID: 25521558 Ref: Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells. PMID: 25527205 Ref: miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner. PMID: 25652124 Ref: Autophagy-mediated HMGB1 release promotes gastric cancer cell survival via RAGE activation of extracellular signal-regulated kinases 1/2. PMID: 25652880 Ref: IL-33 Promotes Gastric Cancer Cell Invasion and Migration Via ST2-ERK1/2 Pathway. PMID: 25655003 Ref: C23 protein meditates bone morphogenetic protein-2-mediated EMT via up-regulation of Erk1/2 and Akt in gastric cancer. PMID: 25698539 Ref: Interleukin-18 enhances breast cancer cell migration via down-regulation of claudin-12 and induction of the p38 MAPK pathway. PMID: 25727011 Ref: RASAL1 attenuates gastric carcinogenesis in nude mice by blocking RAS/ERK signaling. PMID: 25735335 Ref: Silencing profilin-1 inhibits gastric cancer progression via integrin beta1/focal adhesion kinase pathway modulation. PMID: 25741138 Ref: Chrysin inhibits tumor promoter-induced MMP-9 expression by blocking AP-1 via suppression of ERK and JNK pathways in gastric cancer cells. PMID: 25875631 Ref: A peptide derivative serves as a fibroblast growth factor 2 antagonist in human gastric cancer. PMID: 25894376 Ref: Endothelial cell protein C receptor promotes MGC803 gastric cancer cells proliferation and migration by activating ERK1/2. PMID: 25895599 Ref: Ginkgo biloba extract enhances chemotherapy sensitivity and reverses chemoresistance through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer cells. PMID: 25962735 Ref: Gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8. PMID: 25986392 Ref: Cyclophilin A Enhances Cell Proliferation and Xenografted Tumor Growth of Early Gastric Cancer. PMID: 26008617 Ref: The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways. PMID: 26018507 Ref: Epigenetically downregulated Semaphorin 3E contributes to gastric cancer. PMID: 26036259 Ref: CrkL meditates CCL20/CCR6-induced EMT in gastric cancer. PMID: 26044596 Ref: Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells. PMID: 26058661 Ref: Curcumin Suppresses MAPK Pathways to Reverse Tobacco Smoke-induced Gastric Epithelial-Mesenchymal Transition in Mice. PMID: 26074474 Ref: EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition. PMID: 26081723 Ref: The anacardic 6-pentadecyl salicylic acid induces macrophage activation via the phosphorylation of ERK1/2, JNK, P38 kinases and NF-kappaB. PMID: 26371858 Ref: beta-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation. PMID: 26379399 Ref: [Effects of beta-elemene on proliferation and apoptosis of SGC7901 gastric cancer cells in vitro and the underlying mechanisms]. PMID: 26403730 Ref: Downregulation of P-gp, Ras and p-ERK1/2 contributes to the arsenic trioxide-induced reduction in drug resistance towards doxorubicin in gastric cancer cell lines. PMID: 26459009 |
Ref: Interleukin-1B signalling leads to increased survival of gastric carcinoma cells through a CREB-C/EBPbeta-associated mechanism. PMID: 25740226 Ref: CCL18 promotes the invasion and migration of gastric cancer cells via ERK1/2/NF-kappaB signaling pathway. PMID: 26242263 Ref: All-trans retinoic acid protects against doxorubicin-induced cardiotoxicity by activating the ERK2 signalling pathway. PMID: 26507774 Ref: Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage. PMID: 26556626 Ref: Sulforaphene promotes Bax/Bcl2, MAPK-dependent human gastric cancer AGS cells apoptosis and inhibits migration via EGFR, p-ERK1/2 down-regulation. PMID: 26612919 Ref: Sustained ERK activation-mediated proliferation inhibition of farrerol on human gastric carcinoma cell line by G0/G1-phase cell-cycle arrest. PMID: 26656929 Ref: Induction of MAPK- and ROS-dependent autophagy and apoptosis in gastric carcinoma by combination of romidepsin and bortezomib. PMID: 26683357 Ref: Tissue transglutaminase-2 promotes gastric cancer progression via the ERK1/2 pathway. PMID: 26771235 Ref: Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways. PMID: 26802142 Ref: Differences in TGF-beta1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer. PMID: 26846663 Ref: APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis. PMID: 26942872 Ref: Suppression of IL-8-Src signalling axis by 17beta-estradiol inhibits human mesenchymal stem cells-mediated gastric cancer invasion. PMID: 26945908 Ref: CXCR1 promotes malignant behavior of gastric cancer cells in vitro and in vivo in AKT and ERK1/2 phosphorylation. PMID: 26983663 Ref: Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling. PMID: 26987289 Ref: Expression of tumor necrosis factor-alpha-induced protein 8 in stage III gastric cancer and the correlation with DcR3 and ERK1/2. PMID: 26998086 Ref: Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cgamma1 