Primary Site >> Colorectal Cancer
Gene >> MAD2L1
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Ref: Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. PMID: 10543255 |
Ref: Mad2 and p53 expression profiles in colorectal cancer and its clinical significance. PMID: 12970887 |
Ref: Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells. PMID: 14633654 Ref: Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. PMID: 15159543 Ref: Mad2 and p27 expression profiles in colorectal cancer and its clinical significance. PMID: 15457580 |
Ref: Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer. PMID: 17044027 Ref: c-MYC delays prometaphase by direct transactivation of MAD2 and BubR1: identification of mechanisms underlying c-MYC-induced DNA damage and chromosomal instability. PMID: 17297307 Ref: Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. PMID: 17322345 Ref: High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. PMID: 17457043 Ref: APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. PMID: 17570218 |
Ref: Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers. PMID: 18699967 |
Ref: Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2. PMID: 19261806 Ref: Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. PMID: 20032382 |
Ref: Hydrophobic bile acid-induced micronuclei formation, mitotic perturbations, and decreases in spindle checkpoint proteins: relevance to genomic instability in colon carcinogenesis. PMID: 20661832 Ref: Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer. PMID: 20811685 |
Ref: Therapeutic targeting of the mitotic spindle checkpoint through nanoparticle-mediated siRNA delivery inhibits tumor growth in vivo. PMID: 21377782 Ref: Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. PMID: 21598039 |
Ref: Withaferin A modulates the Spindle assembly checkpoint by degradation of Mad2-Cdc20 complex in colorectal cancer cell lines. PMID: 24995417 |
Ref: Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. PMID: 26009897 Ref: MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer. PMID: 26183163 |
Ref: Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities. PMID: 26889953 Ref: Identification of potential therapeutic targets for colorectal cancer by bioinformatics analysis. PMID: 28105216 |
Ref: TRAP1 protein signature predicts outcome in human metastatic colorectal carcinoma. PMID: 28177905 |
Ref: Identification of genes involved in the four stages of colorectal cancer: Gene expression profiling. PMID: 29179987 Ref: Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer. PMID: 29959920 |