Primary Site >> Esophagus Cancer
Gene >> MAP2K7
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Ref: Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway. PMID: 10763823 |
Ref: Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent. PMID: 11297525 |
Ref: Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase. PMID: 15081869 Ref: Selective inhibition of survival signal transduction pathways enhanced radiosensitivity in human esophageal cancer cell lines in vitro. PMID: 15161032 Ref: The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation. PMID: 15375172 |
Ref: Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells. PMID: 16480952 |
Ref: Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility. PMID: 17306610 |
Ref: Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway. PMID: 18452159 |
Ref: The expression and activation of ERK/MAPK pathway in human esophageal cancer cell line EC9706. PMID: 20464500 Ref: BRAF mutations in advanced cancers: clinical characteristics and outcomes. PMID: 22039425 |
Ref: Esophageal cancer exhibits resistance to a novel IGF-1R inhibitor NVP-AEW541 with maintained RAS-MAPK activity. PMID: 22753744 Ref: Downregulation of tropomyosin-1 in squamous cell carcinoma of esophagus, the role of Ras signaling and methylation. PMID: 22965424 |
Ref: Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates. PMID: 23708958 Ref: [Roles of targeting Ras/Raf/MEK/ERK signaling pathways in the treatment of esophageal carcinoma]. PMID: 23888683 |
Ref: Overexpression of transferrin receptor CD71 and its tumorigenic properties in esophageal squamous cell carcinoma. PMID: 24435655 Ref: New directions in perioperative management of locally advanced esophagogastric cancer. PMID: 24857100 Ref: DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways. PMID: 25026173 Ref: Induction of autophagy counteracts the anticancer effect of cisplatin in human esophageal cancer cells with acquired drug resistance. PMID: 25236911 Ref: Aquaporin-8 mediates human esophageal cancer Eca-109 cell migration via the EGFR-Erk1/2 pathway. PMID: 25550802 |
Ref: Phase I and pharmacokinetics/pharmacodynamics study of the MEK inhibitor RO4987655 in Japanese patients with advanced solid tumors. PMID: 25809858 Ref: Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma. PMID: 26040563 Ref: Mutant HRAS as novel target for MEK and mTOR inhibitors. PMID: 26544513 |
Ref: A phase I study of two dosing schedules of oral BI 847325 in patients with advanced solid tumors. PMID: 26650227 Ref: Antitumor activity of 7RH, a discoidin domain receptor 1 inhibitor, alone or in combination with dasatinib exhibits antitumor effects in nasopharyngeal carcinoma cells. PMID: 27900042 |
Ref: FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma. PMID: 28857247 Ref: GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K/AKT and Ras/Raf/MEK/ERK pathways. PMID: 29019267 |
Ref: Chemoresistance to Cancer Treatment: Benzo-alpha-Pyrene as Friend or Foe? PMID: 29673198 Ref: IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment. PMID: 29976575 |