Primary Site >> Colorectal Cancer
Gene >> LGR5
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Ref: Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. PMID: 16575208 |
Ref: Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. PMID: 18765800 Ref: Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue. PMID: 19030762 |
Ref: Stem cells, self-renewal, and differentiation in the intestinal epithelium. PMID: 18808327 Ref: Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. PMID: 19652364 Ref: New Therapeutics Targeting Colon Cancer Stem Cells. PMID: 20148131 |
Ref: Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma. PMID: 19549212 Ref: Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. PMID: 20176655 Ref: Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with beta-catenin. PMID: 20195621 Ref: Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer. PMID: 20384634 Ref: Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. PMID: 20417836 Ref: Colon cancer stem cells: promise of targeted therapy. PMID: 20420952 Ref: Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain. PMID: 20479215 Ref: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. PMID: 20691072 Ref: Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. PMID: 20826154 Ref: Molecular identification and targeting of colorectal cancer stem cells. PMID: 21311095 |
Ref: Significance of Lgr5(+ve) cancer stem cells in the colon and rectum. PMID: 21125339 Ref: Colon cancer stem cells: implications in carcinogenesis. PMID: 21196254 Ref: c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex. PMID: 21196933 Ref: Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis. PMID: 21273608 Ref: Stem cells and their implications for colorectal cancer. PMID: 21293509 Ref: Upregulated CD133 expression in tumorigenesis of colon cancer cells. PMID: 21412503 Ref: The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. PMID: 21419747 Ref: Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. PMID: 21435460 Ref: A gene signature distinguishing CD133hi from CD133- colorectal cancer cells: essential role for EGR1 and downstream factors. PMID: 21436631 Ref: LIN28B promotes colon cancer progression and metastasis. PMID: 21512136 Ref: Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer. PMID: 21577318 Ref: Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies. PMID: 21602532 Ref: LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms. PMID: 21625210 Ref: LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. PMID: 21829496 Ref: Common cancer stem cell gene variants predict colon cancer recurrence. PMID: 21918173 Ref: A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients. PMID: 21978106 Ref: Myb controls intestinal stem cell genes and self-renewal. PMID: 21997934 Ref: Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. PMID: 22056143 |
Ref: Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression. PMID: 22321022 Ref: High-fat diet alters gene expression in the liver and colon: links to increased development of aberrant crypt foci. PMID: 22373862 Ref: Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells. PMID: 22384170 Ref: P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice. PMID: 22480191 Ref: Use of multiple biomarkers for the localization and characterization of colon cancer stem cells by indirect immunocytochemistry. PMID: 22504585 Ref: Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer. PMID: 22605983 Ref: LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PMID: 22615920 Ref: Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. PMID: 22617424 Ref: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22711167 Ref: CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice. PMID: 22723265 Ref: Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. PMID: 22895187 Ref: Induction of LGR5 by H2O2 treatment is associated with cell proliferation via the JNK signaling pathway in colon cancer cells. PMID: 22923033 Ref: Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy. PMID: 22923071 Ref: EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis. PMID: 22925500 Ref: Single nucleotide polymorphisms of the adult intestinal stem cell marker Lgr5 in primary and metastatic colorectal cancer. PMID: 22937206 Ref: Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells. PMID: 22969042 Ref: LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. PMID: 23081779 Ref: Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival. PMID: 23153436 |
