Primary Site >> Colorectal Cancer
Gene >> MAP1LC3A
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: DNA mismatch repair initiates 6-thioguanine--induced autophagy through p53 activation in human tumor cells. PMID: 17317843 Ref: Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. PMID: 17942897 |
Ref: Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy. PMID: 18381446 Ref: Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. PMID: 18616529 Ref: Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells. PMID: 18638451 Ref: LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. PMID: 18695874 |
Ref: Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells. PMID: 19258012 Ref: Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. PMID: 19289106 Ref: Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis. PMID: 20130808 |
Ref: Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell. PMID: 19660860 Ref: Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells. PMID: 19830499 Ref: Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells. PMID: 20104024 Ref: LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas. PMID: 20382705 Ref: Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. PMID: 20639871 Ref: The inhibition of autophagy potentiates anti-angiogenic effects of sulforaphane by inducing apoptosis. PMID: 20694744 Ref: UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy. PMID: 20724836 Ref: p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. PMID: 20937856 |
Ref: Involvement of ROS in Curcumin-induced Autophagic Cell Death. PMID: 21461234 Ref: Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2. PMID: 21503576 Ref: Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer. PMID: 22147978 |
Ref: Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. PMID: 22406476 Ref: Curcumin induces permanent growth arrest of human colon cancer cells: link between senescence and autophagy. PMID: 22613224 Ref: Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species. PMID: 23028492 Ref: alpha-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation. PMID: 23396851 |
Ref: Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells. PMID: 22841540 Ref: Autophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14. PMID: 23178952 Ref: Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy. PMID: 23192274 Ref: bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PMID: 23326480 Ref: Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells. PMID: 23624503 Ref: [Effects of autophagy modulator on autophagy and uridine 5'-diphospho-glucuronosyltransferase 1A1 induced by sulforaphane]. PMID: 23663345 Ref: FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PMID: 23700428 Ref: 13,14-bis(cis-3,5-dimethyl-1-piperazinyl)-beta-elemene, a novel beta-elemene derivative, shows potent antitumor activities via inhibition of mTOR in human breast cancer cells. PMID: 23761818 Ref: Downregulation of Beclin 1 and impairment of autophagy in a small population of colorectal cancer. PMID: 23812859 Ref: Role of intracellular calcium in proteasome inhibitor-induced endoplasmic reticulum stress, autophagy, and cell death. PMID: 23893020 Ref: BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production. PMID: 24322755 |
Ref: Knockdown of p62/sequestosome 1 attenuates autophagy and inhibits colorectal cancer cell growth. PMID: 24065390 Ref: Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization. PMID: 24580730 Ref: Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1. PMID: 24587252 Ref: Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells. PMID: 24626522 Ref: Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation. PMID: 24653797 Ref: WIN induces apoptotic cell death in human colon cancer cells through a block of autophagic flux dependent on PPARgamma down-regulation. PMID: 24696378 Ref: Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells. PMID: 24955726 Ref: Effect of light irradiation by light emitting diode on colon cancer cells. PMID: 25202048 Ref: Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression. PMID: 25364431 |
Ref: Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway. PMID: 25216025 Ref: N3-substituted temozolomide analogs overcome methylguanine-DNA methyltransferase and mismatch repair precipitating apoptotic and autophagic cancer cell death. PMID: 25277441 Ref: Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects. PMID: 25498801 Ref: Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced colon cancer cell death. PMID: 25663926 Ref: Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. PMID: 25832431 Ref: Purvalanol induces endoplasmic reticulum stress-mediated apoptosis and autophagy in a time-dependent manner in HCT116 colon cancer cells. PMID: 25901510 Ref: ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma. PMID: 25973293 Ref: Expression and clinical significances of Beclin1, LC3 and mTOR in colorectal cancer. PMID: 26097572 Ref: [ASPP2 inhibits oxaliplatin-induced autophagy and promotes apoptosis of colon cancer cells]. PMID: 26146058 Ref: Aldose Reductase Inhibitor Fidarestat as a Promising Drug Targeting Autophagy in Colorectal Carcinoma: a Pilot Study. PMID: 26163626 Ref: Suppression of lung metastases by the CD26/DPP4 inhibitor Vildagliptin in mice. PMID: 26233333 Ref: Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo. PMID: 26248051 Ref: Targeted inhibition of p38MAPK-enhanced autophagy in SW620 cells resistant to photodynamic therapy-induced apoptosis. PMID: 26254783 Ref: Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma. PMID: 26306675 Ref: AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro. PMID: 26318663 Ref: Autophagy-related genes Raptor, Rictor, and Beclin1 expression and relationship with multidrug resistance in colorectal carcinoma. PMID: 26363527 |
