Primary Site >> Colorectal Cancer
Gene >> MAP2K4
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Ref: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. PMID: 9622070 |
Ref: Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells. PMID: 10344756 |
Ref: Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1. PMID: 11278263 |
Ref: Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. PMID: 15334063 |
Ref: 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation. PMID: 17085668 |
Ref: Disruption of signaling through SEK1 and MKK7 yields differential responses in hypoxic colon cancer cells treated with oxaliplatin. PMID: 18436711 |
Ref: MAP kinases in proliferating human colon cancer Caco-2 cells. PMID: 19301097 Ref: The association between -1304T>G polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in southern Chinese population. PMID: 19610067 |
Ref: The protective role of polymorphism MKK4-1304 T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus' infection status. PMID: 21702039 |
Ref: c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance. PMID: 23223444 Ref: [Expression and clinicopathological significance of serine-257/threonine-261 phosphorylated MKK4 in colorectal carcinoma]. PMID: 23755811 |
Ref: Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients. PMID: 24170544 Ref: ent-kaurane diterpenoids from Croton tonkinensis induce apoptosis in colorectal cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase MKK4. PMID: 24476312 |
Ref: Internalization property of intestinal bacteria in colon cancer and HIV/AIDS patients. PMID: 27618600 |
Ref: Whole-exome sequencing identified mutational profiles of high-grade colon adenomas. PMID: 28179590 Ref: Downregulation of phosphorylated MKK4 is associated with a poor prognosis in colorectal cancer patients. PMID: 28423721 Ref: miR-141 promotes colon cancer cell proliferation by inhibiting MAP2K4. PMID: 28454307 |