Ref: In situ validation of an intestinal stem cell signature in colorectal cancer. PMID: 22637696 Ref: Transcriptional profiling identifies genes induced by hepatocyte-derived extracellular matrix in metastatic human colorectal cancer cell lines. PMID: 22930170 Ref: Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy. PMID: 22986809 Ref: Differential localization of LGR5 and Nanog in clusters of colon cancer stem cells. PMID: 23098761 Ref: Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. PMID: 23142137 Ref: Celecoxib downregulates CD133 expression through inhibition of the Wnt signaling pathway in colon cancer cells. PMID: 23245395 Ref: Leucine-rich repeat-containing G protein-coupled receptor 5 expression in ductular reactions after chemotherapy for metastatic colorectal cancer. PMID: 23332089 Ref: The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. PMID: 23333391 Ref: LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs. PMID: 23349017 Ref: Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer. PMID: 23356221 Ref: Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling. PMID: 23376422 Ref: Kruppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells. PMID: 23418515 Ref: Intestinal stem cells - types and markers. PMID: 23471862 Ref: Re: (1) "differential localization of LGR5 and Nanog in clusters of colon cancer stem cells" by Amsterdam A, Raanan C, Schreiber L, Freyhan O, Fabrikant Y, Melzer E, Givol D [Acta Histochem. (2012, October 23), pii: S0065-1281(12)00112-2] and (2) "localiz PMID: 23522104 Ref: Methanolic extracts of bitter melon inhibit colon cancer stem cells by affecting energy homeostasis and autophagy. PMID: 23533514 Ref: LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/beta-Catenin Signaling. PMID: 23596566 Ref: MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells. PMID: 23619912 Ref: IFN-gamma selectively exerts pro-apoptotic effects on tumor-initiating label-retaining colon cancer cells. PMID: 23643941 Ref: ROS production and NF-kappaB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. PMID: 23665120 Ref: TLR4 activates the beta-catenin pathway to cause intestinal neoplasia. PMID: 23691015 Ref: Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs. PMID: 23736004 Ref: Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. PMID: 23744940 Ref: The other face of ROS: a driver of stem cell expansion in colorectal cancer. PMID: 23746969 Ref: AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer. PMID: 23752226 Ref: Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer. PMID: 23784051 Ref: [Lgr5 and CD44 expressions in different types of intestinal polyps and colorectal cancer]. PMID: 23895835 Ref: Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. PMID: 23916687 Ref: Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. PMID: 24009080 Ref: Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of beta-catenin/TCF transcription. PMID: 24060489 Ref: Lgr5 promotes cancer stemness and confers chemoresistance through ABCB1 in colorectal cancer. PMID: 24138824 Ref: Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1. PMID: 24185040 Ref: SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. PMID: 24185900 Ref: Differential expression and prognostic role of selected genes in colorectal cancer patients. PMID: 24222123 |
Ref: Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling. PMID: 23318432 Ref: Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. PMID: 23996931 Ref: Over-expression of LGR5 correlates with poor survival of colon cancer in mice as well as in patients. PMID: 24063790 Ref: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner. PMID: 24265293 Ref: Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4. PMID: 24277698 Ref: LGR5 positivity defines stem-like cells in colorectal cancer. PMID: 24282287 Ref: ALDH1 is an independent prognostic factor for patients with stages II-III rectal cancer after receiving radiochemotherapy. PMID: 24327017 Ref: Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5+ colonic stem cells. PMID: 24336194 Ref: The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumourigenesis. PMID: 24452072 Ref: RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer. PMID: 24476626 Ref: The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. PMID: 24532711 Ref: Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA. PMID: 24626093 Ref: Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer. PMID: 24651522 Ref: Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells. PMID: 24677446 Ref: Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities. PMID: 24708412 Ref: Expression of Lgr5, a marker of intestinal stem cells, in colorectal cancer and its clinicopathological significance. PMID: 24751002 Ref: LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells. PMID: 24789370 Ref: Lgr5 over-expression is positively related to the tumor progression and HER2 expression in stage pTNM IV colorectal cancer. PMID: 24817953 Ref: Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta. PMID: 24825889 Ref: ZNF281/ZBP-99: a new player in epithelial-mesenchymal transition, stemness, and cancer. PMID: 24838609 Ref: Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells. PMID: 24921652 Ref: The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression. PMID: 24952462 Ref: LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/beta-catenin