Ref: Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy. PMID: 25594310 Ref: Orexin A induces autophagy in HCT-116 human colon cancer cells through the ERK signaling pathway. PMID: 26572581 Ref: Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo. PMID: 26676801 Ref: [Keratin 18 phosphorylation increases autophagy of colorectal cancer HCT116 cells and enhanced its sensitivity to oxaliplatin]. PMID: 26728375 Ref: BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. PMID: 26802026 Ref: CHNQ, a novel 2-Chloro-1,4-naphthoquinone derivative of quercetin, induces oxidative stress and autophagy both in vitro and in vivo. PMID: 26946942 Ref: BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition. PMID: 27429848 Ref: Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status. PMID: 27444698 Ref: Autophagy regulates Selumetinib (AZD6244) induced-apoptosis in colorectal cancer cells. PMID: 27448918 Ref: Co-expression of autophagic markers following photodynamic therapy in SW620 human colon adenocarcinoma cells. PMID: 27485939 Ref: Downregulation of Enhancer of Zeste Homolog 2 (EZH2) is essential for the Induction of Autophagy and Apoptosis in Colorectal Cancer Cells. PMID: 27706111 Ref: Salidroside induces apoptosis and autophagy in human colorectal cancer cells through inhibition of PI3K/Akt/mTOR pathway. PMID: 27748934 Ref: Downregulation of YEATS4 by miR-218 sensitizes colorectal cancer cells to L-OHP-induced cell apoptosis by inhibiting cytoprotective autophagy. PMID: 27779719 Ref: miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts. PMID: 27793031 |
Ref: Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells. PMID: 27416805 Ref: Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells. PMID: 27737524 Ref: Koelreuteria Formosana Extract Induces Growth Inhibition and Cell Death in Human Colon Carcinoma Cells via G2/M Arrest and LC3-II Activation-Dependent Autophagy. PMID: 27880045 Ref: Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin-evoked peripheral neuropathy. PMID: 28118492 Ref: New findings of silica nanoparticles induced ER autophagy in human colon cancer cell. PMID: 28195184 Ref: mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism. PMID: 28475179 Ref: Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells. PMID: 28489607 Ref: Autophagy in aging and disease. PMID: 28523294 Ref: The Effect of Pyrroloquinoline Quinone on the Expression of WISP1 in Traumatic Brain Injury. PMID: 28883836 Ref: Beclin 1 and LC3 as predictive biomarkers for metastatic colorectal carcinoma. PMID: 28938618 |
Ref: Autophagy mediates cytotoxicity of human colorectal cancer cells treated with garcinielliptone FC. PMID: 28294332 Ref: LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1alpha. PMID: 29017924 Ref: In vitro antitumor effect of a lignan isolated from Combretum fruticosum, trachelogenin, in HCT-116 human colon cancer cells. PMID: 29174024 Ref: Codonopis bulleynana Forest ex Diels inhibits autophagy and induces apoptosis of colon cancer cells by activating the NF-kappaB signaling pathway. PMID: 29286074 Ref: Inhibition of ATG12-mediated autophagy by miR-214 enhances radiosensitivity in colorectal cancer. PMID: 29459645 Ref: Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner. PMID: 29492901 Ref: Graphene oxide sensitizes cancer cells to chemotherapeutics by inducing early autophagy events, promoting nuclear trafficking and necrosis. PMID: 29721093 Ref: Artesunate induces apoptosis and autophagy in HCT116 colon cancer cells, and autophagy inhibition enhances the artesunateinduced apoptosis. PMID: 29901098 Ref: Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells. PMID: 29928348 Ref: Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131). PMID: 30015072 Ref: Autophagy is an important action mode for functionalized selenium nanoparticles to exhibit anti-colorectal cancer activity. PMID: 30091749 Ref: Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. PMID: 30176161 Ref: Silencing of cadherin-17 enhances apoptosis and inhibits autophagy in colorectal cancer cells. PMID: 30227326 Ref: Sodium butyrate induces autophagy in colorectal cancer cells through LKB1/AMPK signaling. PMID: 30362049 Ref: Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. PMID: 30372822 Ref: The Influence of Tumor Microenvironment on ATG4D Gene Expression in Colorectal Cancer Patients. PMID: 30374741 Ref: 2-Deoxyglucose has distinct and cell line-specific effects on the survival of different cancer cells upon antitumor drug treatment. PMID: 30375744 |