Primary Site >> Stomach Cancer
Gene >> MAP2K7
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Ref: Activation of human histidine decarboxylase gene promoter activity by gastrin is mediated by two distinct nuclear factors. PMID: 10409643 |
Ref: Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways. PMID: 11686835 |
Ref: Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. PMID: 12555068 Ref: Transcriptional regulation of the human trefoil factor, TFF1, by gastrin. PMID: 12891554 |
Ref: Reactivation of latent Epstein-Barr virus by methotrexate: a potential contributor to methotrexate-associated lymphomas. PMID: 15547182 |
Ref: A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad. PMID: 15751984 |
Ref: Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines. PMID: 16520550 Ref: Cellular prion protein promotes invasion and metastasis of gastric cancer. PMID: 16877520 |
Ref: Hepatocyte growth factor promotes cell survival by phosphorylation of BAD in gastric cancer cells. PMID: 18488712 Ref: HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells. PMID: 18974395 |
Ref: Inhibition of MEK blocks GRP78 up-regulation and enhances apoptosis induced by ER stress in gastric cancer cells. PMID: 18829155 Ref: Breast cancer resistance protein/ABCG2 is differentially regulated downstream of extracellular signal-regulated kinase. PMID: 19514121 Ref: Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells. PMID: 19755509 |
Ref: ERK/MAPK activation involves hypoxia-induced MGr1-Ag/37LRP expression and contributes to apoptosis resistance in gastric cancer. PMID: 19998339 Ref: Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells. PMID: 20087064 Ref: Critical role of aquaporin-3 in the human epidermal growth factor-induced migration and proliferation in the human gastric adenocarcinoma cells. PMID: 20364107 Ref: Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways. PMID: 20651362 Ref: CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation. PMID: 21047770 |
Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways. PMID: 20498032 Ref: Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. PMID: 21266357 Ref: Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis. PMID: 21346147 Ref: Oncogenic CagA promotes gastric cancer risk via activating ERK signaling pathways: a nested case-control study. PMID: 21698158 Ref: Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB. PMID: 21734448 |
Ref: Regulation of SHP2 by PTEN/AKT/GSK-3beta signaling facilitates IFN-gamma resistance in hyperproliferating gastric cancer. PMID: 22325465 Ref: Induction of sodium/iodide symporter (NIS) expression and radioiodine uptake in non-thyroid cancer cells. PMID: 22359623 Ref: Prognostic value of RKIP and p-ERK in gastric cancer. PMID: 22463874 Ref: Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer. PMID: 22672288 Ref: A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation. PMID: 22745804 Ref: Pro-apoptotic role of the MEK/ERK pathway in ursodeoxycholic acid-induced apoptosis in SNU601 gastric cancer cells. PMID: 22824956 Ref: beta,beta-Dimethylacrylshikonin induces mitochondria dependent apoptosis through ERK pathway in human gastric cancer SGC-7901 cells. PMID: 22848597 Ref: p42.3 gene expression in gastric cancer cell and its protein regulatory network analysis. PMID: 23228105 |
Ref: A systematic approach to therapeutic target selection in oesophago-gastric cancer. PMID: 22773546 Ref: Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9. PMID: 22821546 Ref: KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer. PMID: 23348694 Ref: Inhibition of gastric tumor growth by a novel Hsp90 inhibitor. PMID: 23415900 |
Ref: Inhibition of MEK sensitizes gastric cancer cells to TRAIL-induced apoptosis. PMID: 24299309 Ref: The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway. PMID: 24416349 Ref: Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer. PMID: 24465527 Ref: A novel PP2A enhancer induces caspase-independent apoptosis of MKN28 gastric cancer cells with high MEK activity. PMID: 24508028 Ref: Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer. PMID: 24757178 Ref: Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy. PMID: 24903273 Ref: MEK inhibitor for gastric cancer with MEK1 gene mutations. PMID: 25253779 Ref: PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways. PMID: 27919028 |
Ref: Pb(2)(+) induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells. PMID: 24106166 Ref: OCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancer. PMID: 24717932 Ref: Bone morphogenetic protein 2 mediates epithelial-mesenchymal transition via AKT and ERK signaling pathways in gastric cancer. PMID: 25448881 Ref: Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells. PMID: 25473895 Ref: MALAT2-activated long noncoding RNA indicates a biomarker of poor prognosis in gastric cancer. PMID: 25721209 Ref: RASAL1 attenuates gastric carcinogenesis in nude mice by blocking RAS/ERK signaling. PMID: 25735335 Ref: EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition. PMID: 26081723 Ref: Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer. PMID: 26091251 Ref: Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells. PMID: 26171059 Ref: HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-kappaB activation. PMID: 26259977 Ref: DBD-F induces apoptosis in gastric cancer-derived cells through suppressing HIF2alpha expression. PMID: 26526811 |
Ref: Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir. PMID: 26205347 Ref: DCT015, a new sorafenib derivate, inhibits tumor growth and angiogenesis in gastric cancer models. PMID: 26768619 Ref: The tumor promoting roles of HSP60 and HIF2alpha in gastric cancer cells. PMID: 26810190 Ref: The roles of serum PDCD5 in circulating CD133 positive cells of the patients with gastric cancer. PMID: 27034262 Ref: Stromal interaction molecule 1 plays an important role in gastric cancer progression. PMID: 27035326 Ref: JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients. PMID: 27167206 Ref: MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2. PMID: 27409164 Ref: Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells. PMID: 27699948 Ref: Inhibition of histone deacetylases in melanoma-a perspective from bench to bedside. PMID: 27792246 |
Ref: Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway. PMID: 28114937 Ref: Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer. PMID: 28460635 Ref: FPR2 promotes invasion and metastasis of gastric cancer cells and predicts the prognosis of patients. PMID: 28600569 Ref: Bcl-2 and Bcl-xL mediate resistance to receptor tyrosine kinase-targeted therapy in lung and gastric cancer. PMID: 28885267 Ref: Correlation between MEK signature and Ras gene alteration in advanced gastric cancer. PMID: 29296181 |
Ref: MiR-199a/b-3p inhibits gastric cancer cell proliferation via down-regulating PAK4/MEK/ERK signaling pathway. PMID: 29304764 Ref: Alpha, 2'-dihydroxy-4,4'-dimethoxydihydrochalcone inhibits cell proliferation, invasion, and migration in gastric cancer in part via autophagy. PMID: 29306208 Ref: Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway. PMID: 29374144 Ref: Tanshinone IIA inhibits gastric carcinoma AGS cells by decreasing the protein expression of VEGFR and blocking Ras/Raf/MEK/ERK pathway. PMID: 29393362 Ref: BI2536, a potent and selective inhibitor of polo-like kinase 1, in combination with cisplatin exerts synergistic effects on gastric cancer cells. PMID: 29393385 Ref: Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin-EGFR crosstalk. PMID: 29468433 Ref: Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases. PMID: 29666306 Ref: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. PMID: 29808010 Ref: Acquired JHDM1D-BRAF fusion confers resistance to FGFR inhibition in FGFR2- amplified gastric cancer. PMID: 30045926 Ref: Molecular Signatures of the Insulin-like Growth Factor 1-mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers. PMID: 30111747 Ref: PLK1 as a potential prognostic marker of gastric cancer through MEK-ERK pathway on PDTX models. PMID: 30288059 |