signaling pathway in colorectal cancer cells. PMID: 25025569 Ref: Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. PMID: 25187386 Ref: Prognostic value of LGR5 in colorectal cancer: a meta-analysis. PMID: 25192390 Ref: In vivo imaging of Lgr5-positive cell populations using confocal laser endomicroscopy during early colon tumorigenesis. PMID: 25216325 Ref: Colon carcinogenesis: influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds. PMID: 25280404 Ref: Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis. PMID: 25290188 Ref: Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma. PMID: 25423035 Ref: Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells. PMID: 25483087 Ref: The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018). PMID: 25510341 Ref: Heterogeneity of the level of activity of lgr5+ intestinal stem cells. PMID: 25635248 Ref: Stem cells, colorectal cancer and cancer stem cell markers correlations. PMID: 25729599 Ref: Transcriptome profiling of LGR5 positive colorectal cancer cells. PMID: 26484096 |
Ref: Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a. PMID: 24837369 Ref: CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression. PMID: 25060070 Ref: LGR5, a relevant marker of cancer stem cells, indicates a poor prognosis in colorectal cancer patients: a meta-analysis. PMID: 25193236 Ref: Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis. PMID: 25347154 Ref: Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. PMID: 25419707 Ref: MicroRNA-100 functions as a tumor suppressor by inhibiting Lgr5 expression in colon cancer cells. PMID: 25483280 Ref: Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1. PMID: 25565667 Ref: Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells. PMID: 25611300 Ref: The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells. PMID: 25625841 Ref: Upregulation of circulating cancer stem cell marker, DCLK1 but not Lgr5, in chemoradiotherapy-treated colorectal cancer patients. PMID: 25631749 Ref: Clinical implications of intestinal stem cell markers in colorectal cancer. PMID: 25657049 Ref: LGR5 rs17109924 is a predictive genetic biomarker for time to recurrence in patients with colon cancer treated with 5-fluorouracil-based adjuvant chemotherapy. PMID: 25665511 Ref: Injury-associated reacquiring of intestinal stem cell function. PMID: 25717233 Ref: Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after gamma-irradiation through Wnt/beta-catenin pathway. PMID: 25827435 Ref: Effects of dose rates on radiation-induced replenishment of intestinal stem cells determined by Lgr5 lineage tracing. PMID: 25832104 Ref: An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. PMID: 25834110 Ref: Role of Lgr5-positive cells in colorectal cancer. PMID: 25835970 Ref: The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers. PMID: 25906747 Ref: Prospective derivation of a living organoid biobank of colorectal cancer patients. PMID: 25957691 Ref: A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells. PMID: 25977509 Ref: A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5. PMID: 26003047 Ref: Atonal homolog 1 protein stabilized by tumor necrosis factor alpha induces high malignant potential in colon cancer cell line. PMID: 26017781 Ref: KIT Signaling Promotes Growth of Colon Xenograft Tumors in Mice and Is Up-Regulated in a Subset of Human Colon Cancers. PMID: 26026391 Ref: Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine. PMID: 26046762 Ref: FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function. PMID: 26091938 Ref: LGR5 promotes the proliferation of colorectal cancer cells via the Wnt/beta-catenin signaling pathway. PMID: 26137160 Ref: Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors. PMID: 26185002 Ref: SW480 colorectal cancer cells that naturally express Lgr5 are more sensitive to the most common chemotherapeutic agents than Lgr5-negative SW480 cells. PMID: 26196680 Ref: 4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype. PMID: 26235807 Ref: DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. PMID: 26243310 Ref: Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis. PMID: 26285154 Ref: Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1. PMID: 26366338 Ref: ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer. PMID: 26367378 Ref: REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis. PMID: 26387746 Ref: Clusterin, a gene enriched in intestinal stem cells, is required for L1-mediated colon cancer metastasis. PMID: 26399194 Ref: PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells. PMID: 26399781 Ref: Obesity promotes colonic stem cell expansion during cancer initiation. PMID: 26455770 Ref: Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. PMID: 26503053 Ref: Tissue-Specific Effects of Reduced beta-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium. PMID: 26528816 Ref: Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer. PMID: 26582901 Ref: Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer. PMID: 26599100 Ref: Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer. PMID: 26631266 Ref: Intensive Immunofluorescence Staining Methods for Low Expression Protein: Detection of Intestinal Stem Cell Marker LGR5. PMID: 26633908 Ref: Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis. PMID: 26674601 Ref: A Study on the Mechanism of Low-Expressed Cancer Stem Cell Marker Lgr5 in Inhibition of the Proliferation and Invasion of Colorectal Carcinoma. PMID: 27352328 |