and the ERK1/2 pathway. PMID: 27039174 Ref: MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. PMID: 27157613 Ref: Periplocin Extracted from Cortex Periplocae Induced Apoptosis of Gastric Cancer Cells via the ERK1/2-EGR1 Pathway. PMID: 27160973 Ref: Tspan9 inhibits the proliferation, migration and invasion of human gastric cancer SGC7901 cells via the ERK1/2 pathway. PMID: 27177197 Ref: Suppressive effects on cell proliferation and motility in gastric cancer SGC-7901 cells by introducing ulinastatin in vitro. PMID: 27187019 Ref: MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL-8 secretion in vitro and in vivo. PMID: 27278862 Ref: Carbon monoxide releasing molecule-2 ameliorates IL-1beta-induced IL-8 in human gastric cancer cells. PMID: 27393034 Ref: The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines. PMID: 27409173 Ref: CXCR3A contributes to the invasion and metastasis of gastric cancer cells. PMID: 27461521 Ref: Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling. PMID: 27542217 Ref: Long non-coding RNA CASC2 suppresses the proliferation of gastric cancer cells by regulating the MAPK signaling pathway. PMID: 27648142 Ref: DEC2 suppresses tumor proliferation and metastasis by regulating ERK/NF-kappaB pathway in gastric cancer. PMID: 27648362 Ref: Inhibition of cell proliferation and triggering of apoptosis by agrimonolide through MAP kinase (ERK and p38) pathways in human gastric cancer AGS cells. PMID: 27747355 Ref: YAP1 enhances cell proliferation, migration, and invasion of gastric cancer in vitro and in vivo. PMID: 27835600 |
Ref: Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells. PMID: 27377703 Ref: Dihydroartemisinin induces apoptosis in human gastric cancer cell line BGC-823 through activation of JNK1/2 and p38 MAPK signaling pathways. PMID: 27401020 Ref: Overexpression of KIF11 in Gastric Cancer with Intestinal Mucin Phenotype. PMID: 27459100 Ref: Transducin (beta)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway. PMID: 27694893 Ref: Gastrin Enhances Autophagy and Promotes Gastric Carcinoma Proliferation via Inducing AMPKalpha. PMID: 28059052 Ref: Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation. PMID: 28102288 Ref: MicroRNA-133a Inhibits Proliferation of Gastric Cancer Cells by Downregulating ERBB2 Expression. PMID: 28109082 Ref: Pseudolaric acid B inhibits gastric cancer cell metastasis in vitro and in haematogenous dissemination model through PI3K/AKT, ERK1/2 and mitochondria-mediated apoptosis pathways. PMID: 28132880 Ref: GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer. PMID: 28165032 Ref: Adenovirus-mediated TIPE2 overexpression inhibits gastric cancer metastasis via reversal of epithelial-mesenchymal transition. PMID: 28186089 Ref: Grifolin exhibits anti-cancer activity by inhibiting the development and invasion of gastric tumor cells. PMID: 28206955 Ref: Proapoptotic and Growth-inhibitory Effects of Plumbagin on Human Gastric Cancer Cells Via Suppression of Signal Transducer and Activator of Transcription 3 and Protein Kinase B. PMID: 28236621 Ref: Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer. PMID: 28252644 Ref: microRNA-203 suppresses invasion of gastric cancer cells by targeting ERK1/2/Slug/ E-cadherin signaling. PMID: 28269747 Ref: CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways. PMID: 28281844 Ref: Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells. PMID: 28336852 Ref: NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization. PMID: 28388537 Ref: A novel bispecific c-MET/PD-1 antibody with therapeutic potential in solid cancer. PMID: 28404966 Ref: Synthesis and Antiproliferative Activity of Novel All-Trans-Retinoic Acid-Podophyllotoxin Conjugate towards Human Gastric Cancer Cells. PMID: 28420180 Ref: Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer. PMID: 28460635 Ref: Bradykinin Promotes Cell Proliferation, Migration, Invasion, and Tumor Growth of Gastric Cancer Through ERK Signaling Pathway. PMID: 28464378 Ref: FPR2 promotes invasion and metastasis of gastric cancer cells and predicts the prognosis of patients. PMID: 28600569 Ref: MeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1/2-ERK1/2 signaling pathway by upregulating GIT1. PMID: 28759023 Ref: Regenerating Family Member 4 (Reg4) Enhances 5-Fluorouracil Resistance of Gastric Cancer Through Activating MAPK/Erk/Bim Signaling Pathway. PMID: 28759561 Ref: EGF-induced urokinase plasminogen activator receptor promotes epithelial to mesenchymal transition in human gastric cancer cells. PMID: 28849196 Ref: Creation and Initial Characterization of Isogenic Helicobacter pylori CagA EPIYA Variants Reveals Differential Activation of Host Cell Signaling Pathways. PMID: 28887533 Ref: Antitumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through PI3K/AKT and MAPK signaling pathways. PMID: 28990045 Ref: Store-operated Ca(2+) Entry Facilitates the Lipopolysaccharide-induced Cyclooxygenase-2 Expression in Gastric Cancer Cells. PMID: 29038542 Ref: ERp29 inhibits tumorigenicity by suppressing epithelial mesenchymal transition in gastric cancer. PMID: 29108263 Ref: Effects of WD3 on tumor growth and the expression of integrin alphavbeta3 and ERK1/2 in mice bearing human gastric cancer using the 18FRGD PET/CT imaging system. PMID: 29152665 Ref: Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway. PMID: 29379775 |
