Primary Site >> Colorectal Cancer
Gene >> LOX
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Ref: Comparative antitumour activity of vinblastine-isoleucinate and related vinca alkaloids in human tumour xenografts. PMID: 1524896 |
Ref: Expression and release of plasminogen activators, their inhibitors and receptor by human tumor cell lines. PMID: 7872665 |
Ref: Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. PMID: 7853331 Ref: Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. PMID: 9816054 |
Ref: MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation. PMID: 8564968 Ref: Comparative antitumor activities of halichondrins and vinblastine against human tumor xenografts. PMID: 9414395 |
Ref: Synthesis and evaluation of novel rhodacyanine dyes that exhibit antitumor activity. PMID: 9379434 Ref: Regulation of 15-lipoxygenase expression by cytokines. PMID: 9547609 |
Ref: Inhibition of establishment of primary and micrometastatic tumors by a urokinase plasminogen activator receptor antagonist. PMID: 9502073 |
Ref: Tumor amplified protein expression therapy: Salmonella as a tumor-selective protein delivery vector. PMID: 11216671 |
Ref: In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. PMID: 11221827 Ref: Lipoxygenase modulation to reverse carcinogenesis. PMID: 11522616 |
Ref: Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors. PMID: 11807790 |
Ref: Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway. PMID: 14569062 Ref: Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. PMID: 15073046 Ref: Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells. PMID: 15141037 Ref: 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. PMID: 15165036 Ref: Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking. PMID: 15363593 |
Ref: Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. PMID: 15637091 Ref: A mechanistic study of colon cancer growth promoted by cigarette smoke extract. PMID: 16125168 |
Ref: Expression of 5-lipoxygenase in human colorectal cancer. PMID: 17072961 Ref: Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. PMID: 17121918 |
Ref: Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer. PMID: 17699764 Ref: Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells. PMID: 17880512 |
Ref: Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin. PMID: 18771933 Ref: Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. PMID: 18927292 |
Ref: Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. PMID: 19549529 Ref: Urea and carbamate derivatives of primaquine: synthesis, cytostatic and antioxidant activities. PMID: 19581098 Ref: Role of lipoxins and resolvins as anti-inflammatory and proresolving mediators in colon cancer. PMID: 19601807 Ref: Modular Cre/lox system and genetic therapeutics for colorectal cancer. PMID: 19809520 |
Ref: Three DNA methylation epigenotypes in human colorectal cancer. PMID: 20028768 Ref: Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models. PMID: 20053779 Ref: Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. PMID: 20372792 Ref: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. PMID: 20654727 |
Ref: The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. PMID: 21239473 Ref: The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. PMID: 21282564 Ref: Intestinal epithelial-specific PTEN inactivation results in tumor formation. PMID: 21836055 Ref: Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. PMID: 21846141 Ref: Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention. PMID: 21885812 |
Ref: beta-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. PMID: 22082586 Ref: Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of beta-catenin. PMID: 22115830 Ref: Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells. PMID: 23013454 Ref: beta-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin? PMID: 23033009 |
Ref: Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK. PMID: 22641216 Ref: Eicosanoid profiling in colon cancer: emergence of a pattern. PMID: 22960430 Ref: Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis. PMID: 23188504 Ref: Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. PMID: 23517721 Ref: 5-lipoxygenase antagonist therapy: a new approach towards targeted cancer chemotherapy. PMID: 23752617 Ref: Lysyl oxidase in colorectal cancer. PMID: 24008360 Ref: [Association of 5-lipoxygenase expression and clinicopathological factors in colorectal carcinoma]. PMID: 24062003 |
Ref: Evaluation of serum lysyl oxidase as a blood test for colorectal cancer. PMID: 24246612 Ref: Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities. PMID: 24295787 Ref: Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer. PMID: 24396479 Ref: Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras. PMID: 24632531 Ref: Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer. PMID: 25013352 Ref: Examining the polymorphisms in the hypoxia pathway genes in relation to outcome in colorectal cancer. PMID: 25405996 Ref: [A case of rectal cancer with brain metastasis successfully treated with combined modality therapy - a case report]. PMID: 25731322 |
Ref: Lysyl oxidase rs1800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case-control study of colorectal cancer. PMID: 25112403 Ref: 12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models. PMID: 25576922 Ref: 5-Lipoxygenase and cyclooxygenase inhibitory dammarane triterpenoid 1 from Borassus flabellifer seed coat inhibits tumor necrosis factor-alpha secretion in LPSInduced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 pancreatic cancer cells. PMID: 25642980 Ref: Improved innate immune responses by Frondanol A5, a sea cucumber extract, prevent intestinal tumorigenesis. PMID: 25657017 Ref: The usability of a 15-gene hypoxia classifier as a universal hypoxia profile in various cancer cell types. PMID: 26169282 Ref: Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. PMID: 26216432 |
Ref: Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras. PMID: 26361962 Ref: An Inducible, Large-Intestine-Specific Transgenic Mouse Model for Colitis and Colitis-Induced Colon Cancer Research. PMID: 26631394 Ref: The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. PMID: 26997150 Ref: Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice. PMID: 27016075 Ref: Lysyl Oxidase (LOX) Transcriptionally Regulates SNAI2 Expression and TIMP4 Secretion in Human Cancers. PMID: 27029493 Ref: Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese Population. PMID: 27367711 |
Ref: Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone. PMID: 27742687 Ref: Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer. PMID: 28410235 Ref: Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases. PMID: 28445728 Ref: Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients. PMID: 28947950 Ref: Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1alpha pathway. PMID: 28951129 Ref: [Expression of LOX in Colorectal Cancer Tissues and Its Relationship with Progress and Prognosis]. PMID: 29130678 Ref: Human colorectal cancer progression correlates with LOX-induced ECM stiffening. PMID: 29209148 Ref: Herbal compound Teng-Long-Bu-Zhong-Tang inhibits metastasis in human RKO colon carcinoma. PMID: 29344222 |
Ref: TEMPORARY REMOVAL: Inhibition of COX-2 and 5-LOX regulates the progression of colorectal cancer by promoting PTEN and suppressing PI3K/AKT pathway. PMID: 29339153 Ref: Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis. PMID: 29766649 Ref: Rectal insulin instillation inhibits inflammation and tumor development in chemically-induced colitis. PMID: 30137286 Ref: Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope. PMID: 30388158 |