Ref: Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells. PMID: 25777538 Ref: Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression. PMID: 25915847 Ref: Distribution of intestinal stem cell markers in colorectal precancerous lesions. PMID: 26212207 Ref: EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer. PMID: 26283684 Ref: RNA binding protein RBM3 increases beta-catenin signaling to increase stem cell characteristics in colorectal cancer cells. PMID: 26331352 Ref: A new insight into cancer stem cell markers: Could local and circulating cancer stem cell markers correlate in colorectal cancer? PMID: 26383518 Ref: Prognostic significance of leucine-rich-repeat-containing G-protein-coupled receptor 5, an intestinal stem cell marker, in gastric carcinomas. PMID: 26386561 Ref: Cancer stem cells in human digestive tract malignancies. PMID: 26446457 Ref: CD90(+) stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer. PMID: 26595254 Ref: Homeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogen. PMID: 26717997 Ref: What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue. PMID: 26745821 Ref: Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis. PMID: 26758198 Ref: A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. PMID: 26849305 Ref: Rapid Recognition and Isolation of Live Colon Cancer Stem Cells by Using Metabolic Labeling of Azido Sugar and Magnetic Beads. PMID: 26937691 Ref: Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer. PMID: 27140312 Ref: Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response. PMID: 27143627 Ref: RSPO2 enriches LGR5(+) spheroid colon cancer stem cells and promotes its metastasis by epithelial-mesenchymal transition. PMID: 27158331 Ref: LGR5-Targeted Antibody-Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence. PMID: 27207778 Ref: Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden. PMID: 27432344 Ref: LGR5 and CD133 as prognostic and predictive markers for fluoropyrimidine-based adjuvant chemotherapy in colorectal cancer. PMID: 27435662 Ref: Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKClambda/iota. PMID: 27653691 Ref: Rapidly cycling Lgr5(+) stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk. PMID: 27831561 Ref: Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer. PMID: 27835894 Ref: Salinomycin inhibits metastatic colorectal cancer growth and interferes with Wnt/beta-catenin signaling in CD133(+) human colorectal cancer cells. PMID: 27855654 Ref: Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer. PMID: 27880730 Ref: Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment. PMID: 28119740 Ref: Targeting colorectal cancer (stem-like) cells using LGR5 directed antibody drug conjugates. PMID: 28149870 |
Ref: Differential expression of LEF1/TCFs family members in colonic carcinogenesis. PMID: 27433921 Ref: RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis. PMID: 27511199 Ref: Role of Stem Cells in Colorectal Cancer Progression and Prognostic and Predictive Characteristics of Stem Cell Markers in Colorectal Cancer. PMID: 27593447 Ref: From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells. PMID: 27664423 Ref: Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and beta-Catenin Signaling. PMID: 27983919 Ref: MIF/CD74 axis is a target for novel therapies in colon carcinomatosis. PMID: 28114961 Ref: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. PMID: 28148261 Ref: Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion. PMID: 28176811 Ref: Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis. PMID: 28351943 Ref: Visualization and targeting of LGR5(+) human colon cancer stem cells. PMID: 28355176 Ref: A distinct role for Lgr5(+) stem cells in primary and metastatic colon cancer. PMID: 28358093 Ref: Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. PMID: 28368388 Ref: SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of beta-catenin. PMID: 28390865 Ref: Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study. PMID: 28394276 Ref: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. PMID: 28459449 Ref: Elevated expression of Tie1 is accompanied by acquisition of cancer stemness properties in colorectal cancer. PMID: 28464467 Ref: The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells. PMID: 28467911 Ref: A genome editing approach to study