Primary Site >> Colorectal Cancer
Gene >> LIMK1
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Ref: Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation. PMID: 20347121 |
Ref: A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability. PMID: 22883572 |
Ref: DADS downregulates the Rac1-ROCK1/PAK1-LIMK1-ADF/cofilin signaling pathway, inhibiting cell migration and invasion. PMID: 23233092 Ref: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling. PMID: 23233484 |
Ref: Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. PMID: 23585469 Ref: Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK. PMID: 24704720 |
Ref: The other face of miR-17-92a cluster, exhibiting tumor suppressor effects in prostate cancer. PMID: 27650539 |
Ref: Downregulation of LIMK1-ADF/cofilin by DADS inhibits the migration and invasion of colon cancer. PMID: 28358024 Ref: MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway. PMID: 28440035 Ref: LIM kinase 1 interacts with myosin-9 and alpha-actinin-4 and promotes colorectal cancer progression. PMID: 28664914 |
Ref: LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance. PMID: 29352327 Ref: PRP4 kinase induces actin rearrangement and epithelial-mesenchymal transition through modulation of the actin-binding protein cofilin. PMID: 29787735 Ref: Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting beta-catenin nuclear translocation. PMID: 29970879 |