Primary Site >> Colorectal Cancer
Gene >> LRP6
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Ref: The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. PMID: 15592505 |
Ref: Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. PMID: 16708370 |
Ref: Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray. PMID: 17255260 Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 |
Ref: Snail promotes Wnt target gene expression and interacts with beta-catenin. PMID: 18469861 |
Ref: Integrative genomic analyses of WNT11: transcriptional mechanisms based on canonical WNT signals and GATA transcription factors signaling. PMID: 19578797 |
Ref: LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PMID: 22615920 |
Ref: Cripto-1 enhances the canonical Wnt/beta-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. PMID: 23022962 |
Ref: Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis. PMID: 24172857 |
Ref: CD44 functions in Wnt signaling by regulating LRP6 localization and activation. PMID: 25301071 Ref: Oncogenic KRAS signalling promotes the Wnt/beta-catenin pathway through LRP6 in colorectal cancer. PMID: 25500543 Ref: Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling. PMID: 25810027 Ref: TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells. PMID: 26140605 Ref: Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. PMID: 26224368 Ref: CD44 regulates Wnt signaling at the level of LRP6. PMID: 27308483 |
Ref: Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility. PMID: 26901136 Ref: Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94. PMID: 27072698 Ref: Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth. PMID: 27401612 |
Ref: Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review. PMID: 27713038 Ref: Identification of microRNA-487b as a negative regulator of liver metastasis by regulation of KRAS in colorectal cancer. PMID: 28000854 Ref: Pattern of LRP6 gene expression in tumoral tissues of colorectal cancer. PMID: 28387660 Ref: Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer. PMID: 28521288 Ref: Gene expression profiling demonstrates WNT/beta-catenin pathway genes alteration in Mexican patients with colorectal cancer and diabetes mellitus. PMID: 29135090 Ref: LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics. PMID: 29312635 Ref: LRP6 targeting suppresses gastric tumorigenesis via P14(ARF)-Mdm2-P53-dependent cellular senescence. PMID: 29340077 |
Ref: Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC. PMID: 29408853 Ref: DKK2 imparts tumor immunity evasion through beta-catenin-independent suppression of cytotoxic immune-cell activation. PMID: 29431745 Ref: Raddeanin A inhibits growth and induces apoptosis in human colorectal cancer through downregulating the Wnt/beta-catenin and NF-kappaB signaling pathway. PMID: 29972765 Ref: In Silico studying of the whole protein structure and dynamics of Dickkopf family members showed that N terminal domain of Dickkopf 2 in contrary to other Dickkopfs facilitates its interaction with Low Density Lipoprotein Receptor Related Protein 5/6. PMID: 30035709 |