cancer stem cells in human tumors. PMID: 28468934 Ref: Temporal and spatial changes of cells positive for stem-like markers in different compartments and stages of human colorectal adenoma-carcinoma sequence. PMID: 28484082 Ref: An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia. PMID: 28487386 Ref: Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of beta-Catenin Target Genes. PMID: 28625518 Ref: RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis. PMID: 28689994 Ref: Colorectal Cancer Stem Cells Acquire Chemoresistance Through the Upregulation of F-Box/WD Repeat-Containing Protein 7 and the Consequent Degradation of c-Myc. PMID: 28699179 Ref: MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms. PMID: 28716720 Ref: LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway. PMID: 28739799 Ref: Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells. PMID: 28862656 Ref: SATB2/beta-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer. PMID: 28887549 Ref: R-Spondin1/LGR5 Activates TGFbeta Signaling and Suppresses Colon Cancer Metastasis. PMID: 28939678 Ref: Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells. PMID: 29064439 Ref: The prognostic value of cancer stem-like cell markers SOX2 and CD133 in stage III colon cancer is modified by expression of the immune-related markers FoxP3, PD-L1 and CD3. PMID: 29102042 Ref: Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production. PMID: 29167573 Ref: Small molecules related to adrenomedullin reduce tumor burden in a mouse model of colitis-associated colon cancer. PMID: 29235493 Ref: Leucine-rich repeat-containing G protein-coupled receptor 5 and CD133 expression is associated with tumor progression and resistance to preoperative chemoradiotherapy in low rectal cancer. PMID: 29250176 |
Ref: Overexpression of HOXA4 and HOXA9 genes promotes self-renewal and contributes to colon cancer stem cell overpopulation. PMID: 28464221 Ref: Logarithmic expansion of LGR5(+) cells in human colorectal cancer. PMID: 28958617 Ref: LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity. PMID: 29149105 Ref: miR-3120-5p promotes colon cancer stem cell stemness and invasiveness through targeting Axin2. PMID: 29307822 Ref: CD133 expression predicts post-operative recurrence in patients with colon cancer with peritoneal metastasis. PMID: 29328371 Ref: A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer. PMID: 29329541 Ref: Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers. PMID: 29343849 Ref: BCN057 induces intestinal stem cell repair and mitigates radiation-induced intestinal injury. PMID: 29394953 Ref: Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene. PMID: 29425513 Ref: beta-catenin, leucine-rich repeat-containing G protein-coupled receptor 5 and GATA-binding factor 6 are associated with the normal mucosa-adenoma-adenocarcinoma sequence of colorectal tumorigenesis. PMID: 29434936 Ref: Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals. PMID: 29436668 Ref: Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoid formation in colorectal cancer. PMID: 29463813 Ref: Identification, isolation and characterization of human LGR5-positive colon adenoma cells. PMID: 29467240 Ref: TROY is a promising prognostic biomarker in patients with colorectal cancer. PMID: 29556315 Ref: Lgr5+CD44+EpCAM+ Strictly Defines Cancer Stem Cells in Human Colorectal Cancer. PMID: 29627827 Ref: Jade family PHD finger 3 (JADE3) increases cancer stem cell-like properties and tumorigenicity in colon cancer. PMID: 29660380 Ref: Evaluation of Anti-LGR5 Antibodies by ImmunoPET for Imaging Colorectal Tumors and Development of Antibody-Drug Conjugates. PMID: 29718672 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic? PMID: 29844449 Ref: BMP signaling in homeostasis, transformation and inflammatory response of intestinal epithelium. PMID: 29855793 Ref: DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene. PMID: 29869821 Ref: Cancer Stemness, Immune Cells, and Epithelial-Mesenchymal Transition Cooperatively Predict Prognosis in Colorectal Carcinoma. PMID: 29921496 Ref: Mesenchymal marker and LGR5 expression levels in circulating tumor cells correlate with colorectal cancer prognosis. PMID: 29949050 Ref: LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR4310/LGR5/Wnt/betacatenin signaling pathway. PMID: 29956772 Ref: PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer. PMID: 29970892 Ref: Colonic Stem Cells Expression of Lgr5 and CD133 Proteins as Predictive Markers in Colorectal Cancer among Egyptian Patients. PMID: 29983786 Ref: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells. PMID: 30017821 Ref: Expression Profile of LGR5 and Its Prognostic Significance in Colorectal Cancer Progression. PMID: 30036518 Ref: Heterogeneous expression of Lgr5 as a risk factor for focal invasion and distant metastasis of colorectal carcinoma. 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