Ref: Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-kappab, PKC-delta, ERK1/2, and AMPKalpha. PMID: 28627240 Ref: Cell cycle-dependent translocation and regulatory mechanism of CacyBP/SIP in gastric cancer cells. PMID: 29099417 Ref: Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer. PMID: 29131081 Ref: Gastroprotective effects of Hwanglyeonhaedok-tang against Helicobacter pylori-induced gastric cell injury. PMID: 29410309 Ref: Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC-7901 cells. PMID: 29434918 Ref: Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin-EGFR crosstalk. PMID: 29468433 Ref: Inhibition of TNFalpha-interacting protein alpha (Tipalpha)-associated gastric carcinogenesis by BTG2(/TIS21) via downregulating cytoplasmic nucleolin expression. PMID: 29472702 Ref: Knockdown of EPCR inhibits the proliferation and migration of human gastric cancer cells via the ERK1/2 pathway in a PAR-1-dependent manner. PMID: 29484413 Ref: Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling. PMID: 29549164 Ref: The molecular mechanism of anticancer action of novel octahydropyrazino[2,1-a:5,4-a']diisoquinoline derivatives in human gastric cancer cells. PMID: 29549610 Ref: TRPC1/3/6 inhibition attenuates the TGF-beta1-induced epithelial-mesenchymal transition in gastric cancer via the Ras/Raf1/ERK signaling pathway. PMID: 29570903 Ref: Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway. PMID: 29673586 Ref: Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the AktGSK3beta and MAPK/ERK signaling cascades. PMID: 29693162 Ref: Cancer-adipose tissue interaction and fluid flow synergistically modulate cell kinetics, HER2 expression, and trastuzumab efficacy in gastric cancer. PMID: 29696406 Ref: MAPK/c-Jun signaling pathway contributes to the upregulation of the anti-apoptotic proteins Bcl-2 and Bcl-xL induced by Epstein-Barr virus-encoded BARF1 in gastric carcinoma cells. PMID: 29725459 Ref: DAB2IP Downregulation Enhances the Proliferation and Metastasis of Human Gastric Cancer Cells by Derepressing the ERK1/2 Pathway. PMID: 29743885 Ref: Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity. PMID: 29767555 Ref: Fisetin inhibits the proliferation of gastric cancer cells and induces apoptosis through suppression of ERK 1/2 activation. PMID: 29805580 Ref: miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R. PMID: 29844688 Ref: Synthesis and antitumor activity of novel 6,7,8-trimethoxy N-aryl-substituted-4-aminoquinazoline derivatives. PMID: 29903662 Ref: HGF derived from cancerassociated fibroblasts promotes vascularization in gastric cancer via PI3K/AKT and ERK1/2 signaling. PMID: 29917165 Ref: EPCR promotes MGC803 human gastric cancer cell tumor angiogenesis in vitro through activating ERK1/2 and AKT in a PAR1-dependent manner. PMID: 30008838 Ref: Effect of 5-fluorouracil on excision repair cross-complementing 1 expression and consequent cytotoxicity regulation in human gastric cancer cells. PMID: 30011079 Ref: Yes-associated protein enhances proliferation and attenuates sensitivity to cisplatin in human gastric cancer cells. PMID: 30021363 Ref: Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor. PMID: 30044964 Ref: Discovery of an Indirubin Derivative as a Novel c-Met Kinase Inhibitor with in vitro Anti-Tumor Effects. PMID: 30060294 Ref: Identification of the potential molecular mechanism and driving mutations in the pathogenesis of familial intestinal gastric cancer by whole exome sequencing. PMID: 30106433 Ref: Knockdown of TMPRSS3 inhibits gastric cancer cell proliferation, invasion and EMT via regulation of the ERK1/2 and PI3K/Akt pathways. PMID: 30142546 Ref: Weipixiao attenuate early angiogenesis in rats with gastric precancerous lesions. PMID: 30200948 Ref: Sorcin a Potential Molecular Target for Cancer Therapy. PMID: 30216763 Ref: Enah overexpression is correlated with poor survival and aggressive phenotype in gastric cancer. PMID: 30250066 Ref: Clinicopathological significance of RCAN2 production in gastric carcinoma. PMID: 30307052 Ref: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1. PMID: 30382763 |