Primary Site >> Liver Cancer
Gene >> LGR5
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Ref: Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. PMID: 12601349 |
Ref: Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas. PMID: 16964294 |
Ref: Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma. PMID: 19549212 |
Ref: Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts. PMID: 21937640 |
Ref: Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. PMID: 22811581 |
Ref: Transcriptional profiling identifies genes induced by hepatocyte-derived extracellular matrix in metastatic human colorectal cancer cell lines. PMID: 22930170 Ref: Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells. PMID: 23127514 |
Ref: Overexpression of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 (LGR5) Represents a Typical Wnt/beta-Catenin Pathway-Activated Hepatocellular Carcinoma. PMID: 26280006 |
Ref: Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5(+) liver cancer initiating cells by suppressing negative regulators of beta-catenin signaling. PMID: 25893304 Ref: Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5+ liver cancer initiating cells by suppressing negative regulators of beta-catenin signaling. PMID: 26062983 |
Ref: De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas. PMID: 27191501 Ref: Fibrous nests in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome. PMID: 27545991 |
Ref: miR-33a expression sensitizes Lgr5+ HCC-CSCs to doxorubicin via ABCA1. PMID: 27881008 Ref: Dishevelled-3 phosphorylation is governed by HIPK2/PP1Calpha/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. PMID: 28455968 Ref: LGR5 promotes hepatocellular carcinoma metastasis through inducting epithelial-mesenchymal transition. PMID: 28881613 |
Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR4310/LGR5/Wnt/betacatenin signaling pathway. PMID: 29956772 Ref: Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 predicts poor prognosis in hepatocellular carcinoma. PMID: 30108439 Ref: High Frequency of beta-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist. PMID: 30201494 Ref: Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/beta-Catenin Signaling. PMID: 30257989 Ref: [Expression of stem cell markers CD44 and Lgr5 in colorectal cancer and its relationship with lymph node and liver metastasis]. PMID: 30293346 |